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  1. Article ; Online: Stay hydrated: basolateral fluids shaping tissues.

    Schliffka, Markus Frederik / Maître, Jean-Léon

    Current opinion in genetics & development

    2019  Volume 57, Page(s) 70–77

    Abstract: During development, embryos perform a mesmerizing choreography, which is crucial for the correct shaping, positioning and function of all organs. The cellular properties powering animal morphogenesis have been the focus of much attention. In contrast, ... ...

    Abstract During development, embryos perform a mesmerizing choreography, which is crucial for the correct shaping, positioning and function of all organs. The cellular properties powering animal morphogenesis have been the focus of much attention. In contrast, much less consideration has been given to the invisible engine constituted by the intercellular fluid. Cells are immersed in fluid, of which the composition and physical properties have a considerable impact on development. In this review, we revisit recent studies from the perspective of the fluid, focusing on basolateral fluid compartments and taking the early mouse and zebrafish embryos as models. These examples illustrate how the hydration levels of tissues are spatio-temporally controlled and influence embryonic development.
    MeSH term(s) Animals ; Body Water/cytology ; Body Water/metabolism ; Embryonic Development/genetics ; Extracellular Fluid/cytology ; Extracellular Fluid/metabolism ; Mice ; Morphogenesis/genetics ; Zebrafish/genetics ; Zebrafish/growth & development
    Language English
    Publishing date 2019-08-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2019.06.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Multiscale analysis of single and double maternal-zygotic

    Schliffka, Markus Frederik / Tortorelli, Anna-Francesca / Özgüç, Özge / de Plater, Ludmilla / Polzer, Oliver / Pelzer, Diane / Maître, Jean-Léon

    eLife

    2022  Volume 11

    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.78088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multiscale analysis of single and double maternal-zygotic

    Schliffka, Markus Frederik / Tortorelli, Anna Francesca / Özgüç, Özge / de Plater, Ludmilla / Polzer, Oliver / Pelzer, Diane / Maître, Jean-Léon

    eLife

    2021  Volume 10

    Abstract: During the first days of mammalian development, the embryo forms the blastocyst, the structure responsible for implanting the mammalian embryo. Consisting of an epithelium enveloping the pluripotent inner cell mass and a fluid-filled lumen, the ... ...

    Abstract During the first days of mammalian development, the embryo forms the blastocyst, the structure responsible for implanting the mammalian embryo. Consisting of an epithelium enveloping the pluripotent inner cell mass and a fluid-filled lumen, the blastocyst results from a series of cleavage divisions, morphogenetic movements, and lineage specification. Recent studies have identified the essential role of actomyosin contractility in driving cytokinesis, morphogenesis, and fate specification, leading to the formation of the blastocyst. However, the preimplantation development of contractility mutants has not been characterized. Here, we generated single and double maternal-zygotic mutants of non-muscle myosin II heavy chains (NMHCs) to characterize them with multiscale imaging. We found that
    MeSH term(s) Animals ; Blastocyst/metabolism ; Cell Cycle ; Cell Differentiation ; Cell Division ; Cytokinesis ; Databases, Genetic ; Embryo Culture Techniques ; Female ; Gene Expression Regulation, Developmental ; Humans ; Mice, Inbred C57BL ; Mice, Transgenic ; Microscopy, Video ; Morphogenesis ; Mutation ; Myosin Heavy Chains/genetics ; Myosin Heavy Chains/metabolism ; Nonmuscle Myosin Type IIB/genetics ; Nonmuscle Myosin Type IIB/metabolism ; Time Factors ; Time-Lapse Imaging ; Mice
    Chemical Substances Myh9 protein, mouse ; Nonmuscle Myosin Type IIB (EC 3.6.1.-) ; nonmuscle myosin type IIB heavy chain (EC 3.6.1.-) ; Myosin Heavy Chains (EC 3.6.4.1)
    Language English
    Publishing date 2021-04-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.68536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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