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  1. Article ; Online: The AIDS and Cancer Specimen Resource (ACSR): HIV malignancy specimens and data available at no cost.

    Silver, Sylvia / Schmelz, Monika

    AIDS research and therapy

    2023  Volume 20, Issue 1, Page(s) 61

    Abstract: The goal of the AIDS and Cancer Specimen Resource (ACSR) is to play a major role in the advancement of HIV/AIDS cancer-related research/treatment by providing richly annotated biospecimens and data to researchers at no cost. The ACSR acquires, stores, ... ...

    Abstract The goal of the AIDS and Cancer Specimen Resource (ACSR) is to play a major role in the advancement of HIV/AIDS cancer-related research/treatment by providing richly annotated biospecimens and data to researchers at no cost. The ACSR acquires, stores, and equitably distributes these samples and associated clinical data to investigators conducting HIV/AIDS-related research, at no costs. Currently, it is the only biorepository of human biospecimens from people with HIV and cancer available to eligible researchers globally who are studying HIV associated malignancies.This review describes the history and organizational structure of the ACSR, its types of specimens in its inventory, and the process of requesting specimens. In addition, the review provides an overview of research that was performed over the last 5 years with its support and gives a summary of important new findings acquired by this research into the development of cancers in people with HIV, including both Aids-related and non-Aids-related malignancies.
    MeSH term(s) Humans ; HIV Infections/epidemiology ; Neoplasms ; Acquired Immunodeficiency Syndrome/epidemiology
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2173450-1
    ISSN 1742-6405 ; 1742-6405
    ISSN (online) 1742-6405
    ISSN 1742-6405
    DOI 10.1186/s12981-023-00558-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Letter to the Editor:

    Schmelz, Monika / Silver, Sylvia

    Biopreservation and biobanking

    2022  Volume 21, Issue 2, Page(s) 217–218

    MeSH term(s) Accreditation ; Biological Specimen Banks/standards
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Letter
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2022.0014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Biorepository best practices for research and clinical investigations.

    Sanderson-November, Micheline / Silver, Sylvia / Hooker, Vanessa / Schmelz, Monika

    Contemporary clinical trials

    2021  Volume 116, Page(s) 106572

    Abstract: Translational research requires good quality specimens to ensure the integrity of research results. Clinical research must rely not only on quality specimens, but as well on clinical annotation for consistent, accurate and verifiable scientific and ... ...

    Abstract Translational research requires good quality specimens to ensure the integrity of research results. Clinical research must rely not only on quality specimens, but as well on clinical annotation for consistent, accurate and verifiable scientific and clinical outcomes. In laboratory research performed on a specimen by a single investigator, quality control is easily maintained. In a multi-site clinical research network, the numerous steps for biospecimens from procurement through transport, processing, storage and ultimately testing requires strict standardization of operational workflows and procedures. The practices of a central biorepository can inform and contribute to best practices regarding clinical research specimen integrity for multi-site clinical research.
    MeSH term(s) Humans ; Research Personnel ; Specimen Handling/methods ; Translational Research, Biomedical
    Language English
    Publishing date 2021-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2021.106572
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    Zs.A 1581: Show issues Location:
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  4. Article ; Online: Optimizing assessment of CD30 expression in Hodgkin lymphoma by controlling for low expression.

    Sarwar, Shoib / Tome, Margaret E / Billheimer, Dean / Spier, Catherine / Smith, Catharine L / Persky, Daniel / Schmelz, Monika

    Histology and histopathology

    2023  Volume 39, Issue 3, Page(s) 319–331

    Abstract: Since the approval of brentuximab vedotin (BV), assessment of CD30 status by immunohistochemistry gained increasing importance in the clinical management of patients diagnosed with CD30-expressing lymphomas, including classical Hodgkin lymphoma (CHL). ... ...

    Abstract Since the approval of brentuximab vedotin (BV), assessment of CD30 status by immunohistochemistry gained increasing importance in the clinical management of patients diagnosed with CD30-expressing lymphomas, including classical Hodgkin lymphoma (CHL). Paradoxically, patients with low or no CD30 expression respond to BV. This discrepancy may be due to lack of standardization in CD30 staining methods. In this study, we examined 29 cases of CHL and 4 cases of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) for CD30 expression using a staining protocol that was designed to detect low CD30 expression levels, and an evaluation system similar to the Allred scoring system used for breast cancer evaluation. For CHL, 10% of cases had low scores and 3% were CD30 negative, with 3 cases in which the majority of tumor cells showed very weak staining. Unexpectedly, one of four cases of NLPHL was positive. We demonstrate intra-patient heterogeneity in CD30 expression levels and staining patterns in tumor cells. Three CHL cases with weak staining may have been missed without the use of control tissue for low expression. Thus, standardization of CD30 immunohistochemical staining with use of known low-expressing controls may aid in proper CD30 assessment and subsequent therapeutic stratification of patients.
    MeSH term(s) Humans ; Brentuximab Vedotin/therapeutic use ; Diagnosis, Differential ; Hodgkin Disease/diagnosis ; Hodgkin Disease/drug therapy ; Hodgkin Disease/pathology ; Immunohistochemistry ; Staining and Labeling
    Chemical Substances Brentuximab Vedotin (7XL5ISS668) ; TNFSF8 protein, human
    Language English
    Publishing date 2023-06-21
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 83911-5
    ISSN 1699-5848 ; 0213-3911
    ISSN (online) 1699-5848
    ISSN 0213-3911
    DOI 10.14670/HH-18-644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Plan for Emergency Shutdown and Reopening for a Consortium of Biobanks.

    Schmelz, Monika / Sanderson-November, Micheline / Humeida, Razan / Cloete, Melissa / Mims, Martha / Castro, Patricia / Leong, Alan / Wisner, Lee / Silver, Sylvia

    Biopreservation and biobanking

    2021  Volume 19, Issue 5, Page(s) 394–398

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Biological Specimen Banks ; COVID-19 ; Emergencies ; Humans ; Pandemics ; SARS-CoV-2 ; United States
    Language English
    Publishing date 2021-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2021.0038
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  6. Article: Langerhans Cell Histiocytosis Shows Distinct Cytoplasmic Expression of Major Histocompatibility Class II Antigens.

    Redd, Lucas / Schmelz, Monika / Burack, W Richard / Cook, James R / Day, Antony W / Rimsza, Lisa

    Journal of hematopathology

    2016  Volume 9, Issue 3, Page(s) 107–112

    Abstract: Objectives: Langerhans cell histiocytosis (LCH) is a monoclonal proliferation of antigen presenting cells (APC). In benign APCs, antigen loading occurs in the Major Histocompatibility class II (MHCII)-lysosomal compartment of the endocytic pathway ... ...

    Abstract Objectives: Langerhans cell histiocytosis (LCH) is a monoclonal proliferation of antigen presenting cells (APC). In benign APCs, antigen loading occurs in the Major Histocompatibility class II (MHCII)-lysosomal compartment of the endocytic pathway followed by transport to the cell surface upon antigen stimulation. The pattern of MHC II expression in LCH is not well characterized.
    Methods: The cellular localization of MHCII was determined using immunohistochemisty (IHC). Staining pattern for the representative MHCII molecule, HLA-DR, (cell surface, cytoplasmic granular, or cytoplasmic globular) and intensity (0 to 3+) were recorded for normal tissues and 44 LCH samples along with available clinicopathologic features. Results were confirmed with a different antibody to confirm the appearance.
    Results: In the normal tissue survey, strong HLA-DR cell surface expression was present on APCs, benign B cells, some T cells, and pulmonary macrophages. A granular cytoplasmic staining pattern (without surface expression) was seen in benign Langerhans cells (LCs) in the skin and histiocytes. Strikingly, all 44 LCH samples demonstrated both cytoplasmic granular and an unusual "globular" staining pattern with no surface staining.
    Conclusion: This is the first report of a highly specific HLA-DR staining pattern in LCH detected by IHC. The cytoplasmic perinuclear globular localization of MHCII may possibly be useful in diagnostics and may result from an immature/antigen-naïve differentiation state of the neoplastic cell.
    Language English
    Publishing date 2016-03-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2438687-X
    ISSN 1865-5785 ; 1868-9256
    ISSN (online) 1865-5785
    ISSN 1868-9256
    DOI 10.1007/s12308-016-0272-9
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  7. Article: Pak2 regulates myeloid-derived suppressor cell development in mice.

    Zeng, Yi / Hahn, Seongmin / Stokes, Jessica / Hoffman, Emely A / Schmelz, Monika / Proytcheva, Maria / Chernoff, Jonathan / Katsanis, Emmanuel

    Blood advances

    2017  Volume 1, Issue 22, Page(s) 1923–1933

    Abstract: Myeloid-derived suppressor cells (MDSCs) are ... ...

    Abstract Myeloid-derived suppressor cells (MDSCs) are CD11b
    Language English
    Publishing date 2017-10-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2876449-3
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2017007435
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  8. Article ; Online: A Phase II Exploratory Study of PXD-101 (Belinostat) Followed by Zevalin in Patients with Relapsed Aggressive High-Risk Lymphoma.

    Puvvada, Soham D / Guillén-Rodríguez, José M / Rivera, Xavier I / Heard, Kara / Inclan, Lora / Schmelz, Monika / Schatz, Jonathan H / Persky, Daniel O

    Oncology

    2017  Volume 93, Issue 6, Page(s) 401–405

    Abstract: Objective: Aggressive lymphomas (aNHL) including diffuse large B-cell lymphoma (DLBCL) have poor outcomes in relapsed refractory patients. Prior studies have demonstrated that loss of major histocompatibility complex class II (MHCII) expression in DLBCL ...

    Abstract Objective: Aggressive lymphomas (aNHL) including diffuse large B-cell lymphoma (DLBCL) have poor outcomes in relapsed refractory patients. Prior studies have demonstrated that loss of major histocompatibility complex class II (MHCII) expression in DLBCL is associated with poor survival. The objective of this single-arm phase II study was to evaluate if PXD-101 would increase MHCII expression, synergize with Zevalin, and improve clinical outcomes.
    Methods: This was a single-center open-label phase II trial (NCT01686165) geared toward heavily pretreated patients with CD20-positive aNHL. The primary endpoint was overall response rate (ORR) in aNHL patients treated with 2 cycles of PXD-101 followed by restaging CT and 1 cycle of Zevalin.
    Results: Five patients were enrolled, and all were heavily pretreated. Therapy was well tolerated, with nausea and vomiting being the most frequent adverse events. All patients progressed after receiving therapy; the study did not achieve the required ORR to proceed to the next stage.
    Conclusion: The pleotropic effects of histone deacetylase inhibition and lack of clinical biomarkers have precluded a priori identification of responding patients. Thus, while we report a negative trial of PXD-101 in combination with Zevalin, this study highlights the importance of a clinically feasible biomarker.
    MeSH term(s) Aged ; Antibodies, Monoclonal/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Histone Deacetylase Inhibitors/administration & dosage ; Humans ; Hydroxamic Acids/administration & dosage ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Male ; Sulfonamides/administration & dosage
    Chemical Substances Antibodies, Monoclonal ; Histone Deacetylase Inhibitors ; Hydroxamic Acids ; Sulfonamides ; ibritumomab tiuxetan (4Q52C550XK) ; belinostat (F4H96P17NZ)
    Language English
    Publishing date 2017-09-05
    Publishing country Switzerland
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 250101-6
    ISSN 1423-0232 ; 0030-2414
    ISSN (online) 1423-0232
    ISSN 0030-2414
    DOI 10.1159/000479230
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  9. Article ; Online: Lack and/or aberrant localization of major histocompatibility class II (MHCII) protein in plasmablastic lymphoma.

    Schmelz, Monika / Montes-Moreno, Santiago / Piris, Miguel / Wilkinson, Sarah T / Rimsza, Lisa M

    Haematologica

    2012  Volume 97, Issue 10, Page(s) 1614–1616

    MeSH term(s) CD8 Antigens/metabolism ; HLA-DR Antigens/metabolism ; Histocompatibility Antigens Class II/metabolism ; Humans ; Immunohistochemistry ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/metabolism
    Chemical Substances CD8 Antigens ; HLA-DR Antigens ; Histocompatibility Antigens Class II
    Language English
    Publishing date 2012-06-11
    Publishing country Italy
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2011.060186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Integrin-dependent amplification of the G2 arrest induced by ionizing radiation.

    Kremer, Celeste L / Schmelz, Monika / Cress, Anne E

    The Prostate

    2006  Volume 66, Issue 1, Page(s) 88–96

    Abstract: The progressive loss of laminin 5 and the alpha6beta4 integrin is a characteristic of the transition of prostatic intraepithelial neoplasia (PIN) to invasive human prostate cancer. Our objective was to determine if the loss of the interaction with ... ...

    Abstract The progressive loss of laminin 5 and the alpha6beta4 integrin is a characteristic of the transition of prostatic intraepithelial neoplasia (PIN) to invasive human prostate cancer. Our objective was to determine if the loss of the interaction with laminin 5 would influence the ability of human epithelial cells to respond to DNA damage. Three cellular damage responses to ionizing radiation (IR) were analyzed including G2 progression, cdc2 phosphorylation, and cell survival. The adhesion of normal human prostate epithelial cells to laminin 5 amplified the G2 arrest induced by IR, and depends on a known cell binding domain of laminin 5. The alteration of G2 arrest was confirmed by an inhibition of phospho-cdc2 nuclear translocation. In contrast, a prostate epithelial cancer cell line blocked in G2 independent of adhesion to laminin 5. The survival of these cell lines in response to IR was unaffected by adhesion to laminin 5. These results suggest that cell adhesion to laminin 5 in normal cells will amplify the IR induced G2 cell cycle progression block without altering cell survival. The loss of laminin 5 and the alpha6beta4 integrin in PIN lesions may contribute to the selection and progression of genetically unstable cell types via attenuation of a DNA damage induced G2 arrest.
    MeSH term(s) Cell Adhesion ; Cell Line ; DNA Damage ; Dose-Response Relationship, Radiation ; Epithelial Cells/physiology ; Epithelial Cells/radiation effects ; G2 Phase/physiology ; G2 Phase/radiation effects ; Humans ; Integrin alpha6beta4/physiology ; Integrins/physiology ; Male ; Prostate/cytology ; Prostate/physiology ; Prostate/radiation effects ; Radiation, Ionizing
    Chemical Substances Integrin alpha6beta4 ; Integrins
    Language English
    Publishing date 2006-01-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 604707-5
    ISSN 1097-0045 ; 0270-4137
    ISSN (online) 1097-0045
    ISSN 0270-4137
    DOI 10.1002/pros.20316
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