Article ; Online: Acetone compression improves lymph node yield and metastasis detection in colorectal cancer.
Clinical & experimental metastasis
2024 Volume 41, Issue 1, Page(s) 45–53
Abstract: Lymph node status is one of the most important prognostic factors in colorectal cancer, and accurate pathological nodal staging and detection of lymph node metastases is crucial for determination of post-operative management. Current guidelines, ... ...
| Abstract | Lymph node status is one of the most important prognostic factors in colorectal cancer, and accurate pathological nodal staging and detection of lymph node metastases is crucial for determination of post-operative management. Current guidelines, including the TNM staging system and European Society for Medical Oncology (ESMO) guidelines, recommend examination of at least 12 lymph nodes. However, identification of an adequate number of lymph nodes can be challenging, especially in the setting of neoadjuvant treatment, which may reduce nodal size. In this study, we investigated 384 colorectal cancer resections that were processed at our department of pathology between January 2012 and December 2022, in which the number of detected lymph nodes was less than 12 subsequent to conventional preparation of mesocolic fat tissue. By means of acetone compression, lymph node harvest increased significantly (p < 0.0001), and the intended number of ≥ 12 lymph nodes was achieved in 98% of resection specimens. The number of nodal positive cases increased significantly from n = 95 (24.7%) before versus n = 131 (34.1%) after acetone compression due to additionally identified lymph node metastases (p < 0.001). In 36 patients (9.4%) initially considered as nodal negative, acetone compression led to a staging adjustment to a nodal positive category and thereby drove a recommendation to offer post-operative therapy. In conclusion, acetone compression is a reliable and useful method implementable in routine surgical pathology for the retrieval of lymph nodes in colorectal cancer specimen, allowing for an adequate lymph node sampling and an increase in nodal staging reliability. |
|---|---|
| MeSH term(s) | Humans ; Lymphatic Metastasis/pathology ; Acetone ; Reproducibility of Results ; Colorectal Neoplasms/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Neoplasm Staging ; Lymph Node Excision |
| Chemical Substances | Acetone (1364PS73AF) |
| Language | English |
| Publishing date | 2024-01-04 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 604952-7 |
| ISSN | 1573-7276 ; 0262-0898 |
| ISSN (online) | 1573-7276 |
| ISSN | 0262-0898 |
| DOI | 10.1007/s10585-023-10259-x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1855: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.