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Article ; Conference proceedings: CONTRAST MEDIUM INJECTION THROUGH HOT-AXIOS STENT: SMALL TRICK, GREAT SAFETY FOR ENDOSCOPIC ULTRASOUND-GUIDED GASTROENTEROSTOMY (PRELIMINARY RESULTS)

Heilmaier, M. / Schmid, R.M. / Abdelhafez, M.

2022 Volume 54, Issue S 01

Event/congress	ESGE Days 2022, Prague, Czech Republic, 2022-04-28
Language	English
Publishing date	2022-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0042-1744985
Database	Thieme publisher's database

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Article: Einführung zum Thema: Pankreaserkrankungen

Schmid, R. M. / Fried, M.

Der Gastroenterologe

2018 Volume 13, Issue 6, Page(s) 409

Language	German
Document type	Article
ZDB-ID	2240307-3
ISSN	1861-9681
Database	Current Contents Medicine

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Article ; Online: Erstbeschreibung der Krankheit «Kontagiöse ovine digitale Dermatitis» in der Schweiz.

Alsaaod, M / Schmid, R M / Zwahlen, N / Soto, S / Wildi, N / Seuberlich, T / Steiner, A

Schweizer Archiv fur Tierheilkunde

2022 Volume 164, Issue 12, Page(s) 851–859

Abstract: Introduction: Contagious ovine digital dermatitis (CODD) is an emerging infectious foot disease in sheep. To date, CODD has been described in Great Britain, Ireland, Sweden and Germany and now in Switzerland for the first time. Unlike foot rot, the CODD ...

Title translation	First case description of contagious ovine digital dermatitis in Switzerland.
Abstract	Introduction: Contagious ovine digital dermatitis (CODD) is an emerging infectious foot disease in sheep. To date, CODD has been described in Great Britain, Ireland, Sweden and Germany and now in Switzerland for the first time. Unlike foot rot, the CODD lesions do not spread from the interdigital space, but usually begin at the dorsal/abaxial coronary band. The changes can spread to the hoof wall and the sole and finally can lead to exungulation, similar to foot rot. Treponema spp. are often found in CODD lesions analogous to digital dermatitis (Mortellaro's disease) in cattle. Involvement of Dichelobacter nodosus (D. nodosus) is considered a risk factor, but the presence of the bacterium is not mandatory. In February 2022, ulcerative lesions in the dorso-axial coronary band area were noticed on both claws of the left forelimb in an ewe. Histology of the biopsy showed hyperkeratosis and erosion with exocytosis and crust formation. Treponema spp. PCR and fluorescence in situ hybridization (FISH) were positive for Treponema phylotype 1 (PT1). In addition, D. nodosus and Porphyromonas levii could be detected in the biopsy using PCR. A single local application of chlortetracycline spray led to clinical healing within two weeks, no recurrence was seen within the following two months. Three control sheep, which were kept together with the diseased sheep, did not show any clinical signs of CODD. Treponema spp could not be found in interdigital and coronary band biopsies by PCR or FISH. This is the first description of CODD in Switzerland and aims to sensitize veterinarians to CODD as a differential diagnosis for foot diseases in sheep.
MeSH term(s)	Animals ; Female ; Dichelobacter nodosus ; Digital Dermatitis/diagnosis ; Digital Dermatitis/drug therapy ; Foot Rot/diagnosis ; Foot Rot/drug therapy ; In Situ Hybridization, Fluorescence/veterinary ; Sheep ; Sheep Diseases/diagnosis ; Sheep Diseases/drug therapy ; Switzerland ; Treponema/genetics
Language	German
Publishing date	2022-12-01
Publishing country	Switzerland
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	391726-5
ISSN	1664-2848 ; 0036-7281
ISSN (online)	1664-2848
ISSN	0036-7281
DOI	10.17236/sat00378
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Conference proceedings: A NEW ENDOSCOPIC CLASSIFICATION SCORE SYSTEM FOR SERRATED ADENOMAS IN THE COLORECTUM – THE EUROPEAN SERRATED POLYP CLASSIFICATION SCORE (ESCO)

Klare, P. / Kainz, F. / Haller, B. / Rath, T. / Yamamoto, S. / Schmid, R.M.

Endoscopy

2022 Volume 54, Issue S 01

Event/congress	ESGE Days 2022, Prague, Czech Republic, 2022-04-28
Language	English
Publishing date	2022-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0042-1744700
Database	Thieme publisher's database

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Article ; Online: Invasive pulmonary aspergillosis in severe coronavirus disease 2019 pneumonia.

Lahmer, T / Rasch, S / Spinner, C / Geisler, F / Schmid, R M / Huber, W

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2020 Volume 26, Issue 10, Page(s) 1428–1429

MeSH term(s)	Acute Kidney Injury/complications ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/microbiology ; Acute Kidney Injury/virology ; Aged ; Aged, 80 and over ; Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; Biomarkers/blood ; Bronchoalveolar Lavage Fluid/chemistry ; C-Reactive Protein/metabolism ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/microbiology ; Coronavirus Infections/virology ; Disease Progression ; Fatal Outcome ; Humans ; Interleukin-6/blood ; Invasive Pulmonary Aspergillosis/complications ; Invasive Pulmonary Aspergillosis/diagnosis ; Invasive Pulmonary Aspergillosis/microbiology ; Invasive Pulmonary Aspergillosis/virology ; Male ; Mannans/blood ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/microbiology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/complications ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/microbiology ; Severe Acute Respiratory Syndrome/virology
Chemical Substances	Biomarkers ; IL6 protein, human ; Interleukin-6 ; Mannans ; galactomannan (11078-30-1) ; C-Reactive Protein (9007-41-4)
Keywords	covid19
Language	English
Publishing date	2020-06-02
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2020.05.032
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.MO 284: Show issues

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Article ; Online: Adjunctive Hydrocortisone Improves Hemodynamics in Critically Ill Patients with Septic Shock: An Observational Study Using Transpulmonary Thermodilution.

Jochheim, Leonie / Jochheim, David / Habenicht, Livia / Herner, Alexander / Ulrich, Jörg / Wiessner, Johannes / Heilmaier, Markus / Rasch, Sebastian / Schmid, R M / Lahmer, T / Mayr, Ulrich

Journal of intensive care medicine

2023 Volume 38, Issue 8, Page(s) 717–726

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Shock, Septic ; Hydrocortisone/therapeutic use ; Thermodilution/methods ; Critical Illness/therapy ; Hemodynamics ; Norepinephrine ; Vasoconstrictor Agents/therapeutic use ; Vasoconstrictor Agents/pharmacology
Chemical Substances	Hydrocortisone (WI4X0X7BPJ) ; Norepinephrine (X4W3ENH1CV) ; Vasoconstrictor Agents
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	632828-3
ISSN	1525-1489 ; 0885-0666
ISSN (online)	1525-1489
ISSN	0885-0666
DOI	10.1177/08850666231160664
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rapid point-of-care detection of SARS-CoV-2 infection in exhaled breath using ion mobility spectrometry: a pilot study.

Voit, Florian / Erber, J / Feuerherd, M / Fries, H / Bitterlich, N / Diehl-Wiesenecker, E / Gladis, S / Lieb, J / Protzer, U / Schneider, J / Geisler, F / Somasundaram, R / Schmid, R M / Bauer, W / Spinner, C D

European journal of medical research

2023 Volume 28, Issue 1, Page(s) 318

Abstract: Background: An effective testing strategy is essential for pandemic control of the novel Coronavirus disease 2019 (COVID-19) caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Breath gas analysis can expand the ... ...

Abstract	Background: An effective testing strategy is essential for pandemic control of the novel Coronavirus disease 2019 (COVID-19) caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Breath gas analysis can expand the available toolbox for diagnostic tests by using a rapid, cost-beneficial, high-throughput point-of-care test. We conducted a bi-center clinical pilot study in Germany to evaluate breath gas analysis using multi-capillary column ion mobility spectrometry (MCC-IMS) to detect SARS-CoV-2 infection. Methods: Between September 23, 2020, and June 11, 2021, breath gas measurements were performed on 380 patients (SARS-CoV-2 real-time polymerase chain reaction (PCR) positive: 186; PCR negative: 194) presenting to the emergency department (ED) with respiratory symptoms. Results: Breath gas analysis using MCC-IMS identified 110 peaks; 54 showed statistically significant differences in peak intensity between the SARS-CoV-2 PCR-negative and PCR-positive groups. A decision tree analysis classification resulted in a sensitivity of 83% and specificity of 86%, but limited robustness to dataset changes. Modest values for the sensitivity (74%) and specificity (52%) were obtained using linear discriminant analysis. A systematic search for peaks led to a sensitivity of 77% and specificity of 67%; however, validation by transferability to other data is questionable. Conclusions: Despite identifying several peaks by MCC-IMS with significant differences in peak intensity between PCR-negative and PCR-positive samples, finding a classification system that allows reliable differentiation between the two groups proved to be difficult. However, with some modifications to the setup, breath gas analysis using MCC-IMS may be a useful diagnostic toolbox for SARS-CoV-2 infection. Trial registration: This study was registered at ClinicalTrials.gov on September 21, 2020 (NCT04556318; Study-ID: HC-N-H-2004).
MeSH term(s)	Humans ; COVID-19/diagnosis ; Point-of-Care Systems ; SARS-CoV-2 ; Pilot Projects ; Ion Mobility Spectrometry
Language	English
Publishing date	2023-09-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-023-01284-3
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Article ; Conference proceedings: Computer assisted measuring of colorectal polyps (The CAMP Study)

Jung, M. P. / Mukul, R. Soberanis / Hasenöhrl, M. / Boedeker, S. / Von Delius, S. / Schmid, R. M. / Klare, P.

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765360
Database	Thieme publisher's database

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Article ; Online: A proof of concept study for the differentiation of SARS-CoV-2, hCoV-NL63, and IAV-H1N1 in vitro cultures using ion mobility spectrometry.

Feuerherd, M / Sippel, A-K / Erber, J / Baumbach, J I / Schmid, R M / Protzer, U / Voit, F / Spinner, C D

Scientific reports

2021 Volume 11, Issue 1, Page(s) 20143

Abstract: Rapid, high-throughput diagnostic tests are essential to decelerate the spread of the novel coronavirus disease 2019 (COVID-19) pandemic. While RT-PCR tests performed in centralized laboratories remain the gold standard, rapid point-of-care antigen tests ...

Abstract	Rapid, high-throughput diagnostic tests are essential to decelerate the spread of the novel coronavirus disease 2019 (COVID-19) pandemic. While RT-PCR tests performed in centralized laboratories remain the gold standard, rapid point-of-care antigen tests might provide faster results. However, they are associated with markedly reduced sensitivity. Bedside breath gas analysis of volatile organic compounds detected by ion mobility spectrometry (IMS) may enable a quick and sensitive point-of-care testing alternative. In this proof-of-concept study, we investigated whether gas analysis by IMS can discriminate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from other respiratory viruses in an experimental set-up. Repeated gas analyses of air samples collected from the headspace of virus-infected in vitro cultures were performed for 5 days. A three-step decision tree using the intensities of four spectrometry peaks correlating to unidentified volatile organic compounds allowed the correct classification of SARS-CoV-2, human coronavirus-NL63, and influenza A virus H1N1 without misassignment when the calculation was performed with data 3 days post infection. The forward selection assignment model allowed the identification of SARS-CoV-2 with high sensitivity and specificity, with only one of 231 measurements (0.43%) being misclassified. Thus, volatile organic compound analysis by IMS allows highly accurate differentiation of SARS-CoV-2 from other respiratory viruses in an experimental set-up, supporting further research and evaluation in clinical studies.
MeSH term(s)	Animals ; Antigens, Viral/isolation & purification ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Serological Testing/instrumentation ; COVID-19 Serological Testing/methods ; Chlorocebus aethiops ; Coronavirus NL63, Human/immunology ; Coronavirus NL63, Human/isolation & purification ; Diagnosis, Differential ; High-Throughput Screening Assays/instrumentation ; High-Throughput Screening Assays/methods ; Humans ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza A Virus, H1N1 Subtype/isolation & purification ; Ion Mobility Spectrometry ; Point-of-Care Testing ; Proof of Concept Study ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Vero Cells
Chemical Substances	Antigens, Viral
Language	English
Publishing date	2021-10-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-99742-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical characteristics and outcome of patients with enterococcal liver abscess.

Große, K / Ohm, D / Würstle, S / Brozat, J F / Schmid, R M / Trautwein, C / Stallmach, A / Bruns, T / Reuken, Philipp A

Scientific reports

2021 Volume 11, Issue 1, Page(s) 22265

Abstract: Epidemiology of bacteria isolated from pyogenic liver abscesses change, and an increase in enterococci has been reported in European hospitals. The aim of this study was to investigate the clinical characteristics and outcome of enterococcal PLA. We ... ...

Abstract	Epidemiology of bacteria isolated from pyogenic liver abscesses change, and an increase in enterococci has been reported in European hospitals. The aim of this study was to investigate the clinical characteristics and outcome of enterococcal PLA. We performed a retrospective analysis of patients with microbiologically confirmed PLA at three German university centers. Indicators of enterococcal PLA were determined using binary logistic regression, and survival analysis was performed using Kaplan-Meier statistics and Cox regression analysis. Enterococci were isolated in 51/133 (38%) patients with PLA. Patients with enterococcal PLA had smaller abscess diameter (4.8 vs. 6.7 cm, p = 0.03) than patients with non-enterococcal PLA, but had more frequent polymicrobial culture results. In univariate logistic regression analysis, alcohol abuse (OR 3.94, 95% CI 1.24-12.49, p = 0.02), hepatobiliary malignancies (OR 3.90, 95% CI 1.86-8.18, p < 0.001) and cirrhosis (OR 6.36, 95% CI 1.27-31.96, p = 0.02) were associated with enterococcal PLA. Patients with enterococcal PLA had a higher mortality than patients with non-enterococcal PLA (hazard ratio 2.92; 95% confidence interval 1.09-7.80; p = 0.03), which remained elevated even after excluding patients with hepatobiliary malignancies, cirrhosis, and transplant recipients in a sensitivity analysis. The increased mortality was associated with non-fecal enterococci but not in patients with Enterococcus faecalis. In this retrospective, multicenter study, enterococcal PLA was common and indicated an increased risk of mortality, underscoring the need for close clinical monitoring and appropriate treatment protocols in these patients.
MeSH term(s)	Aged ; Aged, 80 and over ; Comorbidity ; Cross-Sectional Studies ; Disease Management ; Disease Susceptibility ; Enterococcus ; Female ; Germany/epidemiology ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Liver Abscess, Pyogenic/diagnosis ; Liver Abscess, Pyogenic/epidemiology ; Liver Abscess, Pyogenic/microbiology ; Male ; Middle Aged ; Patient Outcome Assessment ; Prognosis ; Retrospective Studies ; Symptom Assessment
Language	English
Publishing date	2021-11-15
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-01620-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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