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Article ; Online: [No title information]

Schmid, Roland M

2021 Volume 71, Issue S 01, Page(s) S19–S20

Title translation	Gastrointestinale Onkologie – Therapiestrategien der Zukunft.
MeSH term(s)	Medical Oncology
Language	German
Publishing date	2021-11-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2703847-6
ISSN	2194-9387 ; 2194-9379
ISSN (online)	2194-9387
ISSN	2194-9379
DOI	10.1055/a-1606-5872
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: „Ich habe ungewollt abgenommen“.

Phillip, Veit / Schmid, Roland M / Geisler, Fabian

MMW Fortschritte der Medizin

2024 Volume 166, Issue 6, Page(s) 42–45

Title translation	I am losing weight unintentionally.
MeSH term(s)	Humans ; Weight Loss
Language	German
Publishing date	2024-04-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1478211-x
ISSN	1613-3560 ; 1438-3276
ISSN (online)	1613-3560
ISSN	1438-3276
DOI	10.1007/s15006-024-3713-x
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Article: Gastrointestinale Onkologie – Therapiestrategien der Zukunft

Schmid, Roland M.

Drug Research

2021 Volume 71, Issue S 01, Page(s) S19–S20

Language	German
Publishing date	2021-11-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2703847-6
ISSN	2194-9387 ; 2194-9379
ISSN (online)	2194-9387
ISSN	2194-9379
DOI	10.1055/a-1606-5872
Database	Thieme publisher's database

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Article: Evolving Treatment Paradigms for Pancreatic Cancer.

Abbassi, Rami / Schmid, Roland M

Visceral medicine

2019 Volume 35, Issue 6, Page(s) 362–372

Abstract: Background: Pancreatic adenocarcinoma is an extremely aggressive tumor which is supposed to become the second deadliest malignancy in 2030. For a long time the possibilities to treat this complex disease were very limited.: Summary: In the last years ...

Abstract	Background: Pancreatic adenocarcinoma is an extremely aggressive tumor which is supposed to become the second deadliest malignancy in 2030. For a long time the possibilities to treat this complex disease were very limited. Summary: In the last years the development of new chemotherapeutic regimens has led to a better outcome in the ad-juvant, neoadjuvant, and palliative setting. Furthermore, progress in sequencing technologies has enabled a detailed investigation of the genetic alterations, mutational burden, expression pattern, and stroma composition in pancreatic cancer and led to the identification of subtypes of this disease. Messages: This analysis will increase our understanding of tumor heterogeneity and hopefully translate into new potential targets, biomarkers, and the development of individual therapeutic approaches in the future.
Language	English
Publishing date	2019-11-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2850733-2
ISSN	2297-475X ; 2297-4725
ISSN (online)	2297-475X
ISSN	2297-4725
DOI	10.1159/000503797
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Herpes Simplex Virus Bronchopneumonitis in Critically Ill Patients with Acute on Chronic Liver Failure: A Retrospective Analysis.

Dibos, Miriam / Triebelhorn, Julian / Schneider, Jochen / Rasch, Sebastian / Schmid, Roland M / Lahmer, Tobias / Mayr, Ulrich

Viruses

2024 Volume 16, Issue 3

Abstract: 1) Background: Critically ill patients are frequently diagnosed with pulmonary Herpes simplex virus-1 (HSV) reactivation, which then can lead to HSV bronchopneumonitis and is associated with higher mortality and longer mechanical ventilation. For the ... ...

Abstract	(1) Background: Critically ill patients are frequently diagnosed with pulmonary Herpes simplex virus-1 (HSV) reactivation, which then can lead to HSV bronchopneumonitis and is associated with higher mortality and longer mechanical ventilation. For the particular subgroup of critically ill patients with acute on chronic liver failure (ACLF), however, the impact of HSV reactivation is unknown. We investigated the impact of HSV reactivation in these patients. (2) Methods: We conducted a retrospective analysis, evaluating data from 136 mechanically ventilated patients with ACLF between January 2016 and August 2023. Clinical parameters were compared between patients with and without HSV bronchopneumonitis. (3) Results: 10.3% were diagnosed with HSV bronchopneumonitis (HSV group). Mortality did not differ between the HSV and non-HSV group (85.7% vs. 75.4%,
MeSH term(s)	Humans ; Acute-On-Chronic Liver Failure ; Retrospective Studies ; Critical Illness ; Herpesvirus 1, Human ; Disease Progression ; Herpes Simplex
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16030419
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of a questionnaire to assess the indication for screening colonoscopy for asymptomatic patients.

Phillip, Veit / Hapfelmeier, Alexander / Walter, Benjamin / Schmid, Roland M / Rasch, Sebastian

Zeitschrift fur Gastroenterologie

2023

Abstract: Introduction: Colorectal cancer is the second most common cause of cancer death worldwide. Screening colonoscopy is a very effective measure to prevent colorectal cancer and can reduce mortality at the population level. However, the participation rates ... ...

Title translation	Evaluierung eines Fragebogens zur Abschätzung der Indikation für eine Vorsorgekoloskopie bei asymptomatischen Patienten.
Abstract	Introduction: Colorectal cancer is the second most common cause of cancer death worldwide. Screening colonoscopy is a very effective measure to prevent colorectal cancer and can reduce mortality at the population level. However, the participation rates of screening programs are low.To provide easily accessible information on screening colonoscopy and to increase the participation rates of screening programs, we developed a questionnaire for asymptomatic patients based on the German guidelines to assess the indication for screening colonoscopy. We evaluated the questionnaire with reference to the indications given by specialists in gastroenterology. Methods: Patients who visited a specialist in gastroenterology in an outpatient clinic of a tertiary hospital for other reasons than a colonoscopy were eligible for the study. A maximum of seven questions to assess the indication for screening colonoscopy were answered by the patients. Afterward, the indication for screening colonoscopy was given or not by a specialist in gastroenterology. The accuracy of the questionnaire was measured in terms of sensitivity, specificity, and predictive values. Results: In total, 335 patients were included in the analyses, of whom 50 and 285 patients were given and were not given an indication for screening colonoscopy by the specialists, respectively. In 0/50 patients, the questionnaire was false negative and in 8/285 patients false positive. Thus, the questionnaire had a sensitivity of 100% (95% confidence interval: 93-100%), a specificity of 97% (95-99%), a negative predictive value of 100% (99-100%), and a positive predictive value of 86% (75-94%).A subgroup analysis including patients who had never had a colonoscopy (n=109) showed comparable results: sensitivity of 100% (92-100%), specificity of 92% (83-97%), negative predictive value of 100% (94-100%), and positive predictive value of 90% (87-97%). Conclusion: The self-assessment questionnaire for asymptomatic individuals to assess the recommendation for screening colonoscopy is very sensitive and specific compared to a specialist in gastroenterology.The questionnaire can be found at: https://www.interdisziplinaere-endoskopie.mri.tum.de/de/infos-patienten/index.php.
Language	English
Publishing date	2023-10-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-2181-1706
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 111: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 111/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article: EASIX Is an Accurate and Easily Available Prognostic Score in Critically Ill Patients with Advanced Liver Disease.

Schult, David / Rasch, Sebastian / Schmid, Roland M / Lahmer, Tobias / Mayr, Ulrich

Journal of clinical medicine

2023 Volume 12, Issue 7

Abstract: Acute-on-chronic liver failure (ACLF) is associated with high mortality. Objective prognostic scores are important for treatment decisions. EASIX (Endothelial Activation and Stress Index) is a simple biomarker consisting of LDH, platelets, and creatinine, ...

Abstract	Acute-on-chronic liver failure (ACLF) is associated with high mortality. Objective prognostic scores are important for treatment decisions. EASIX (Endothelial Activation and Stress Index) is a simple biomarker consisting of LDH, platelets, and creatinine, reflecting endothelial dysfunction after allogeneic stem cell transplantation. Considering endothelial dysfunction in the pathogenesis of ACLF, this study aimed to test the discriminative ability of EASIX in advanced liver disease. We retrospectively analysed the prognostic potential of EASIX to predict 28-day and 3-month mortality in a total of 188 liver cirrhotic patients requiring treatment at the intensive care unit. We evaluated the ability of EASIX to rule out early infections and predict the need for hemodialysis. EASIX performed moderately better than established scores in predicting 28-day mortality (AUC = 0.771) and was nearly equivalent (AUC = 0.791) to SOFA and APACHE-II in the prediction of 3-month mortality. Importantly, EASIX showed better diagnostic potential in ruling out clinically apparent infections than common proinflammatory markers (AUC = 0.861,
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12072553
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Article ; Online: Risk factors for total laryngectomy associated proximal esophageal stricture formation in head and neck cancer patients.

Schulz, Dominik / Koob, Isabelle / Pickhard, Anja / Schmid, Roland M / Abdelhafez, Mohamed

Zeitschrift fur Gastroenterologie

2023 Volume 62, Issue 2, Page(s) 193–198

Abstract: Background: Development of esophageal strictures is common after the total laryngectomy of head and neck cancer patients. While endoscopic techniques like dilatation by balloon or Salvary bougies are well established, risk factors and pathophysiology ... ...

Title translation	Risikofaktoren für die Bildung einer proximalen Ösophagusstenose nach totaler Laryngektomie bei Patienten mit Kopf- und Halstumoren.
Abstract	Background: Development of esophageal strictures is common after the total laryngectomy of head and neck cancer patients. While endoscopic techniques like dilatation by balloon or Salvary bougies are well established, risk factors and pathophysiology for development of refractory strictures are less well understood. Objective: To evaluate risk factors associated with occurrence and recurrence of total-laryngectomy-associated esophageal strictures in head and neck cancer patients. Methods: We analyzed retrospectively a cohort of 170 head and neck squamous cell carcinoma patients, who underwent total laryngectomy between 2007 and 2017. The outcome measure was laryngectomy-associated proximal esophageal stricture needing an endoscopic dilatation by using a balloon or Savary dilators. Results: Of the 170 patients in the cohort, 32 (18.8%) developed strictures. Mean time between surgery and first endoscopic intervention was 24.4 months. Significant predictive factors were age ≥ 65 (p=0.017), nodal status N> 1 (p=0.003), continued alcohol abuse after surgery (p=0.005) and diabetes mellitus (p=0.005). In a subgroup, 17 of 32 patients developed refractory strictures and needed more than three dilatations to relieve dysphagia. Postoperative mean (p=0.016) and maximum (p=0.015) C-reactive protein (CRP) were predictive for refractory strictures. Conclusion: Symptomatic strictures occurred in 18.8% of the cases. Age, nodal status N>1, continued alcohol abuse and diabetes mellitus were predictive factors. For refractory stenosis (>3 dilatations needed) mean and maximum postoperative CRP were predictive. This may indicate that systemic inflammatory response post-surgery is involved in the stricture formation process.
MeSH term(s)	Humans ; Esophageal Stenosis/diagnosis ; Esophageal Stenosis/epidemiology ; Esophageal Stenosis/etiology ; Constriction, Pathologic/surgery ; Constriction, Pathologic/complications ; Retrospective Studies ; Alcoholism/complications ; Laryngectomy/adverse effects ; Treatment Outcome ; Esophagoscopy/methods ; Head and Neck Neoplasms/complications ; Risk Factors ; Diabetes Mellitus
Language	English
Publishing date	2023-09-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-2150-2689
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 111: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 111/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article: Do patients referred to emergency departments after being assessed in primary care differ from other ED patients? Retrospective analysis of a random sample from two German metropolitan EDs.

Umgelter, Andreas / Faust, Markus / Wenske, Slatomir / Umgelter, Katrin / Schmid, Roland M / Walter, Georg

International journal of emergency medicine

2023 Volume 16, Issue 1, Page(s) 64

Abstract: Background: To assess differences between patients referred to emergency departments by a primary care physician (PCP) and those presenting directly and the impact of referral on the likelihood of admission.: Design of study: Retrospective cohort ... ...

Abstract	Background: To assess differences between patients referred to emergency departments by a primary care physician (PCP) and those presenting directly and the impact of referral on the likelihood of admission. Design of study: Retrospective cohort study. Setting: EDs of two nonacademic general hospitals in a German metropolitan region. Participants: Random sample of 1500 patients out of 80,845 presentations during the year 2019. Results: Age was 55.8 ± 22.9 years, and 51.4% was female. A total of 34.7% presented by emergency medical services (EMS), and 47.7% were walk-ins. One-hundred seventy-four (11.9%) patients were referred by PCPs. Referrals were older (62.4 ± 20.1 vs 55.0 ± 23.1 years, p < .001) and had a higher Charlson Comorbidity Index (CCI) (3 (1-5) vs 2 (0-4); p < .001). Referrals received more ultrasound examinations independently from their admission status (27.6% vs 15.7%; p < .001) and more CT and laboratory investigations. There were no differences in sex, Manchester Triage System (MTS) category, or pain-scale values. Referrals presented by EMS less often (9.2% vs 38.5%; p < .001). Admission rates were 62.6% in referrals and 37.1% in non-referrals (p < .001). Referral (OR 3.976 95% CI: 2.595-6.091), parenteral medication in ED (OR 2.674 (1.976-3.619)), higher MTS category (1.725 (1.421-2.093)), transport by EMS (1.623 (1.212-2.172)), abnormal vital parameters (1.367 (0.953-1.960)), higher CCI (1.268 (1.196-1.344)), and trauma (1.268 (1.196-1.344)) were positively associated with admission in multivariable analysis, whereas ultrasound in ED (0.450 (0.308-0.658)) and being a nursing home resident (0.444 (0.270-0.728)) were negatively associated. Conclusion: Referred patients were more often admitted. They received more laboratory investigations, ultrasound examinations, and computed tomographies. Difficult decisions regarding the necessity of admission requiring typical resources of EDs may be a reason for PCP referrals.
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2411462-5
ISSN	1865-1380 ; 1865-1372
ISSN (online)	1865-1380
ISSN	1865-1372
DOI	10.1186/s12245-023-00542-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Ethische Perspektiven der Gentherapie 1995

Richter, Gerd / Schmid, Roland M.

(Medizinethische Materialien ; 105)

1996

Author's details	Gerd Richter und Roland M. Schmid
Series title	Medizinethische Materialien ; 105
Collection
Keywords	Gene Therapy ; Ethics, Medical ; Gentherapie ; Ethik
Subject	Ethische Theorie ; Moral ; Philosophische Ethik ; Sittenlehre ; Moralphilosophie ; Somatische Gentherapie
Language	German
Size	41, [10] S.
Publisher	Zentrum für Med. Ethik
Publishing place	Bochum
Document type	Book
HBZ-ID	HT006847750
ISBN	3-927855-83-9 ; 978-3-927855-83-0
Database	Catalogue ZB MED Medicine, Health

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1996 B 264	order for loan	Magazin

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