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  1. Book ; Audio / Video ; Thesis: Evaluation eines elektronischen Werkzeugs zur Analyse und Optimierung potenziell komplexer Arzneimitteltherapien unter Einbeziehung von Patient:innenpräferenzen - die HIOPP-6-Pilotstudie

    Schmidt, Steffen Johannes

    2022  

    Author's details vorgelegt von Steffen Johannes Schmidt
    Subject code 610
    Language German
    Size 1 CD-ROM, Illustrationen
    Publishing place Witten/Herdecke
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Witten/Herdecke, 2023
    HBZ-ID HT030357393
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 MO 100 order for loan Magazin

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  2. Article ; Conference proceedings: POCUS im interdisziplinären pädiatrischen Notfallzentrum

    Schmidt, Steffen

    Ultraschall in der Medizin - European Journal of Ultrasound

    2022  Volume 43, Issue S 01

    Event/congress Interdisziplinärer Kongress | Ultraschall 2022, Zürich, 2022-06-29
    Language German
    Publishing date 2022-06-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
    ISSN (online) 1438-8782
    ISSN 0172-4614 ; 1439-0914 ; 1431-4894
    DOI 10.1055/s-0042-1749517
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Conference proceedings ; Online: POLYMERE FUR SYNTHETISCHE MEMBRANEN UND IHRE CHEMISCHE MODIFIKATION

    Staude, Eberhard / Schmidt-Steffen, Alfred / Paßlak, Jürgen

    2023  

    Abstract: Ohne das klassische Membranpolymer Cellulose und ihre Derivate wäre die Entwicklung der Theorien zum Transport durch Membranen und auch die praktische Anwendung undenkbar. Vorzügliche Dienste leistete in der Anfangsphase die Nitrocellulose, zu Beginn der ...

    Abstract Ohne das klassische Membranpolymer Cellulose und ihre Derivate wäre die Entwicklung der Theorien zum Transport durch Membranen und auch die praktische Anwendung undenkbar. Vorzügliche Dienste leistete in der Anfangsphase die Nitrocellulose, zu Beginn der sechziger Jahre war jedoch Cellulose-2,5-acetat dominant, dem wiederum vollsynthetische Polymere überlegen sind, zumal durch chemische Modifikation das Anwendungsspektrum verbreitert werden kann. So ist z.B. Polysulfon ein geeignetes Material für die Herstellung von Ultrafiltrationsmembranen; nach Sulfonierung eignet es sich als Membranpolymer für die Hyperfiltration und, da es nunmehr negative Festionenladung trägt, auch zur Herstellung homogener Elektrodialysemembranen. Chemische Modifikation von Membranpolymeren zielt auf Verbesserung der Gebrauchseigenschaften ab, etwa hinsichtlich Rückhalt oder Volumenfluß aber auch zur Erhöhung der Hydrophilie der resultierenden Membranen, zur Verbesserung der Kompatibilität, wenn Interpolymermembranen hergestellt werden sollen oder zur Einführung von geeigneten Gruppen, die eine chemische Fixierung von Enzymen an der Membran ermöglichen.
    Subject code 660
    Language German
    Publishing date 2023-05-10
    Publishing country de
    Document type Article ; Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Book ; Thesis: Variabilität von Enzymen

    Schmidt, Steffen

    Klassifikation, Stoffwechselrekonstruktion und medical target prediction

    2002  

    Author's details vorgelegt von Steffen Schmidt
    Language German
    Size 99, XII Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2002
    HBZ-ID HT013664864
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 E 1713 order for loan Magazin

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  5. Book: Biodiversität in Eichenwirtschaftswäldern

    Ziesche, Tim / Kätzel, Ralf / Schmidt, Steffen

    Empfehlungen zur Bewirtschaftung von stabilen, artenreichen, naturnahen Eichenwäldern in Nordostdeutschland ; F+E-Vorhaben: 3507 84 010

    (Naturschutz und biologische Vielfalt ; 114)

    2011  

    Author's details Tim Ziesche ; Ralf Kätzel ; Steffen Schmidt. Unter Mitarb. von: Annette Gräff
    Series title Naturschutz und biologische Vielfalt ; 114
    Collection
    Keywords Eichenwald ; Bewirtschaftung ; Biodiversität
    Subject Biologische Vielfalt ; Vielfalt ; Rationierung ; Eiche
    Language German
    Size 204, IV S. : Ill., graph. Darst., Kt.
    Publisher Bundesamt für Naturschutz
    Publishing place Bonn-Bad Godesberg
    Publishing country Germany
    Document type Book
    Note Zsfassung in engl. Sprache. - Literaturverz. S. 184 - 204
    HBZ-ID HT017109902
    ISBN 978-3-7843-4014-2 ; 3-7843-4014-8
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    128/165 available for loan (reading room) Freihandmagazin (U1)

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  6. Article ; Online: Associations between physical activity, physical fitness, and body composition in adults living in Germany: A cross-sectional study.

    Schilling, Raphael / Schmidt, Steffen C E / Fiedler, Janis / Woll, Alexander

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0293555

    Abstract: Background & aims: Body composition (BC) changes with age and is associated with morbidity and mortality. A physically active lifestyle influences BC and represents an important predictor of successful aging. To emphasize this, the World Health ... ...

    Abstract Background & aims: Body composition (BC) changes with age and is associated with morbidity and mortality. A physically active lifestyle influences BC and represents an important predictor of successful aging. To emphasize this, the World Health Organization established activity recommendations for all age groups. We describe BC during adulthood using a cross-sectional sample from a German community and investigate the associations between physical activity (PA), physical fitness (PF), and BC.
    Methods: Data from 329 men and women aged 35 to 86 years were analyzed. PA was measured by questionnaire and classified into sport activity and habitual activity. PF was measured through physical performance tests and BC by bioelectrical impedance analysis. Fat mass index (FMI) and fat-free mass index (FFMI) were calculated to represent height-adjusted BC. Associations between PA, PF, and BC were analyzed using linear regression models.
    Results: For both sexes, strength was positively associated with FFMI (♂: ß = 0.313; ♀: ß = 0.213) and phase angle (♂: ß = 0.357; ♀: ß = 0.409). For FMI, a significant negative association with strength was found only in women (ß = -0.189). Cardiorespiratory fitness showed a negative association with FMI (ß = -0.312) and FFMI (ß = -0.201) for men, while in women a positive association was found for FFMI (ß = 0.186). For coordination, a significant association with FMI was observed only in women (ß = -0.190). Regarding PA only one significant relationship between sport activity and FMI among women (ß = -0.170) was found.
    Conclusions: In our sample, PF was closer related to BC than PA. Strength and cardiorespiratory fitness were the strongest predictors for BC. This supports the World Health Organization's activity recommendations to include both resistance and endurance training in the weekly sports program to maintain a healthy BC.
    MeSH term(s) Male ; Humans ; Adult ; Female ; Cross-Sectional Studies ; Body Composition ; Physical Fitness ; Exercise ; Germany ; Body Mass Index
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0293555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Thesis: Untersuchungen über das Immunglobulin-E-System des Neu-Welt-Affen Callithrix jacchus

    Schmidt, Steffen

    1996  

    Author's details vorgelegt von Steffen Schmidt
    Language German
    Size 68 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1996
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT007329630
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 MB 2796 order for loan Magazin

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  8. Book ; Thesis: Ergebnisse der konservativen stationären Behandlung lumbaler Bandscheibenprotrusionen und -prolapse

    Schmidt, Steffen Peter

    2000  

    Author's details vorgelegt von Steffen Peter Schmidt
    Language German
    Size 75 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bochum, Univ., Diss., 2001
    HBZ-ID HT013163161
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 E 2713 order for loan Magazin

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  9. Article: The Use of Compression Stockings to Reduce Water Retention in the Legs During Gaming and Esports: Randomized Controlled Field Study.

    Schmidt, Steffen Christian Ekkehard / Sell, Stefan / Woll, Alexander

    Interactive journal of medical research

    2022  Volume 11, Issue 2, Page(s) e25886

    Abstract: Background: With the increasing digitalization of daily life, internet-based entertainment such as gaming and streaming has advanced to one of the megatrends of the 21st century. Besides offering a multitude of controversially discussed opportunities ... ...

    Abstract Background: With the increasing digitalization of daily life, internet-based entertainment such as gaming and streaming has advanced to one of the megatrends of the 21st century. Besides offering a multitude of controversially discussed opportunities for entertainment and social interaction, there is reasonable concern about health issues caused by the absence of physical activity among activities linked to gaming and streaming.
    Objective: The aim of this study is to compare the water balance of recreational gamers with and those without compression stockings during a gaming event.
    Methods: We measured body composition and water balance with 8-electrode bioelectrical impedance analysis among 46 recreational gamers with an average age of 27.1 (SD 6.5) years (5/46, 11% women and 41/46, 89% men) before and after 24 hours at a gaming event. Of the 46 gamers, 23 (50%) gamers wore compression stockings for the duration of the study.
    Results: Our study shows that prolonged gaming and associated behaviors during a 24-hour time frame lead to an increase in total body water (+0.76 L; P<.001) and a decrease of phase angle in the lower extremities (-0.47°; P<.001) but not in the upper extremities (+0.09°; P=.80), when no compression is used. Gamers using compression socks did not show any significant negative effects on their body composition.
    Conclusions: Prolonged gaming and streaming are serious risk factors for diseases associated with water retention in the legs, and these risks can be measured by bioelectrical impedance and reduced by wearing compression stockings. We conclude that these findings should be discussed and replicated in larger studies and that there is a considerably large market for compression stockings among gamers and live streamers.
    Language English
    Publishing date 2022-09-29
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2697014-4
    ISSN 1929-073X
    ISSN 1929-073X
    DOI 10.2196/25886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: ProtGPT2 is a deep unsupervised language model for protein design.

    Ferruz, Noelia / Schmidt, Steffen / Höcker, Birte

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 4348

    Abstract: Protein design aims to build novel proteins customized for specific purposes, thereby holding the potential to tackle many environmental and biomedical problems. Recent progress in Transformer-based architectures has enabled the implementation of ... ...

    Abstract Protein design aims to build novel proteins customized for specific purposes, thereby holding the potential to tackle many environmental and biomedical problems. Recent progress in Transformer-based architectures has enabled the implementation of language models capable of generating text with human-like capabilities. Here, motivated by this success, we describe ProtGPT2, a language model trained on the protein space that generates de novo protein sequences following the principles of natural ones. The generated proteins display natural amino acid propensities, while disorder predictions indicate that 88% of ProtGPT2-generated proteins are globular, in line with natural sequences. Sensitive sequence searches in protein databases show that ProtGPT2 sequences are distantly related to natural ones, and similarity networks further demonstrate that ProtGPT2 is sampling unexplored regions of protein space. AlphaFold prediction of ProtGPT2-sequences yields well-folded non-idealized structures with embodiments and large loops and reveals topologies not captured in current structure databases. ProtGPT2 generates sequences in a matter of seconds and is freely available.
    MeSH term(s) Amino Acid Sequence ; Amino Acids ; Databases, Protein ; Humans ; Language ; Proteins/chemistry ; Proteins/genetics
    Chemical Substances Amino Acids ; Proteins
    Language English
    Publishing date 2022-07-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-32007-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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