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  1. Book ; Thesis: Cysteine-rich protein 2

    Schmidtko, Achim

    a substrate of cGMP-dependent protein kinase I in nociceptive processing

    2008  

    Author's details vorgelegt von Achim Schmidtko
    Subject code 612.8
    Language English
    Size IV, 47 S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2008
    HBZ-ID HT016208405
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 D 65 order for loan Magazin

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  2. Book: Pharmakologie kompakt

    Mutschler, Ernst / Geisslinger, Gerd / Menzel, Sabine / Ruth, Peter / Schmidtko, Achim

    allgemeine und klinische Pharmakologie, Toxikologie : mit 61 Abbildungen und 99 Tabellen

    2016  

    Author's details Ernst Mutschler, Gerd Geisslinger, Sabine Menzel, Peter Ruth, Achim Schmidtko
    Keywords Pharmakologie ; Toxikologie
    Subject Giftkunde ; Klinische Toxikologie ; Arzneimittellehre ; Arzneimittelwirkung ; Arzneiwirkung ; Experimentelle Pharmakologie
    Language German
    Size XX, 665 Seiten, 61 Illustrationen, 24 cm x 17 cm
    Edition 1. Auflage
    Publisher WVG, Wissenschaftliche Verlagsgesellschaft
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT019002599
    ISBN 978-3-8047-3551-4 ; 3-8047-3551-7 ; 9783804735941 ; 9783804735958 ; 3804735940 ; 3804735959
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 123 available for loan (reading room) Lesesaal EG

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  3. Article: NADPH Oxidases in Pain Processing

    Kallenborn-Gerhardt, Wiebke / Schröder, Katrin / Schmidtko, Achim

    Antioxidants. 2022 June 14, v. 11, no. 6

    2022  

    Abstract: Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate that reactive oxygen species (ROS), such as ... ...

    Abstract Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate that reactive oxygen species (ROS), such as superoxide anion or hydrogen peroxide, are produced in the nociceptive system during chronic inflammatory and neuropathic pain and act as specific signaling molecules in pain processing. Among potential ROS sources in the somatosensory system are NADPH oxidases, a group of electron-transporting transmembrane enzymes whose sole function seems to be the generation of ROS. Interestingly, the expression and relevant function of the Nox family members Nox1, Nox2, and Nox4 in various cells of the nociceptive system have been demonstrated. Studies using knockout mice or specific knockdown of these isoforms indicate that Nox1, Nox2, and Nox4 specifically contribute to distinct signaling pathways in chronic inflammatory and/or neuropathic pain states. As selective Nox inhibitors are currently being developed and investigated in various physiological and pathophysiological settings, targeting Nox1, Nox2, and/or Nox4 could be a novel strategy for the treatment of chronic pain. Here, we summarize the distinct roles of Nox1, Nox2, and Nox4 in inflammatory and neuropathic processing and discuss the effectiveness of currently available Nox inhibitors in the treatment of chronic pain conditions.
    Keywords hydrogen peroxide ; inflammation ; nervous system ; oxidoreductases ; pain ; superoxide anion
    Language English
    Dates of publication 2022-0614
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11061162
    Database NAL-Catalogue (AGRICOLA)

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  4. Book ; Online ; Thesis: Specific functions of Slack potassium channels in sensory neurons and spinal dorsal horn neurons in pain processing

    Zhou, Fangyuan [Verfasser] / Schmidtko, Achim [Akademischer Betreuer] / Schmidtko, Achim [Gutachter] / Geisslinger, Gerd [Gutachter]

    2023  

    Author's details Fangyuan Zhou ; Gutachter: Achim Schmidtko, Gerd Geißlinger ; Betreuer: Achim Schmidtko
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  5. Book ; Online ; Thesis: Natrium-abhängige Kaliumkanäle im sensorischen System

    Flauaus, Cathrin [Verfasser] / Schmidtko, Achim [Akademischer Betreuer] / Lu, Ruirui [Akademischer Betreuer] / Schmidtko, Achim [Gutachter] / Proschak, Ewgenij [Gutachter]

    2023  

    Author's details Cathrin Flauaus ; Gutachter: Achim Schmidtko, Eugen Proschak ; Achim Schmidtko, Ruirui Lu
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  6. Article: NADPH Oxidases in Pain Processing.

    Kallenborn-Gerhardt, Wiebke / Schröder, Katrin / Schmidtko, Achim

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 6

    Abstract: Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate that reactive oxygen species (ROS), such as ... ...

    Abstract Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate that reactive oxygen species (ROS), such as superoxide anion or hydrogen peroxide, are produced in the nociceptive system during chronic inflammatory and neuropathic pain and act as specific signaling molecules in pain processing. Among potential ROS sources in the somatosensory system are NADPH oxidases, a group of electron-transporting transmembrane enzymes whose sole function seems to be the generation of ROS. Interestingly, the expression and relevant function of the Nox family members Nox1, Nox2, and Nox4 in various cells of the nociceptive system have been demonstrated. Studies using knockout mice or specific knockdown of these isoforms indicate that Nox1, Nox2, and Nox4 specifically contribute to distinct signaling pathways in chronic inflammatory and/or neuropathic pain states. As selective Nox inhibitors are currently being developed and investigated in various physiological and pathophysiological settings, targeting Nox1, Nox2, and/or Nox4 could be a novel strategy for the treatment of chronic pain. Here, we summarize the distinct roles of Nox1, Nox2, and Nox4 in inflammatory and neuropathic processing and discuss the effectiveness of currently available Nox inhibitors in the treatment of chronic pain conditions.
    Language English
    Publishing date 2022-06-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11061162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Nitric oxide-mediated pain processing in the spinal cord.

    Schmidtko, Achim

    Handbook of experimental pharmacology

    2015  Volume 227, Page(s) 103–117

    Abstract: A large body of evidence indicates that nitric oxide (NO) plays an important role in the processing of persistent inflammatory and neuropathic pain in the spinal cord. Several animal studies revealed that inhibition or knockout of NO synthesis ... ...

    Abstract A large body of evidence indicates that nitric oxide (NO) plays an important role in the processing of persistent inflammatory and neuropathic pain in the spinal cord. Several animal studies revealed that inhibition or knockout of NO synthesis ameliorates persistent pain. However, spinal delivery of NO donors caused dual pronociceptive and antinociceptive effects, pointing to multiple downstream signaling mechanisms of NO. This review summarizes the localization and function of NO-dependent signaling mechanisms in the spinal cord, taking account of the recent progress made in this field.
    MeSH term(s) Animals ; Cyclic GMP/physiology ; Humans ; Nitric Oxide/physiology ; Pain/physiopathology ; Peroxynitrous Acid/biosynthesis ; Signal Transduction ; Spinal Cord/physiology
    Chemical Substances Peroxynitrous Acid (14691-52-2) ; Nitric Oxide (31C4KY9ESH) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2015
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/978-3-662-46450-2_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  8. Book ; Online ; Thesis: Nociception and pain in the electroencephalogram

    Anders, Malte [Verfasser] / Schmidtko, Achim [Gutachter] / Geisslinger, Gerd [Gutachter]

    2023  

    Author's details Malte Jürgen Anders ; Gutachter: Achim Schmidtko, Gerd Geisslinger
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  9. Article ; Online: The 10th International Conference on cGMP 2022: recent trends in cGMP research and development-meeting report.

    Friebe, Andreas / Kraehling, Jan R / Russwurm, Michael / Sandner, Peter / Schmidtko, Achim

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 396, Issue 8, Page(s) 1669–1686

    Abstract: Increasing cGMP is a unique therapeutic principle, and drugs inhibiting cGMP-degrading enzymes or stimulating cGMP production are approved for the treatment of various diseases such as erectile dysfunction, coronary artery disease, pulmonary hypertension, ...

    Abstract Increasing cGMP is a unique therapeutic principle, and drugs inhibiting cGMP-degrading enzymes or stimulating cGMP production are approved for the treatment of various diseases such as erectile dysfunction, coronary artery disease, pulmonary hypertension, chronic heart failure, irritable bowel syndrome, or achondroplasia. In addition, cGMP-increasing therapies are preclinically profiled or in clinical development for quite a broad set of additional indications, e.g., neurodegenerative diseases or different forms of dementias, bone formation disorders, underlining the pivotal role of cGMP signaling pathways. The fundamental understanding of the signaling mediated by nitric oxide-sensitive (soluble) guanylyl cyclase and membrane-associated receptor (particulate) guanylyl cyclase at the molecular and cellular levels, as well as in vivo, especially in disease models, is a key prerequisite to fully exploit treatment opportunities and potential risks that could be associated with an excessive increase in cGMP. Furthermore, human genetic data and the clinical effects of cGMP-increasing drugs allow back-translation into basic research to further learn about signaling and treatment opportunities. The biannual international cGMP conference, launched nearly 20 years ago, brings all these aspects together as an established and important forum for all topics from basic science to clinical research and pivotal clinical trials. This review summarizes the contributions to the "10th cGMP Conference on cGMP Generators, Effectors and Therapeutic Implications," which was held in Augsburg in 2022 but will also provide an overview of recent key achievements and activities in the field of cGMP research.
    MeSH term(s) Male ; Humans ; Guanylate Cyclase/metabolism ; Soluble Guanylyl Cyclase/metabolism ; Cyclic GMP/metabolism ; Signal Transduction ; Research ; Nitric Oxide/metabolism
    Chemical Substances Guanylate Cyclase (EC 4.6.1.2) ; Soluble Guanylyl Cyclase (EC 4.6.1.2) ; Cyclic GMP (H2D2X058MU) ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-04-20
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02484-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: cGMP signalling in dorsal root ganglia and the spinal cord: Various functions in development and adulthood.

    Schmidt, Hannes / Böttcher, Alexandra / Gross, Tilman / Schmidtko, Achim

    British journal of pharmacology

    2021  Volume 179, Issue 11, Page(s) 2361–2377

    Abstract: Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and pathophysiological processes. In recent years, more and more studies have uncovered multiple roles of cGMP signalling pathways in the somatosensory system. Accumulating ... ...

    Abstract Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and pathophysiological processes. In recent years, more and more studies have uncovered multiple roles of cGMP signalling pathways in the somatosensory system. Accumulating evidence suggests that cGMP regulates different cellular processes from embryonic development through to adulthood. During embryonic development, a cGMP-dependent signalling cascade in the trunk sensory system is essential for axon bifurcation, a specific form of branching of somatosensory axons. In adulthood, various cGMP signalling pathways in distinct cell populations of sensory neurons and dorsal horn neurons in the spinal cord play an important role in the processing of pain and itch. Some of the involved enzymes might serve as a target for future therapies. In this review, we summarise the knowledge regarding cGMP-dependent signalling pathways in dorsal root ganglia and the spinal cord during embryonic development and adulthood, and the potential of targeting these pathways. LINKED ARTICLES: This article is part of a themed issue on cGMP Signalling in Cell Growth and Survival. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.11/issuetoc.
    MeSH term(s) Axons/metabolism ; Cyclic GMP/metabolism ; Female ; Ganglia, Spinal/metabolism ; Humans ; Pregnancy ; Sensory Receptor Cells/metabolism ; Spinal Cord/metabolism
    Chemical Substances Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2021-06-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.146: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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