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Book ; Thesis: Das Surfactantsystem der Lunge in der postnatalen Entwicklung der Ratte

Schmiedl, Andreas

2007

Author's details	vorgelegt von Andreas Schmiedl
Language	German ; English
Size	22, [27] Bl., Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hannover, Univ., Diss., 2007
HBZ-ID	HT015545802
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung.

Roeder, Franziska / Knudsen, Lars / Schmiedl, Andreas

PloS one

2024 Volume 19, Issue 3, Page(s) e0297889

Abstract: Objective: Surfactant-specific proteins (SP) are responsible for the functional and structural integrity as well as for the stabilization of the intra-alveolar surfactant. Morphological lung maturation starts in rat lungs after birth. The aim of this ... ...

Abstract	Objective: Surfactant-specific proteins (SP) are responsible for the functional and structural integrity as well as for the stabilization of the intra-alveolar surfactant. Morphological lung maturation starts in rat lungs after birth. The aim of this study was to investigate whether the expression of the hydrophilic SP-A and the hydrophobic SP-B is associated with characteristic postnatal changes characterizing morphological lung maturation. Methods: Stereological methods were performed on the light microscope. Using immunohistochemical and molecular biological methods (Western Blot, RT-qPCR), the SP-A and SP-B of adult rat lungs and of those with different postnatal developmental stages (3, 7, 14 and 21 days after birth) were characterized. Results: As signs of alveolarization the total septal surface and volume increased and the septal thickness decreased. The significantly highest relative surface fraction of SP-A labeled alveolar epithelial cells type II (AEII) was found together with the highest relative SP-A gene expression before the alveolarization (3th postnatal day). With the downregulation of SP-A gene expression during and after alveolarization (between postnatal days 7 and 14), the surface fraction of the SP-A labeled AEII also decreased, so they are lowest in adult animals. The surface fraction of SP-B labeled AEII and the SP-B gene expression showed the significantly highest levels in adults, the protein expression increased also significantly at the end of morphological lung maturation. There were no alterations in the SP-B expression before and during alveolarization until postnatal day 14. The protein expression as well as the gene expression of SP-A and SP-B correlated very well with the total surface of alveolar septa independent of the postnatal age. Conclusion: The expression of SP-A and SP-B is differentially associated with morphological lung maturation and correlates with increased septation of alveoli as indirect clue for alveolarization.
MeSH term(s)	Rats ; Animals ; Surface-Active Agents/metabolism ; Pulmonary Surfactants/metabolism ; Lung/metabolism ; Pulmonary Alveoli ; Pulmonary Surfactant-Associated Proteins/genetics ; Pulmonary Surfactant-Associated Proteins/metabolism ; Lipoproteins/metabolism
Chemical Substances	Surface-Active Agents ; Pulmonary Surfactants ; Pulmonary Surfactant-Associated Proteins ; Lipoproteins
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297889
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Article ; Online: The postnatal development of the compartments in human lymph nodes up to 15 years of age.

Pabst, R / Debertin, A S / Todt-Brenneke, M / Herden, A / Schmiedl, A

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

2023 Volume 250, Page(s) 152140

Abstract: The postnatal development of normal human lymph nodes (LN) is largely unknown but is of relevance for intranodal desensitization and for comparison to lymphoma. Superficial inguinal lymphoid (LN) of 25 children (newborn up to 14 years) were studied by ... ...

Abstract	The postnatal development of normal human lymph nodes (LN) is largely unknown but is of relevance for intranodal desensitization and for comparison to lymphoma. Superficial inguinal lymphoid (LN) of 25 children (newborn up to 14 years) were studied by routine histology and immunohistology for T and B lymphocytes. The LN were obtained from the legal medicine department at necropsy. The cortex and medulla were identifiable in LN of children of less than 1 month of age. Later high endothelial venules as typical structures for the T cell area are present. Secondary follicles were obvious from 3 months of age onwards in lymph nodes of adolescents also the histology of the LN was similar to adults. The structural elements for an intranodal desensitization are given in human children. The normal development of LN structure is essential to identify pathology like lymphoma in children.
MeSH term(s)	Child ; Infant, Newborn ; Humans ; Adolescent ; Lymph Nodes ; T-Lymphocytes ; B-Lymphocytes ; Lymphoma/pathology
Language	English
Publishing date	2023-07-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1106738-x
ISSN	1618-0402 ; 0940-9602
ISSN (online)	1618-0402
ISSN	0940-9602
DOI	10.1016/j.aanat.2023.152140
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Book ; Thesis: Tolerables Oxalat und Calciumoxalat-Kristallisation im Urin von gesunden Probanden und RCU-Patienten mit und ohne Alkali-Citrat-Behandlung

Schmiedl, Angelika

1993

Author's details	vorgelegt von Angelika Schmiedel
Language	German
Size	1 Mikrofiche : 24x
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Erlangen, Nürnberg, Univ., Diss., 1993
Note	Mikroreprod. eines Ms. 69 Bl.: graph. Darst.
HBZ-ID	HT005035473
Database	Catalogue ZB MED Medicine, Health

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Book ; Thesis: Die Morbidität, Mortalität und das Outcome ehemaliger Frühgeborener mit einem Geburtsgewicht <= 1000 g, geboren zwischen dem 01.01.1988 und 31.12.1995 in Rostock

Schmiedl, Antje

2002

Author's details	vorgelegt von Antje Schmiedl, geb. Schirmer
Language	German
Size	[4], 269, IV S. : graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Rostock, Univ., Diss., 2002
HBZ-ID	HT013511689
Database	Catalogue ZB MED Medicine, Health

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2003 D 35	order for loan	Magazin

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Article ; Online: Ultrastructural analysis of the intracellular surfactant in lungs of healthy and ovalbumin sensitized and challenged

Schmiedl, Andreas / Frank, Stefanie / Tschernig, Thomas / Hohlfeld, Jens M

Experimental lung research

2023 Volume 49, Issue 1, Page(s) 142–151

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Animals ; Rats ; Surface-Active Agents/pharmacology ; Ovalbumin ; Pulmonary Surfactants ; Alveolar Epithelial Cells ; Asthma/chemically induced
Chemical Substances	Surface-Active Agents ; Ovalbumin (9006-59-1) ; Pulmonary Surfactants
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.1080/01902148.2023.2238232
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Article ; Online: Teaching gross anatomy during the Covid-19 pandemic: Effects on medical students' gain of knowledge, confidence levels and pandemic-related concerns.

Schulte, Henri / Schmiedl, Andreas / Mühlfeld, Christian / Knudsen, Lars

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

2022 Volume 244, Page(s) 151986

Abstract: For medical students the dissection course is the preferred method to learn gross anatomy. However, the added value of active cadaver dissection on knowledge gain in multimodal curricula offering a diversity of e-learning resources is unknown. The Covid- ... ...

Abstract	For medical students the dissection course is the preferred method to learn gross anatomy. However, the added value of active cadaver dissection on knowledge gain in multimodal curricula offering a diversity of e-learning resources is unknown. The Covid-19-related lockdown forced educators to replace the dissection course by e-learning resources. At the end of the summer term 2020 loosening of pandemic-related regulations allowed offering a compact, voluntary active dissection course of the head-neck region to first-year medical students at Hannover Medical School. A study was conducted comparing a dissection group (G1, n = 115) and a non-dissection group (G2, n = 23). Knowledge gain and confidence level were measured with a multiple-choice (MC-)test. The use of e-learning resources was recorded. A questionnaire measured motivation, interest and level of concern regarding Covid-19 and anatomy teaching. No differences between groups were found regarding motivation and interest in anatomy of the head-neck region. G2, however, had significantly higher concerns regarding the Covid-19 pandemic than G1. Neither before nor after the educational intervention, differences in the scores of the MC-test were found. However, after the course G1 answered more MC-questions with highest confidence level than G2 (6.7 ± 6.0 vs. 3.6 ± 4.6, p < 0.05) and demonstrated by trend an increased improvement in the scores of image-based questions (30.8 ± 18.2 % vs. 17.1 ± 14.8 %, p = 0.06). In general, frequent users of online quizzes, a part of the e-learning resources, scored significantly better in the knowledge test. Active dissection improves self-assurance to identify anatomical structures and should be re-implemented in multimodal, blended-learning-based anatomical curricula in the post-pandemic era.
MeSH term(s)	Humans ; Students, Medical ; Education, Medical, Undergraduate/methods ; COVID-19 ; Pandemics ; Communicable Disease Control ; Cadaver ; Curriculum ; Anatomy/education ; Teaching ; Educational Measurement
Language	English
Publishing date	2022-07-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1106738-x
ISSN	1618-0402 ; 0940-9602
ISSN (online)	1618-0402
ISSN	0940-9602
DOI	10.1016/j.aanat.2022.151986
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Article ; Online: The relationship between the subclavian vessels and brachial plexus and the overlying clavicle: Anatomical study with application to plate osteosynthesis.

Schmiedl, Andreas / Buchhorn, Andreas / Schönberger, Michael

Clinical anatomy (New York, N.Y.)

2022 Volume 36, Issue 3, Page(s) 377–385

Abstract: A subclavian artery aneurysm after clavicle fracture and plate osteosynthesis in a suspected case of a screw that was too long led us to investigate body donor cadavers. The aim was to verify clavicle variability, and the course of the neurovascular ... ...

Abstract	A subclavian artery aneurysm after clavicle fracture and plate osteosynthesis in a suspected case of a screw that was too long led us to investigate body donor cadavers. The aim was to verify clavicle variability, and the course of the neurovascular bundle in relation to the clavicle and to the osteosynthesis plate, in order to clarify safe zones for plate and screw fixation. We used one fresh frozen and 25 embalmed donors for in situ measurements: (1) length and craniocaudal thickness of the clavicle, (2) distances between the sternal end of the clavicle and the center of parts of the neurovascular bundle. The clavicle was 15.15 cm long. The mean distances from the sternal end of the clavicle were 5.62 cm to the subclavian vein, 6.75 cm to the subclavian artery and 8.42 cm to the cords of the brachial plexus. The subclavius muscle was 1 cm thick. Because of sex differences in length and distances, we recorded the distances between the sternal end and parts of the neurovascular bundle as ratios of clavicle length (at-risk area) to provide sex-independent parameters: 0.379 for the vein, 0.449 for the artery and 0.554 for the nerve. The neurovascular bundle runs below the clavicle between the medial fourth and three fifths of clavicle length. To avoid iatrogenic neurovascular injuries, special caution is necessary during drilling and screwing the osteosynthesis. We also recommend using screws shorter than 1.4 cm.
MeSH term(s)	Humans ; Male ; Female ; Clavicle/blood supply ; Clavicle/injuries ; Clavicle/surgery ; Fracture Fixation, Internal ; Fractures, Bone/surgery ; Shoulder ; Subclavian Artery ; Brachial Plexus
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025505-9
ISSN	1098-2353 ; 0897-3806
ISSN (online)	1098-2353
ISSN	0897-3806
DOI	10.1002/ca.23948
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Article ; Online: Integrating appraisal processes in the study demands-resources framework - a diary study.

Schmiedl, Annika / Schulte, Eva-Maria / Kauffeld, Simone

Anxiety, stress, and coping

2022 Volume 36, Issue 4, Page(s) 444–459

Abstract: Background and objectives: Students face various demands that can lead to health complaints. Hindering demands appear to be especially harmful. Since the perception of demands differs between persons, their individual appraisal determines stress ... ...

Abstract	Background and objectives: Students face various demands that can lead to health complaints. Hindering demands appear to be especially harmful. Since the perception of demands differs between persons, their individual appraisal determines stress perception. However, individual appraisal processes are largely neglected in research. Therefore, this study builds on the study demands-resources model in examining the dynamics of students' demand-appraisal processes and their effects on well-being. Design: During ten days in a four-week period, 247 students participated in a diary study. Methods: We analyzed our data via multilevel path analysis. Results: Our analyses revealed that the student's appraisal of the same demands varied across days and depended on available resources, i.e., the received support quality on the respective day. Appraising demands as hindering was positively linked to the perception of stress on the same day. Daily perception of stress was positively linked to person-level strain and health complaints after four weeks. Conclusions: The results highlight the importance of assessing the individual appraisal of demands rather than pre-categorizing demands. Furthermore, our findings identify social support as a crucial resource in reducing hindering appraisal; hence, it should be included in student-focused stress-management interventions. Limitations and further implications are also discussed.
MeSH term(s)	Humans ; Social Support ; Students
Language	English
Publishing date	2022-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1115932-7
ISSN	1477-2205 ; 1061-5806
ISSN (online)	1477-2205
ISSN	1061-5806
DOI	10.1080/10615806.2022.2117306
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Article ; Online: Lung infection caused by Pseudomonas aeruginosa in a CD26/DPP4 deficient F344 rat model.

Neuhaus, M / Munder, A / Schipke, J / Schmiedl, A

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2019 Volume 68, Issue 7, Page(s) 529–544

Abstract: Background: Pseudomonas aeruginosa (PA) is the most important opportunistic pathogen in causing nosocomial infections and, furthermore, poses a permanent threat for severe chronic infections in patients with cystic fibrosis or COPD. The transmembrane ... ...

Abstract	Background: Pseudomonas aeruginosa (PA) is the most important opportunistic pathogen in causing nosocomial infections and, furthermore, poses a permanent threat for severe chronic infections in patients with cystic fibrosis or COPD. The transmembrane protein CD26 with dipeptidyl peptidase-4 (DPP4) activity shows an increased expression in inflamed tissue. We tested whether CD26/DPP4 deficiency leads to reduced inflammation and decreased structural damage when infected with PA. Methods: CD26/DPP4 Results: Compared to saline treated controls, in both infected groups (1) the acinar airspace was significantly increased, (2) the volume density of the alveolar epithelium was significantly decreased, (3) the septal thickness was significantly reduced, (4) more than 40% of the alveolar epithelial surface was damaged, and up to 36% of the epithelial surface was covered with edema. In infected CD26 Conclusions: CD26/DPP4 deficiency resulted in reduced pulmonary edema under sublethal PA infection, implicating a role for CD26 in infection progression. The partly pronounced structural damage may mask further possible influences of CD26 on the inflammatory response.
MeSH term(s)	Animals ; Dipeptidyl Peptidase 4/genetics ; Disease Models, Animal ; Lung/microbiology ; Lung/pathology ; Lung/ultrastructure ; Lung Diseases/genetics ; Lung Diseases/microbiology ; Lung Diseases/pathology ; Pseudomonas Infections/genetics ; Pseudomonas Infections/microbiology ; Pseudomonas Infections/pathology ; Pseudomonas aeruginosa ; Rats, Inbred F344 ; Rats, Transgenic
Chemical Substances	DPP4 protein, rat (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
Keywords	covid19
Language	English
Publishing date	2019-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-019-01236-w
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