LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 168

Search options

  1. Book ; Thesis: Molecular mechanisms of vascular transformation in children on peritoneal dialysis and after kidney transplantations

    Zhang, Conghui / Schmitt, Claus P.

    2022  

    Institution Universität Heidelberg
    Author's details vorgelegt von Conghui Zhang; Doktorvater: Herr Prof. Dr. med. Claus P. Schmitt
    Subject code 616.994 ; 610
    Language English
    Size 134 Seiten, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2023
    Note Text auf englisch, Zusammenfassung in englischer und deutscher Sprache
    HBZ-ID HT030697815
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 534 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Sodium handling in pediatric patients on maintenance dialysis.

    Paglialonga, Fabio / Schmitt, Claus Peter

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 38, Issue 12, Page(s) 3909–3921

    Abstract: The risk of cardiovascular disease remains exceedingly high in pediatric patients with chronic kidney disease stage 5 on dialysis (CKD 5D). Sodium ( ... ...

    Abstract The risk of cardiovascular disease remains exceedingly high in pediatric patients with chronic kidney disease stage 5 on dialysis (CKD 5D). Sodium (Na
    MeSH term(s) Humans ; Child ; Renal Dialysis/adverse effects ; Sodium ; Peritoneal Dialysis/adverse effects ; Dialysis Solutions ; Kidney Failure, Chronic/therapy
    Chemical Substances Sodium (9NEZ333N27) ; Dialysis Solutions
    Language English
    Publishing date 2023-05-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-05999-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The authors reply.

    Mühlig, Anne K / Schmitt, Claus-Peter / Oh, Jun

    Kidney international

    2024  Volume 105, Issue 2, Page(s) 390

    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Letter
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.10.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book ; Thesis: Protektive Effekte von Carnosin in renealen Zellen unter diabetischen Bedingungen

    Singler, Benjamin / Schmitt, Claus P.

    2018  

    Institution Universität Heidelberg
    Author's details vorgelegt von Benjamin Andreas Singler ; Doktorvater: Herr Prof. Dr. med. Claus Peter Schmitt
    Language German
    Size 148 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2020
    HBZ-ID HT020623222
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 E 1401 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Molecular Mechanisms of Peritoneal Membrane Pathophysiology.

    Zarogiannis, Sotirios G / Schmitt, Claus Peter

    Biomolecules

    2022  Volume 12, Issue 6

    Abstract: The peritoneal membrane is the largest internal membrane of the human body, having a surface area that approximates the surface area of the skin [ ... ]. ...

    Abstract The peritoneal membrane is the largest internal membrane of the human body, having a surface area that approximates the surface area of the skin [...].
    MeSH term(s) Humans ; Membranes ; Peritoneal Dialysis ; Peritoneum ; Skin
    Language English
    Publishing date 2022-05-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12060757
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Impact of Cinacalcet and Etelcalcetide on Bone Mineral and Cardiovascular Disease in Dialysis Patients.

    Bernardor, Julie / De Mul, Aurélie / Bacchetta, Justine / Schmitt, Claus Peter

    Current osteoporosis reports

    2023  Volume 21, Issue 2, Page(s) 193–204

    Abstract: Purposes of review: With chronic kidney disease (CKD) progression, secondary hyperparathyroidism (sHPT) and mineral and bone metabolism disease (MBD) almost inevitably develop and result in renal osteodystrophy and cardiovascular disease (CVD). Together ...

    Abstract Purposes of review: With chronic kidney disease (CKD) progression, secondary hyperparathyroidism (sHPT) and mineral and bone metabolism disease (MBD) almost inevitably develop and result in renal osteodystrophy and cardiovascular disease (CVD). Together with active vitamin D, calcimimetics are the main therapy for sHPT in CKD. This review provides an overview of the therapeutic effects of oral cinacalcet and intravenous etelcalcetide on CKD-MBD and vascular disease, with a focus on pediatric dialysis patients.
    Recent findings: Randomized controlled trials in adults and children demonstrate efficient lowering of parathyroid hormone (PTH) by the calcimimetics together with a reduction in serum calcium and phosphate when combined with low-dose active vitamin D, while therapy with active vitamin D analogs alone increases serum calcium and phosphate. Cinacalcet and etelcalcetide both improve bone formation and correct adynamic bone, i.e., have a direct bone anabolic effect. They decrease serum calciprotein particles, which are involved in endothelial dysfunction, atherogenesis, and vascular calcification. Clinical trials in adults suggest a modest slowing of the progression of cardiovascular calcification with cinacalcet. Calcimimetic agents represent a major pharmacological tool for improved control of CKD-MBD, by efficiently counteracting sHPT and allowing for better control of calcium/phosphate and bone homeostasis. Albeit definite evidence is lacking, the beneficial effects of calcimimetics on CVD are promising. Routine use of cinacalcet has been suggested in children.
    MeSH term(s) Adult ; Humans ; Child ; Cinacalcet/therapeutic use ; Renal Dialysis ; Calcium/therapeutic use ; Chronic Kidney Disease-Mineral and Bone Disorder/drug therapy ; Chronic Kidney Disease-Mineral and Bone Disorder/complications ; Cardiovascular Diseases ; Hyperparathyroidism, Secondary/drug therapy ; Hyperparathyroidism, Secondary/etiology ; Calcimimetic Agents/therapeutic use ; Parathyroid Hormone ; Vitamin D/therapeutic use ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Minerals ; Phosphates/metabolism
    Chemical Substances Cinacalcet (UAZ6V7728S) ; etelcalcetide hydrochloride (72PT5993DU) ; Calcium (SY7Q814VUP) ; Calcimimetic Agents ; Parathyroid Hormone ; Vitamin D (1406-16-2) ; Minerals ; Phosphates
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186581-4
    ISSN 1544-2241 ; 1544-1873
    ISSN (online) 1544-2241
    ISSN 1544-1873
    DOI 10.1007/s11914-023-00782-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6146: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: How peritoneal dialysis transforms the peritoneum and vasculature in children with chronic kidney disease-what can we learn for future treatment?

    Bartosova, Maria / Zarogiannis, Sotirios G / Schmitt, Claus Peter

    Molecular and cellular pediatrics

    2022  Volume 9, Issue 1, Page(s) 9

    Abstract: Children with chronic kidney disease (CKD) suffer from inflammation and reactive metabolite-induced stress, which massively accelerates tissue and vascular aging. Peritoneal dialysis (PD) is the preferred dialysis mode in children, but currently used PD ... ...

    Abstract Children with chronic kidney disease (CKD) suffer from inflammation and reactive metabolite-induced stress, which massively accelerates tissue and vascular aging. Peritoneal dialysis (PD) is the preferred dialysis mode in children, but currently used PD fluids contain far supraphysiological glucose concentrations for fluid and toxin removal and glucose degradation products (GDP). While the peritoneal membrane of children with CKD G5 exhibits only minor alterations, PD fluids trigger numerous molecular cascades resulting in major peritoneal membrane inflammation, hypervascularization, and fibrosis, with distinct molecular and morphological patterns depending on the GDP content of the PD fluid used. PD further aggravates systemic vascular disease. The systemic vascular aging process is particularly pronounced when PD fluids with high GDP concentrations are used. GDP induce endothelial junction disintegration, apoptosis, fibrosis, and intima thickening. This review gives an overview on the molecular mechanisms of peritoneal and vascular transformation and strategies to improve peritoneal and vascular health in patients on PD.
    Language English
    Publishing date 2022-05-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2785551-X
    ISSN 2194-7791
    ISSN 2194-7791
    DOI 10.1186/s40348-022-00141-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Hemodiafiltration in the pediatric population.

    de Zan, Francesca / Schmitt, Claus Peter / Shroff, Rukshana

    Seminars in dialysis

    2022  Volume 35, Issue 5, Page(s) 427–430

    Abstract: Hemodiafiltration (HDF) is increasingly adopted as a safe and effective treatment compared to conventional hemodialysis (HD) in children. We describe the outcomes of prospective observational studies in children on HDF versus HD showing that HDF was ... ...

    Abstract Hemodiafiltration (HDF) is increasingly adopted as a safe and effective treatment compared to conventional hemodialysis (HD) in children. We describe the outcomes of prospective observational studies in children on HDF versus HD showing that HDF was associated with an attenuation of the cardiovascular risk profile, improved blood pressure control, reduced inflammation, improved bone health and growth, and most importantly, an improved health-related quality of life.
    MeSH term(s) Child ; Hemodiafiltration/adverse effects ; Humans ; Prospective Studies ; Quality of Life ; Renal Dialysis/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1028193-9
    ISSN 1525-139X ; 0894-0959
    ISSN (online) 1525-139X
    ISSN 0894-0959
    DOI 10.1111/sdi.13072
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2879: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book ; Thesis: Fibroblasten verschiedener Spezies eliminieren TGF-beta-vermittellt [TGF-beta-vermittelt] transformierte Zellen unabhängig vom zugrundeliegenden Transformationsprinzip

    Schmitt, Claus Peter

    1992  

    Title variant Fibroblasten verschiedener Spezies eliminieren TGF-beta-vermittellt transformierte Zellen unabhängig vom zugrundeliegenden Transformationsprinzip
    Author's details vorgelegt von Claus Peter Schmitt
    Language German
    Size 142 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 1993
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT006655951
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 MB 1185 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease.

    Zaloszyc, Ariane / Bernardor, Julie / Bacchetta, Justine / Laverny, Gilles / Schmitt, Claus Peter

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Patients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD-MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of novel ... ...

    Abstract Patients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD-MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of novel therapeutic approaches, mouse models are essential. CKD can be induced by surgical reduction of a functional kidney mass, by nephrotoxic compounds and by genetic engineering specifically interfering with kidney development. These models develop a large range of bone diseases, recapitulating different types of human CKD-MBD and associated sequelae, including vascular calcifications. Bones are usually studied by quantitative histomorphometry, immunohistochemistry and micro-CT, but alternative strategies have emerged, such as longitudinal in vivo osteoblast activity quantification by tracer scintigraphy. The results gained from the CKD-MBD mouse models are consistent with clinical observations and have provided significant knowledge on specific pathomechanisms, bone properties and potential novel therapeutic strategies. This review discusses available mouse models to study bone disease in CKD.
    MeSH term(s) Mice ; Animals ; Humans ; Chronic Kidney Disease-Mineral and Bone Disorder ; Quality of Life ; Renal Insufficiency, Chronic/complications ; Bone Diseases ; Minerals
    Chemical Substances Minerals
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065325
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top