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  1. Book ; Thesis: Studies of the pathogenesis of lgA nephropathy and Henoch-Schönlein purpura, with special reference to Streptococcus pyogenes infections and complement

    Schmitt, Roland

    (Doctoral dissertation series ; 2012,38)

    2012  

    Author's details Roland Schmitt
    Series title Doctoral dissertation series ; 2012,38
    Collection
    Language English ; Swedish
    Size Getr. Zählung : graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lund, Univ., Diss., 2012
    Note Zsfassung in schwed. Sprache
    HBZ-ID HT017236866
    ISBN 978-91-87189-00-5 ; 91-87189-00-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 E 872 order for loan Magazin

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  2. Book: Zur Geschichte des Weinbaus im Bliesgau und an der oberen Saar (Saar-Blies-Winkel)

    Schmitt, Roland

    (Schriften zur Weingeschichte ; 167)

    2010  

    Author's details von Roland Schmitt
    Series title Schriften zur Weingeschichte ; 167
    Collection
    Keywords Bliesgau ; Saartal ; Weinbau ; Geschichte
    Subject Weinanbau ; Rebbau
    Language German
    Size 32 S. : Ill., Kt., 21 cm
    Edition Privatdr.
    Publisher Ges. für Geschichte des Weines
    Publishing place Wiesbaden
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016407037
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    108/864 available for loan (reading room) Freihandmagazin (U1)

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  3. Article: Blockierung des Renin-Angiotensin-Aldosteron-Systems: Einfluss auf die Progression der chronischen Nierenerkrankung.

    Schmitt, Roland

    Der nephrologe

    2021  Volume 17, Issue 1, Page(s) 26–33

    Abstract: Chronic kidney diseases (CKD) are often progressive and usually associated with a relatively slow loss of function. This principally offers the opportunity for drug interventions over a prolonged period. The prerequisite is that clear therapeutic targets ...

    Title translation Inhibition of the renin-angiotensin-aldosterone system.
    Abstract Chronic kidney diseases (CKD) are often progressive and usually associated with a relatively slow loss of function. This principally offers the opportunity for drug interventions over a prolonged period. The prerequisite is that clear therapeutic targets can be identified. One of the most important targets is the renin-angiotensin-aldosterone system (RAAS), the activation of which is a key contributor to the progression and deterioration of renal function. This article reviews the pathomechanistic principles of RAAS-mediated renal damage and the pharmaceutical possibilities for inhibition of the RAAS. The evidence from clinical studies on nephroprotection is summarized and the international guideline recommendations are discussed. As a future perspective, the novel possibility of a combined add-on treatment with nonsteroidal mineralocorticoid receptor antagonists is discussed based on the FIDELIO-DKD study.
    Language German
    Publishing date 2021-08-23
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2274530-0
    ISSN 1862-0418 ; 1862-040X
    ISSN (online) 1862-0418
    ISSN 1862-040X
    DOI 10.1007/s11560-021-00525-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6649: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Purple Urine in the Catheter Bag.

    Hillebrand, Uta / Schmitt, Roland

    Deutsches Arzteblatt international

    2023  Volume 119, Issue 45, Page(s) 764

    MeSH term(s) Humans ; Urinary Tract Infections/diagnosis ; Catheters ; Kidney Diseases
    Language English
    Publishing date 2023-01-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2022.0197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Messungen zur epithelialen Barrierefunktion des Darmes bei Patienten mit chronisch entzündlicher Darmerkrankung und Einfluß einer Coronavirus-Infektion

    Schmitt, Roland

    (Berichte aus der Medizin)

    2003  

    Author's details Roland Schmitt
    Series title Berichte aus der Medizin
    Keywords Chronische Darmentzündung ; Coronaviren ; Virusinfektion ; Darm ; Permeabilität
    Subject Durchlässigkeit ; Darmtrakt ; Intestinum ; Virale Infektion ; Coronavirus ; Coronaviridae ; Inflammatory bowel disease ; Irritable Bowel Syndrome ; Entzündliche Darmkrankheit ; Chronisch-entzündliche Darmerkrankung
    Language German
    Size V, 103 S., graph. Darst., 21 cm, 168 gr.
    Publisher Shaker
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 2002
    HBZ-ID HT013727454
    ISBN 3-8322-1268-X ; 978-3-8322-1268-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 1707 order for loan Magazin

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  6. Article ; Online: ZAG-a novel biomarker for cardiovascular risk in ESRD patients?

    Schmitt, Roland

    Kidney international

    2018  Volume 94, Issue 5, Page(s) 858–860

    Abstract: End-stage renal disease (ESRD) is associated with an exceedingly high risk of cardiovascular disease. Traditional risk factors function differently in ESRD, which has prompted a search for novel mechanisms and biomarkers. In an observational study, ... ...

    Abstract End-stage renal disease (ESRD) is associated with an exceedingly high risk of cardiovascular disease. Traditional risk factors function differently in ESRD, which has prompted a search for novel mechanisms and biomarkers. In an observational study, Bouchara et al. identified zinc-alpha2-glycoprotein (ZAG) as a prognostic marker for cardiovascular events and mortality in patients on dialysis. Although the study raises important questions, the results should be interpreted cautiously and need to be confirmed in independent studies.
    MeSH term(s) Adipokines ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Glycoproteins ; Humans ; Kidney Failure, Chronic/blood ; Renal Dialysis ; Risk Factors ; Zinc
    Chemical Substances Adipokines ; Biomarkers ; Glycoproteins ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2018-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2018.08.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: More than a Marker: Arginase-1 in Kidney Repair.

    von Vietinghoff, Sibylle / Schmitt, Roland

    Journal of the American Society of Nephrology : JASN

    2022  Volume 33, Issue 6, Page(s) 1051–1053

    MeSH term(s) Acute Kidney Injury ; Arginase ; Humans ; Kidney ; Kidney Tubules, Proximal
    Chemical Substances Arginase (EC 3.5.3.1)
    Language English
    Publishing date 2022-05-16
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2022020161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Senotherapy: growing old and staying young?

    Schmitt, Roland

    Pflugers Archiv : European journal of physiology

    2017  Volume 469, Issue 9, Page(s) 1051–1059

    Abstract: Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue ... ...

    Abstract Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue repair. Instead, senescent cells disturb the microenvironment by secreting a plethora of bioactive factors that may lead to inflammation, regenerative dysfunction and tumor progression. Recent understanding of stimuli and pathways that induce and maintain cellular senescence offers the possibility to selectively eliminate senescent cells. This novel strategy, which so far has not been tested in humans, has been coined senotherapy or senolysis. In mice, senotherapy proofed to be effective in models of accelerated aging and also during normal chronological aging. Senotherapy prolonged lifespan, rejuvenated the function of bone marrow, muscle and skin progenitor cells, improved vasomotor function and slowed down atherosclerosis progression. While initial studies used genetic approaches for the killing of senescent cells, recent approaches showed similar effects with senolytic drugs. These observations open up exciting possibilities with a great potential for clinical development. However, before the integration of senotherapy into patient care can be considered, we need further research to improve our insight into the safety and efficacy of this strategy during short- and long-term use.
    MeSH term(s) Aging/pathology ; Animals ; Atherosclerosis/pathology ; Cellular Senescence/physiology ; Humans ; Inflammation/pathology
    Language English
    Publishing date 2017-04-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-017-1972-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.35: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Article ; Online: Cellular senescence and kidney aging.

    Rex, Nikolai / Melk, Anette / Schmitt, Roland

    Clinical science (London, England : 1979)

    2023  Volume 137, Issue 24, Page(s) 1805–1821

    Abstract: Life expectancy is increasing worldwide, and by 2050 the proportion of the world's population over 65 years of age is estimated to surpass 1.5 billion. Kidney aging is associated with molecular and physiological changes that cause a loss of renal ... ...

    Abstract Life expectancy is increasing worldwide, and by 2050 the proportion of the world's population over 65 years of age is estimated to surpass 1.5 billion. Kidney aging is associated with molecular and physiological changes that cause a loss of renal function and of regenerative potential. As the aging population grows, it is crucial to understand the mechanisms underlying these changes, as they increase the susceptibility to developing acute kidney injury (AKI) and chronic kidney disease (CKD). Various cellular processes and molecular pathways take part in the complex process of kidney aging. In this review, we will focus on the phenomenon of cellular senescence as one of the involved mechanisms at the crossroad of kidney aging, age-related disease, and CKD. We will highlight experimental and clinical findings about the role of cellular senescence in kidney aging and CKD. In addition, we will review challenges in senescence research and emerging therapeutic aspects. We will highlight the great potential of senolytic strategies for the elimination of harmful senescent cells to promote healthy kidney aging and to avoid age-related disease and CKD. This review aims to give insight into recent discoveries and future developments, providing a comprehensive overview of current knowledge on cellular senescence and anti-senescent therapies in the kidney field.
    MeSH term(s) Humans ; Acute Kidney Injury/drug therapy ; Aging/physiology ; Cellular Senescence ; Kidney/physiology ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20230140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.220: Show issues Location:
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  10. Book ; Thesis: Die Expression von Natrium-Transportproteinen im distalen Rattennephron während der Ontogenese

    Schmitt, Roland

    2000  

    Author's details von Roland Schmitt
    Language German
    Size 85 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2000
    HBZ-ID HT013081769
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 E 2101 order for loan Magazin

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