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  1. Book ; Thesis: Reduziert die postinterventionelle Nulldruckableitung das Infektionsrisiko nach ureterorenoskopischer Steinsanierung?

    Schmitz, Elena

    2021  

    Institution Westfälische Wilhelms-Universität Münster
    Author's details vorgelegt von Schmitz, Elena aus Soest
    Language German
    Size 84 Blätter, Diagramme
    Publishing place Münster
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Westfälische Wilhelms-Universität Münster, 2021
    HBZ-ID HT021071875
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 E 1217 order for loan Magazin

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  2. Book ; Thesis: Potentieller Einfluss gepulster Stimulation auf sympathische kardiale Neurozyten

    Schmitz, Eva

    2015  

    Author's details vorgelegt von Eva Schmitz
    Language German
    Size 114 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Diss., 2015
    HBZ-ID HT018734456
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 D 577 order for loan Magazin

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  3. Article ; Online: Adaptive Fine-tuning based Transfer Learning for the Identification of MGMT Promoter Methylation Status.

    Schmitz, Erich / Guo, Yunhui / Wang, Jing

    ArXiv

    2024  

    Abstract: Glioblastoma Multiforme (GBM) is an aggressive form of malignant brain tumor with a generally poor prognosis. Treatment usually includes a mix of surgical resection, radiation therapy, and akylating chemotherapy but, even with these intensive treatments, ...

    Abstract Glioblastoma Multiforme (GBM) is an aggressive form of malignant brain tumor with a generally poor prognosis. Treatment usually includes a mix of surgical resection, radiation therapy, and akylating chemotherapy but, even with these intensive treatments, the 2-year survival rate is still very low. O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been shown to be a predictive bio-marker for resistance to chemotherapy, but it is invasive and time-consuming to determine the methylation status. Due to this, there has been effort to predict the MGMT methylation status through analyzing MRI scans using machine learning, which only requires pre-operative scans that are already part of standard-of-care for GBM patients. We developed a 3D SpotTune network with adaptive fine-tuning capability to improve the performance of conventional transfer learning in the identification of MGMT promoter methylation status. Using the pretrained weights of MedicalNet coupled with the SpotTune network, we compared its performance with two equivalent networks: one that is initialized with MedicalNet weights, but with no adaptive fine-tuning and one initialized with random weights. These three networks are trained and evaluated using the UPENN-GBM dataset, a public GBM dataset provided by the University of Pennsylvania. The SpotTune network enables transfer learning to be adaptive to individual patients, resulting in improved performance in predicting MGMT promoter methylation status in GBM using MRIs as compared to using a network with randomly initialized weights.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Retroperitoneal Sarcoma Care in 2021.

    Schmitz, Erika / Nessim, Carolyn

    Cancers

    2022  Volume 14, Issue 5

    Abstract: Soft-tissue sarcomas are biologically heterogenous tumors arising from connective tissues with over 100 subtypes. Although sarcomas account for <1% of all adult malignancies, retroperitoneal sarcomas are a distinct subgroup accounting for <10% of all ... ...

    Abstract Soft-tissue sarcomas are biologically heterogenous tumors arising from connective tissues with over 100 subtypes. Although sarcomas account for <1% of all adult malignancies, retroperitoneal sarcomas are a distinct subgroup accounting for <10% of all sarcomatous tumors. There have been considerable advancements in the understanding and treatment of retroperitoneal sarcoma in the last decade, with standard treatment consisting of upfront primary surgical resection. The evidence surrounding the addition of radiation therapy remains controversial. There remains no standard with regards to systemic therapy, including immunotherapy. Adjunctive therapy remains largely dictated by expert consensus and preferences at individual centers or participation in clinical trials. In this 2021 review, we detail the anatomical boundaries of the retroperitoneum, clinical characteristics, contemporary standard of care and well as recent advancements in retroperitoneal sarcoma care. Ongoing international collaborations are encouraged to advance our understanding of this complex disease.
    Language English
    Publishing date 2022-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14051293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Article ; Online: The impact of Brexit uncertainties on international trade

    Schmitz, Emerson

    Evidence from Belgium

    2019  

    Abstract: This paper investigates the short-run effects of the uncertainties brought along with the Brexit referendum on the bilateral trade between Belgium and its main trading partners. I find that import and export markets have specific dynamics and react ... ...

    Abstract This paper investigates the short-run effects of the uncertainties brought along with the Brexit referendum on the bilateral trade between Belgium and its main trading partners. I find that import and export markets have specific dynamics and react differently to changes in political uncertainty and economic variables. While import flows are more rigid and do not react to the uncertainties related to the Brexit referendum, export flows are more sensitive to this event. Consequently, I find that the instable environment created by the Brexit referendum leads to lower intensive margin of Belgian exports to the UK in comparison to Belgium's' main neighboring countries. The impact of uncertainties is more pronounced in larger Belgian exporting firms in the period preceding the Brexit referendum, since these firms are better able to absorb the associated costs of postponing or diverting exports. The results for Belgian manufacturing firms, which are more responsive to changes in competitiveness, also suggest more intense reaction to the Brexit uncertainties than commodities' producers but are not conclusive.
    Keywords ddc:330 ; F13 ; F14 ; F15 ; F31 ; F60 ; Brexit ; European Union ; political uncertainty ; international trade ; exchange rates
    Subject code 381
    Language English
    Publisher Brussels: National Bank of Belgium
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Warming weather changes the chemical composition of oat hulls.

    Schmitz, E / Nordberg Karlsson, E / Adlercreutz, P

    Plant biology (Stuttgart, Germany)

    2020  Volume 22, Issue 6, Page(s) 1086–1091

    Abstract: The current threats of climate change are driving attention away from the petrochemical industry towards more sustainable and bio-based production processes for fuels and speciality chemicals. These processes require suitable low-cost starting material. ... ...

    Abstract The current threats of climate change are driving attention away from the petrochemical industry towards more sustainable and bio-based production processes for fuels and speciality chemicals. These processes require suitable low-cost starting material. One potential material assessed here is the oat hull. Its overall chemical composition has so far not been fully characterized. Furthermore, it is not known how it is affected by extreme weather events. Oat hulls (Kerstin and Galant varieties) grown during 'normal' weather years (2016 and 2017) are compared to the harvest of the warmer and drier year (2018). Standard methods for determination of plant chemical composition, with focus on carbohydrate composition, are utilized. Oat hulls grown in 'normal' weather conditions (2017) are rich in lignocellulose (84%), consisting of 35% hemicellulose, 25% lignin and 23% cellulose. Arabinoxylan was found to be the major biopolymer (32%). However, this composition is greatly influenced by weather variations during the oat growth phase. A lignocellulose reduction of 25% was recorded in the warmer and drier 2018 harvest. Additionally, a 6.6-fold increase in starch content, a four-fold increase in protein content and a 60% decrease in phenolic content was noted. Due to its high lignocellulose composition, with an exceptionally large hemicellulose fraction, the chemical composition of oat hulls is unique among agricultural by-products. However, this characteristic is significantly reduced when grown in warmer and drier weather, which could compromise its suitability for use in a successful biorefinery.
    MeSH term(s) Avena/chemistry ; Biomass ; Carbohydrates/chemistry ; Climate Change ; Lignin/chemistry ; Polysaccharides/chemistry ; Seeds/chemistry ; Xylans/chemistry
    Chemical Substances Carbohydrates ; Polysaccharides ; Xylans ; lignocellulose (11132-73-3) ; hemicellulose (8024-50-8) ; Lignin (9005-53-2) ; arabinoxylan (9040-27-1)
    Language English
    Publishing date 2020-09-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464075-2
    ISSN 1438-8677 ; 1435-8603
    ISSN (online) 1438-8677
    ISSN 1435-8603
    DOI 10.1111/plb.13171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 99/704: Show issues

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  7. Article ; Online: Ultrasound for critical care physicians

    Schmitz E

    Southwest Journal of Pulmonary and Critical Care, Vol 8, Iss 3, Pp 176-

    hypotension after a MVA

    2014  Volume 178

    Abstract: No abstract available. Article truncated after first page. A 25 year old woman was a restrained driver in a rollover motor vehicle accident (MVA) and suffered a C5-C6 fracture-dislocation with spinal cord injury. She was lucid and able to follow commands ...

    Abstract No abstract available. Article truncated after first page. A 25 year old woman was a restrained driver in a rollover motor vehicle accident (MVA) and suffered a C5-C6 fracture-dislocation with spinal cord injury. She was lucid and able to follow commands and could move her upper extremities but not her lower extremities. She was given approximately 6 liters of fluid but required vasopressors to maintain her blood pressure. Initial ECG revealed a normal sinus rhythm without significant ST changes (Figure 1). Upon initial evaluation her blood pressure was low. Bedside ultrasound of the left anterior second intercostal space revealed a sliding lung sign and a 4 chamber view of her heart was performed (Figure 2). Which of the following is the most likely cause of her hypotension? 1. Blunt cardiac injury; 2. Intravascular volume depletion; 3. Neurogenic stunned myocardium; 4. Pericardial tamponade; 5. Pneumothorax .
    Keywords trauma ; cardiac trauma ; hypotension ; ultrasound ; echocardiography ; neurogenic stunned myocardium ; stress-induced cardiomyopathy ; Takatsubo's cardiomyopathy ; neuorgenic shock ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Thesis: Einsatzmöglichkeiten eines Rettungshubschraubers in einem geschlossenen Stadtgebiet

    Schmitz, Elisabeth

    Erfahrungen aus dem ersten Betriebsjahr des RTH Christoph 31 in Berlin (West)

    1996  

    Author's details vorgelegt von: Elisabeth Schmitz
    Language German
    Size 51, IV Bl. : graph. Darst., Kt.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1996
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT007537362
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 MB 838 order for loan Magazin

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  9. Book ; Thesis: Lungentuberkulose

    Schmitz, Elisabeth

    Literaturüberblick und retrospektive Studie

    1993  

    Author's details vorgelegt von Elisabeth Schmitz
    Language German
    Size 197 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 1993
    HBZ-ID HT006147595
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    94 D 198 order for loan Magazin

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  10. Book ; Online: Adaptive Fine-tuning based Transfer Learning for the Identification of MGMT Promoter Methylation Status

    Schmitz, Erich / Guo, Yunhui / Wang, Jing

    2023  

    Abstract: Glioblastoma Multiforme (GBM) is an aggressive form of malignant brain tumor with a generally poor prognosis. Treatment usually includes a mix of surgical resection, radiation therapy, and akylating chemotherapy but, even with these intensive treatments, ...

    Abstract Glioblastoma Multiforme (GBM) is an aggressive form of malignant brain tumor with a generally poor prognosis. Treatment usually includes a mix of surgical resection, radiation therapy, and akylating chemotherapy but, even with these intensive treatments, the 2-year survival rate is still very low. O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been shown to be a predictive bio-marker for resistance to chemotherapy, but it is invasive and time-consuming to determine the methylation status. Due to this, there has been effort to predict the MGMT methylation status through analyzing MRI scans using machine learning, which only requires pre-operative scans that are already part of standard-of-care for GBM patients. We developed a 3D SpotTune network with adaptive fine-tuning capability to improve the performance of conventional transfer learning in the identification of MGMT promoter methylation status. Using the pretrained weights of MedicalNet coupled with the SpotTune network, we compared its performance with two equivalent networks: one that is initialized with MedicalNet weights, but with no adaptive fine-tuning and one initialized with random weights. These three networks are trained and evaluated using the UPENN-GBM dataset, a public GBM dataset provided by the University of Pennsylvania. The SpotTune network enables transfer learning to be adaptive to individual patients, resulting in improved performance in predicting MGMT promoter methylation status in GBM using MRIs as compared to using a network with randomly initialized weights.

    Comment: 21 pages, 5 figures. Preprint
    Keywords Physics - Medical Physics
    Subject code 570
    Publishing date 2023-10-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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