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  1. Book: Allogeneic peripheral blood progenitor cell transplantation

    Schmitz, N.

    the role of haematopoietic growth factors

    (Consultant series / Amgen (Europe) ; 22)

    2001  

    Author's details N. Schmitz
    Series title Consultant series / Amgen (Europe) ; 22
    Collection
    Language English
    Size 65 S. : graph. Darst.
    Publisher Amgen (Europe) AG
    Publishing place Lucerne
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015418499
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 1202 order for loan Magazin

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  2. Article ; Online: Ibrutinib in the treatment of relapsed FL and MZL?

    Schmitz, Norbert / Karsten, Imke E

    Blood advances

    2023  Volume 7, Issue 22, Page(s) 7139–7140

    MeSH term(s) Piperidines/therapeutic use ; Adenine
    Chemical Substances ibrutinib (1X70OSD4VX) ; Piperidines ; Adenine (JAC85A2161)
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Conference proceedings: Proceedings of the 2nd International Symposium on Allogeneic Peripheral Blood and Cord Blood Transplantation

    Schmitz, N.

    an EBMT symposium ; 30 October - 1 November 1997, Geneva, Switzerland

    (Bone marrow transplantation ; 21, Suppl. 3)

    1998  

    Institution European Cooperative Group for Bone Marrow Transplantation
    Event/congress International Symposium on Allogeneic Peripheral Blood and Cord Blood Transplantation (2, 1997, Genf)
    Author's details ed. N. Schmitz
    Series title Bone marrow transplantation ; 21, Suppl. 3
    Collection
    Language English
    Size S123 S. : graph. Darst.
    Publisher Stockton
    Publishing place Basingstoke, Hampshire
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT008813896
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2168 -21,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: CNS prophylaxis in DLBCL: time to say goodbye?

    Schmitz, Norbert / Frontzek, Fabian

    Blood

    2022  Volume 139, Issue 3, Page(s) 315–317

    MeSH term(s) Central Nervous System Neoplasms/prevention & control ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021014043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  5. Article ; Online: A decade of chronic lymphocytic leukaemia therapy in Germany: Real-world treatment patterns and outcomes (2010-2022).

    Wartmann, Hannes / Kabilka, Anna / Deiters, Barthold / Schmitz, Norbert / Volmer, Timm

    EJHaem

    2024  Volume 5, Issue 2, Page(s) 346–352

    Abstract: Pharmacotherapy options for chronic lymphocytic leukaemia (CLL) have expanded significantly in recent years. These options include chemotherapy, chemoimmunotherapy and signalling pathway inhibitors. A notable shift in the treatment landscape began with ... ...

    Abstract Pharmacotherapy options for chronic lymphocytic leukaemia (CLL) have expanded significantly in recent years. These options include chemotherapy, chemoimmunotherapy and signalling pathway inhibitors. A notable shift in the treatment landscape began with the widespread adoption of ibrutinib in 2016. This analysis of claims data focuses on understanding how the use of novel therapies has evolved in clinical practice over the past decade in Germany. Anonymized claims data (2010-2022) from German statutory health insurance was used, covering patient demographics, treatments, and prescriptions. The study population included patients with two confirmed CLL diagnoses. Treatment patterns were analysed, and survival outcomes were compared using time-to-event analyses. In the analysed cohort of 2983 incident CLL patients, 1041 started first-line therapy between 2011 and 2022, with a median duration of 18 months from diagnosis to the first prescription. Chemoimmunotherapy, the predominant 1L therapy until 2019, decreased significantly, while targeted therapy usage increased from 3% in 2015 to 77% in 2022. Targeted therapies became dominant in patients receiving treatment for relapsed or refractory disease after 2016. Median treatment durations were: 122 days for chemo, 176 days for chemo-immuno, and 373 days for targeted therapy. The overall survival for patients diagnosed in or after 2016 was significantly better (hazard ratio 0.56, 95% confidence interval, 0.44-0.69)). The adoption of targeted therapies like ibrutinib and venetoclax has transformed CLL treatment in Germany, leading to improved patient outcomes. Additionally, we demonstrate successful adherence to evolving clinical guidelines.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Digital Health Interventions and Patient Safety in Abdominal Surgery: A Systematic Review and Meta-Analysis.

    Grygorian, Artem / Montano, Diego / Shojaa, Mahdieh / Ferencak, Maximilian / Schmitz, Norbert

    JAMA network open

    2024  Volume 7, Issue 4, Page(s) e248555

    Abstract: Importance: Over the past 2 decades, several digital technology applications have been used to improve clinical outcomes after abdominal surgery. The extent to which these telemedicine interventions are associated with improved patient safety outcomes ... ...

    Abstract Importance: Over the past 2 decades, several digital technology applications have been used to improve clinical outcomes after abdominal surgery. The extent to which these telemedicine interventions are associated with improved patient safety outcomes has not been assessed in systematic and meta-analytic reviews.
    Objective: To estimate the implications of telemedicine interventions for complication and readmission rates in a population of patients with abdominal surgery.
    Data sources: PubMed, Cochrane Library, and Web of Science databases were queried to identify relevant randomized clinical trials (RCTs) and nonrandomized studies published from inception through February 2023 that compared perioperative telemedicine interventions with conventional care and reported at least 1 patient safety outcome.
    Study selection: Two reviewers independently screened the titles and abstracts to exclude irrelevant studies as well as assessed the full-text articles for eligibility. After exclusions, 11 RCTs and 8 cohort studies were included in the systematic review and meta-analysis and 7 were included in the narrative review.
    Data extraction and synthesis: Data were extracted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guideline and assessed for risk of bias by 2 reviewers. Meta-analytic estimates were obtained in random-effects models.
    Main outcomes and measures: Number of complications, emergency department (ED) visits, and readmissions.
    Results: A total of 19 studies (11 RCTs and 8 cohort studies) with 10 536 patients were included. The pooled risk ratio (RR) estimates associated with ED visits (RR, 0.78; 95% CI, 0.65-0.94) and readmissions (RR, 0.67; 95% CI, 0.58-0.78) favored the telemedicine group. There was no significant difference in the risk of complications between patients in the telemedicine and conventional care groups (RR, 1.05; 95% CI, 0.77-1.43).
    Conclusions and relevance: Findings of this systematic review and meta-analysis suggest that perioperative telehealth interventions are associated with reduced risk of readmissions and ED visits after abdominal surgery. However, the mechanisms of action for specific types of abdominal surgery are still largely unknown and warrant further research.
    MeSH term(s) Humans ; Telemedicine/methods ; Patient Safety/statistics & numerical data ; Patient Readmission/statistics & numerical data ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Abdomen/surgery ; Digital Health
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Systematic Review ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.8555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Oral health-related quality of life and depressive symptoms in adults: longitudinal associations of the English Longitudinal Study of Ageing (ELSA).

    Zwick, Luisa / Schmitz, Norbert / Shojaa, Mahdieh

    BMC oral health

    2023  Volume 23, Issue 1, Page(s) 1029

    Abstract: Background: Little is known about the relationship between oral health status and depressive symptoms in adults in England. The aim of this study was to examine the longitudinal association between oral health parameters and depressive symptoms in ... ...

    Abstract Background: Little is known about the relationship between oral health status and depressive symptoms in adults in England. The aim of this study was to examine the longitudinal association between oral health parameters and depressive symptoms in adults in England.
    Methods: Data were obtained from the English Longitudinal Study of Aging (ELSA), which included information on self-rated oral health, oral impairment in daily life (Oral Impacts on Daily Performances, OIDP), and depressive symptoms (Center for Epidemiologic Studies Depression Scale, CES-D) in 6790 adults aged ≥ 50 years. Wave 3 data were used as baseline, while Waves 5 and 7 were used for follow-up assessments. Logistic regression was used to determine whether depressive symptoms at baseline anticipated self-rated oral health and OIDP and whether oral health status (at baseline) was associated with the development of depressive symptoms at follow-up assessment.
    Results: Participants with poor self-rated oral health were at higher risk of developing depressive symptoms, even after adjusting for behavioral, clinical, and sociodemographic characteristics (OR = 1.69, 95% CI 1.38-2.07). Similarly, having oral impacts on daily performances were associated with the development of depressive symptoms: The OR for developing depressive symptoms at Wave 5 or 7 was 2.19 (95% CI 1.62-2.96) after adjustment for all covariates. Participants with depressive symptoms at baseline were more likely to report poor self-rated oral health (OR = 1.93, 95% CI 1.52-2.44) or one or more oral impacts (OR = 1.86, 95% CI 1.45-2.40) at follow-up than those without depressive symptoms at baseline, even after adjusting for confounders.
    Conclusions: In the present study, a bidirectional association was found between depressive symptoms and poor oral health in older adults. Maintaining good oral health in older adults may be a protective factor against depressive symptoms. Therefore, more attention should be paid to promoting oral health awareness in older adults, including encouraging regular dental checkups, proper toothbrushing and flossing techniques, and healthy lifestyles.
    MeSH term(s) Aged ; Humans ; Aging ; Depression/epidemiology ; Logistic Models ; Longitudinal Studies ; Quality of Life ; Oral Health ; Middle Aged
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-03722-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Thesis: Zur diagnostischen Aussagekraft der Knochenszintigraphie im Vergleich zur Kernspintomographie bei der Diagnostik von Wirbelkörpermetastasen

    Schmitz, Norbert

    1999  

    Author's details vorgelegt von Norbert Schmitz
    Language German
    Size 79 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 1999
    HBZ-ID HT011085183
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 D 169 order for loan Magazin

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  9. Article ; Online: Anti-CD25 antibody-drug conjugates: improving the delivery of death to lymphoma cells?

    Schmitz, Norbert / Lenz, Georg

    The Lancet. Haematology

    2021  Volume 8, Issue 6, Page(s) e387–e389

    MeSH term(s) Antineoplastic Agents ; Humans ; Immunoconjugates ; Lymphoma/drug therapy
    Chemical Substances Antineoplastic Agents ; Immunoconjugates
    Language English
    Publishing date 2021-05-28
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(21)00139-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Childhood maltreatment and the risk of impaired glucose metabolism or type 2 diabetes in young adults: Findings from the Lifelines Cohort Study.

    Deschênes, Sonya S / Nearchou, Finiki / McInerney, Amy / Schmitz, Norbert / Pouwer, Frans / Nouwen, Arie

    Journal of health psychology

    2024  , Page(s) 13591053241243285

    Abstract: We examined the associations between childhood maltreatment and the risk of impaired glucose metabolism (IGM) or type 2 diabetes (T2D) in young adults aged 18-35. Participants ( ...

    Abstract We examined the associations between childhood maltreatment and the risk of impaired glucose metabolism (IGM) or type 2 diabetes (T2D) in young adults aged 18-35. Participants (
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2021897-7
    ISSN 1461-7277 ; 1359-1053
    ISSN (online) 1461-7277
    ISSN 1359-1053
    DOI 10.1177/13591053241243285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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