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  1. Article ; Online: A Direct Comparison of Spatial Attention and Stimulus-Response Compatibility between Mice and Humans.

    Schnabel, Ulf H / Van der Bijl, Tobias / Roelfsema, Pieter R / Lorteije, Jeannette A M

    Journal of cognitive neuroscience

    2021  Volume 33, Issue 5, Page(s) 771–783

    Abstract: Mice are becoming an increasingly popular model for investigating the neural substrates of visual processing and higher cognitive functions. To validate the translation of mouse visual attention and sensorimotor processing to humans, we compared their ... ...

    Abstract Mice are becoming an increasingly popular model for investigating the neural substrates of visual processing and higher cognitive functions. To validate the translation of mouse visual attention and sensorimotor processing to humans, we compared their performance in the same visual task. Mice and human participants judged the orientation of a grating presented on either the right or left side in the visual field. To induce shifts of spatial attention, we varied the stimulus probability on each side. As expected, human participants showed faster RTs and a higher accuracy for the side with a higher probability, a well-established effect of visual attention. The attentional effect was only present in mice when their response was slow. Although the task demanded a judgment of grating orientation, the accuracy of the mice was strongly affected by whether the side of the stimulus corresponded to the side of the behavioral response. This stimulus-response compatibility (Simon) effect was much weaker in humans and only significant for their fastest responses. Both species exhibited a speed-accuracy trade-off in their responses, because slower responses were more accurate than faster responses. We found that mice typically respond very fast, which contributes to the stronger stimulus-response compatibility and weaker attentional effects, which were only apparent in the trials with slowest responses. Humans responded slower and had stronger attentional effects, combined with a weak influence of stimulus-response compatibility, which was only apparent in trials with fast responses. We conclude that spatial attention and stimulus-response compatibility influence the responses of humans and mice but that strategy differences between species determine the dominance of these effects.
    MeSH term(s) Animals ; Functional Laterality ; Humans ; Mice ; Psychomotor Performance ; Reaction Time ; Visual Fields
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1007410-7
    ISSN 1530-8898 ; 0898-929X ; 1096-8857
    ISSN (online) 1530-8898
    ISSN 0898-929X ; 1096-8857
    DOI 10.1162/jocn_a_01681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2623: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A neuronal basis of iconic memory in macaque primary visual cortex.

    Teeuwen, Rob R M / Wacongne, Catherine / Schnabel, Ulf H / Self, Matthew W / Roelfsema, Pieter R

    Current biology : CB

    2021  Volume 31, Issue 24, Page(s) 5401–5414.e4

    Abstract: After a briefly presented visual stimulus disappears, observers retain a detailed representation of this stimulus for a short period of time. This sensory storage is called iconic memory. We measured iconic memory in the perception of monkeys and its ... ...

    Abstract After a briefly presented visual stimulus disappears, observers retain a detailed representation of this stimulus for a short period of time. This sensory storage is called iconic memory. We measured iconic memory in the perception of monkeys and its neuronal correlates in the primary visual cortex (area V1). We determined how many milliseconds extra viewing time iconic memory is worth and how it decays by varying the duration of a brief stimulus and the timing of a mask. The V1 activity that persists after the disappearance of a stimulus predicted accuracy, with a time course resembling the worth and decay of iconic memory. Finally, we examined how iconic memory interacts with attention. A cue presented after the stimulus disappears boosts attentional influences pertaining to a relevant part of the stimulus but only if it appears before iconic memory decayed. Our results relate iconic memory to neuronal activity in early visual cortex.
    MeSH term(s) Animals ; Attention/physiology ; Macaca ; Memory, Short-Term/physiology ; Photic Stimulation ; Primary Visual Cortex ; Visual Perception/physiology
    Language English
    Publishing date 2021-10-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.09.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Mouse visual cortex contains a region of enhanced spatial resolution.

    van Beest, Enny H / Mukherjee, Sreedeep / Kirchberger, Lisa / Schnabel, Ulf H / van der Togt, Chris / Teeuwen, Rob R M / Barsegyan, Areg / Meyer, Arne F / Poort, Jasper / Roelfsema, Pieter R / Self, Matthew W

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 4029

    Abstract: The representation of space in mouse visual cortex was thought to be relatively uniform. Here we reveal, using population receptive-field (pRF) mapping techniques, that mouse visual cortex contains a region in which pRFs are considerably smaller. This ... ...

    Abstract The representation of space in mouse visual cortex was thought to be relatively uniform. Here we reveal, using population receptive-field (pRF) mapping techniques, that mouse visual cortex contains a region in which pRFs are considerably smaller. This region, the "focea," represents a location in space in front of, and slightly above, the mouse. Using two-photon imaging we show that the smaller pRFs are due to lower scatter of receptive-fields at the focea and an over-representation of binocular regions of space. We show that receptive-fields of single-neurons in areas LM and AL are smaller at the focea and that mice have improved visual resolution in this region of space. Furthermore, freely moving mice make compensatory eye-movements to hold this region in front of them. Our results indicate that mice have spatial biases in their visual processing, a finding that has important implications for the use of the mouse model of vision.
    MeSH term(s) Animals ; Eye Movements/physiology ; Female ; Head Movements/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Photic Stimulation ; Visual Cortex/physiology ; Visual Fields/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-24311-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The essential role of recurrent processing for figure-ground perception in mice.

    Kirchberger, Lisa / Mukherjee, Sreedeep / Schnabel, Ulf H / van Beest, Enny H / Barsegyan, Areg / Levelt, Christiaan N / Heimel, J Alexander / Lorteije, Jeannette A M / van der Togt, Chris / Self, Matthew W / Roelfsema, Pieter R

    Science advances

    2021  Volume 7, Issue 27

    Abstract: The segregation of figures from the background is an important step in visual perception. In primary visual cortex, figures evoke stronger activity than backgrounds during a delayed phase of the neuronal responses, but it is unknown how this figure- ... ...

    Abstract The segregation of figures from the background is an important step in visual perception. In primary visual cortex, figures evoke stronger activity than backgrounds during a delayed phase of the neuronal responses, but it is unknown how this figure-ground modulation (FGM) arises and whether it is necessary for perception. Here, we show, using optogenetic silencing in mice, that the delayed V1 response phase is necessary for figure-ground segregation. Neurons in higher visual areas also exhibit FGM and optogenetic silencing of higher areas reduced FGM in V1. In V1, figures elicited higher activity of vasoactive intestinal peptide-expressing (VIP) interneurons than the background, whereas figures suppressed somatostatin-positive interneurons, resulting in an increased activation of pyramidal cells. Optogenetic silencing of VIP neurons reduced FGM in V1, indicating that disinhibitory circuits contribute to FGM. Our results provide insight into how lower and higher areas of the visual cortex interact to shape visual perception.
    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abe1833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Figure-ground perception in the awake mouse and neuronal activity elicited by figure-ground stimuli in primary visual cortex.

    Schnabel, Ulf H / Bossens, Christophe / Lorteije, Jeannette A M / Self, Matthew W / Op de Beeck, Hans / Roelfsema, Pieter R

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 17800

    Abstract: Figure-ground segregation is the process by which the visual system identifies image elements of figures and segregates them from the background. Previous studies examined figure-ground segregation in the visual cortex of monkeys where figures elicit ... ...

    Abstract Figure-ground segregation is the process by which the visual system identifies image elements of figures and segregates them from the background. Previous studies examined figure-ground segregation in the visual cortex of monkeys where figures elicit stronger neuronal responses than backgrounds. It was demonstrated in anesthetized mice that neurons in the primary visual cortex (V1) of mice are sensitive to orientation contrast, but it is unknown whether mice can perceptually segregate figures from a background. Here, we examined figure-ground perception of mice and found that mice can detect figures defined by an orientation that differs from the background while the figure size, position or phase varied. Electrophysiological recordings in V1 of awake mice revealed that the responses elicited by figures were stronger than those elicited by the background and even stronger at the edge between figure and background. A figural response could even be evoked in the absence of a stimulus in the V1 receptive field. Current-source-density analysis suggested that the extra activity was caused by synaptic inputs into layer 2/3. We conclude that the neuronal mechanisms of figure-ground segregation in mice are similar to those in primates, enabling investigation with the powerful techniques for circuit analysis now available in mice.
    MeSH term(s) Animals ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/physiology ; Orientation/physiology ; Pattern Recognition, Visual/physiology ; Photic Stimulation/methods ; Visual Cortex/physiology ; Visual Perception/physiology ; Wakefulness/physiology
    Language English
    Publishing date 2018-12-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-36087-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Electromagnetic tracking of motion in the proximity of computer generated graphical stimuli: a tutorial.

    Schnabel, Ulf H / Hegenloh, Michael / Müller, Hermann J / Zehetleitner, Michael

    Behavior research methods

    2013  Volume 45, Issue 3, Page(s) 696–701

    Abstract: Electromagnetic motion-tracking systems have the advantage of capturing the tempo-spatial kinematics of movements independently of the visibility of the sensors. However, they are limited in that they cannot be used in the proximity of electromagnetic ... ...

    Abstract Electromagnetic motion-tracking systems have the advantage of capturing the tempo-spatial kinematics of movements independently of the visibility of the sensors. However, they are limited in that they cannot be used in the proximity of electromagnetic field sources, such as computer monitors. This prevents exploiting the tracking potential of the sensor system together with that of computer-generated visual stimulation. Here we present a solution for presenting computer-generated visual stimulation that does not distort the electromagnetic field required for precise motion tracking, by means of a back projection medium. In one experiment, we verify that cathode ray tube monitors, as well as thin-film-transistor monitors, distort electro-magnetic sensor signals even at a distance of 18 cm. Our back projection medium, by contrast, leads to no distortion of the motion-tracking signals even when the sensor is touching the medium. This novel solution permits combining the advantages of electromagnetic motion tracking with computer-generated visual stimulation.
    MeSH term(s) Behavioral Research/instrumentation ; Biomechanical Phenomena ; Computer Graphics ; Computer-Assisted Instruction/methods ; Data Display ; Electromagnetic Phenomena ; Equipment Design ; Motion ; Movement ; Reproducibility of Results ; Touch
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 231560-9
    ISSN 1554-3528 ; 0743-3808 ; 1554-351X
    ISSN (online) 1554-3528
    ISSN 0743-3808 ; 1554-351X
    DOI 10.3758/s13428-012-0277-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 76/512: Show issues

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