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  1. Article ; Online: Made for TV, A Student Role-Playing Activity.

    Schneider, Linda

    Nurse educator

    2023  Volume 49, Issue 1, Page(s) 59

    MeSH term(s) Humans ; Nursing Education Research ; Television ; Students
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1034267-9
    ISSN 1538-9855 ; 0363-3624
    ISSN (online) 1538-9855
    ISSN 0363-3624
    DOI 10.1097/NNE.0000000000001452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2904: Show issues Location:
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  2. Book ; Thesis: Expressionsanalyse Interferon-α-positiver und -negativer humaner plasmacytoider dendritischer Zellen

    Schneider, Linda

    (Edition Scientifique)

    2014  

    Author's details vorgelegt von Linda Schneider
    Series title Edition Scientifique
    Keywords Dendritische Zelle ; Immunreaktion ; Cytokine ; Interferon ; Genexpression
    Subject Abwehrreaktion ; Immunantwort ; Immunoreaktivität ; Immunabwehr ; Zytokine
    Language German
    Edition 1. Aufl.
    Publisher VVB Laufersweiler Verlag
    Publishing place Gießen, Lahn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Gießen, Univ., Diss., 2014
    HBZ-ID HT018195708
    ISBN 978-3-8359-6117-3 ; 3-8359-6117-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 1023 available for loan (reading room) Lesesaal EG

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  3. Book ; Thesis: Retrospektive Untersuchung freier mikrovaskulärer Lappenplastiken

    Schneider, Linda Sarah

    2009  

    Author's details vorgelegt von Linda Sarah Schneider
    Language German
    Size 88 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2010
    HBZ-ID HT016830756
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 MB 269 order for loan Magazin

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  4. Book ; Online: A 2D Sinogram-Based Approach to Defect Localization in Computed Tomography

    Zhou, Yuzhong / Schneider, Linda-Sophie / Fan, Fuxin / Maier, Andreas

    2024  

    Abstract: The rise of deep learning has introduced a transformative era in the field of image processing, particularly in the context of computed tomography. Deep learning has made a significant contribution to the field of industrial Computed Tomography. However, ...

    Abstract The rise of deep learning has introduced a transformative era in the field of image processing, particularly in the context of computed tomography. Deep learning has made a significant contribution to the field of industrial Computed Tomography. However, many defect detection algorithms are applied directly to the reconstructed domain, often disregarding the raw sensor data. This paper shifts the focus to the use of sinograms. Within this framework, we present a comprehensive three-step deep learning algorithm, designed to identify and analyze defects within objects without resorting to image reconstruction. These three steps are defect segmentation, mask isolation, and defect analysis. We use a U-Net-based architecture for defect segmentation. Our method achieves the Intersection over Union of 92.02% on our simulated data, with an average position error of 1.3 pixels for defect detection on a 512-pixel-wide detector.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 006
    Publishing date 2024-01-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Microglia-Derived Interleukin 23: A Crucial Cytokine in Alzheimer's Disease?

    Nitsch, Louisa / Schneider, Linda / Zimmermann, Julian / Müller, Marcus

    Frontiers in neurology

    2021  Volume 12, Page(s) 639353

    Abstract: Neuronal cell death, amyloid β plaque formation and development of neurofibrillary tangles are among the characteristics of Alzheimer's disease (AD). In addition to neurodegeneration, inflammatory processes such as activation of microglia and astrocytes ... ...

    Abstract Neuronal cell death, amyloid β plaque formation and development of neurofibrillary tangles are among the characteristics of Alzheimer's disease (AD). In addition to neurodegeneration, inflammatory processes such as activation of microglia and astrocytes are crucial in the pathogenesis and progression of AD. Cytokines are essential immune mediators of the immune response in AD. Recent data suggest a role of interleukin 23 (IL-23) and its p40 subunit in the pathogenesis of AD and corresponding animal models, in particular concerning microglia activation and amyloid β plaque formation. Moreover, in animal models, the injection of anti-p40 antibodies resulted in reduced amyloid β plaque formation and improved cognitive performance. Here, we discuss the pathomechanism of IL-23 mediated inflammation and its role in AD.
    Language English
    Publishing date 2021-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.639353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Conference proceedings: The psychology of human eating disorders

    Schneider, Linda H.

    preclinical and clinical perspectives ; [result of a Conference Entitled the Psychobiology of Human Eating Disorders, which was held in New York City on October 13 - 15, 1988]

    (Annals of the New York Academy of Sciences ; 575)

    1989  

    Title variant The psychobiology of human eating disorders
    Event/congress Conference Entitled the Psychobiology of Human Eating Disorders (1988, NewYorkNY)
    Author's details ed. by Linda H. Schneider
    Series title Annals of the New York Academy of Sciences ; 575
    Collection
    Keywords Eating Disorders / psychology / congresses ; Essstörung ; Psychobiologie
    Subject Biologische Psychologie ; Essgewohnheit ; Essstörungen
    Language English
    Size XII, 626 S. : Ill., graph. Darst.
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003504393
    ISBN 0-89766-541-4 ; 0-89766-542-2 ; 978-0-89766-541-4 ; 978-0-89766-542-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 110 -575- verfügbar in Königswinter Königswinter

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  7. Book ; Online ; Thesis: Expressionsanalyse Interferon-alpha-positiver und -negativer humaner plasmacytoider dendritischer Zellen

    Schneider, Linda

    (Edition scientifique)

    2014  

    Author's details Linda Schneider
    Series title Edition scientifique
    Language German
    Size Online-Ressource
    Publisher Universitätsbibliothek
    Publishing place Gießen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Gießen, Justus-Liebig-Universität, Diss., 2014
    Note In: Giessen : VVB Laufersweiler
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

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  8. Article ; Online: β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery.

    Leven, Patrick / Schneider, Reiner / Schneider, Linda / Mallesh, Shilpashree / Vanden Berghe, Pieter / Sasse, Philipp / Kalff, Jörg C / Wehner, Sven

    Journal of neuroinflammation

    2023  Volume 20, Issue 1, Page(s) 255

    Abstract: Background: Enteric glia contribute to the pathophysiology of various intestinal immune-driven diseases, such as postoperative ileus (POI), a motility disorder and common complication after abdominal surgery. Enteric gliosis of the intestinal muscularis ...

    Abstract Background: Enteric glia contribute to the pathophysiology of various intestinal immune-driven diseases, such as postoperative ileus (POI), a motility disorder and common complication after abdominal surgery. Enteric gliosis of the intestinal muscularis externa (ME) has been identified as part of POI development. However, the glia-restricted responses and activation mechanisms are poorly understood. The sympathetic nervous system becomes rapidly activated by abdominal surgery. It modulates intestinal immunity, innervates all intestinal layers, and directly interfaces with enteric glia. We hypothesized that sympathetic innervation controls enteric glia reactivity in response to surgical trauma.
    Methods: Sox10
    Results: With ~ 4000 differentially expressed genes, the most substantial enteric glia response occurs early after intestinal manipulation. During POI, enteric glia switch into a reactive state and continuously shape their microenvironment by releasing inflammatory and migratory factors. Sympathetic denervation reduced the inflammatory response of enteric glia in the early postoperative phase. Optogenetic and pharmacological stimulation of β-adrenergic downstream signaling triggered enteric glial reactivity. Finally, distinct adrenergic agonists revealed β-1/2 adrenoceptors as the molecular targets of sympathetic-driven enteric glial reactivity.
    Conclusions: Enteric glia act as early responders during post-traumatic intestinal injury and inflammation. Intact sympathetic innervation and active β-adrenergic receptor signaling in enteric glia is a trigger of the immediate glial postoperative inflammatory response. With immune-activating cues originating from the sympathetic nervous system as early as the initial surgical incision, adrenergic signaling in enteric glia presents a promising target for preventing POI development.
    MeSH term(s) Animals ; Mice ; Gliosis ; Adrenergic Agents ; Neuroglia ; Signal Transduction ; Sympathetic Nervous System ; Enteric Nervous System
    Chemical Substances Adrenergic Agents
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-023-02937-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Resolving Genotype-Phenotype Discrepancies of the Kidd Blood Group System Using Long-Read Nanopore Sequencing.

    Gueuning, Morgan / Thun, Gian Andri / Trost, Nadine / Schneider, Linda / Sigurdardottir, Sonja / Engström, Charlotte / Larbes, Naemi / Merki, Yvonne / Frey, Beat M / Gassner, Christoph / Meyer, Stefan / Mattle-Greminger, Maja P

    Biomedicines

    2024  Volume 12, Issue 1

    Abstract: Due to substantial improvements in read accuracy, third-generation long-read sequencing holds great potential in blood group diagnostics, particularly in cases where traditional genotyping or sequencing techniques, primarily targeting exons, fail to ... ...

    Abstract Due to substantial improvements in read accuracy, third-generation long-read sequencing holds great potential in blood group diagnostics, particularly in cases where traditional genotyping or sequencing techniques, primarily targeting exons, fail to explain serological phenotypes. In this study, we employed Oxford Nanopore sequencing to resolve all genotype-phenotype discrepancies in the Kidd blood group system (JK, encoded by
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Novel regulatory variant in ABO intronic RUNX1 binding site inducing A

    Thun, Gian Andri / Gueuning, Morgan / Sigurdardottir, Sonja / Meyer, Eduardo / Gourri, Elise / Schneider, Linda / Merki, Yvonne / Trost, Nadine / Neuenschwander, Kathrin / Engström, Charlotte / Frey, Beat M / Meyer, Stefan / Mattle-Greminger, Maja P

    Vox sanguinis

    2024  Volume 119, Issue 4, Page(s) 377–382

    Abstract: Background and objectives: Mixed-field agglutination in ABO phenotyping (A: Materials and methods: We used long-read sequencing by Oxford Nanopore Technologies to sequence the entire ABO gene, amplified in two overlapping long-range PCR fragments, in ...

    Abstract Background and objectives: Mixed-field agglutination in ABO phenotyping (A
    Materials and methods: We used long-read sequencing by Oxford Nanopore Technologies to sequence the entire ABO gene, amplified in two overlapping long-range PCR fragments, in a blood donor presented with A
    Results: Our data revealed a novel heterozygous g.10924C>A variant on the ABO*A allele located in the transcription factor binding site for RUNX1 in intron 1 (+5.8 kb site). Inheritance was shown by the results of the donor's mother, who shared the novel variant and the anti-A specific mixed-field agglutination.
    Conclusion: We discovered a regulatory variant in the 8-bp RUNX1 motif of ABO, which extends current knowledge of three other variants affecting the same motif and also leading to A
    MeSH term(s) Humans ; Introns/genetics ; Core Binding Factor Alpha 2 Subunit/genetics ; Phenotype ; Alleles ; Binding Sites ; ABO Blood-Group System/genetics ; Genotype
    Chemical Substances Core Binding Factor Alpha 2 Subunit ; ABO Blood-Group System ; RUNX1 protein, human
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 74: Show issues Location:
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