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  1. Article ; Online: Ditching the Itch with Anti-Type 2 Cytokine Therapies for Atopic Dermatitis.

    Schneider, Lynda C

    The New England journal of medicine

    2017  Volume 376, Issue 9, Page(s) 878–879

    MeSH term(s) Cytokines ; Dermatitis, Atopic/therapy ; Eczema ; Humans ; Pruritus/therapy
    Chemical Substances Cytokines
    Language English
    Publishing date 2017--02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1616072
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  2. Article ; Online: What Parents Should Know About Atopic Dermatitis.

    Wheeler, Kathryn E / Chu, Derek K / Schneider, Lynda

    JAMA pediatrics

    2022  Volume 176, Issue 11, Page(s) 1156

    MeSH term(s) Humans ; Dermatitis, Atopic/diagnosis ; Parents ; Surveys and Questionnaires
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2022.3109
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  3. Article ; Online: Global warming and implications for epithelial barrier disruption and respiratory and dermatologic allergic diseases.

    Çelebi Sözener, Zeynep / Treffeisen, Elsa R / Özdel Öztürk, Betül / Schneider, Lynda C

    The Journal of allergy and clinical immunology

    2023  Volume 152, Issue 5, Page(s) 1033–1046

    Abstract: Global warming has direct and indirect effects, as well as short- and long-term impacts on the respiratory and skin barriers. Extreme temperature directly affects the airway epithelial barrier by disrupting the structural proteins and by triggering ... ...

    Abstract Global warming has direct and indirect effects, as well as short- and long-term impacts on the respiratory and skin barriers. Extreme temperature directly affects the airway epithelial barrier by disrupting the structural proteins and by triggering airway inflammation and hyperreactivity. It enhances tidal volume and respiratory rate by affecting the thermoregulatory system, causing specific airway resistance and reflex bronchoconstriction via activation of bronchopulmonary vagal C fibers and upregulation of transient receptor potential vanilloid (TRPV) 1 and TRPV4. Heat shock proteins are activated under heat stress and contribute to both epithelial barrier dysfunction and airway inflammation. Accordingly, the frequency and severity of allergic rhinitis and asthma have been increasing. Heat activates TRPV3 in keratinocytes, causing the secretion of inflammatory mediators and eventually pruritus. Exposure to air pollutants alters the expression of genes that control skin barrier integrity and triggers an immune response, increasing the incidence and prevalence of atopic dermatitis. There is evidence that extreme temperature, heavy rains and floods, air pollution, and wildfires increase atopic dermatitis flares. In this narrative review, focused on the last 3 years of literature, we explore the effects of global warming on respiratory and skin barrier and their clinical consequences.
    MeSH term(s) Humans ; Dermatitis, Atopic ; Global Warming ; Respiratory Rate ; Rhinitis, Allergic ; Inflammation
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.09.001
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  4. Article ; Online: Mental health interventions for atopic dermatitis: knowledge gaps, pilot programmes and future directions.

    Chatrath, Sheena / LeBovidge, Jennifer / Jack, Carolyn / Abuabara, Katrina / Schneider, Lynda C / Capozza, Korey / Kelley, Keri / Silverberg, Jonathan I

    Clinical and experimental dermatology

    2023  Volume 49, Issue 1, Page(s) 9–17

    Abstract: Atopic dermatitis (AD) is associated with high levels of psychosocial burden, often resulting in poor mental health outcomes. Despite this association, few studies have evaluated the efficacy of mental health interventions within this population. ... ...

    Abstract Atopic dermatitis (AD) is associated with high levels of psychosocial burden, often resulting in poor mental health outcomes. Despite this association, few studies have evaluated the efficacy of mental health interventions within this population. Utilization of multidisciplinary and peer-led support, in addition to equipping patients with psychological tools, may be beneficial in improving mental health outcomes. Future research is needed to determine which interventions and formats are desired by, effective in and accessible to patients and caregivers with AD.
    MeSH term(s) Humans ; Dermatitis, Atopic/epidemiology ; Mental Health ; Caregivers/psychology ; Quality of Life
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llad315
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  5. Article ; Online: Atopic Dermatitis and Food Allergy: Best Practices and Knowledge Gaps-A Work Group Report from the AAAAI Allergic Skin Diseases Committee and Leadership Institute Project.

    Singh, Anne Marie / Anvari, Sara / Hauk, Pia / Lio, Peter / Nanda, Anil / Sidbury, Robert / Schneider, Lynda

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 3, Page(s) 697–706

    Abstract: Allergists are often asked to evaluate children with atopic dermatitis (AD) for allergen triggers to disease. Testing, particularly for food triggers, often leads to elimination diets in an effort to improve AD control. However, the dual exposure ... ...

    Abstract Allergists are often asked to evaluate children with atopic dermatitis (AD) for allergen triggers to disease. Testing, particularly for food triggers, often leads to elimination diets in an effort to improve AD control. However, the dual exposure hypothesis suggests that oral tolerance to food antigens is promoted through high-dose oral exposure, where sensitization occurs through lower dose cutaneous exposure. This suggests that strict elimination diets may pose some risks in children with AD. In addition, emerging evidence suggests an important role of skin inflammation in further allergic disease and the importance of dietary exposure to maintain oral tolerance. This work group report reviews current guidelines-based management for children with moderate-to-severe AD, the evidence for current recommendations for the evaluation and management of these children, provides a nuanced examination of these studies, and addresses current knowledge gaps in the care of these children.
    MeSH term(s) Allergens ; Child ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/therapy ; Food Hypersensitivity/diagnosis ; Humans ; Leadership ; Skin
    Chemical Substances Allergens
    Language English
    Publishing date 2022-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.12.037
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  6. Article ; Online: Safely Reducing Hospitalizations for Anaphylaxis in Children Through an Evidence-Based Guideline.

    Gaffney, Lukas K / Porter, John / Gerling, Megan / Schneider, Lynda C / Stack, Anne M / Shah, Dhara / Michelson, Kenneth A

    Pediatrics

    2022  Volume 149, Issue 2

    Abstract: Background: Emergency department visits for anaphylaxis have increased considerably over the past few decades, especially among children. Despite this, anaphylaxis management remains highly variable and contributes to significant health care spending. ... ...

    Abstract Background: Emergency department visits for anaphylaxis have increased considerably over the past few decades, especially among children. Despite this, anaphylaxis management remains highly variable and contributes to significant health care spending. On the basis of emerging evidence, in this quality improvement project we aimed to safely decrease hospitalization rates, increase the use of cetirizine, and decrease use of corticosteroids for children with anaphylaxis by December 31, 2019.
    Methods: A multipronged intervention strategy including a revised evidence-based guideline was implemented at a tertiary children's teaching hospital by using the Model for Improvement. Statistical process control was used to evaluate for changes in key measures. Length of stay and unplanned return visits within 72 hours were monitored as process and balancing measures, respectively. As a national comparison, hospitalization rates were compared with other hospitals' data from the Pediatric Health Information System.
    Results: Hospitalizations decreased significantly from 28.5% to 11.2% from preimplementation to implementation, and the balancing measure of 72-hour revisits was stable. The proportion of patients receiving cetirizine increased significantly from 4.2% to 59.7% and use of corticosteroids decreased significantly from 72.6% to 32.4% in patients without asthma. The proportion of patients meeting length of stay criteria increased from 53.3% to 59.9%. Hospitalization rates decreased nationally over time.
    Conclusions: We reduced hospitalizations for anaphylaxis by 17.3% without concomitant increases in revisits, demonstrating that unnecessary hospitalizations can be safely avoided. The use of a local evidence-based guideline paired with close outcome monitoring and sustained messaging and feedback to clinicians can effectively improve anaphylaxis management.
    MeSH term(s) Adolescent ; Anaphylaxis/diagnosis ; Anaphylaxis/epidemiology ; Anaphylaxis/therapy ; Boston/epidemiology ; Child ; Child, Preschool ; Evidence-Based Medicine/standards ; Evidence-Based Medicine/trends ; Female ; Guideline Adherence/standards ; Guideline Adherence/trends ; Hospitalization/trends ; Hospitals, Pediatric/standards ; Hospitals, Pediatric/trends ; Humans ; Male ; Practice Guidelines as Topic/standards ; Quality Improvement/standards ; Quality Improvement/trends
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-045831
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  7. Article: History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis.

    Moran, Mary C / Klose, Alanna / Yoshida, Takeshi / De Benedetto, Anna / Schneider, Lynda C / Ong, Peck Y / Simpson, Eric L / Leung, Donald Y M / Miller, Benjamin L / Seplaki, Christopher L / Beck, Lisa A

    Dermatology and therapy

    2023  Volume 13, Issue 10, Page(s) 2417–2429

    Abstract: Introduction: Patients with atopic dermatitis (AD) are uniquely susceptible to a number of serious viral skin complications, including eczema herpeticum (EH), caused by herpes simplex virus. This study explored the associations between biomarkers of ... ...

    Abstract Introduction: Patients with atopic dermatitis (AD) are uniquely susceptible to a number of serious viral skin complications, including eczema herpeticum (EH), caused by herpes simplex virus. This study explored the associations between biomarkers of epithelial barrier dysfunction, type 2 immunity, Staphylococcus aureus infection, and S. aureus-specific immunoglobulin responses in a cohort of AD subjects with and without a history of EH (EH+ and EH-, respectively).
    Methods: A total of 112 subjects with AD (56 EH+, 56 EH-), matched by age and AD severity, were selected from a registry of over 3000 AD subjects. Logistic regression was used to test the association between history of S. aureus skin infection and history of EH, while controlling for a number of confounders.
    Results: Compared to those without a history of S. aureus skin infection, subjects with a history of S. aureus skin infection were found to have more than sixfold increased odds of having a history of EH (6.60, 95% confidence interval [CI]: 2.00-21.83), after adjusting for history of other viral skin infections (molluscum contagiosum virus, human papillomavirus), serum total IgE, and IgG against the S. aureus virulence factor SElX.
    Conclusions: These findings indicate an important relationship between S. aureus skin infections and EH.
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680284-3
    ISSN 2190-9172 ; 2193-8210
    ISSN (online) 2190-9172
    ISSN 2193-8210
    DOI 10.1007/s13555-023-00996-y
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  8. Article ; Online: A holistic view on dermatitis: patch testing should be considered in patients with atopic dermatitis. Reply.

    Schneider, Lynda C / Tilles, Stephen

    The Journal of allergy and clinical immunology

    2013  Volume 132, Issue 3, Page(s) 772

    MeSH term(s) Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/therapy ; Humans
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Comment ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2013.05.023
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  9. Article ; Online: Combining teledermatology with nonphysician members of the health care team to address access and compliance barriers in pediatric atopic dermatitis: A needs assessment.

    Kourosh, Arianne S / Schneider, Lynda / Hawryluk, Elena B / Tong, Lana X / Rea, Corinna J / Kvedar, Joseph

    Journal of the American Academy of Dermatology

    2019  Volume 83, Issue 1, Page(s) 237–239

    MeSH term(s) Aftercare/organization & administration ; Appointments and Schedules ; Child ; Dermatitis, Atopic/therapy ; Dermatology/methods ; Dermatology/organization & administration ; Health Services Accessibility/organization & administration ; Health Services Needs and Demand ; Humans ; Needs Assessment ; Nurse Practitioners/statistics & numerical data ; Patient Care Team/organization & administration ; Patient Compliance ; Physicians/statistics & numerical data ; Surveys and Questionnaires/statistics & numerical data ; Telemedicine/organization & administration ; United States
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2019.12.012
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  10. Article ; Online: Reply.

    Yee, Christina S K / El Khoury, Kristel / Albuhairi, Sultan / Broyles, Ana / Schneider, Lynda / Rachid, Rima

    The journal of allergy and clinical immunology. In practice

    2019  Volume 7, Issue 4, Page(s) 1376–1377

    MeSH term(s) Child ; Humans ; Tertiary Care Centers ; Urticaria
    Language English
    Publishing date 2019-04-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2019.01.020
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