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  1. Article ; Online: Balls to the Wall: Human Pluripotent Cell-Derived Cardiac Muscle Spheres Enhance Preclinical Heart Repair.

    Schneider, Michael D

    JACC. Basic to translational science

    2021  Volume 6, Issue 3, Page(s) 255–256

    Language English
    Publishing date 2021-03-22
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2020.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Retooling the cardiac toolbox: the enduring legacy of Jeffrey Robbins.

    Schneider, Michael D / Dorn, Gerald W

    Cardiovascular research

    2022  Volume 119, Issue 2, Page(s) e118–e119

    MeSH term(s) Heart ; Myosin Heavy Chains
    Chemical Substances Myosin Heavy Chains (EC 3.6.4.1)
    Language English
    Publishing date 2022-06-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvad025
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  3. Article ; Online: Upstairs, Downstairs: Atrial and Ventricular Cardiac Myocytes from Human Pluripotent Stem Cells.

    Schneider, Michael D

    Cell stem cell

    2017  Volume 21, Issue 2, Page(s) 151–152

    Abstract: Cardiomyocyte creation by human pluripotent stem cells (hPSCs) has generated opportunities for heart repair, disease modeling, and drug development. In this issue of Cell Stem Cell,Lee et al. (2017) report prospective markers of atrial versus ventricular ...

    Abstract Cardiomyocyte creation by human pluripotent stem cells (hPSCs) has generated opportunities for heart repair, disease modeling, and drug development. In this issue of Cell Stem Cell,Lee et al. (2017) report prospective markers of atrial versus ventricular myocyte formation from hPSCs and their use in directed differentiation of cardiac sub-lineages.
    MeSH term(s) Cell Differentiation ; Heart Ventricles ; Humans ; Mesoderm ; Myocytes, Cardiac ; Pluripotent Stem Cells ; Prospective Studies
    Language English
    Publishing date 2017-08-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2017.07.006
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  4. Article ; Online: Intensive care for human hearts in pluripotent stem cell models.

    Golforoush, Pelin / Schneider, Michael D

    NPJ Regenerative medicine

    2020  Volume 5, Page(s) 4

    Abstract: Successful drug discovery is ultimately contingent on the availability of workable, relevant, predictive model systems. Conversely, for cardiac muscle, the lack of human preclinical models to inform target validation and compound development has likely ... ...

    Abstract Successful drug discovery is ultimately contingent on the availability of workable, relevant, predictive model systems. Conversely, for cardiac muscle, the lack of human preclinical models to inform target validation and compound development has likely contributed to the perennial problem of clinical trial failures, despite encouraging non-human results. By contrast, human cardiomyocytes produced from pluripotent stem cell models have recently been applied to safety pharmacology, phenotypic screening, target validation and high-throughput assays, facilitating cardiac drug discovery. Here, we review the impact of human pluripotent stem cell models in cardiac drug discovery, discussing the range of applications, readouts, and disease models employed, along with the challenges and prospects to advance this fruitful mode of research further.
    Language English
    Publishing date 2020-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2057-3995
    ISSN (online) 2057-3995
    DOI 10.1038/s41536-020-0090-7
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  5. Article ; Online: Heartbreak hotel: a convergence in cardiac regeneration.

    Schneider, Michael D

    Development (Cambridge, England)

    2016  Volume 143, Issue 9, Page(s) 1435–1441

    Abstract: In February 2016, The Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on 'Transdifferentiation and Tissue Plasticity in Cardiovascular ...

    Abstract In February 2016, The Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on 'Transdifferentiation and Tissue Plasticity in Cardiovascular Rejuvenation'. As I review here, participants at the workshop revealed how understanding cardiac growth and lineage decisions at their most fundamental level has transformed the strategies in hand that presently energize the prospects for human heart repair.
    MeSH term(s) Animals ; Cell Transdifferentiation ; Cell- and Tissue-Based Therapy/methods ; Heart/growth & development ; Heart/physiology ; Humans ; Lymphangiogenesis/physiology ; Myocytes, Cardiac/cytology ; Regeneration/physiology ; Regenerative Medicine ; Stem Cell Transplantation/methods ; Stem Cells/cytology
    Language English
    Publishing date 2016-04-22
    Publishing country England
    Document type Congress
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.133652
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  6. Article ; Online: Probing dark energy with lensing magnification in photometric surveys.

    Schneider, Michael D

    Physical review letters

    2014  Volume 112, Issue 6, Page(s) 61301

    Abstract: I present an estimator for the angular cross correlation of two tracers of the cosmological large-scale structure that utilizes redshift information to isolate separate physical contributions. The estimator is derived by solving the Limber equation for a ...

    Abstract I present an estimator for the angular cross correlation of two tracers of the cosmological large-scale structure that utilizes redshift information to isolate separate physical contributions. The estimator is derived by solving the Limber equation for a reweighting of the foreground tracer that nulls either clustering or lensing contributions to the cross correlation function. Applied to future photometric surveys, the estimator can enhance the measurement of gravitational lensing magnification effects to provide a competitive independent constraint on the dark energy equation of state.
    Language English
    Publishing date 2014-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.112.061301
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  7. Article ; Online: Design of optical systems that maximize as-built performance using tolerance/compensator-informed optimization.

    Bauman, Brian J / Schneider, Michael D

    Optics express

    2018  Volume 26, Issue 11, Page(s) 13819–13840

    Abstract: We describe an approach that enables the design of optical systems for optimal performance when built, i.e., when user-selected tolerances and compensators are taken into account. The approach does not require significant raytracing or computing time ... ...

    Abstract We describe an approach that enables the design of optical systems for optimal performance when built, i.e., when user-selected tolerances and compensators are taken into account. The approach does not require significant raytracing or computing time beyond what is used to optimize the nominal design. The approach uses nodal aberration theory to describe the effects of decentered optics; double Zernike polynomials to describe and quantify system performance; and an analytic approach to determining the necessary compensation and residual wavefront error due to a tolerance. We design a triplet using this approach and compare its Monte-Carlo-modeled as-built performance to that of a conventionally-optimized design which optimizes only nominal performance. We also describe several extensions to the theory.
    Language English
    Publishing date 2018-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.26.013819
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  8. Article ; Online: EPO and super-EPO: erythropoietins direct neoangiogenesis by cardiac progenitor cells.

    Schneider, Michael D

    Cell stem cell

    2011  Volume 9, Issue 2, Page(s) 95–96

    Abstract: Erythropoietin, the red blood cell-making cytokine, is also a potential cytoprotective agent in heart disease. In this issue of Cell Stem Cell, Hoch et al. (2011) use two heart failure models, including chemotherapeutic cardiotoxicity, to reveal a ... ...

    Abstract Erythropoietin, the red blood cell-making cytokine, is also a potential cytoprotective agent in heart disease. In this issue of Cell Stem Cell, Hoch et al. (2011) use two heart failure models, including chemotherapeutic cardiotoxicity, to reveal a mechanistic connection between reduced cardiomyocyte production of erythropoietin and neoangiogenesis by cardiac progenitors.
    MeSH term(s) Animals ; Antineoplastic Agents/adverse effects ; Cell Differentiation/drug effects ; Endothelial Cells/cytology ; Erythropoietin/pharmacology ; Heart Failure/drug therapy ; Humans ; Myocardium/pathology ; Stem Cells/cytology
    Chemical Substances Antineoplastic Agents ; Erythropoietin (11096-26-7)
    Language English
    Publishing date 2011-08-05
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2011.07.008
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  9. Article ; Online: Development. A cardiac nonproliferation treaty.

    Schneider, Michael D

    Science (New York, N.Y.)

    2010  Volume 332, Issue 6028, Page(s) 426–427

    MeSH term(s) Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Proliferation ; Gene Expression Regulation, Developmental ; Heart/anatomy & histology ; Heart/embryology ; Heart/growth & development ; Mice ; Myocardium/cytology ; Myocardium/metabolism ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; Organ Size ; Phosphoproteins/metabolism ; Phosphorylation ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Wnt Proteins/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Cell Cycle Proteins ; Phosphoproteins ; Sav1 protein, mouse ; Wnt Proteins ; Yap1 protein, mouse ; beta Catenin ; Stk3 protein, mouse (EC 2.7.1.-) ; Stk4 protein, mouse (EC 2.7.1.-) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2010-11-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1205972
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  10. Article ; Online: Making muscle: overview to "Cardiovascular lineage commitment during development and regeneration" series.

    Schneider, Michael D

    Circulation research

    2010  Volume 107, Issue 5, Page(s) 575–578

    MeSH term(s) Animals ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Humans ; Morphogenesis ; Muscle Development ; Myocytes, Cardiac/physiology ; Regeneration ; Signal Transduction ; Stem Cells/physiology
    Language English
    Publishing date 2010-09-03
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.110.223784
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