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  1. Book ; Thesis: Einfluss von Myostatin und Aktivinrezeptor-llb-Blockierung unter Verwendung von CRISPR/Cas9 auf die myogene Differenzierung

    Schneider, Viktoria

    (Édition scientifique)

    2022  

    Title variant Myostatin und Aktivinrezeptor-llB-Blockierung mit CRISPR/Cas9
    Institution Justus-Liebig-Universität Gießen
    Author's details eingereicht von Viktoria Schneider
    Series title Édition scientifique
    Keywords Hochschulschrift ; Dissertation
    Subject Doktorarbeit ; Dissertationen
    Language German
    Size X, 149 Seiten, Illustrationen, Diagramme
    Edition 1. Auflage
    Publisher VVB Laufersweiler Verlag
    Publishing place Giessen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Justus-Liebig-Universität Gießen, 2022
    HBZ-ID HT021684317
    ISBN 978-3-8359-7061-8 ; 3-8359-7061-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 A 12 available for loan (reading room) Lesesaal EG

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  2. Book: Einfluss von Myostatin und Aktivinrezeptor-IIb-Blockierung unter Verwendung von CRISPR/Cas9 auf die myogene Differenzierung

    Schneider, Viktoria

    (Edition Scientifique)

    2022  

    Abstract: In dieser Arbeit erfolgte eine Geneditierung mittels der CRISPR/Cas9-Methode der Gene Mstn und ActRIIb. So konnten drei Mstn-KOs und drei ActRIIb-KOs erschaffen werden. Anschließend wurden die Zellen mit den funktionellen Knock-outs auf Unterschiede in ... ...

    Series title Edition Scientifique
    Abstract In dieser Arbeit erfolgte eine Geneditierung mittels der CRISPR/Cas9-Methode der Gene Mstn und ActRIIb. So konnten drei Mstn-KOs und drei ActRIIb-KOs erschaffen werden. Anschließend wurden die Zellen mit den funktionellen Knock-outs auf Unterschiede in der myogenen Differenzierung untersucht. -- Nachfolgende Ergebnisse konnten dabei erzielt werden: -- 1.
    Keywords CRISPR ; CAS9 ; Myostatin
    Language German
    Size 163 p.
    Publisher VVB Laufersweiler Verlag
    Document type Book
    Note Hochschulschriften Medizin
    Format 148 x 215
    ISBN 9783835970618 ; 3835970615
    Database PDA

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  3. Book ; Thesis: Inzidenz, Risikofaktoren und klinischer Verlauf einer Lungenarterienembolie als Komorbidität nach intrakraniellen Eingriffen bei neurochirurgischen Patienten

    Schneider, Viktoria

    2023  

    Institution Goethe-Universität Frankfurt am Main
    Author's details vorgelegt von Julia Viktoria Schneider
    Subject code 616.1
    Language German
    Size VII, 51 Seiten, Diagramme, 21 cm
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2023
    Note Zusammenfassung auf Deutsch und Englisch ; Literaturverzeichnis: Seite 42-49
    HBZ-ID HT030620651
    Database Catalogue ZB MED Medicine, Health

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    2023 D 387 order for loan Magazin

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  4. Book: Simulating the effects of marine reserves as an additional management tool to paua harvest around Stewart Island

    Schneider, Viktoria

    an economic analysis

    (Economics discussion papers / University of Otago ; 0407)

    2004  

    Author's details Viktoria Schneider
    Series title Economics discussion papers / University of Otago ; 0407
    Keywords Fischereiressourcen ; Simulation ; Schätzung ; Neuseeland
    Language English
    Size 34 S, graph. Darst
    Publisher Dep. of Economics
    Publishing place Dunedin
    Document type Book
    Database ECONomics Information System

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  5. Article ; Online: Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action.

    Scheenstra, Maaike R / van den Belt, Matthias / Tjeerdsma-van Bokhoven, Johanna L M / Schneider, Viktoria A F / Ordonez, Soledad R / van Dijk, Albert / Veldhuizen, Edwin J A / Haagsman, Henk P

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 4780

    Abstract: Host defense peptides (HDPs) play a pivotal role in innate immunity and have, in addition to antimicrobial activity, also important immunomodulatory functions. Bacteria are less likely to develop resistance against HDPs because these peptides target and ... ...

    Abstract Host defense peptides (HDPs) play a pivotal role in innate immunity and have, in addition to antimicrobial activity, also important immunomodulatory functions. Bacteria are less likely to develop resistance against HDPs because these peptides target and kill bacteria in multiple ways, as well as modulate the immune system. Therefore, HDPs, and derivatives thereof, are promising alternatives to traditional antibiotics. Hardly anything is known about the immunomodulatory functions of porcine cathelicidin PMAP-36. In this study, we aimed to determine both antibacterial and immunomodulatory activities of PMAP-36 comparing the properties of PMAP-36 analogs with two well-studied peptides, human LL-37 and chicken CATH-2. Transmission electron microscopy revealed different killing mechanisms of E. coli for PMAP-36, CATH-2 and LL-37. LL-37 binds LPS very weakly in contrast to PMAP-36, but it inhibits LPS activation of macrophages the strongest. The first 11 amino acids of the N-terminal side of PMAP-36 are dispensable for E. coli killing, LPS-neutralization and binding. Deletion of four additional amino acids resulted in a strong decrease in activity. The activity of full length PMAP-36 was not affected by monomerization, whereas the shorter analogs require dimerization for proper immunomodulatory activity but not for their antibacterial activity.
    MeSH term(s) Animals ; Antimicrobial Cationic Peptides/metabolism ; Antimicrobial Cationic Peptides/pharmacology ; Cells, Cultured ; Chickens ; Escherichia coli/drug effects ; Hemolysis ; Humans ; Lipopolysaccharides/metabolism ; Mice ; Protein Binding ; Protein Multimerization ; RAW 264.7 Cells ; Swine
    Chemical Substances Antimicrobial Cationic Peptides ; CMAP27 protein, chicken ; Lipopolysaccharides ; PMAP-36 ; ropocamptide (3DD771JO2H)
    Language English
    Publishing date 2019-03-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-41246-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Schizophrenie-Therapie hat viele Facetten

    Schneider, Viktoria

    Psycho

    1996  Volume 22, Issue 9, Page(s) 669–672

    Abstract: Veränderungen im Bereich der Schizophrenie-Therapie werden diskutiert. Es wird darauf hingewiesen, dass Psychoedukation und Lebensqualität in der Behandlung der Schizophrenie an Bedeutung gewonnen haben. In diesem Zusammenhang wird auch auf die ... ...

    Title translation Therapy of schizophreniaa has many components
    Abstract Veränderungen im Bereich der Schizophrenie-Therapie werden diskutiert. Es wird darauf hingewiesen, dass Psychoedukation und Lebensqualität in der Behandlung der Schizophrenie an Bedeutung gewonnen haben. In diesem Zusammenhang wird auch auf die Entwicklung neuer atypischer Neuroleptika wie Risperidon eingegangen. Als Vorteile der modernen Neuroleptikatherapie werden genannt, dass sie sich nicht auf die Plussymptomatik beschränkt, sondern sich auch auf die Negativsymtomatik positiv auswirkt und deutlich weniger Nebenwirkungen aufweist als herkömmliche Medikamente.
    Keywords Aufklärung von Klientinnen und Klienten ; Client Education ; Compliance (Behandlung) ; Drug Therapy ; Medikamentöse Therapie ; Neuroleptic Drugs ; Neuroleptika ; Risperidon ; Risperidone ; Schizophrenia ; Schizophrenie ; Therapeutic Processes ; Therapeutische Prozesse ; Therapie ; Treatment ; Treatment Compliance
    Language German
    Document type Article
    ZDB-ID 128719-9
    ISSN 0340-7845
    ISSN 0340-7845
    Database PSYNDEX

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  7. Article ; Online: Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity.

    Schneider, Viktoria A F / van Dijk, Albert / van der Sar, Astrid M / Kraaij, Marina D / Veldhuizen, Edwin J A / Haagsman, Henk P

    Developmental and comparative immunology

    2016  Volume 60, Page(s) 108–114

    Abstract: Chicken cathelicidin-2 (CATH-2) is a host defense peptide that exhibits immunomodulatory and antibacterial properties. Here we examined effects of CATH-2 in zebrafish embryos in the absence and presence of infection. Yolk-injection of 0.2-1.5 h post- ... ...

    Abstract Chicken cathelicidin-2 (CATH-2) is a host defense peptide that exhibits immunomodulatory and antibacterial properties. Here we examined effects of CATH-2 in zebrafish embryos in the absence and presence of infection. Yolk-injection of 0.2-1.5 h post-fertilized (hpf) zebrafish embryos with 2.6 ng/kg CATH-2 increased proliferation of phagocytic cells at 48 hpf by 30%. A lethal infection model was developed to test the prophylactic protective effect of CATH-2 peptide. Embryos (0.2-1.5 hpf) were injected with 2.6 ng/kg CATH-2, challenged with a lethal dose of fluorescently labeled Salmonella enteritidis pGMDs3 at 28 hpf and monitored for survival. Prophylactic treatment with CATH-2 was found to delay infection starting at 22 h post-infection (hpi). At 18-20 hpi, significantly lower (2-fold) fluorescence intensity and decreased bacterial loads were detected in peptide-treated embryos. Thus prophylactic administration of low CATH-2 concentrations confer partial protection in zebrafish embryos by boosting the innate immune system.
    MeSH term(s) Adjuvants, Immunologic/administration & dosage ; Animals ; Antimicrobial Cationic Peptides/administration & dosage ; Cell Proliferation ; Drug Evaluation, Preclinical ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/immunology ; Fish Diseases/immunology ; Fish Diseases/microbiology ; Fish Diseases/prevention & control ; Immunity, Innate/drug effects ; Phagocytes/physiology ; Salmonella Infections, Animal/immunology ; Salmonella Infections, Animal/microbiology ; Salmonella Infections, Animal/prevention & control ; Salmonella enteritidis/immunology ; Zebrafish/immunology
    Chemical Substances Adjuvants, Immunologic ; Antimicrobial Cationic Peptides ; CMAP27 protein, chicken
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2016.02.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1327: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity

    Schneider, Viktoria A.F / Albert van Dijk / Astrid M. van der Sar / Edwin J.A. Veldhuizen / Henk P. Haagsman / Marina D. Kraaij

    Developmental and comparative immunology. 2016 July, v. 60

    2016  

    Abstract: Chicken cathelicidin-2 (CATH-2) is a host defense peptide that exhibits immunomodulatory and antibacterial properties. Here we examined effects of CATH-2 in zebrafish embryos in the absence and presence of infection. Yolk-injection of 0.2–1.5 h post- ... ...

    Abstract Chicken cathelicidin-2 (CATH-2) is a host defense peptide that exhibits immunomodulatory and antibacterial properties. Here we examined effects of CATH-2 in zebrafish embryos in the absence and presence of infection. Yolk-injection of 0.2–1.5 h post-fertilized (hpf) zebrafish embryos with 2.6 ng/kg CATH-2 increased proliferation of phagocytic cells at 48 hpf by 30%. A lethal infection model was developed to test the prophylactic protective effect of CATH-2 peptide. Embryos (0.2–1.5 hpf) were injected with 2.6 ng/kg CATH-2, challenged with a lethal dose of fluorescently labeled Salmonella enteritidis pGMDs3 at 28 hpf and monitored for survival. Prophylactic treatment with CATH-2 was found to delay infection starting at 22 h post-infection (hpi). At 18–20 hpi, significantly lower (2-fold) fluorescence intensity and decreased bacterial loads were detected in peptide-treated embryos. Thus prophylactic administration of low CATH-2 concentrations confer partial protection in zebrafish embryos by boosting the innate immune system.
    Keywords antibacterial properties ; chickens ; Danio rerio ; fluorescence ; innate immunity ; lethal dose ; microbial load ; models ; phagocytes ; protective effect ; Salmonella Enteritidis
    Language English
    Dates of publication 2016-07
    Size p. 108-114.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2016.02.023
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Chicken cathelicidins display antimicrobial activity against multiresistant bacteria without inducing strong resistance.

    Veldhuizen, Edwin J A / Brouwer, Ellen C / Schneider, Viktoria A F / Fluit, Ad C

    PloS one

    2013  Volume 8, Issue 4, Page(s) e61964

    Abstract: The increased prevalence of multidrug-resistant (MDR) bacteria in combination with the relatively limited development of new antibiotics presents a serious threat to public health. In chicken, especially Extended-Spectrum ß-Lactamase (ESBL) carrying ... ...

    Abstract The increased prevalence of multidrug-resistant (MDR) bacteria in combination with the relatively limited development of new antibiotics presents a serious threat to public health. In chicken, especially Extended-Spectrum ß-Lactamase (ESBL) carrying Enterobacteriaceae are often asymptomatically present but can infect humans. Due to their broad range antimicrobial activity cathelicidins and other host defence peptides, are considered to be an attractive alternative to conventional antibiotics. In this study, the antimicrobial activity of three chicken cathelicidins against a broad array of multidrug resistant bacteria was determined. All three peptides showed high antibacterial activity independent of the presence of MDR characteristics. Induction experiments using S. aureus and K. pneumoniae showed that although an increase in resistance was initially observed, susceptibility towards chicken cathelicidins remained high and no major resistance was developed. The combined results underline the potential of chicken cathelicidins as a new alternative to antibiotics.
    MeSH term(s) Amino Acid Sequence ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/pharmacology ; Bacteria/drug effects ; Chickens ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Multiple/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Sequence Data
    Chemical Substances Anti-Bacterial Agents ; Antimicrobial Cationic Peptides ; ropocamptide (3DD771JO2H)
    Language English
    Publishing date 2013-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0061964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The bioeconomics of marine reserves

    Grafton, R. Quentin / Kompas, Tom / Schneider, Viktoria

    Journal of bioeconomics Vol. 7, No. 2 , p. 161-178

    a selected review with policy implications

    2005  Volume 7, Issue 2, Page(s) 161–178

    Author's details R. Quentin Grafton, Tom Kompas, Viktoria Schneider
    Keywords Fischereiressourcen ; Bioökonomik ; 49#5
    Language English
    Publisher Springer
    Publishing place Dordrecht [u.a.]
    Document type Article
    ZDB-ID 1438734-7
    Database ECONomics Information System

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