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  1. Article ; Online: Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans.

    Schnierle, Barbara S

    Viruses

    2022  Volume 14, Issue 9

    Abstract: In the late 1970s, global vaccination programs resulted in the eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to the smallpox-inducing variola virus, was previously endemic only in Sub-Saharan Africa but is currently ... ...

    Abstract In the late 1970s, global vaccination programs resulted in the eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to the smallpox-inducing variola virus, was previously endemic only in Sub-Saharan Africa but is currently spreading worldwide. Only older people who have been vaccinated against smallpox are expected to be sufficiently protected against poxviruses. Here I will summarize current knowledge about the virus, the disease caused by MPXV infections, and strategies to limit its spread.
    MeSH term(s) Aged ; Humans ; Longitudinal Studies ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/prevention & control ; Monkeypox virus ; Smallpox/epidemiology ; Smallpox/prevention & control ; Variola virus
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14091874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply to Ringlander et al.

    Schnierle, Barbara S

    The Journal of infectious diseases

    2021  Volume 223, Issue 10, Page(s) 1833

    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

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  3. Article: Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development.

    Schmidt, Christin / Schnierle, Barbara S

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) ... ...

    Abstract The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed.
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12010138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans

    Schnierle, Barbara S.

    Viruses. 2022 Aug. 25, v. 14, no. 9

    2022  

    Abstract: In the late 1970s, global vaccination programs resulted in the eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to the smallpox-inducing variola virus, was previously endemic only in Sub-Saharan Africa but is currently ... ...

    Abstract In the late 1970s, global vaccination programs resulted in the eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to the smallpox-inducing variola virus, was previously endemic only in Sub-Saharan Africa but is currently spreading worldwide. Only older people who have been vaccinated against smallpox are expected to be sufficiently protected against poxviruses. Here I will summarize current knowledge about the virus, the disease caused by MPXV infections, and strategies to limit its spread.
    Keywords Monkeypox virus ; Variola virus ; people ; smallpox ; vaccination ; viruses ; Sub-Saharan Africa
    Language English
    Dates of publication 2022-0825
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14091874
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Chikungunya Vaccine Candidates: Current Landscape and Future Prospects.

    Schmidt, Christin / Schnierle, Barbara S

    Drug design, development and therapy

    2022  Volume 16, Page(s) 3663–3673

    Abstract: Chikungunya virus (CHIKV) is an alphavirus that has spread globally in the last twenty years. Although mortality is rather low, infection can result in debilitating arthralgia that can persist for years. Unfortunately, no treatments or preventive ... ...

    Abstract Chikungunya virus (CHIKV) is an alphavirus that has spread globally in the last twenty years. Although mortality is rather low, infection can result in debilitating arthralgia that can persist for years. Unfortunately, no treatments or preventive vaccines are currently licensed against CHIKV infections. However, a large range of promising preclinical and clinical vaccine candidates have been developed during recent years. This review will give an introduction into the biology of CHIKV and the immune responses that are induced by infection, and will summarize CHIKV vaccine development.
    MeSH term(s) Humans ; Chikungunya Fever ; Viral Vaccines ; Chikungunya virus
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2022-10-20
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S366112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cellular Attachment and Entry Factors for Chikungunya Virus.

    Schnierle, Barbara S

    Viruses

    2019  Volume 11, Issue 11

    Abstract: Chikungunya virus (CHIKV) is clinically the most relevant member of ... ...

    Abstract Chikungunya virus (CHIKV) is clinically the most relevant member of the
    MeSH term(s) Animals ; Cell Line ; Chikungunya Fever/virology ; Chikungunya virus/physiology ; Host-Pathogen Interactions ; Humans ; Models, Biological ; Viral Tropism ; Virus Attachment ; Virus Internalization ; Virus Replication
    Language English
    Publishing date 2019-11-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11111078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A New Host Factor Essential for Chikungunya Virus.

    Schnierle, Barbara S

    Trends in microbiology

    2019  Volume 28, Issue 1, Page(s) 2–4

    Abstract: FHL1 has been identified as a host protein that is essential for chikungunya virus (CHIKV) replication. FHL1 interacts with the chikungunya non-structural protein 3, which is thought to recruit cellular proteins to the viral replication complex. ... ...

    Abstract FHL1 has been identified as a host protein that is essential for chikungunya virus (CHIKV) replication. FHL1 interacts with the chikungunya non-structural protein 3, which is thought to recruit cellular proteins to the viral replication complex. Inhibition of this interaction is a promising target for drug development.
    MeSH term(s) Alphavirus ; Animals ; Chikungunya Fever/virology ; Chikungunya virus/physiology ; Humans ; Intracellular Signaling Peptides and Proteins ; LIM Domain Proteins ; Mice, Knockout ; Muscle Proteins ; RNA, Viral ; Viral Nonstructural Proteins/chemistry ; Virus Replication/physiology
    Chemical Substances Intracellular Signaling Peptides and Proteins ; LIM Domain Proteins ; Muscle Proteins ; RNA, Viral ; Viral Nonstructural Proteins
    Language English
    Publishing date 2019-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2019.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3738: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: A New Host Factor Essential for Chikungunya Virus

    Schnierle, Barbara S

    Trends in microbiology. 2020 Jan., v. 28, no. 1

    2020  

    Abstract: FHL1 has been identified as a host protein that is essential for chikungunya virus (CHIKV) replication. FHL1 interacts with the chikungunya non-structural protein 3, which is thought to recruit cellular proteins to the viral replication complex. ... ...

    Abstract FHL1 has been identified as a host protein that is essential for chikungunya virus (CHIKV) replication. FHL1 interacts with the chikungunya non-structural protein 3, which is thought to recruit cellular proteins to the viral replication complex. Inhibition of this interaction is a promising target for drug development.
    Keywords Chikungunya virus ; drug development ; viral nonstructural proteins ; virus replication
    Language English
    Dates of publication 2020-01
    Size p. 2-4.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2019.11.002
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/714: Show issues

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  9. Article: Cellular Attachment and Entry Factors for Chikungunya Virus

    Schnierle, Barbara S

    Viruses. 2019 Nov. 19, v. 11, no. 11

    2019  

    Abstract: Chikungunya virus (CHIKV) is clinically the most relevant member of the Alphavirus genus. Like alphaviruses in general, CHIKV has the capacity to infect a large variety of cells, tissues, and species. This broad host tropism of CHIKV indicates that the ... ...

    Abstract Chikungunya virus (CHIKV) is clinically the most relevant member of the Alphavirus genus. Like alphaviruses in general, CHIKV has the capacity to infect a large variety of cells, tissues, and species. This broad host tropism of CHIKV indicates that the virus uses a ubiquitously expressed receptor to infect cells. This review summarizes the current knowledge available on cellular CHIKV receptors and the attachment factors used by CHIKV.
    Keywords Chikungunya virus ; receptors ; tissues ; viruses
    Language English
    Dates of publication 2019-1119
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11111078
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Development of a Sensitive Detection Method for Alphaviruses and Its Use as a Virus Neutralization Assay.

    Schmidt, Christin / Perkovic, Mario / Schnierle, Barbara S

    Viruses

    2021  Volume 13, Issue 7

    Abstract: Alphaviruses have a single-stranded, positive-sense RNA genome that contains two open reading frames encoding either the non-structural or the structural genes. Upon infection, the genomic RNA is translated into the non-structural proteins (nsPs). NsPs ... ...

    Abstract Alphaviruses have a single-stranded, positive-sense RNA genome that contains two open reading frames encoding either the non-structural or the structural genes. Upon infection, the genomic RNA is translated into the non-structural proteins (nsPs). NsPs are required for viral RNA replication and transcription driven from the subgenomic promoter (sgP). Transfection of an RNA encoding the luciferase gene under the control of the sgP into cells enabled the detection of replication-competent chikungunya virus (CHIKV) or Mayaro virus (MAYV) with high sensitivity as a function of the induced luciferase activity. This assay principle was additionally used to analyze virus-neutralizing antibodies in sera and might be an alternative to standard virus neutralization assays based on virus titration or the use of genetically modified tagged viruses.
    MeSH term(s) Alphavirus/classification ; Alphavirus/immunology ; Alphavirus Infections/blood ; Alphavirus Infections/diagnosis ; Alphavirus Infections/immunology ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Cell Line ; Chikungunya virus/genetics ; Cross Reactions ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Luciferases/genetics ; Mice ; Mice, Inbred BALB C ; RNA, Viral/genetics ; Sensitivity and Specificity ; Serologic Tests/methods ; Serologic Tests/standards
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M ; RNA, Viral ; Luciferases (EC 1.13.12.-)
    Language English
    Publishing date 2021-06-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13071191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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