Article ; Online: Progrediente Luftnot und Schwäche bei einer 61-jährigen Patientin.
2018 Volume 60, Issue 2, Page(s) 186–192
Abstract: A 61-year-old woman was admitted with a suspected diagnosis of atypical pneumonia. Extended diagnostic measures revealed interstitial lung disease (ILD), polyserositis, polyarthritis and myopathy. With detection of an antibody against PL-7 (anti-threonyl- ...
Title translation | Progressive respiratory failure and weakness in a 61-year-old woman. |
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Abstract | A 61-year-old woman was admitted with a suspected diagnosis of atypical pneumonia. Extended diagnostic measures revealed interstitial lung disease (ILD), polyserositis, polyarthritis and myopathy. With detection of an antibody against PL-7 (anti-threonyl-transfer-RNA synthetase) the diagnosis of anti-synthetase syndrome (ASS) was established. ASS are rare inflammatory myopathies which frequently present as multisystemic diseases with severe organ involvement. An immunosuppressive regimen with steroids and cyclophosphamide led to successful induction of disease remission. Maintenance therapy will be conducted with azathioprine. ASS should always be considered in the differential diagnosis of myopathies and ILDs. |
MeSH term(s) | Amino Acyl-tRNA Synthetases/immunology ; Antibodies, Antinuclear ; Autoantibodies/immunology ; Azathioprine/therapeutic use ; Combined Modality Therapy ; Cyclophosphamide/therapeutic use ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Lung/pathology ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/drug therapy ; Methylprednisolone/therapeutic use ; Middle Aged ; Muscle, Skeletal/physiopathology ; Myositis/diagnosis ; Myositis/physiopathology ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/drug therapy ; Treatment Outcome |
Chemical Substances | Antibodies, Antinuclear ; Autoantibodies ; Immunosuppressive Agents ; SS-A antibodies ; Cyclophosphamide (8N3DW7272P) ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-) ; Azathioprine (MRK240IY2L) ; Methylprednisolone (X4W7ZR7023) |
Language | German |
Publishing date | 2018-09-14 |
Publishing country | Germany |
Document type | Case Reports ; Journal Article |
ZDB-ID | 2913-0 |
ISSN | 1432-1289 ; 0020-9554 |
ISSN (online) | 1432-1289 |
ISSN | 0020-9554 |
DOI | 10.1007/s00108-018-0490-6 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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