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  1. Article ; Online: Erythropoietin-producing cells in the kidney: Novel insights in their long-term fate during hypoxaemia and renal tissue remodelling.

    Scholz, Holger

    Acta physiologica (Oxford, England)

    2022  Volume 234, Issue 3, Page(s) e13786

    MeSH term(s) Animals ; Erythropoietin ; Hypoxia ; Kidney ; Mice
    Chemical Substances Erythropoietin (11096-26-7)
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: WT1 in Adipose Tissue: From Development to Adult Physiology.

    Kirschner, Karin M / Scholz, Holger

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 854120

    Abstract: Much of the fascination of the Wilms tumor protein (WT1) emanates from its unique roles in development and disease. ... ...

    Abstract Much of the fascination of the Wilms tumor protein (WT1) emanates from its unique roles in development and disease. Ubiquitous
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.854120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: "Einfluß mechanischer Stimulation des Knochengewebes auf die Serumkonzentration verschiedener Parameter des Knochenumbaus in vivo"

    Scholz, Holger

    2000  

    Author's details vorgelegt von Holger Scholz
    Keywords Knochen ; Mechanische Beanspruchung ; Marker ; Knochenumbau
    Subject Knochentransformation ; Markierungssubstanz ; Bone ; Bones ; Os ; Knochengewebe
    Language German
    Size 77 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster (Westfalen), Univ., Diss., 2000
    HBZ-ID HT013263390
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 MB 845 order for loan Magazin

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  4. Book ; Collection: Bikablo

    Scholz, Holger / Haussmann, Martin

    2006  

    Institution Kommunikationslotsen Scholz & Vesper GmbH & Co. KG
    bikablo® akademie GmbH & Co.KG
    Author's details [Vorw. Holger Scholz .... Text, Gestaltung und Ill.: Martin Haußmann. Kommunikationslotsen]
    Language German ; English
    Dates of publication 2006-9999
    Publisher Neuland
    Publishing place Eichenzell
    Publishing country Germany
    Document type Book ; Collection (display volumes)
    Note Teilw. mit Erscheinungsvermerk Köln, Bikablo-Akademie ; Bikablo = Bilder-Karten-Block
    HBZ-ID HT016850707
    Database Catalogue ZB MED Medicine, Health

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  5. Article: Editorial: Pathogenomics of the genus

    Cloeckaert, Axel / Roop, R Martin / Scholz, Holger C / Whatmore, Adrian M / Zygmunt, Michel S

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1370330

    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1370330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Spätergebnisse nach der Versorgung zentraler und zentrolateraler Frakturen des Mittelgesichts mit kraniofazialen Aufhängungen und Miniplattenosteosynthesen

    Scholz, Holger

    eine Analyse von 56 Fällen aus den Jahren 1987 bis 1991

    1993  

    Author's details vorgelegt von Holger Scholz
    Language German
    Size 89 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 1994
    HBZ-ID HT007077159
    Database Catalogue ZB MED Medicine, Health

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  7. Article: Virulence and resistance patterns of

    Schmidt, Katarzyna / Scholz, Holger C / Appelt, Sandra / Michel, Jana / Jacob, Daniela / Dupke, Susann

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1282135

    Abstract: Global warming has caused an increase in the emergence ... ...

    Abstract Global warming has caused an increase in the emergence of
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1282135
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  8. Book ; Online ; Thesis: Elucidating the (re-)emergence of human pathogens with Bayesian phylogenetics

    Esquivel Gómez, Luis Roger [Verfasser] / Krause, Johannes [Gutachter] / Kühnert, Denise [Gutachter] / Scholz, Holger [Gutachter]

    2024  

    Author's details Luis Roger Esquivel Gómez ; Gutachter: Johannes Krause, Denise Kühnert, Holger Scholz
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Friedrich-Schiller-Universität Jena
    Publishing place Jena
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Book ; Thesis: Intrazelluläre Ableitungen am Vas afferens der hydronephrotischen Mäuseniere

    Scholz, Holger

    1986  

    Size 50 Bl. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 1987
    HBZ-ID HT003229586
    Database Catalogue ZB MED Medicine, Health

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  10. Article ; Online: WT1 regulates HOXB9 gene expression in a bidirectional way.

    Schmidt, Valentin / Sieckmann, Tobias / Kirschner, Karin M / Scholz, Holger

    Biochimica et biophysica acta. Gene regulatory mechanisms

    2021  Volume 1864, Issue 11-12, Page(s) 194764

    Abstract: The homeoboxB9 (HOXB9) gene is necessary for specification of the anterior-posterior body axis during embryonic development and expressed in various types of cancer. Here we show that the Wilms tumor transcription factor WT1 regulates the HOXB9 gene in a ...

    Abstract The homeoboxB9 (HOXB9) gene is necessary for specification of the anterior-posterior body axis during embryonic development and expressed in various types of cancer. Here we show that the Wilms tumor transcription factor WT1 regulates the HOXB9 gene in a bidirectional manner. Silencing of WT1 activates HOXB9 in Wt1 expressing renal cell adenocarcinoma-derived 786-0 cells, mesonephric M15 cells and ex vivo cultured murine embryonic kidneys. In contrast, HOXB9 expression in U2OS osteosarcoma and human embryonic kidney (HEK) 293 cells, which lack endogenous WT1, is enhanced by overexpression of WT1. Consistently, Hoxb9 promoter activity is stimulated by WT1 in transiently transfected U2OS and HEK293 cells, but inhibited in M15 cells with CRISPR/Cas9-mediated Wt1 deletion. Electrophoretic mobility shift assay and chromatin immunoprecipitation demonstrate binding of WT1 to the HOXB9 promoter in WT1-overexpressing U2OS cells and M15 cells. BASP1, a transcriptional co-repressor of WT1, is associated with the HOXB9 promoter in the chromatin of these cell lines. Co-transfection of U2OS and HEK293 cells with BASP1 plus WT1 prevents the stimulatory effect of WT1 on the HOXB9 promoter. Our findings identify HOXB9 as a novel downstream target gene of WT1. Depending on the endogenous expression of WT1, forced changes in WT1 can either stimulate or repress HOXB9, and the inhibitory effect of WT1 on transcription of HOXB9 involves BASP1. Consistent with inhibition of Hoxb9 expression by WT1, both transcripts are distributed in an almost non-overlapping pattern in embryonic mouse kidneys. Regulation of HOXB9 expression by WT1 might become relevant during kidney development and cancer progression.
    MeSH term(s) Animals ; Cell Line, Tumor ; Embryo, Mammalian ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; HEK293 Cells ; Homeodomain Proteins/genetics ; Humans ; Kidney/embryology ; Kidney/pathology ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Mice ; Organ Culture Techniques ; Promoter Regions, Genetic ; Transcriptional Activation ; WT1 Proteins/genetics ; WT1 Proteins/metabolism ; Wilms Tumor/genetics ; Wilms Tumor/pathology
    Chemical Substances HOXB9 protein, human ; Homeodomain Proteins ; Hoxb9 protein, mouse ; WT1 Proteins ; WT1 protein, human ; WT1 protein, mouse
    Language English
    Publishing date 2021-09-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2918786-2
    ISSN 1876-4320 ; 1874-9399
    ISSN (online) 1876-4320
    ISSN 1874-9399
    DOI 10.1016/j.bbagrm.2021.194764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7156: Show issues Location:
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