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  1. Article: An update on the genetic predisposition of testicular germ cell tumors.

    Islam, Rashidul / Hansen, Aylin / Liesen, Annalena / Schorle, Hubert

    Translational andrology and urology

    2024  Volume 13, Issue 3, Page(s) 476–478

    Language English
    Publishing date 2024-02-01
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau-23-560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; Thesis: Molecular determinants of prostate cancer aggressiveness

    Kremer, Anika [Verfasser] / Kristiansen, Glen [Akademischer Betreuer] / Schorle, Hubert [Gutachter]

    an analysis of the interconnection between biomarkers,disease drivers and resistance mechanisms towardsnovel diagnostic, theranostic and therapeutic approaches

    2023  

    Author's details Anika Kremer ; Gutachter: Hubert Schorle ; Betreuer: Glen Kristiansen
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Book ; Online ; Thesis: Identification of cisplatin resistance mechanisms and alternative treatment options for testicular germ cell tumors

    Funke, Kai [Verfasser] / Schorle, Hubert [Akademischer Betreuer] / Gruß, Oliver [Gutachter]

    2023  

    Author's details Kai Funke ; Gutachter: Oliver Gruß ; Betreuer: Hubert Schorle
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Protamines: lessons learned from mouse models.

    Arévalo, Lena / Esther Merges, Gina / Schneider, Simon / Schorle, Hubert

    Reproduction (Cambridge, England)

    2022  Volume 164, Issue 3, Page(s) R57–R74

    Abstract: In brief: Protamines package and shield the paternal DNA in the sperm nucleus and have been studied in many mouse models over decades. This review recapitulates and updates our knowledge about protamines and reveals a surprising complexity in protamine ... ...

    Abstract In brief: Protamines package and shield the paternal DNA in the sperm nucleus and have been studied in many mouse models over decades. This review recapitulates and updates our knowledge about protamines and reveals a surprising complexity in protamine function and their interactions with other sperm nuclear proteins.
    Abstract: The packaging and safeguarding of paternal DNA in the sperm cell nucleus is a critical feature of proper sperm function. Histones cannot mediate the necessary hypercondensation and shielding of chromatin required for motility and transit through the reproductive tracts. Paternal chromatin is therefore reorganized and ultimately packaged by protamines. In most mammalian species, one protamine is present in mature sperm (PRM1). In rodents and primates among others, however, mature sperm contain a second protamine (PRM2). Unlike PRM1, PRM2 is cleaved at its N-terminal end. Although protamines have been studied for decades due to their role in chromatin hypercondensation and involvement in male infertility, key aspects of their function are still unclear. This review updates and integrates our knowledge of protamines and their function based on lessons learned from mouse models and starts to answer open questions. The combined insights from recent work reveal that indeed both protamines are crucial for the production of functional sperm and indicate that the two protamines perform distinct functions beyond simple DNA compaction. Loss of one allele of PRM1 leads to subfertility whereas heterozygous loss of PRM2 does not. Unprocessed PRM2 seems to play a distinct role related to the eviction of intermediate DNA-bound proteins and the incorporation of both protamines into chromatin. For PRM1, on the other hand, heterozygous loss leads to strongly reduced sperm motility as the main phenotype, indicating that PRM1 might be important for processes ensuring correct motility, apart from DNA compaction.
    MeSH term(s) Animals ; Chromatin/metabolism ; DNA ; Male ; Mammals/genetics ; Mice ; Protamines/genetics ; Protamines/metabolism ; Semen/metabolism ; Sperm Motility ; Spermatozoa/metabolism
    Chemical Substances Chromatin ; Protamines ; DNA (9007-49-2)
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2034501-X
    ISSN 1741-7899 ; 1470-1626 ; 1476-3990
    ISSN (online) 1741-7899
    ISSN 1470-1626 ; 1476-3990
    DOI 10.1530/REP-22-0107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.362: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.

    Vogtmann, Rebekka / Riedel, Alina / Sassmannshausen, Ivanka / Langer, Sarah / Kühnel-Terjung, Elisabeth / Kimmig, Rainer / Schorle, Hubert / Winterhager, Elke / Gellhaus, Alexandra

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Preeclampsia (PE) is characterized by maternal hypertension and placental dysfunction, often leading to fetal growth restriction (FGR). It is associated with an overexpression of the anti-angiogenic sFLT1 protein, which originates from the placenta and ... ...

    Abstract Preeclampsia (PE) is characterized by maternal hypertension and placental dysfunction, often leading to fetal growth restriction (FGR). It is associated with an overexpression of the anti-angiogenic sFLT1 protein, which originates from the placenta and serves as a clinical biomarker to predict PE. To analyze the impact of sFLT1 on placental function and fetal growth, we generated transgenic mice with placenta-specific human sFLT1 (hsFLT1) overexpression. Immunohistochemical, morphometrical, and molecular analyses of the placentas on 14.5 dpc and 18.5 dpc were performed with a focus on angiogenesis, nutrient transport, and inflammation. Additionally, fetal development upon placental hsFLT1 overexpression was investigated. Dams exhibited a mild increase in serum hsFLT1 levels upon placental hsFLT1 expression and revealed growth restriction of the fetuses in a sex-specific manner. Male FGR fetuses expressed higher amounts of placental
    MeSH term(s) Mice ; Animals ; Pregnancy ; Humans ; Male ; Female ; Mice, Transgenic ; Fetal Growth Retardation/metabolism ; Vascular Endothelial Growth Factor Receptor-1/genetics ; Vascular Endothelial Growth Factor Receptor-1/metabolism ; Placenta/metabolism ; Pre-Eclampsia/genetics ; Inflammation/genetics
    Chemical Substances FLT1 protein, human (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042040
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  6. Article: Signals and transcription factors for specification of human germ cells.

    Jostes, Sina / Schorle, Hubert

    Stem cell investigation

    2018  Volume 5, Page(s) 13

    Language English
    Publishing date 2018-04-29
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2884645-X
    ISSN 2313-0792 ; 2306-9759
    ISSN (online) 2313-0792
    ISSN 2306-9759
    DOI 10.21037/sci.2018.04.01
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  7. Book ; Online ; Thesis: Generation of an in vitro embryo model based on cellular reprogramming paradigms in embryonic stem cells

    Langkabel, Jan [Verfasser] / Schorle, Hubert [Akademischer Betreuer] / Toma, Marieta [Gutachter]

    2022  

    Author's details Jan Michael Langkabel ; Gutachter: Marieta Toma ; Betreuer: Hubert Schorle
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
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  8. Book ; Online ; Thesis: Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization PFN4 is Required for Acrosome Biogenesis by Regulating Autophagy through PI3K/AKT/mTOR Pathway

    Tariq, Naila [Verfasser] / Schorle, Hubert [Akademischer Betreuer] / Witke, Walter [Gutachter]

    2022  

    Author's details Naila Tariq ; Gutachter: Walter Witke ; Betreuer: Hubert Schorle
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Book ; Online ; Thesis: Deciphering the role of orphan nuclear receptor GCNF in germ layer specification and early neural induction by utilizing CRISPR/Cas9

    Braun, Nils [Verfasser] / Brüstle, Oliver [Akademischer Betreuer] / Schorle, Hubert [Gutachter]

    2022  

    Author's details Nils Christian Braun ; Gutachter: Hubert Schorle ; Betreuer: Oliver Brüstle
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
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  10. Article ; Online: Cultivation of Testicular Germ Cell Cancer Cell Lines and Establishment of Gene-Edited Subclones Using CRISPR/Cas9.

    Jostes, Sina / Nettersheim, Daniel / Schneider, Simon / Schorle, Hubert

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2195, Page(s) 85–97

    Abstract: Type II testicular germ cell tumors (GCTs) can be classified as seminoma or embryonal carcinoma. Both subtypes present distinct cellular morphologies and characteristics. Seminomas closely resemble primordial germ cells (PGCs) with respect to their ... ...

    Abstract Type II testicular germ cell tumors (GCTs) can be classified as seminoma or embryonal carcinoma. Both subtypes present distinct cellular morphologies and characteristics. Seminomas closely resemble primordial germ cells (PGCs) with respect to their transcriptome and epigenetic signature (DNA hypomethylation). They express the pluripotency markers LIN28, NANOG, and OCT3/4 and the PGC markers SOX17, PRDM1, TFAP2C, DMRT1, and cKIT. Embryonal carcinomas show increased levels of DNA methylation (hypermethylation). They also express the pluripotency markers LIN28, NANOG, and OCT3/4, but additionally DNMT3B and SOX2. In contrast to seminomas, these tumors are pluripotent to totipotent and thus able to differentiate into cells of all three germ layers (teratoma) and extraembryonic tissues (yolk-sac tumor, choriocarcinoma). This protocol summarizes the essential techniques for standard cultivation of seminoma (TCam-2), embryonal carcinoma (NCCIT, NT2/D1, 2102EP), and choriocarcinoma (JEG-3, JAR) cell lines, as well as the methods to establish gene-edited subclones using the CRISPR/Cas9 system.
    MeSH term(s) Biomarkers, Tumor ; CRISPR-Cas Systems ; Cell Culture Techniques ; Cell Line, Tumor ; Clonal Evolution ; Gene Editing/methods ; Gene Knockout Techniques ; Humans ; Male ; Neoplasms, Germ Cell and Embryonal/etiology ; Neoplasms, Germ Cell and Embryonal/pathology ; Plasmids/genetics ; Testicular Neoplasms/etiology ; Testicular Neoplasms/pathology ; Transfection
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0860-9_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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