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  1. Book: Oxford textbook of cognitive neurology and dementia

    Husain, Masud / Schott, Jonathan M.

    (Oxford textbooks in clinical neurology)

    2016  

    Author's details ed. by Masud Husain, Jonathan M. Schott
    Series title Oxford textbooks in clinical neurology
    Language English
    Size XVII, 481 S. : Ill., graf. Darst.
    Publisher Oxford Univ. Pr
    Publishing place Oxford
    Publishing country United States
    Document type Book
    HBZ-ID HT019055030
    ISBN 978-0-19-965594-6 ; 0-19-965594-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1828 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Not just neurological stamp collecting: when rare diagnoses lead to fundamental advances.

    Schott, Jonathan M

    Practical neurology

    2022  Volume 23, Issue 1, Page(s) 98–99

    MeSH term(s) Humans ; Rare Diseases ; Nervous System Diseases/diagnosis
    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Editorial
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2022-003573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How preventable is dementia?

    Schott, Jonathan M

    Practical neurology

    2022  Volume 22, Issue 6, Page(s) 446–447

    MeSH term(s) Humans ; Dementia/prevention & control ; Risk Factors
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Editorial
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2022-003418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Identifying Genetic Risk for Amyloid-Related Imaging Abnormalities.

    Hardy, John / Schott, Jonathan M

    Neurology

    2023  Volume 102, Issue 3, Page(s) e208096

    Abstract: In the last 2 years, there have been 3 successful trials of antiamyloid antibodies in Alzheimer disease (AD): aducanemab, now controversially US Food and Drug Administration-approved under the accelerated approval ... ...

    Abstract In the last 2 years, there have been 3 successful trials of antiamyloid antibodies in Alzheimer disease (AD): aducanemab, now controversially US Food and Drug Administration-approved under the accelerated approval pathway
    MeSH term(s) United States ; Humans ; Amyloidogenic Proteins ; Diagnostic Imaging ; Amyloid beta-Peptides ; Inflammation ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics
    Chemical Substances donanemab ; Amyloidogenic Proteins ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000208096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Blood biomarkers for Alzheimer's disease and related disorders.

    Zetterberg, Henrik / Schott, Jonathan M

    Acta neurologica Scandinavica

    2022  Volume 146, Issue 1, Page(s) 51–55

    Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease and the single commonest cause of dementia. Many other diseases can, however, cause dementia, and differential diagnosis can be challenging, especially in early disease stages. For most ... ...

    Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease and the single commonest cause of dementia. Many other diseases can, however, cause dementia, and differential diagnosis can be challenging, especially in early disease stages. For most neurodegenerative dementias, accumulation of brain pathologies starts many years before clinical onset; the ability to detect these pathologies paves the way for targeted disease-modifying prevention trials. AD is associated with β-amyloid and tau pathologies, which can be quantified using cerebrospinal fluid and imaging biomarkers and, more recently, using highly sensitive blood tests. While for the most part, specific biomarkers of non-AD neurodegenerative dementias are lacking, non-specific biomarkers of neurodegeneration are available. This review summarizes recent advances in the neurodegenerative dementia blood biomarker research and discusses the next steps required for clinical implementation.
    MeSH term(s) Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers ; Humans ; Neurodegenerative Diseases ; Peptide Fragments ; tau Proteins/cerebrospinal fluid
    Chemical Substances Amyloid beta-Peptides ; Biomarkers ; Peptide Fragments ; tau Proteins
    Language English
    Publishing date 2022-04-25
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 90-5
    ISSN 1600-0404 ; 0001-6314
    ISSN (online) 1600-0404
    ISSN 0001-6314
    DOI 10.1111/ane.13628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Objectifying Subjective Cognitive Decline: The Prognostic Role of Alzheimer Biomarkers.

    Zetterberg, Henrik / Schott, Jonathan M

    Neurology

    2022  Volume 99, Issue 17, Page(s) 735–736

    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Prognosis ; Amyloid beta-Peptides ; tau Proteins ; Biomarkers ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Neuropsychological Tests
    Chemical Substances Amyloid beta-Peptides ; tau Proteins ; Biomarkers
    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Preparing for disease-modifying therapies in Alzheimer's disease.

    Belder, Christopher R S / Schott, Jonathan M / Fox, Nick C

    The Lancet. Neurology

    2023  Volume 22, Issue 9, Page(s) 782–783

    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Brain
    Language English
    Publishing date 2023-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00274-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: When dementia is misdiagnosed.

    Howard, Robert / Schott, Jonathan M

    International journal of geriatric psychiatry

    2021  Volume 36, Issue 6, Page(s) 799–801

    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.5538
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  9. Article ; Online: Predicting progression to Alzheimer's disease dementia using cognitive measures.

    Macdougall, Amy / Whitfield, Tim / Needham, Kelly / Schott, Jonathan M / Frost, Chris / Walker, Zuzana

    International journal of geriatric psychiatry

    2024  Volume 39, Issue 2, Page(s) e6067

    Abstract: Objectives: It is important to determine if cognitive measures identified as being prognostic in dementia research cohorts also have utility in memory clinics. We aimed to identify measures with the greatest power to predict future Alzheimer's disease ( ... ...

    Abstract Objectives: It is important to determine if cognitive measures identified as being prognostic in dementia research cohorts also have utility in memory clinics. We aimed to identify measures with the greatest power to predict future Alzheimer's disease (AD) dementia in a clinical setting where expensive biomarkers are not widely available.
    Methods: This study utilized routine Memory Clinic data collected over 18 years. From 2214 patients assessed in the clinic, we selected 328 patients with an initial diagnosis of subjective cognitive decline or mild cognitive impairment. We compared two types of statistical model for the prediction of AD dementia. The first model included baseline cognitive test scores only, while the second model also included change scores between baseline and the first follow-up.
    Results: Baseline scores on tests of global cognitive function (Mini-mental state examination and Cambridge Cognitive Examination-Revised), verbal episodic memory and psychomotor speed were the best predictors of conversion to AD dementia. The inclusion of cognitive change scores over 1 year of follow-up improved predictive accuracy versus baseline scores alone.
    Conclusions: We found that the best cognitive predictors of AD dementia in a clinical setting were similar to those previously identified using research cohorts. Taking change in cognitive function into account enabled the onset of AD dementia to be predicted with greater accuracy.
    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Disease Progression ; Cognitive Dysfunction/diagnosis ; Prognosis ; Biomarkers ; Cognition ; Neuropsychological Tests
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.6067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Imaging the ageing brain: identifying early disease or opening Pandora's box?

    Schott, Jonathan M

    The Lancet. Neurology

    2017  Volume 16, Issue 6, Page(s) 411–413

    MeSH term(s) Aging ; Brain
    Language English
    Publishing date 2017-04-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(17)30116-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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