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Buch ; Dissertation / Habilitation: Etablierung zweier Expressionssysteme für SFTA3 in Scherichia coli und der humanen embryonalen Nierenzelllinie HEK 293T

Schröder, Henrik

2017

Verfasserangabe	vorgelegt von Henrik Schröder
Sprache	Deutsch ; Englisch
Umfang	25 verschieden gezählte Seiten, Illustrationen, Diagramme
Erscheinungsort	Erlangen ; Nürnberg
Erscheinungsland	Deutschland
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Dissertation, Friedrich-Alexander-Universität Erlangen-Nürnberg, 2017
Anmerkung	Enthält Sonderabdrucke in englischer Sprache
HBZ-ID	HT019451728
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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Buch ; Dissertation / Habilitation: Behandlung fortgeschrittener hepatozellulärer Karzinome mit der multisequentiellen transarteriellen Chemoembolisation

Schröder, Henrik

Verlaufsbeobachtung und bildmorphologische Kriterien für das Ansprechen auf die Therapie in der Computertomographie

2000

Verfasserangabe	von Henrik Schröder
Sprache	Deutsch
Umfang	IV, 70 Bl., Ill., graph. Darst., 30 cm
Ausgabenhinweis	[Mikrofiche-Ausg.]
Erscheinungsland	Deutschland
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Berlin, Humboldt-Univ., Diss., 2000
HBZ-ID	HT013270918
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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2002 MB 1203	bestellbar zur Ausleihe	Magazin

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Artikel ; Online: Patient-reported outcomes and satisfaction after revisions of medial unicompartmental knee arthroplasties for unexplained pain vs aseptic loosening.

Arndt, Kristine Bollerup / Schrøder, Henrik Morville / Troelsen, Anders / Lindberg-Larsen, Martin

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

2023 Band 31, Heft 11, Seite(n) 4766–4772

Abstract: Purpose: Does patients revised for unexplained pain after mUKA present the same PROM and satisfaction scores 1-3 years after revision as patients revised for aseptic loosening?".: Methods: 104 patients undergoing revision of mUKA's for the ... ...

Abstract	Purpose: Does patients revised for unexplained pain after mUKA present the same PROM and satisfaction scores 1-3 years after revision as patients revised for aseptic loosening?". Methods: 104 patients undergoing revision of mUKA's for the indications unexplained pain and aseptic loosening were included in the period January 1, 2018 to December 31, 2020. from the Danish Knee Arthroplasty Register. 52 patients were revised for unexplained pain and 52 for aseptic loosening. Patient demographics did not differ between the two groups. PROMs [Oxford Knee Score (OKS), EQ-5D-5L, Forgotten Joint Score (FJS)] and questions about satisfaction with the surgery were sent to digitally secured mailboxes. Pearson's Chi-square test and Wilcoxon Rank Sum test were used to test for statistical differences between groups. Results: The median OKS 1-3 years after revision was 26 (IQR 22) for unexplained pain vs 34 (IQR 12) for aseptic loosening, p = 0.033. The median EQ-5D-5L Index after revision was 0.7 (IQR 0.6) for unexplained vs 0.8 (IQR 0.1) for aseptic loosening, p = 0.014. The median FJS after revision was 48 (IQR 10) for unexplained pain vs 52 (IQR 14) for aseptic loosening, p = 0.1. The mean satisfaction with the surgery on a 0-100 scale (100 = not satisfied; 0 = very satisfied) was 55 (IQR 60) for unexplained pain vs 50 (IQR 67) for aseptic loosening, p = 0.087, and patients revised for unexplained pain were less likely to find their knee problem importantly improved (p = 0.032). Conclusion: Patients undergoing revision of mUKAs for unexplained pain presented poor postoperative PROM scores, and PROM scores were worse compared to those of patients revised for aseptic loosening. Patients revised for unexplained pain were less likely to find their knee problem importantly improved. This study support the evidence against revisions for unexplained pain. Level of evidence: Level III.
Mesh-Begriff(e)	Humans ; Arthroplasty, Replacement, Knee/adverse effects ; Patient Satisfaction ; Reoperation ; Pain/surgery ; Patient Reported Outcome Measures ; Treatment Outcome ; Prosthesis Failure ; Knee Prosthesis ; Knee Joint/surgery
Sprache	Englisch
Erscheinungsdatum	2023-07-27
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1159064-6
ISSN	1433-7347 ; 0942-2056
ISSN (online)	1433-7347
ISSN	0942-2056
DOI	10.1007/s00167-023-07483-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Dissertation / Habilitation: Die Beeinflussung der Mixed Lymphocyte Culture (MLC) durch verschiedene Antibiotika in vitro und in vivo

Schroeder, Henrik

1989

Verfasserangabe	vorgelegt von Henrik Schroeder
Umfang	94 Bl. : Ill.
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Heidelberg, Univ., Diss., 1989
HBZ-ID	HT003756610
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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Artikel ; Online: Tibial Component Undersizing Is Related to High Degrees of Implant Migration Following Cementless Total Knee Arthroplasty: A Study of Radiostereometric Analysis Data for 111 Patients with 2-Year Follow-up.

Andersen, Mikkel Rathsach / Winther, Nikolaj / Lind, Thomas / Schrøder, Henrik / Flivik, Gunnar / Petersen, Michael Mørk

JB & JS open access

2023 Band 8, Heft 3

Abstract: Radiostereometric analysis (RSA) studies have shown that the continuous migration of tibial components is predictive of aseptic loosening following total knee arthroplasty (TKA). In the present study, we investigated whether accurate sizing and placement ...

Abstract	Radiostereometric analysis (RSA) studies have shown that the continuous migration of tibial components is predictive of aseptic loosening following total knee arthroplasty (TKA). In the present study, we investigated whether accurate sizing and placement of tibial components are related to the degree of implant migration as measured with use of RSA. Methods: A total of 111 patients who underwent TKA surgery with a cementless tibial component were followed for a period of 2 years postoperatively, during which implant migration was assessed with use of RSA. RSA was performed within 7 days postoperatively and after 3, 6, 12, and 24 months. Postoperative radiographs were evaluated for component size and placement in the tibia. The evaluations were performed by experienced knee surgeons who were blinded to the migration data and clinical outcomes. A multivariable linear regression analysis was conducted. Results: Continuous implant migration (i.e., migration occurring between 12 and 24 months postoperatively) had a negative association with tibial component size (coefficient [B], -0.2; 95% confidence interval [CI], -0.33 to -0.08). Subsidence was associated with the absence of posterior cortical bone support (B, -0.7; 95% CI, -1.09 to -0.28), the absence of lateral cortical bone support (B, 0.8; 95% CI, 0.29 to 1.37), frontal-plane varus malalignment (B, 0.6; 95% CI, 0.12 to 1.16), and component undersizing (B, -0.4; 95% CI, -0.06 to -0.68). Posterior tilt was associated only with undersizing (B, 0.6; 95% CI, 0.27 to 1.11). Conclusions: Undersized cementless tibial components are at a higher risk for poor fixation with continuous migration following TKA. Therefore, a higher risk of aseptic loosening should be expected. Level of evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Sprache	Englisch
Erscheinungsdatum	2023-08-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2472-7245
ISSN (online)	2472-7245
DOI	10.2106/JBJS.OA.23.00032
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: "Pain without loosening"-revisions of knee arthroplasties in the Danish Knee Arthroplasty Register.

Arndt, Kristine Bollerup / Schrøder, Henrik Morville / Troelsen, Anders / Andersen, Mikkel Rathsach / Rasmussen, Lasse Enkebølle / Lindberg-Larsen, Martin

Danish medical journal

2024 Band 71, Heft 2

Abstract: Introduction: We aimed to investigate "pain without loosening" as an indication for knee arthroplasty revisions and to screen for other indications potentially hidden in this category to improve future registration and enhance data quality in the Danish ...

Abstract	Introduction: We aimed to investigate "pain without loosening" as an indication for knee arthroplasty revisions and to screen for other indications potentially hidden in this category to improve future registration and enhance data quality in the Danish Knee Arthroplasty Register. Methods: We included 104 patients undergoing revision knee arthroplasty for the indication "pain without loosening" from 1 January 2016 to 31 December 2018 at five Danish centres. Medical records, radiographs and computed tomographies were reviewed. Results: In 103 of 104 cases, we confirmed "pain without loosening" as an indication for revision. We found hidden indications in 44 cases; malposition of components (n = 19), stiffness (n = 13), progression of arthrosis (n = 6), instability (n = 3), liner dislocation (n = 1), residual cement (n = 1) and aseptic loosening (n = 1). The Kellgren-Lawrence arthrosis grades prior to primary knee arthroplasty were 1-2 (31%) and 3-4 (69%). Conclusions: The indication "pain without loosening" covered patients revised due to pain, but other hidden indications were also present. Stiffness and malposition of components were hidden indications and these are not provided as indication options in the DKR and other registers. The relatively high frequency of arthrosis grade 1-2 prior to primary knee arthroplasty is concerning and may explain the occurrence of knee pain without any other pathology present. Funding: The Danish Rheumatism Association, the Region of Southern Denmark, the Research Fund of Region Zeeland and Region of Southern Denmark, and the University of Southern Denmark. Trial registration: Not relevant.
Mesh-Begriff(e)	Humans ; Arthroplasty, Replacement, Knee/adverse effects ; Reoperation ; Prosthesis Failure ; Pain ; Osteoarthritis ; Denmark/epidemiology
Sprache	Englisch
Erscheinungsdatum	2024-01-15
Erscheinungsland	Denmark
Dokumenttyp	Journal Article
ZDB-ID	2648771-8
ISSN	2245-1919 ; 2245-1919
ISSN (online)	2245-1919
ISSN	2245-1919
DOI	10.61409/A04230242
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Prosthesis survival after revision knee arthroplasty for "pain without loosening" versus "aseptic loosening": a Danish nationwide study.

Arndt, Kristine Bollerup / Schrøder, Henrik M / Troelsen, Anders / Lindberg-Larsen, Martin

Acta orthopaedica

2022 Band 93, Seite(n) 103–110

Abstract: Background and purpose - Patients having a knee arthroplasty revision for the indication "pain without loosening" may have a higher risk of re-revisions than patients revised for other indications. The primary aim of this study was to compare the ... ...

Abstract	Background and purpose - Patients having a knee arthroplasty revision for the indication "pain without loosening" may have a higher risk of re-revisions than patients revised for other indications. The primary aim of this study was to compare the survival of knee arthroplasties revised for "pain without loosening" compared with "aseptic loosening." The second was to investigate the prosthesis survival rates in 3 surgical subgroups (total knee arthroplasty (TKA)-TKA; partial revision (revision of tibial or femoral component); unicompartmental knee arthroplasty-TKA) and to compare the prosthesis survival rates for 1997-2009 and 2010-2018. Patients and methods - 4,299 revisions were identified in the period 1997-2018 from the Danish Knee Arthroplasty Register. Of these, 1,111 (26%) were performed due to "pain without loosening" without any other indications, 674 (16%) due to "pain without loosening" combined with other indications, and 2,514 (59%) due to "aseptic loosening". Survival analysis was performed by a Cox multivariate analysis and Kaplan-Meier curves were presented. Results - The cumulated proportions of re-revision after 2, 5, and 20 years were 12% (95% CI 10-14), 18% (CI 16-20), and 23% (CI 20-25) for "pain without loosening" versus 11% (CI 9.3-12), 16% (CI 14-17), and 19% (CI 18-21) for "aseptic loosening." There were no statistically significant differences between the 2 indications in repeated analyses for each of the surgical subgroups. The hazard ratio for re-revision comparing "pain without loosening" with "aseptic loosening" was 1.03 (CI 0.87-1.2). The 8-year risk of re-revision for "pain without loosening" was 22% (CI 19-26) versus 22% (CI 20-25) for "aseptic loosening" in the period from 1997-2009, and 18% (CI 15-22) versus 14% (CI 13-16) in the period from 2010-2018. Interpretation - The risk of re-revision was similar for patients having a knee arthroplasty revision for the indication "pain without loosening" compared with "aseptic loosening." However, we observed a slight improvement of prosthesis survival rates after revisions for both indications from 1997-2009 to 2010-2018. We cannot recommend for or against revision in cases with "pain without loosening" based on these data alone.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Knee/methods ; Cohort Studies ; Denmark ; Female ; Humans ; Knee Prosthesis ; Male ; Middle Aged ; Prosthesis Design ; Prosthesis Failure ; Registries ; Reoperation/methods ; Retrospective Studies
Sprache	Englisch
Erscheinungsdatum	2022-01-03
Erscheinungsland	Sweden
Dokumenttyp	Comparative Study ; Journal Article
ZDB-ID	2180677-9
ISSN	1745-3682 ; 1745-3674
ISSN (online)	1745-3682
ISSN	1745-3674
DOI	10.1080/17453674.2021.1999069
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Quality of life in patients with myositis is associated with functional capacity, body composition, and disease activity-Baseline data from a randomized controlled trial.

Jensen, Kasper Yde / Aagaard, Per / Suetta, Charlotte / Nielsen, Jakob L / Schrøder, Henrik D / Grønset, Charlotte / Simonsen, Casper / Diederichsen, Louise P

International journal of rheumatic diseases

2024 Band 27, Heft 3, Seite(n) e15132

Abstract: Objective: To investigate the potential associations between functional capacity, muscle strength, body composition, and disease-related measures and quality of life in patients with myositis.: Methods: Baseline measures of functional capacity ( ... ...

Abstract	Objective: To investigate the potential associations between functional capacity, muscle strength, body composition, and disease-related measures and quality of life in patients with myositis. Methods: Baseline measures of functional capacity (functional index 3 (FI3), 2-minute walk test (2MWT), timed up and go (TUG) and 30-s sit-to-stand (30-STS)), muscle strength (incl. leg and handgrip strength), maximal leg extensor power, body composition (appendicular lean mass, fat percentage/mass) and disease-related measures (disease activity & damage core sets) were examined for their associations with quality of life (physical- and mental component summary scores, Short Form 36 questionnaire (SF-36)) by means of Spearman's correlation analysis. Results: A total of 32 patients with myositis were included. Positive correlations between SF-36 physical component summary score (PCS) and FI3, 30-STS, TUG, 2MWT, leg extensor power, leg strength, bench press strength, and handgrip strength were observed. In contrast, fat percentage and fat mass correlated negatively with PCS. In disease-related measures, Extramuscular global assessment, health assessment questionnaire, physician global damage, and patient global damage scores were negatively associated with SF-36 PCS. No correlations to the mental component summary score of SF-36 were observed. Conclusion: All measures of functional capacity were positively related to the SF-36 physical component summary score, indicating higher functional capacity positively affects quality of life in patients with myositis. Health assessment questionnaire and patient global damage scores demonstrated the strongest correlations with SF-36 physical component summary scores, further supporting these patient-reported outcomes as viable monitoring tools in patients with myositis.
Mesh-Begriff(e)	Humans ; Quality of Life ; Hand Strength ; Myositis ; Muscle Strength/physiology ; Body Composition
Sprache	Englisch
Erscheinungsdatum	2024-03-20
Erscheinungsland	England
Dokumenttyp	Randomized Controlled Trial ; Journal Article
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.15132
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Patient-Reported Outcomes and Satisfaction 1 to 3 Years After Revisions of Total Knee Arthroplasties for Unexplained Pain Versus Aseptic Loosening.

Arndt, Kristine Bollerup / Schrøder, Henrik Morville / Troelsen, Anders / Lindberg-Larsen, Martin

The Journal of arthroplasty

2022 Band 38, Heft 3, Seite(n) 535–540.e3

Abstract: Background: It is unknown if patients are relieved of pain after knee arthroplasty revision for unexplained pain. The aim of this cross-sectional case-control study was to compare patient-reported outcome measures (PROMs) and satisfaction 1 to 3 years ... ...

Abstract	Background: It is unknown if patients are relieved of pain after knee arthroplasty revision for unexplained pain. The aim of this cross-sectional case-control study was to compare patient-reported outcome measures (PROMs) and satisfaction 1 to 3 years after revision of total knee arthroplasties (TKAs) for the indications of unexplained pain versus aseptic loosening. Methods: We included 384 patients undergoing TKA revision for the indications of unexplained pain and aseptic loosening from January 1, 2018 to December 31, 2020 from the Danish Knee Arthroplasty Register. A total of 81 patients were revised for unexplained pain and 303 for aseptic loosening. Questionnaires including PROMs (Oxford Knee Score, EQ-5D-5L, and Forgotten Joint Score) and satisfaction with the surgery on a 0-100 scale (100 = not satisfied; 0 = very satisfied) were sent to digitally secured mailboxes. Time from revision to data collection was a median 3.1 years (range, 1.4-4.4 years). Results: Median Oxford Knee Score was 25 (interquartile range [IQR] 15) versus 31 (IQR 18) 1-3 years after revisions for unexplained pain versus aseptic loosening, P = .009. Median EQ-5D-5L was 0.6 (IQR 0.4) versus 0.8 (IQR 0.3) for unexplained pain versus aseptic loosening, P = .009. Median Forgotten Joint Score was 50 (IQR 7) versus 50 (IQR 16) for unexplained pain versus aseptic loosening, P = .905. Satisfaction was 75 (IQR 38) for unexplained pain and 50 (IQR 73) for aseptic loosening, P < .001. Conclusion: Patients undergoing TKA revision for the indication of unexplained pain had worse results on PROMs than those revised for aseptic loosening. Likewise, patients revised for unexplained pain were less satisfied compared to patients revised for aseptic loosening. This information is valuable to both surgeons and patients when candidates for revision surgery are selected, to obtain the best possible outcomes.
Mesh-Begriff(e)	Humans ; Arthroplasty, Replacement, Knee/methods ; Case-Control Studies ; Cross-Sectional Studies ; Patient Satisfaction ; Prosthesis Failure ; Pain/surgery ; Reoperation ; Surveys and Questionnaires ; Patient Reported Outcome Measures ; Knee Prosthesis/adverse effects ; Knee Joint/surgery ; Retrospective Studies
Sprache	Englisch
Erscheinungsdatum	2022-10-17
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2022.10.019
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Opioid and Analgesic Use Before and After Revision Knee Arthroplasty for the Indications "Pain Without Loosening" Versus "Aseptic Loosening" - A Danish Nationwide Study.

Arndt, Kristine Bollerup / Schrøder, Henrik M / Troelsen, Anders / Lindberg-Larsen, Martin

The Journal of arthroplasty

2022 Band 37, Heft 8, Seite(n) 1618–1625.e3

Abstract: Background: It is uncertain if patients undergoing revision knee arthroplasty for "pain without loosening" are relieved of pain. This study aimed to compare pre- and postoperative analgesic consumption by patients undergoing revision for "pain without ... ...

Abstract	Background: It is uncertain if patients undergoing revision knee arthroplasty for "pain without loosening" are relieved of pain. This study aimed to compare pre- and postoperative analgesic consumption by patients undergoing revision for "pain without loosening" versus "aseptic loosening" and to determine predictors for postoperative long-term opioid use. Methods: A retrospective nationwide study of 1,037 revisions for "pain without loosening" and 2,317 revisions for "aseptic loosening" during 1997-2018 from the Danish Knee Arthroplasty Register was carried out. Analgesic use was defined by prescription reimbursement, and long-term opioid use by prescription reimbursement in 4 consecutive quarters. Results: In the preoperative year, 37% and 29% of patients revised for "pain without loosening" and "aseptic loosening" were opioid users compared to 32% and 30% in the postoperative year. Non-steroidal anti-inflammatory drug (NSAID) use was significantly lower postoperatively for both indications (35% versus 28% for "pain without loosening" and 33% versus 25% for "aseptic loosening"). Use of other analgesics was unchanged. Long-term opioid use increased postoperatively by 4% for patients with "pain without loosening" (P = .029) and by 3% for "aseptic loosening" (P = .003). New long-term opioid users (without preoperative long-term use) were 9% for "pain without loosening" and 8% for "aseptic loosening". Predictors of new long-term opioid use were other opioid-requiring diagnoses or procedures within the first postoperative year, Charlson Comorbidity Index (CCI) ≥3, and preoperative long-term NSAID use. Conclusion: The consumption of opioids decreased slightly after knee arthroplasty revision for the indication "pain without loosening", but not for "aseptic loosening". The amount of new long-term opioid users increased for both indications.
Mesh-Begriff(e)	Analgesics, Opioid/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal ; Arthroplasty, Replacement, Knee/methods ; Denmark ; Humans ; Pain ; Prosthesis Failure ; Reoperation ; Retrospective Studies
Chemische Substanzen	Analgesics, Opioid ; Anti-Inflammatory Agents, Non-Steroidal
Sprache	Englisch
Erscheinungsdatum	2022-04-01
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2022.03.077
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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