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  1. Book ; Thesis: Untersuchung der Marker der zirrhotischen Kardiomyopathie bei Kindern vor und nach Lebertransplantation

    Schröder, Julian Robert

    2018  

    Author's details vorgelegt von Julian Robert Schröder
    Language German
    Size 106, XVIII Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2019
    HBZ-ID HT020391747
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 E 432 order for loan Magazin

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  2. Book ; Online ; Thesis: Der konjunktivale Provokationstest als zuverlässiger Biomarker für die allergenspezifische Immuntherapie

    Schröder, Julian / Mösges, Ralph / Hunzelmann, Nicolas

    ein Überblick

    2021  

    Institution Universität zu Köln / Institut für Medizinische Statistik und Bioinformatik
    Author's details vorgelegt von Julian Schröder ; 1. Gutachter: Universitätsprofessor Dr. med. R W. Mösges, 2. Gutachter: Professor Dr. med. N. Hunzelmann ; aus dem Institut für Medizinische Statistik und Bioinformatik der Universität zu Köln
    Subject code 610
    Language German ; English
    Size 1 Online-Ressource (55 Seiten)
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    Note Enthält Sonderabdruck aus Zeitschrift in englischer Sprache ; Open Acces
    HBZ-ID HT021199104
    DOI 10.4126/FRL01-006431127
    Database Repository for Life Sciences

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  3. Book ; Thesis: Der konjunktivale Provokationstest als zuverlässiger Biomarker für die allergenspezifische Immuntherapie

    Schröder, Julian / Mösges, Ralph / Hunzelmann, Nicolas

    ein Überblick

    2021  

    Institution Universität zu Köln / Institut für Medizinische Statistik und Bioinformatik
    Author's details vorgelegt von Julian Schröder ; 1. Gutachter: Universitätsprofessor Dr. med. R W. Mösges, 2. Gutachter: Professor Dr. med. N. Hunzelmann ; aus dem Institut für Medizinische Statistik und Bioinformatik der Universität zu Köln
    Subject code 610
    Language German ; English
    Size 56 Seiten
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    Note Enthält Sonderabdruck aus Zeitschrift in englischer Sprache
    HBZ-ID HT021296921
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 D 136 order for loan Magazin

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  4. Article ; Online: Distinct guard cell-specific remodeling of chromatin accessibility during abscisic acid- and CO

    Seller, Charles A / Schroeder, Julian I

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 52, Page(s) e2310670120

    Abstract: In plants, epidermal guard cells integrate and respond to numerous environmental signals to control stomatal pore apertures, thereby regulating gas exchange. Chromatin structure controls transcription factor (TF) access to the genome, but whether large- ... ...

    Abstract In plants, epidermal guard cells integrate and respond to numerous environmental signals to control stomatal pore apertures, thereby regulating gas exchange. Chromatin structure controls transcription factor (TF) access to the genome, but whether large-scale chromatin remodeling occurs in guard cells during stomatal movements, and in response to the hormone abscisic acid (ABA) in general, remains unknown. Here, we isolate guard cell nuclei from
    MeSH term(s) Abscisic Acid/pharmacology ; Abscisic Acid/metabolism ; Arabidopsis Proteins/metabolism ; Carbon Dioxide/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Plant Stomata/metabolism ; Arabidopsis/metabolism
    Chemical Substances Abscisic Acid (72S9A8J5GW) ; Arabidopsis Proteins ; Carbon Dioxide (142M471B3J) ; Chromatin
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2310670120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Distinct guard cell specific remodeling of chromatin accessibility during abscisic acid and CO

    Seller, Charles A / Schroeder, Julian I

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In plants, epidermal guard cells integrate and respond to numerous environmental signals to control stomatal pore apertures thereby regulating gas exchange. Chromatin structure controls transcription factor access to the genome, but whether large-scale ... ...

    Abstract In plants, epidermal guard cells integrate and respond to numerous environmental signals to control stomatal pore apertures thereby regulating gas exchange. Chromatin structure controls transcription factor access to the genome, but whether large-scale chromatin remodeling occurs in guard cells during stomatal movements, and in response to the hormone abscisic acid (ABA) in general, remain unknown. Here we isolate guard cell nuclei from
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.11.540345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hydrotropism mechanisms and their interplay with gravitropism.

    Wexler, Yonatan / Schroeder, Julian I / Shkolnik, Doron

    The Plant journal : for cell and molecular biology

    2024  

    Abstract: Plants partly optimize their water recruitment from the growth medium by directing root growth toward a moisture source, a phenomenon termed hydrotropism. The default mechanism of downward growth, termed gravitropism, often functions to counteract ... ...

    Abstract Plants partly optimize their water recruitment from the growth medium by directing root growth toward a moisture source, a phenomenon termed hydrotropism. The default mechanism of downward growth, termed gravitropism, often functions to counteract hydrotropism when the water-potential gradient deviates from the gravity vector. This review addresses the identity of the root sites in which hydrotropism-regulating factors function to attenuate gravitropism and the interplay between these various factors. In this context, the function of hormones, including auxin, abscisic acid, and cytokinins, as well as secondary messengers, calcium ions, and reactive oxygen species in the conflict between these two opposing tropisms is discussed. We have assembled the available data on the effects of various chemicals and genetic backgrounds on both gravitropism and hydrotropism, to provide an up-to-date perspective on the interactions that dictate the orientation of root tip growth. We specify the relevant open questions for future research. Broadening our understanding of root mechanisms of water recruitment holds great potential for providing advanced approaches and technologies that can improve crop plant performance under less-than-optimal conditions, in light of predicted frequent and prolonged drought periods due to global climate change.
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1088037-9
    ISSN 1365-313X ; 0960-7412
    ISSN (online) 1365-313X
    ISSN 0960-7412
    DOI 10.1111/tpj.16683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 6071: Show issues

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  7. Article ; Online: Protein kinase sensors: an overview of new designs for visualizing kinase dynamics in single plant cells.

    Zhang, Li / Takahashi, Yohei / Schroeder, Julian I

    Plant physiology

    2022  Volume 187, Issue 2, Page(s) 527–536

    Abstract: Protein kinase dynamics play key roles in regulation of cell differentiation, growth, development and in diverse cell signaling networks. Protein kinase sensors enable visualization of protein kinase activity in living cells and tissues in time and space. ...

    Abstract Protein kinase dynamics play key roles in regulation of cell differentiation, growth, development and in diverse cell signaling networks. Protein kinase sensors enable visualization of protein kinase activity in living cells and tissues in time and space. These sensors have therefore become important and powerful molecular tools for investigation of diverse kinase activities and can resolve long-standing and challenging biological questions. In the present Update, we review new advanced approaches for genetically encoded protein kinase biosensor designs developed in animal systems together with the basis of each biosensor's working principle and components. In addition, we review recent first examples of real time plant protein kinase activity biosensor development and application. We discuss how these sensors have helped to resolve how stomatal signal transduction in response to elevated CO2 merges with abscisic acid signaling downstream of a resolved basal SnRK2 kinase activity in guard cells. Furthermore, recent advances, combined with the new strategies described in this Update, can help deepen the understanding of how signaling networks regulate unique functions and responses in distinct plant cell types and tissues and how different stimuli and signaling pathways can interact.
    MeSH term(s) Biosensing Techniques/instrumentation ; Plant Cells/metabolism ; Protein Kinases/metabolism ; Single-Cell Analysis/instrumentation ; Single-Cell Analysis/methods
    Chemical Substances Protein Kinases (EC 2.7.-)
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiab277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  8. Article ; Online: Toward a better understanding of signaling networks in plants: yeast has the power!

    Dubeaux, Guillaume / Schroeder, Julian I

    The EMBO journal

    2019  Volume 38, Issue 17, Page(s) e102478

    Abstract: In response to abiotic stresses, plants produce the hormone abscisic acid (ABA). The ABA signaling pathway is highly complex and relies on a large number of gene copies encoding homologous signaling components, theoretically enabling numerous ... ...

    Abstract In response to abiotic stresses, plants produce the hormone abscisic acid (ABA). The ABA signaling pathway is highly complex and relies on a large number of gene copies encoding homologous signaling components, theoretically enabling numerous permutations. In this issue, Ruschhaupt et al (2019) used yeast as a reconstitution system to examine the functionality, plasticity, and efficiency of this complex and highly multiplexed core signaling pathway.
    MeSH term(s) Abscisic Acid ; Arabidopsis ; Gene Expression Regulation, Plant ; Signal Transduction ; Stress, Physiological
    Chemical Substances Abscisic Acid (72S9A8J5GW)
    Language English
    Publishing date 2019-08-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2019102478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1808: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 100: Show issues

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  9. Article ; Online: Arabidopsis PLANT U-BOX44 down-regulates osmotic stress signaling by mediating Ca2+-DEPENDENT PROTEIN KINASE4 degradation.

    Fan, Wei / Liao, Xiliang / Tan, Yanqiu / Wang, Xiruo / Schroeder, Julian I / Li, Zixing

    The Plant cell

    2023  Volume 35, Issue 10, Page(s) 3870–3888

    Abstract: Calcium (Ca2+)-dependent protein kinases (CPKs) are essential regulators of plant responses to diverse environmental stressors, including osmotic stress. CPKs are activated by an increase in intracellular Ca2+ levels triggered by osmotic stress. However, ...

    Abstract Calcium (Ca2+)-dependent protein kinases (CPKs) are essential regulators of plant responses to diverse environmental stressors, including osmotic stress. CPKs are activated by an increase in intracellular Ca2+ levels triggered by osmotic stress. However, how the levels of active CPK protein are dynamically and precisely regulated has yet to be determined. Here, we demonstrate that NaCl/mannitol-induced osmotic stress promoted the accumulation of CPK4 protein by disrupting its 26S proteasome-mediated CPK4 degradation in Arabidopsis (Arabidopsis thaliana). We isolated PLANT U-BOX44 (PUB44), a U-box type E3 ubiquitin ligase that ubiquitinates CPK4 and triggers its degradation. A calcium-free or kinase-inactive CPK4 variant was preferentially degraded compared to the Ca2+-bound active form of CPK4. Furthermore, PUB44 exhibited a CPK4-dependent negative role in the response of plants to osmotic stress. Osmotic stress induced the accumulation of CPK4 protein by inhibiting PUB44-mediated CPK4 degradation. The present findings reveal a mechanism for regulating CPK protein levels and establish the relevance of PUB44-dependent CPK4 regulation in modulating plant osmotic stress responses, providing insights into osmotic stress signal transduction mechanisms.
    MeSH term(s) Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Calcium/metabolism ; Osmotic Pressure ; Signal Transduction ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Gene Expression Regulation, Plant
    Chemical Substances Arabidopsis Proteins ; Calcium (SY7Q814VUP) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    DOI 10.1093/plcell/koad173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4952: Show issues

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  10. Article ; Online: Conjunctival provocation tests: prediction of seasonal allergy.

    Schröder, Julian / Mösges, Ralph

    Current opinion in allergy and clinical immunology

    2018  Volume 18, Issue 5, Page(s) 393–397

    Abstract: Purpose of review: The conjunctival provocation test (CPT) is often used to clearly identify the specific allergen causing the symptoms of allergic rhinoconjunctivitis but also to assess the clinical efficacy of an allergen immunotherapy (AIT). As there ...

    Abstract Purpose of review: The conjunctival provocation test (CPT) is often used to clearly identify the specific allergen causing the symptoms of allergic rhinoconjunctivitis but also to assess the clinical efficacy of an allergen immunotherapy (AIT). As there is no consensus about its predictive value, the aim of this publication is to evaluate under which conditions the CPT can predict the symptom severity during the allergy season after previous AIT.
    Recent findings: Three out of four randomized controlled trials (RCTs) showed a correlation between CPT reactivity and symptoms occurring under natural allergen exposure after previous AIT. Furthermore, one RCT found that performing the CPT 4 weeks after initiating AIT can identify early responders who also show a benefit during the season. Another RCT suggested that conducting the CPT prior to starting AIT can be used to identify patients who may benefit more from treatment than others.
    Summary: The assessment of the reviewed literature led us to the conclusion that the CPT has a predictive value and can consequently be used to assess the efficacy of an administered AIT if performed according to a standardized challenge protocol with high-quality allergen extracts.
    MeSH term(s) Allergens/adverse effects ; Allergens/immunology ; Conjunctivitis, Allergic/diagnosis ; Conjunctivitis, Allergic/etiology ; Conjunctivitis, Allergic/immunology ; Conjunctivitis, Allergic/therapy ; Desensitization, Immunologic/methods ; Humans ; Predictive Value of Tests ; Rhinitis, Allergic, Seasonal/diagnosis ; Rhinitis, Allergic, Seasonal/etiology ; Rhinitis, Allergic, Seasonal/immunology ; Rhinitis, Allergic, Seasonal/therapy ; Risk Assessment ; Seasons ; Severity of Illness Index
    Chemical Substances Allergens
    Language English
    Publishing date 2018-10-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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