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  1. AU="Schreibing, Felix"
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  1. Book ; Thesis: Vitamin K-Transport in urämisch veränderten Lipoproteinen

    Schreibing, Felix

    2020  

    Author's details vorgelegt von Felix Schreibing
    Language German
    Size 60 Seiten, Illustrationen
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2020
    HBZ-ID HT020377191
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 D 416 order for loan Magazin

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  2. Article ; Online: Mapping the human kidney using single-cell genomics.

    Schreibing, Felix / Kramann, Rafael

    Nature reviews. Nephrology

    2022  Volume 18, Issue 6, Page(s) 347–360

    Abstract: The field of single-cell genomics and spatial technologies is rapidly evolving and has already provided unprecedented insights into complex tissues. Major advances have been made in dissecting the cellular composition and spatiotemporal interactions that ...

    Abstract The field of single-cell genomics and spatial technologies is rapidly evolving and has already provided unprecedented insights into complex tissues. Major advances have been made in dissecting the cellular composition and spatiotemporal interactions that mediate developmental processes in the fetal kidney. Single-cell technologies have also provided detailed insights into the heterogeneity of cell types within the healthy adult and shed light on the complex cellular mechanisms that contribute to kidney disease. The in-depth characterization of specific cell types associated with acute kidney injury and glomerular diseases has potential for the development of prognostic biomarkers and new therapeutics. Analyses of pathway activity in clear-cell renal cell carcinoma can predict the sensitivity of tumour cells to specific inhibitors. The identification of the cell of origin of renal cell carcinoma and of new cell types within the tumour microenvironment also has implications for the development of targeted therapeutics. Similarly, single-cell sequencing has provided new insights into the mechanisms underlying kidney fibrosis, specifically our understanding of myofibroblast origins and the contribution of cell crosstalk within the fibrotic niche to disease progression. These and future studies will enable the creation of a map to aid our understanding of the cellular processes and interactions in the developing, healthy and diseased kidney.
    MeSH term(s) Carcinoma, Renal Cell/pathology ; Fibrosis ; Genomics ; Humans ; Kidney/pathology ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00553-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fibrosis in Pathology of Heart and Kidney: From Deep RNA-Sequencing to Novel Molecular Targets.

    Schreibing, Felix / Anslinger, Teresa M / Kramann, Rafael

    Circulation research

    2023  Volume 132, Issue 8, Page(s) 1013–1033

    Abstract: Diseases of the heart and the kidney, including heart failure and chronic kidney disease, can dramatically impair life expectancy and the quality of life of patients. The heart and kidney form a functional axis; therefore, functional impairment of 1 ... ...

    Abstract Diseases of the heart and the kidney, including heart failure and chronic kidney disease, can dramatically impair life expectancy and the quality of life of patients. The heart and kidney form a functional axis; therefore, functional impairment of 1 organ will inevitably affect the function of the other. Fibrosis represents the common final pathway of diseases of both organs, regardless of the disease entity. Thus, inhibition of fibrosis represents a promising therapeutic approach to treat diseases of both organs and to resolve functional impairment. However, despite the growing knowledge in this field, the exact pathomechanisms that drive fibrosis remain elusive. RNA-sequencing approaches, particularly single-cell RNA-sequencing, have revolutionized the investigation of pathomechanisms at a molecular level and facilitated the discovery of disease-associated cell types and mechanisms. In this review, we give a brief overview over the evolution of RNA-sequencing techniques, summarize most recent insights into the pathogenesis of heart and kidney fibrosis, and discuss how transcriptomic data can be used, to identify new drug targets and to develop novel therapeutic strategies.
    MeSH term(s) Humans ; RNA/metabolism ; Quality of Life ; Kidney/metabolism ; Renal Insufficiency, Chronic/metabolism ; Fibrosis ; Myofibroblasts/metabolism
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.122.321761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease.

    Kaesler, Nadine / Schreibing, Felix / Speer, Thimoteus / Puente-Secades, Sofia de la / Rapp, Nikolas / Drechsler, Christiane / Kabgani, Nazanin / Kuppe, Christoph / Boor, Peter / Jankowski, Vera / Schurgers, Leon / Kramann, Rafael / Floege, Jürgen

    Kidney international

    2021  Volume 101, Issue 2, Page(s) 338–348

    Abstract: Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification, in part correlating with functional vitamin K deficiency. Here, we sought to determine causes for vitamin K deficiency beyond reduced dietary intake. Initially, ... ...

    Abstract Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification, in part correlating with functional vitamin K deficiency. Here, we sought to determine causes for vitamin K deficiency beyond reduced dietary intake. Initially, vitamin K uptake and distribution into circulating lipoproteins after a single administration of vitamin K1 plus K2 (menaquinone 4 and menaquinone 7, respectively) was determined in patients on dialysis therapy and healthy individuals. The patients incorporated very little menaquinone 7 but more menaquinone 4 into high density lipoprotein (HDL) and low-density lipoprotein particles than did healthy individuals. In contrast to healthy persons, HDL particles from the patients could not be spiked with menaquinone 7 in vitro and HDL uptake was diminished in osteoblasts. A reduced carboxylation activity (low vitamin K activity) of uremic HDL particles spiked with menaquinone 7 vs. that of controls was confirmed in a bioassay using human primary vascular smooth muscle cells. Kidney menaquinone 4 tissue levels were reduced in 5/6-nephrectomized versus sham-operated C57BL/6 mice after four weeks of a vitamin K rich diet. From the analyzed enzymes involved in vitamin K metabolism, kidney HMG-CoA reductase protein was reduced in both rats and patients with CKD. In a trial on the efficacy and safety of atorvastatin in 1051 patients with type 2 diabetes receiving dialysis therapy, no pronounced vitamin K deficiency was noted. However, the highest levels of PIVKA-II (biomarker of subclinical vitamin K deficiency) were noted when a statin was combined with a proton pump inhibitor. Thus, profound disturbances in lipoprotein mediated vitamin K transport and metabolism in uremia suggest that menaquinone 7 supplementation to patients on dialysis therapy has reduced efficacy.
    MeSH term(s) Animals ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; Rats ; Renal Insufficiency, Chronic/metabolism ; Tissue Distribution ; Vitamin K/metabolism ; Vitamin K/therapeutic use ; Vitamin K 1/metabolism ; Vitamin K 1/therapeutic use ; Vitamin K 2/metabolism ; Vitamin K 2/therapeutic use ; Vitamin K Deficiency/complications ; Vitamin K Deficiency/metabolism
    Chemical Substances Vitamin K 2 (11032-49-8) ; Vitamin K (12001-79-5) ; Vitamin K 1 (84-80-0)
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.10.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling.

    Schreibing, Felix / Hannani, Monica T / Kim, Hyojin / Nagai, James S / Ticconi, Fabio / Fewings, Eleanor / Bleckwehl, Tore / Begemann, Matthias / Torow, Natalia / Kuppe, Christoph / Kurth, Ingo / Kranz, Jennifer / Frank, Dario / Anslinger, Teresa M / Ziegler, Patrick / Kraus, Thomas / Enczmann, Jürgen / Balz, Vera / Windhofer, Frank /
    Balfanz, Paul / Kurts, Christian / Marx, Gernot / Marx, Nikolaus / Dreher, Michael / Schneider, Rebekka K / Saez-Rodriguez, Julio / Costa, Ivan / Hayat, Sikander / Kramann, Rafael

    Frontiers in immunology

    2022  Volume 13, Page(s) 1066176

    Abstract: Introduction: SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying ... ...

    Abstract Introduction: SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal vaccines against new SARS-CoV-2 variants.
    Methods: We combined single-cell RNA and T cell receptor sequencing with CITE-seq antibodies to characterize the CD8
    Results: We observed increased CD8
    Discussion: We propose a model in which differences in the surrounding inflammatory milieu lead to crucial differences in NK-like differentiation of CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; COVID-19 ; SARS-CoV-2 ; Antibodies
    Chemical Substances Antibodies
    Language English
    Publishing date 2022-12-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1066176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell epitope mapping

    Schreibing, Felix / Hannani, Monica / Ticconi, Fabio / Fewings, Eleanor / Nagai, James Shiniti / Begemann, Matthias / Kuppe, Christoph / Kurth, Ingo / Kranz, Jennifer / Frank, Dario / Anslinger, Teresa M / Ziegler, Patrick / Kraus, Thomas / Enczmann, Jürgen / Balz, Vera / Windhofer, Frank / Balfanz, Paul / Kurts, Christian / Marx, Gernot /
    Marx, Nikolaus / Dreher, Michael / Schneider, Rebekka K / Saez-Rodriguez, Julio / Costa Filho, Ivan Gesteira / Kramann, Rafael

    bioRxiv

    Abstract: The current COVID-19 pandemic represents a global challenge. A better understanding of the immune response against SARS-CoV-2 is key to unveil the differences in disease severity and to develop future vaccines targeting novel SARS-CoV-2 variants. Feature ...

    Abstract The current COVID-19 pandemic represents a global challenge. A better understanding of the immune response against SARS-CoV-2 is key to unveil the differences in disease severity and to develop future vaccines targeting novel SARS-CoV-2 variants. Feature barcode technology combined with CITE-seq antibodies and DNA-barcoded peptide-MHC I Dextramer reagents enabled us to identify relevant SARS-CoV-2-derived epitopes and compare epitope-specific CD8<sup>+</sup> T cell populations between mild and severe COVID-19. We identified a strong CD8<sup>+</sup> T cell response against an S protein-derived epitope. CD8+ effector cells in severe COVID-19 displayed hyperactivation, T cell exhaustion and were missing characteristics of long-lived memory T cells. We identify A*0101 WTAGAAAYY as an immunogenic CD8<sup>+</sup> T cell epitope with the ability to drive clonal expansion. We provide an in-depth characterization of the CD8<sup>+</sup> T cell-mediated response to SARS-CoV-2 infection which will be relevant for the development of molecular and targeted therapies and potential adjustments of vaccination strategies.
    Keywords covid19
    Language English
    Publishing date 2021-03-03
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2021.03.03.432690
    Database COVID19

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