LIVIVO - Search results -

Search results

Result 1 - 10 of total 63

Search options

Book ; Audio / Video ; Thesis: Molekulare Mechanismen und biologische Effekte der Invasion von Staphylococcus aureus in humane Endothelzellen

Schreiner, Bettina

2002

Author's details	vorgelegt von Bettina Schreiner
Language	German
Size	1 CD-ROM, 12 cm
Publishing country	Germany
Document type	Book ; Audio / Video ; Thesis
Thesis / German Habilitation thesis	Tübingen, Univ., Diss., 2002
HBZ-ID	HT013698342
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2003 MO 266	order for loan	Magazin

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Neuromuskuläres Praxiswissen: Fokus Muskelschwäche.

Schubert, Kai Michael / Schreiner, Bettina

Praxis

2023 Volume 112, Issue 9, Page(s) 459–468

Abstract: Introduction: Muscle weakness is a common symptom in the general practice. The diagnostic work-up starts with distinguishing true muscle weakness from fatigue. The localization, time course and severity of muscle weakness as well as associated symptoms, ...

Title translation	Neuromuscular Practical Knowledge: Focus On Muscle Weakness.
Abstract	Introduction: Muscle weakness is a common symptom in the general practice. The diagnostic work-up starts with distinguishing true muscle weakness from fatigue. The localization, time course and severity of muscle weakness as well as associated symptoms, concomitant diseases, medication and family history can help classify the weakness into certain main categories. These are genetic, inflammatory, infectious, neoplastic, toxic and metabolic/endocrine causes. Further laboratory investigations, ENMG, MRI, muscle biopsy and genetic testing can help to further narrow the differential diagnosis. Due to recent advances, particularly in the field of genetics and targeted immunomodulatory therapies, a growing number of diseases which present with muscular weakness can be treated successfully.
MeSH term(s)	Humans ; Muscle Weakness/etiology ; Paresis ; Fatigue ; Biopsy ; Diagnosis, Differential
Language	German
Publishing date	2023-08-26
Publishing country	Switzerland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	209026-0
ISSN	1661-8165 ; 1661-8157 ; 0369-8394
ISSN (online)	1661-8165
ISSN	1661-8157 ; 0369-8394
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.118: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 12: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Thesis: Molekular-zytogenetische Charakterisierung induzierter, duktaler Pankreastumoren in transgenen Mausmodellen

Schreiner, Bettina

2002

Author's details	vorgelegt von Bettina Schreiner
Language	German
Size	161 Bl., Ill., graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Ulm, Univ., Diss., 2003
HBZ-ID	HT013749265
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2003 E 2515	order for loan	Magazin

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Thesis: Molekulare Mechanismen und biologische Effekte der Invasion von Staphylococcus aureus in humane Endothelzellen

Schreiner, Bettina

2002

Author's details	vorgelegt von Bettina Schreiner
Language	German
Size	120 S., Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Tübingen, Univ., Diss., 2002 (Nicht für den Austausch)
HBZ-ID	HT013417319
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2002 D 2663	order for loan	Magazin

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Immune checkpoint inhibitors induced side effects of the peripheral nervous system.

Hundsberger, Thomas / Schreiner, Bettina / Roth, Patrick

Current opinion in neurology

2023 Volume 36, Issue 5, Page(s) 427–431

Abstract: Purpose of review: This review highlights recent knowledge on the diagnosis and treatment of immune checkpoint inhibitor-induced neurological side effects (irNAE) focussing on the neuromuscular system.: Recent findings: irNAEs mainly resemble ... ...

Abstract	Purpose of review: This review highlights recent knowledge on the diagnosis and treatment of immune checkpoint inhibitor-induced neurological side effects (irNAE) focussing on the neuromuscular system. Recent findings: irNAEs mainly resemble sporadic neuromuscular autoimmune diseases and paraneoplastic neurological syndromes. However, neurological symptoms may be unspecific (muscle weakness, fatigue) in the oncological setting and carry the risk of misdiagnosis and delayed therapeutic intervention. The role of disease-specific neuromuscular autoantibodies in the diagnosis is controversial as preexisting autoantibodies may otherwise be present before immune checkpoint inhibitor (ICI) treatment without clinical symptoms and may not develop in case of irNAE manifestation. A new necrotising form of myositis (irMyositis) has been described presenting with facial weakness and ptosis mimicking myasthenia gravis. It comes along with a high rate of severe myocarditis accounting for a triad overlap syndrome (myasthenia/myositis/myocarditis). The role of modern biologicals in the treatment of irNAEs has to be determined. Summary: irNAEs are rare but carry the risk of permanent morbidity and mortality. Early suspicion and diagnosis are key to prevent neurological sequelae. Beyond interruption of ICI administration, treatment corresponds to sporadic autoimmune diseases. The myasthenia/myositis/myocarditis overlap syndrome deserves special attention as it carries the highest risk of mortality. The role of neurotoxic pretreatment regimens, preexisting subclinical neurological autoimmune diseases and the risk of ICI-re-challenge after irNAEs has to be further investigated.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/adverse effects ; Myocarditis ; Drug-Related Side Effects and Adverse Reactions ; Peripheral Nervous System ; Myasthenia Gravis/chemically induced ; Myasthenia Gravis/drug therapy ; Myositis/chemically induced ; Myositis/drug therapy ; Autoantibodies
Chemical Substances	Immune Checkpoint Inhibitors ; Autoantibodies
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1182686-1
ISSN	1473-6551 ; 1350-7540
ISSN (online)	1473-6551
ISSN	1350-7540
DOI	10.1097/WCO.0000000000001188
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2524: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: EMPhasis on Mutant Microglia: Dysregulation of Brain Sentinels Induces Neurodegeneration.

Schreiner, Bettina / Greter, Melanie

Cell stem cell

2017 Volume 21, Issue 5, Page(s) 566–568

Abstract: Reactive microglia are often implicated in the pathology of neurodegenerative disease. In a recent study in Nature, Mass et al. (2017) demonstrate that targeted mutation of Braf in early erythro-myeloid precursors (EMPs) causes histiocytosis-associated ... ...

Abstract	Reactive microglia are often implicated in the pathology of neurodegenerative disease. In a recent study in Nature, Mass et al. (2017) demonstrate that targeted mutation of Braf in early erythro-myeloid precursors (EMPs) causes histiocytosis-associated late onset neurodegeneration driven by activated microglia.
MeSH term(s)	Brain ; Humans ; Microglia ; Mutation ; Myeloid Progenitor Cells ; Neurodegenerative Diseases/genetics
Language	English
Publishing date	2017-11-02
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2017.10.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6589: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 75: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Accuracy of Repetitive Ocular Vestibular-Evoked Myogenic Potentials to Diagnose Myasthenia Gravis in Patients With Ptosis or Diplopia.

Valko, Yulia / Wirth, Magdalena A / Fierz, Fabienne C / Schesny, Marianne K / Rosengren, Sally / Schmückle-Meier, Tanja / Bockisch, Christopher J / Straumann, Dominik / Schreiner, Bettina / Weber, Konrad P

Neurology

2024 Volume 102, Issue 10, Page(s) e209395

Abstract: Background and objectives: We developed repetitive ocular vestibular-evoked myogenic potentials (roVEMP) as an electrophysiologic test that allows us to elicit the characteristic decrement of extraocular muscles in patients with ocular myasthenia gravis ...

Abstract	Background and objectives: We developed repetitive ocular vestibular-evoked myogenic potentials (roVEMP) as an electrophysiologic test that allows us to elicit the characteristic decrement of extraocular muscles in patients with ocular myasthenia gravis (OMG). Case-control studies demonstrated that roVEMP reliably differentiates patients with OMG from healthy controls. We now aimed to evaluate the diagnostic accuracy of roVEMP for OMG diagnosis in patients with ptosis and/or diplopia. Methods: In this blinded prospective diagnostic accuracy trial, we compared roVEMP in 89 consecutive patients presenting with ptosis and/or diplopia suspicious of OMG with a multimodal diagnostic approach, including clinical examination, antibodies, edrophonium testing, repetitive nerve stimulation of accessory and facial nerves, and single-fiber EMG (SFEMG). We calculated the roVEMP decrement as the ratio between the mean of the first 2 responses compared with the mean of the sixth-ninth responses in the train and used cutoff of >9% (unilateral decrement) in a 30 Hz stimulation paradigm. Results: Following a complete diagnostic work-up, 39 patients (44%) were diagnosed with ocular MG, while 50 patients (56%) had various other neuro-ophthalmologic conditions, but not MG (non-MG). roVEMP yielded 88.2% sensitivity, 30.2% specificity, 50% positive predictive value (PPV), and 76.5% negative predictive value (NPV). For comparison, SFEMG resulted in 75% sensitivity, 56% specificity, 55.1% PPV, and 75.7% NPV. All other diagnostic tests (except for the ice pack test) also yielded significantly higher positive results in patients with MG compared with non-MG. Discussion: The study revealed a high sensitivity of 88.2% for roVEMP in OMG, but specificity and PPV were too low to allow for the OMG diagnosis as a single test. Thus, differentiating ocular MG from other neuro-ophthalmologic conditions remains challenging, and the highest diagnostic accuracy is still obtained by a multimodal approach. In this study, roVEMP can complement the diagnostic armamentarium for the diagnosis of MG. Classification of evidence: This study provides Class I evidence that in patients with diplopia and ptosis, roVEMP alone does not accurately distinguish MG from non-MG disorders. Trial registration information: ClinicalTrials.gov: NCT03049956.
MeSH term(s)	Humans ; Myasthenia Gravis/diagnosis ; Myasthenia Gravis/physiopathology ; Myasthenia Gravis/complications ; Male ; Female ; Diplopia/diagnosis ; Diplopia/physiopathology ; Diplopia/etiology ; Middle Aged ; Vestibular Evoked Myogenic Potentials/physiology ; Adult ; Blepharoptosis/diagnosis ; Blepharoptosis/physiopathology ; Blepharoptosis/etiology ; Aged ; Prospective Studies ; Electromyography/methods ; Sensitivity and Specificity ; Oculomotor Muscles/physiopathology ; Young Adult
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000209395
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 18: Show issues
Zs.MO 374: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Perspectives on cytokine-directed therapies in multiple sclerosis.

Schreiner, Bettina / Becher, Burkhard

Swiss medical weekly

2015 Volume 145, Page(s) w14199

Abstract: Multiple sclerosis (MS) is the most common inflammatory demyelinating disorder of the central nervous system (CNS). Over the past 10 years there has been a heated debate as to whether MS pathogenesis commences in the CNS or whether it is actually ... ...

Abstract	Multiple sclerosis (MS) is the most common inflammatory demyelinating disorder of the central nervous system (CNS). Over the past 10 years there has been a heated debate as to whether MS pathogenesis commences in the CNS or whether it is actually primarily a disease of the immune system. The combined clinical data, therapy responses, pathology, animal models and genetic studies now provide overwhelming support for the concept that MS is a disease of the immune system and that the CNS is only the unfortunate target of a misguided immune attack. Immune cells communicate through the use of cytokines and these proteins can orchestrate the most complex behaviour in immune cells. We propose that MS is a disease where immune communication is derailed, which makes MS very amenable to immunotherapy and in particular makes cytokines an attractive target to repair this miscommunication disorder.
MeSH term(s)	Autoimmunity ; Central Nervous System/immunology ; Cytokines/immunology ; Cytokines/therapeutic use ; Humans ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2015
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2015.14199
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.152: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates.

Ingelfinger, Florian / Kramer, Michael / Lutz, Mirjam / Widmer, Corinne C / Piccoli, Luca / Kreutmair, Stefanie / Wertheimer, Tobias / Woodhall, Mark / Waters, Patrick / Sallusto, Federica / Lanzavecchia, Antonio / Mundt, Sarah / Becher, Burkhard / Schreiner, Bettina

Neurology(R) neuroimmunology & neuroinflammation

2023 Volume 10, Issue 2

Abstract: Background and objectives: Myasthenia gravis (MG) can in rare cases be an autoimmune phenomenon associated with hematologic malignancies such as chronic lymphocytic leukemia (CLL). It is unclear whether in patients with MG and CLL, the leukemic B cells ... ...

Abstract	Background and objectives: Myasthenia gravis (MG) can in rare cases be an autoimmune phenomenon associated with hematologic malignancies such as chronic lymphocytic leukemia (CLL). It is unclear whether in patients with MG and CLL, the leukemic B cells are the ones directly driving the autoimmune response against neuromuscular endplates. Methods: We identified patients with acetylcholine receptor antibody-positive (AChR Results: A computational immune cell screen revealed a subgroup of 5/38 patients with MG and 0/21 healthy controls who displayed a CLL-like B-cell phenotype. In follow-up hematologic flow cytometry, 2 of these 5 patients were diagnosed with an MBL. An additional patient with AChR Discussion: Our study suggests that AChR autoantibodies are produced by nonmalignant, polyclonal B cells The new anti-CD20 treatment obinutuzumab might be considered in effectively treating AChR Classification of evidence: This is a single case study and provides Class IV evidence that obinutuzumab is safe to use in patients with MG.
MeSH term(s)	Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Myasthenia Gravis/complications ; Receptors, Cholinergic ; B-Lymphocytes ; Antibodies, Monoclonal ; Autoantibodies ; Autoantigens
Chemical Substances	Receptors, Cholinergic ; Antibodies, Monoclonal ; Autoantibodies ; Autoantigens
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2767740-0
ISSN	2332-7812 ; 2332-7812
ISSN (online)	2332-7812
ISSN	2332-7812
DOI	10.1212/NXI.0000000000200087
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report.

Koch, Christian / Fleischer, Juliane / Popov, Todor / Frontzek, Karl / Schreiner, Bettina / Roth, Patrick / Manz, Markus G / Unseld, Simone / Müller, Antonia M S / Russkamp, Norman F

Journal for immunotherapy of cancer

2023 Volume 11, Issue 1

Abstract: Background: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse event of CD19-directed chimeric antigen receptor (CAR) T cell therapy. Other neurological adverse events, however, have not methodically been described and ... ...

Abstract	Background: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse event of CD19-directed chimeric antigen receptor (CAR) T cell therapy. Other neurological adverse events, however, have not methodically been described and studied. Furthermore, safety data on CAR-T cell therapy in patients with central nervous system (CNS) lymphoma remain limited. Main body: We here report occurrence of a Guillain-Barré-like syndrome (GBS) and central diabetes insipidus (cDI) following tisagenlecleucel therapy for relapsed high-grade lymphoma with CNS involvement. Both complications were refractory to standard treatment of ICANS. Weakness of respiratory muscles required mechanical ventilation and tracheostomy while cDI was treated with desmopressin substitution for several weeks. Muscle-nerve biopsy and nerve conduction studies confirmed an axonal pattern of nerve damage. T cell-rich infiltrates and detection of the CAR transgene in muscle-nerve sections imply a direct or indirect role of CAR-T cell-mediated inflammation. In line with current treatment guidelines for GBS, intravenous immunoglobulin was administered and gradual but incomplete recovery was observed over the course of several months. Conclusions: This case report highlights the risk of rare but severe neurological adverse events, such as acute GBS or cDI, in patients treated with CAR-T cells. It further underlines the importance of appropriate patient surveillance and systematic reporting of rare complications to eventually improve treatment.
MeSH term(s)	Humans ; Receptors, Chimeric Antigen ; Immunotherapy, Adoptive/adverse effects ; Lymphoma, Non-Hodgkin ; Central Nervous System Neoplasms ; Diabetes Insipidus/etiology ; Cell- and Tissue-Based Therapy ; Diabetes Mellitus
Chemical Substances	Receptors, Chimeric Antigen ; cell-associated neurotoxicity
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-006059
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito