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  1. Article ; Online: Microbiological Screening of Donor Human Milk.

    Schreiner, Christine / Müller, Andreas / Dresbach, Till

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

    2023  Volume 18, Issue 12, Page(s) 901–907

    Abstract: Mother's own milk is recognized as the optimal feeding not only for term but also for preterm infants. In addition to risk reduction for sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity in the early infancy, ... ...

    Abstract Mother's own milk is recognized as the optimal feeding not only for term but also for preterm infants. In addition to risk reduction for sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity in the early infancy, feeding preterm infants with mother's own milk is also associated with a better neurodevelopmental outcome; lower rates of otitis media, gastroenteritis, and respiratory infections; and a reduced risk of cardiovascular disease, obesity, and diabetes later in life. Donor human milk is the best alternative if mother's own milk is not available or with short supply. There is growing evidence that the benefits of human milk are mediated by the human milk microbiota and by human milk oligosaccharides through their influence on the infant's gut microbiota. Unfortunately, although human milk contains beneficial bacteria, it may also contain pathogenic bacteria. The antimicrobial properties of human milk protect those infants fed with their own mother's raw milk. In donor human milk, however, the antimicrobial activity is diminished due to storage and in particular by pasteurization, hereby lowering the resistance against bacterial infections. Subsequently, microbiological screening of donor human milk might enhance its safety for preterm infants. Up to date, a consensus on recommendations for the microbiological testing of donor human milk is lacking. Existing local and national guidelines for the microbiological screening vary significantly in terms of timing and frequency of testing as well as their specific acceptance and discard criteria. We reviewed the literature about microbiological testing of donor human milk to provide evidence-based recommendations for donor human milk.
    MeSH term(s) Infant ; Female ; Infant, Newborn ; Humans ; Milk, Human ; Infant, Premature ; Infant Nutritional Physiological Phenomena ; Breast Feeding ; Anti-Infective Agents
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2234680-6
    ISSN 1556-8342 ; 1556-8253
    ISSN (online) 1556-8342
    ISSN 1556-8253
    DOI 10.1089/bfm.2023.0155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Conference proceedings: Ernährung von Frühgeborenen von CMV-seropositiven Müttern auf deutschen neonatologischen Intensivstationen

    Dresbach, Till / Müller, Andreas / Schreiner, Christine / Scholten, Nadine

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue 03

    Event/congress Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1769192
    Database Thieme publisher's database

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  3. Article ; Conference proceedings: Mikrobiologische Kriterien für Humanmilch in Deutschland: Ein rechtsfreier Raum?

    Schreiner, Christine / Scholten, Nadine / Dresbach, Till / Müller, Andreas

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue 03

    Event/congress Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1769291
    Database Thieme publisher's database

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  4. Article: Prenatal diagnosis and management of a giant intrahepatic arteriovenous malformation-Sonographic findings, clinical implications, and treatment.

    Walter, Adeline / Calite, Elina / Müller, Andreas / Kalff, Jörg C / Meyer, Carsten / Geipel, Annegret / Gembruch, Ulrich / Schreiner, Christine

    Clinical case reports

    2022  Volume 10, Issue 8, Page(s) e6175

    Abstract: Prenatal detection of complex giant hepatic arteriovenous malformation requires an examination of the affected fetal hemodynamic situation with emphasis on the affected arterial supply pattern. Early pediatric surgeon presentation is needed, as timely ... ...

    Abstract Prenatal detection of complex giant hepatic arteriovenous malformation requires an examination of the affected fetal hemodynamic situation with emphasis on the affected arterial supply pattern. Early pediatric surgeon presentation is needed, as timely surgical intervention appears to be essential.
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Structured lactation support and human donor milk for German NICUs-Protocol on an intervention design based on a multidimensional status quo and needs assessment (Neo-MILK).

    Scholten, Nadine / Fitzgerald, Alicia / Matthias, Katja / Okumu, Mi-Ran / Ohnhäuser, Tim / Schmitz, Katharina / Schreiner, Christine / Schwab, Isabella / Stirner, Anna / Wullenkord, Ricarda / Dresbach, Till

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0284621

    Abstract: Introduction: Mother's own milk is the best nutrition for every newborn and especially for vulnerable infants such as preterm infants with a very low birth weight below 1,500 grams (VLBW). If no MOM is available, human donor milk is the alternative of ... ...

    Abstract Introduction: Mother's own milk is the best nutrition for every newborn and especially for vulnerable infants such as preterm infants with a very low birth weight below 1,500 grams (VLBW). If no MOM is available, human donor milk is the alternative of choice. Mothers of preterm born infants face challenging conditions that impair sufficient milk production. For this reason, it is particularly important to provide structural lactation support and, at the same time, to promote the establishment of human donor milk banks.
    Methods and analysis: Via a multidisciplinary approach the Neo-MILK study will develop an intervention for structured breastfeeding and lactation support. This will be based on a comprehensive status quo and needs assessment. In addition, the implementation of human donor milk banks (HDMB) will be supported by the development of standards.
    Ethics and dissemination: Intervention development is participatory, involving different disciplines and stakeholders. All surveys are subject to approval by the ethics committee. During the course of the project, the results will be communicated to the scientific community and the general public via publications, the project homepage and social media.
    Trial registration number: DRKS00024799 (German Clinical Trials Register).
    MeSH term(s) Female ; Humans ; Infant ; Infant, Newborn ; Breast Feeding ; Infant Nutritional Physiological Phenomena ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care Units, Neonatal ; Lactation ; Milk, Human ; Mothers ; Needs Assessment
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Glucocorticoid Receptor Gene Variants and Neonatal Outcome in Very-Low-Birth-Weight Preterm Infants.

    Schreiner, Christine / Schreiner, Felix / Härtel, Christoph / Heckmann, Matthias / Heep, Axel / Bartmann, Peter / Woelfle, Joachim / Müller, Andreas / Herting, Egbert / Göpel, Wolfgang

    Neonatology

    2017  Volume 111, Issue 1, Page(s) 22–29

    Abstract: Background: Induction of lung maturation by prenatal steroid treatment has become the standard of care for pregnant women at risk for preterm birth. In addition to the beneficial effects on lung maturation, prenatal steroids have been shown to reduce ... ...

    Abstract Background: Induction of lung maturation by prenatal steroid treatment has become the standard of care for pregnant women at risk for preterm birth. In addition to the beneficial effects on lung maturation, prenatal steroids have been shown to reduce the incidence of neonatal death, necrotizing enterocolitis, sepsis, and intraventricular hemorrhage. However, little is known about the role of interindividual differences in corticoid sensitivity arising from polymorphisms in the glucocorticoid receptor (GR) gene.
    Objectives: To assess the impact of GR polymorphisms N363S (rs56149945), R23K (rs6190), and BclI (rs41423247) on neonatal outcome.
    Methods: The GR polymorphisms N363S, R23K, and BclI were examined in 10,490 very-low-birth-weight (VLBW) preterm infants from 49 German tertiary level neonatal units (German Neonatal Network, GNN) with respect to neonatal outcome.
    Results: Infants carrying the BclI genotype were at higher risk to develop bronchopulmonary dysplasia (BPD) (OR 1.12 per BclI allele, 95% CI: 1.02-1.23, p = 0.013) in a logistic regression model adjusted for gestational age, mechanical ventilation, and small for gestational age status. A similar relative risk was seen in the children (89.4%) who received antenatal betamethasone treatment (OR 1.16, 95% CI: 1.05-1.27, p = 0.003), whereas no such effect was detectable in infants without antenatal steroids. N363S and R23K did not show any stable association with neonatal outcome parameters.
    Conclusion: Except for a slightly higher risk of BPD in carriers of the GRBclI variant, the GR gene polymorphisms BclI, N363S, and R23K did not affect neonatal outcome parameters in this large multicenter cohort of VLBW preterm infants.
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000446908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetic variants of the vitamin K dependent coagulation system and intraventricular hemorrhage in preterm infants.

    Schreiner, Christine / Suter, Sévérine / Watzka, Matthias / Hertfelder, Hans-Jörg / Schreiner, Felix / Oldenburg, Johannes / Bartmann, Peter / Heep, Axel

    BMC pediatrics

    2014  Volume 14, Page(s) 219

    Abstract: Background: Pathogenesis of intraventricular hemorrhage (IVH) in premature infants is multifactorial. Little is known about the impact of genetic variants in the vitamin K-dependent coagulation system on the development of IVH.: Methods: ... ...

    Abstract Background: Pathogenesis of intraventricular hemorrhage (IVH) in premature infants is multifactorial. Little is known about the impact of genetic variants in the vitamin K-dependent coagulation system on the development of IVH.
    Methods: Polymorphisms in the genes encoding vitamin K epoxide reductase complex 1 (VKORC1 -1639G>A) and coagulation factor 7 (F7 -323Ins10) were examined prospectively in 90 preterm infants <32 weeks gestational age with respect to coagulation profile and IVH risk.
    Results: F7-323Ins10 was associated with lower factor VII levels, but not with individual IVH risk. In VKORC1-wildtype infants, logistic regression analysis revealed a higher IVH risk compared to carriers of the -1639A allele. Levels of the vitamin K-dependent coagulation parameters assessed in the first hour after birth did not differ between VKORC1-wildtype infants and those carrying -1639A alleles.
    Conclusions: Our data support the assumption that genetic variants in the vitamin K-dependent coagulation system influence the coagulation profile and the IVH risk in preterm infants. Further studies focussing on short-term changes in vitamin K-kinetics and the coagulation profile during the first days of life are required to further understand a possible link between development of IVH and genetic variants affecting the vitamin K-metabolism.
    MeSH term(s) Biomarkers/blood ; Blood Coagulation/genetics ; Factor VII/genetics ; Female ; Genetic Markers ; Genetic Predisposition to Disease ; Genotyping Techniques ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/blood ; Infant, Premature, Diseases/genetics ; Intracranial Hemorrhages/blood ; Intracranial Hemorrhages/genetics ; Logistic Models ; Male ; Polymorphism, Single Nucleotide ; Prospective Studies ; Vitamin K Deficiency Bleeding/blood ; Vitamin K Deficiency Bleeding/genetics ; Vitamin K Epoxide Reductases/genetics
    Chemical Substances Biomarkers ; Genetic Markers ; Factor VII (9001-25-6) ; VKORC1 protein, human (EC 1.17.4.4) ; Vitamin K Epoxide Reductases (EC 1.17.4.4)
    Language English
    Publishing date 2014-09-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/1471-2431-14-219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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