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  1. Article ; Online: The Local Anaesthetic Procaine Prodrugs ProcCluster

    Häring, Clio / Jungwirth, Johannes / Schroeder, Josefine / Löffler, Bettina / Engert, Beatrice / Ehrhardt, Christina

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: As vaccination efforts against SARS-CoV-2 progress in many countries, there is still an urgent need for efficient antiviral treatment strategies for those with severer disease courses, and lately, considerable efforts have been undertaken to repurpose ... ...

    Abstract As vaccination efforts against SARS-CoV-2 progress in many countries, there is still an urgent need for efficient antiviral treatment strategies for those with severer disease courses, and lately, considerable efforts have been undertaken to repurpose existing drugs as antivirals. The local anaesthetic procaine has been investigated for antiviral properties against several viruses over the past decades. Here, we present data on the inhibitory effect of the procaine prodrugs ProcCluster
    MeSH term(s) Animals ; Chlorocebus aethiops ; SARS-CoV-2 ; COVID-19 ; Antiviral Agents/pharmacology ; Anesthetics, Local/pharmacology ; Prodrugs/pharmacology ; Vero Cells ; Procaine/pharmacology ; Virus Replication
    Chemical Substances Antiviral Agents ; Anesthetics, Local ; Prodrugs ; Procaine (4Z8Y51M438)
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The influenza A virus promotes fungal growth of Aspergillus fumigatus via direct interaction in vitro.

    König, Sarah / Schroeder, Josefine / Nietzsche, Sandor / Heinekamp, Thorsten / Brakhage, Axel A / Zell, Roland / Löffler, Bettina / Ehrhardt, Christina

    Microbes and infection

    2023  Volume 26, Issue 3, Page(s) 105264

    Abstract: Seasonal influenza A virus (IAV) infections still pose a major burden for public health worldwide. Severe disease progression or even death is often related to superinfections of the virus and a secondary bacterial pathogen. However, fungi, especially ... ...

    Abstract Seasonal influenza A virus (IAV) infections still pose a major burden for public health worldwide. Severe disease progression or even death is often related to superinfections of the virus and a secondary bacterial pathogen. However, fungi, especially Aspergillus fumigatus, are also frequently diagnosed during IAV infection. Although, clinical studies have reported the severity of influenza-associated pulmonary aspergillosis, the molecular mechanisms underlying this type of disease are poorly understood. Here, a new in vitro model is introduced that allows the investigation of complex pathogen-host and pathogen-pathogen interactions during coinfection of lung epithelial cells with IAV and A. fumigatus. Our data reveal a reduced IAV load and IAV-induced cytokine and chemokine expression in the presence of A. fumigatus. At the same time, IAV infection promotes the growth of A. fumigatus. Even in the absence of the human host cell, purified IAV particles are able to induce hyphal growth, due to a direct interaction of the virus particles with the fungal surface. Thus, our study gives first insights into the complex interplay between IAV, A. fumigatus and the host cell as well as the two pathogens alone.
    MeSH term(s) Humans ; Aspergillus fumigatus ; Influenza A virus ; Influenza, Human ; Lung/microbiology ; Epithelial Cells
    Language English
    Publishing date 2023-11-24
    Publishing country France
    Document type Journal Article
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2023.105264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The local anaesthetic procaine prodrugs ProcCluster® and Procaine-hydrochloride impair SARS-CoV-2 replication in vitro

    Häring, Clio / Schroeder, Josefine / Loeffler, Bettina / Engert, Beatrice / Ehrhardt, Christina

    bioRxiv

    Abstract: The SARS-CoV-2 pandemic has had the world in suspense for more than a year. Even if more and more vaccines are approved there is still an urgent need for efficient antiviral treatment strategies. Here, we present data on the inhibitory effect of the ... ...

    Abstract The SARS-CoV-2 pandemic has had the world in suspense for more than a year. Even if more and more vaccines are approved there is still an urgent need for efficient antiviral treatment strategies. Here, we present data on the inhibitory effect of the local anaesthetic procaine, especially the prodrugs ProcCluster® and Procaine-hydrochloride on SARS-CoV-2 infection in vitro. Remarkably, similar effects could be shown on the replication of influenza A viruses in cell culture systems. Since the active ingredient procaine is well-tolerated and already used in the clinics for anaesthetic purposes, the further investigation of this substance could enable its reuse in antiviral therapy, including SARS-CoV-2.
    Keywords covid19
    Language English
    Publishing date 2021-06-07
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2021.06.07.447335
    Database COVID19

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