LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Schubiger, Margrit"
  2. AU=Murray Gregg R
  3. AU="Reckord, Nadine"
  4. AU="Becerra-Posada, Francisco"
  5. AU=Pereira Jose
  6. AU="Ashwin, Helen"
  7. AU="Skeldon, Alexander"
  8. AU="Robles, Ignacio"
  9. AU="Karla Correia Lima Miranda"
  10. AU="Benaim, G"
  11. AU="Bongers, Coen CWG"
  12. AU="Demontis, Ditte"
  13. AU="Cheng, Risheng"
  14. AU="Mendoza, Ismael Ballesteros"
  15. AU=Du Yin AU=Du Yin
  16. AU="Du, Dan-yu"
  17. AU="Collier, John L"
  18. AU="Min, Ai-Lian"
  19. AU="Chen, Jingyuan"
  20. AU="Salama, Asmaa"
  21. AU=Johnson R
  22. AU="Straathof, Karin"
  23. AU="Scanlon, Robert"
  24. AU="de la Fuente, M"
  25. AU="Li, Hezhang"
  26. AU="Portillo, María P."
  27. AU="Winter, Theresa"
  28. AU="Antoine Fakhry Abdelmassih"
  29. AU=Barazzoni Rocco
  30. AU="Yuan, Mingyang"

Suchergebnis

Treffer 1 - 7 von insgesamt 7

Suchoptionen

  1. Artikel ; Online: The three leg imaginal discs of Drosophila: "Vive la différence".

    Schubiger, Gerold / Schubiger, Margrit / Sustar, Anne

    Developmental biology

    2012  Band 369, Heft 1, Seite(n) 76–90

    Abstract: The imaginal discs of Drosophila are the larval primordia for the adult cuticular structures of the adult fly. Fate maps of different discs have been generated that show the localization of prospective adult structures. Even though the three legs differ ... ...

    Abstract The imaginal discs of Drosophila are the larval primordia for the adult cuticular structures of the adult fly. Fate maps of different discs have been generated that show the localization of prospective adult structures. Even though the three legs differ in their morphology, only the fate map for the T1 (prothoracic) leg disc has been generated. Here we present fate maps for the T2 (meso-) and T3 (metathoracic) leg discs. We show that there are many similarities to the map of the T1 leg disc. However, there are also significant differences in the contributions of each disc to the thorax, in the morphology of joints connecting the legs to the thorax, in bristle patterns, and in the positioning of some sensory organs. We also tested the developmental potential of disc fragments and observed that T2 and T3 leg discs have more limited plasticity and are unable to transdetermine. The differences in the cuticle patterns between legs are robust and conserved in many species of dipterans. While most previous analyses of imaginal disc development have not distinguished between the different leg discs, we believe that the underlying differences of the three leg discs demonstrated here cannot be ignored when studying leg disc development.
    Mesh-Begriff(e) Aging/physiology ; Animals ; Biomarkers/metabolism ; Body Patterning ; Drosophila melanogaster/growth & development ; Extremities/growth & development ; Imaginal Discs/growth & development ; Imaginal Discs/transplantation ; Regeneration/physiology
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2012-06-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2012.05.025
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 508: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Drosophila twin spot clones reveal cell division dynamics in regenerating imaginal discs.

    Sustar, Anne / Bonvin, Marianne / Schubiger, Margrit / Schubiger, Gerold

    Developmental biology

    2011  Band 356, Heft 2, Seite(n) 576–587

    Abstract: Cell proliferation is required for tissue regeneration, yet the dynamics of proliferation during regeneration are not well understood. Here we investigated the proliferation of eye and leg regeneration in fragments of Drosophila imaginal discs. Using ... ...

    Abstract Cell proliferation is required for tissue regeneration, yet the dynamics of proliferation during regeneration are not well understood. Here we investigated the proliferation of eye and leg regeneration in fragments of Drosophila imaginal discs. Using twin spot clones, we followed the proliferation and fates of sister cells arising from the same mother cell in the regeneration blastema. We show that the mother cell gives rise to two sisters that participate equally in regeneration. However, when cells switch disc identity and transdetermine to another fate, they fail to turn off the cell cycle and continue dividing long after regeneration is complete. We further demonstrate that the regeneration blastema moves as a sweep of proliferation, in which cells are displaced. Our results suggest that regenerating cells stop dividing once the missing parts are formed, but if they undergo a switch in cell fate, the proliferation clock is reset.
    Mesh-Begriff(e) Animals ; Bromodeoxyuridine/metabolism ; Cell Division ; Cell Proliferation ; Drosophila melanogaster/cytology ; Drosophila melanogaster/embryology ; Extremities/embryology ; Eye/embryology ; Regeneration
    Chemische Substanzen Bromodeoxyuridine (G34N38R2N1)
    Sprache Englisch
    Erscheinungsdatum 2011-06-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2011.06.018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 508: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Regeneration and transdetermination: the role of wingless and its regulation.

    Schubiger, Margrit / Sustar, Anne / Schubiger, Gerold

    Developmental biology

    2010  Band 347, Heft 2, Seite(n) 315–324

    Abstract: Imaginal discs of Drosophila have the remarkable ability to regenerate. After fragmentation wound healing occurs, ectopic wg is induced and a blastema is formed. In some, but not all fragments, the blastema will replace missing structures and a few cells ...

    Abstract Imaginal discs of Drosophila have the remarkable ability to regenerate. After fragmentation wound healing occurs, ectopic wg is induced and a blastema is formed. In some, but not all fragments, the blastema will replace missing structures and a few cells can become more plastic and transdetermine to structures of other discs. A series of systematic cuts through the first leg disc revealed that a cut must transect the dorsal-proximal disc area and that the fragment must also include wg-competent cells. Fragments that fail to both transdetermine and regenerate missing structures will do both when provided with exogenous Wg, demonstrating the necessity of Wg in regenerative processes. In intact leg discs ubiquitously expressed low levels of Wg also leads to blastema formation, regeneration and transdetermination. Two days after exogenous wg induction the endogenous gene is activated, leading to elevated levels of Wg in the dorsal aspect of the leg disc. We identified a wg enhancer that regulates ectopic wg expression. Deletion of this enhancer increases transdetermination, but lowers the amount of ectopic Wg. We speculate that this lessens repression of dpp dorsally, and thus creates a permissive condition under which the balance of ectopic Wg and Dpp is favorable for transdetermination.
    Mesh-Begriff(e) Animals ; Animals, Genetically Modified ; Base Sequence ; DNA Primers/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/physiology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/physiology ; Enhancer Elements, Genetic ; Extremities/growth & development ; Extremities/physiology ; Genes, Insect ; Regeneration/genetics ; Regeneration/physiology ; Transcriptional Activation ; Wnt1 Protein/genetics ; Wnt1 Protein/physiology
    Chemische Substanzen DNA Primers ; Drosophila Proteins ; Wnt1 Protein ; dpp protein, Drosophila ; wg protein, Drosophila
    Sprache Englisch
    Erscheinungsdatum 2010-09-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2010.08.034
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 508: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel: Ligand-dependent de-repression via EcR/USP acts as a gate to coordinate the differentiation of sensory neurons in the Drosophila wing.

    Schubiger, Margrit / Carré, Clément / Antoniewski, Christophe / Truman, James W

    Development (Cambridge, England)

    2005  Band 132, Heft 23, Seite(n) 5239–5248

    Abstract: Loss of function of either the ecdysone receptor (EcR) or Ultraspiracle (USP), the two components of the ecdysone receptor, causes precocious differentiation of the sensory neurons on the wing of Drosophila. We propose that the unliganded receptor ... ...

    Abstract Loss of function of either the ecdysone receptor (EcR) or Ultraspiracle (USP), the two components of the ecdysone receptor, causes precocious differentiation of the sensory neurons on the wing of Drosophila. We propose that the unliganded receptor complex is repressive and that this repression is relieved as the hormone titers increase at the onset of metamorphosis. The point in development where the receptor complex exerts this repression varies for different groups of sensilla. For the chemosensory organ precursors along the wing margin, the block is at the level of senseless expression and is indirect, via the repressive control of broad expression. Misexpressing broad or senseless can circumvent the repression by the unliganded receptor and leads to precocious differentiation of the sensory neurons. This precocious differentiation results in the misguidance of their axons. The sensory precursors of some of the campaniform sensilla on the third longitudinal vein are born prior to the rise in ecdysone. Their differentiation is also repressed by the unliganded EcR/USP complex but the block occurs after senseless expression but before the precursors undertake their first division. We suggest that in imaginal discs the unliganded EcR/USP complex acts as a ligand-sensitive ;gate' that can be imposed at various points in a developmental pathway, depending on the nature of the cells involved. In this way, the ecdysone signal can function as a developmental timer coordinating development within the imaginal disc.
    Mesh-Begriff(e) Animals ; Cell Differentiation ; DNA-Binding Proteins/agonists ; DNA-Binding Proteins/physiology ; Drosophila/growth & development ; Drosophila Proteins ; Ligands ; Metamorphosis, Biological ; Neurons, Afferent/cytology ; Receptors, Steroid/agonists ; Receptors, Steroid/physiology ; Transcription Factors/agonists ; Transcription Factors/physiology ; Wings, Animal/growth & development ; Wings, Animal/innervation
    Chemische Substanzen DNA-Binding Proteins ; Drosophila Proteins ; Ligands ; Receptors, Steroid ; Transcription Factors ; USP protein, Drosophila ; ecdysone receptor
    Sprache Englisch
    Erscheinungsdatum 2005-11-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.02093
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ub I Zs.183: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 91: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel: Isoform specific control of gene activity in vivo by the Drosophila ecdysone receptor.

    Schubiger, Margrit / Tomita, Shuichiro / Sung, Carl / Robinow, Steven / Truman, James W

    Mechanisms of development

    2003  Band 120, Heft 8, Seite(n) 909–918

    Abstract: The steroid hormone 20-hydroxyecdysone induces metamorphosis in insects. The receptor for the hormone is the ecdysone receptor, a heterodimer of two nuclear receptors, EcR and USP. In Drosophila the EcR gene encodes 3 isoforms (EcR-A, EcR-B1 and EcR-B2) ... ...

    Abstract The steroid hormone 20-hydroxyecdysone induces metamorphosis in insects. The receptor for the hormone is the ecdysone receptor, a heterodimer of two nuclear receptors, EcR and USP. In Drosophila the EcR gene encodes 3 isoforms (EcR-A, EcR-B1 and EcR-B2) that vary in their N-terminal region but not in their DNA binding and ligand binding domains. The stage and tissue specific distribution of the isoforms during metamorphosis suggests distinct functions for the different isoforms. By over-expressing the three isoforms in animals we present results supporting this hypothesis. We tested for the ability of the different isoforms to rescue the lack of dendritic pruning that is characteristic of mutants lacking both EcR-B1 and EcR-B2. By expressing the different isoforms specifically in the affected neurons, we found that both EcR-B isoforms were able to rescue the neuronal defect cell autonomously, but that EcR-A was less effective. We also analyzed the effect of over-expressing the isoforms in a wild-type background. We determined a sensitive period when high levels of either EcR-B isoform were lethal, indicating that the low levels of EcR-B at this time are crucial to ensure normal development. Over-expressing EcR-A in contrast had no detrimental effect. However, high levels of EcR-A expressed in the posterior compartment suppressed puparial tanning, and resulted in down-regulation of some of the tested target genes in the posterior compartment of the wing disc. EcR-B1 or EcR-B2 over-expression had little or no effect.
    Mesh-Begriff(e) Animals ; Drosophila/physiology ; Gene Expression Regulation ; Genes, Insect ; Metamorphosis, Biological ; Neurons/metabolism ; Protein Isoforms/physiology ; Receptors, Steroid/chemistry ; Receptors, Steroid/physiology ; Time Factors
    Chemische Substanzen Protein Isoforms ; Receptors, Steroid ; ecdysone receptor
    Sprache Englisch
    Erscheinungsdatum 2003-08
    Erscheinungsland Ireland
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1055986-3
    ISSN 1872-6356 ; 0925-4773
    ISSN (online) 1872-6356
    ISSN 0925-4773
    DOI 10.1016/s0925-4773(03)00134-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1152: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 35: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel: three leg imaginal discs of Drosophila: “Vive la différence”

    Schubiger, Gerold / Schubiger, Margrit / Sustar, Anne

    Developmental biology

    Band v. 369,, Heft no. 1

    Abstract: The imaginal discs of Drosophila are the larval primordia for the adult cuticular structures of the adult fly. Fate maps of different discs have been generated that show the localization of prospective adult structures. Even though the three legs differ ... ...

    Abstract The imaginal discs of Drosophila are the larval primordia for the adult cuticular structures of the adult fly. Fate maps of different discs have been generated that show the localization of prospective adult structures. Even though the three legs differ in their morphology, only the fate map for the T1 (prothoracic) leg disc has been generated. Here we present fate maps for the T2 (meso-) and T3 (metathoracic) leg discs. We show that there are many similarities to the map of the T1 leg disc. However, there are also significant differences in the contributions of each disc to the thorax, in the morphology of joints connecting the legs to the thorax, in bristle patterns, and in the positioning of some sensory organs. We also tested the developmental potential of disc fragments and observed that T2 and T3 leg discs have more limited plasticity and are unable to transdetermine. The differences in the cuticle patterns between legs are robust and conserved in many species of dipterans. While most previous analyses of imaginal disc development have not distinguished between the different leg discs, we believe that the underlying differences of the three leg discs demonstrated here cannot be ignored when studying leg disc development.
    Schlagwörter imaginal discs ; thorax ; larvae ; adults ; legs ; sense organs ; Drosophila
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0012-1606
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  7. Artikel: Drosophila twin spot clones reveal cell division dynamics in regenerating imaginal discs

    Sustar, Anne / Bonvin, Marianne / Schubiger, Margrit / Schubiger, Gerold

    Developmental biology

    Band v. 356,, Heft no. 2

    Abstract: Cell proliferation is required for tissue regeneration, yet the dynamics of proliferation during regeneration are not well understood. Here we investigated the proliferation of eye and leg regeneration in fragments of Drosophila imaginal discs. Using ... ...

    Abstract Cell proliferation is required for tissue regeneration, yet the dynamics of proliferation during regeneration are not well understood. Here we investigated the proliferation of eye and leg regeneration in fragments of Drosophila imaginal discs. Using twin spot clones, we followed the proliferation and fates of sister cells arising from the same mother cell in the regeneration blastema. We show that the mother cell gives rise to two sisters that participate equally in regeneration. However, when cells switch disc identity and transdetermine to another fate, they fail to turn off the cell cycle and continue dividing long after regeneration is complete. We further demonstrate that the regeneration blastema moves as a sweep of proliferation, in which cells are displaced. Our results suggest that regenerating cells stop dividing once the missing parts are formed, but if they undergo a switch in cell fate, the proliferation clock is reset.
    Schlagwörter clones ; tissue repair ; imaginal discs ; cell proliferation ; sisters ; cell division ; Drosophila ; eyes
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0012-1606
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang