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  1. Article ; Online: In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh.

    Płoska, Agata / Wozniak, Marcin / Hedhli, Jamila / Konopka, Christian J / Skondras, Antonios / Matatov, Sarah / Stawarz, Andrew / Schuh, Sarah / Czerwinski, Andrzej / Dobrucki, Lawrence W / Kalinowski, Leszek / Dobrucki, Iwona T

    International journal of molecular sciences

    2023  Volume 24, Issue 24

    Abstract: As a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 ... ...

    Abstract As a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts was used to determine the influence of BC and DOX administration on tumor growth and metabolism. The number of apoptotic cells after incubation with both DOX and BC was significantly increased (~100%) compared to the control. Treatment with DOX altered the potential of MCF-7 cells to form colonies; however, coincubation with BC did not affect this process. In vivo, PET-CT imaging showed that combined treatment of DOX and BC induced a significant reduction in both metabolic activity (29%) and angiogenesis (32%). Both DOX and BC treatments inhibited tumor growth by 20% and 12%, respectively, and combined by 57%, vs. control. We successfully demonstrated that BC increases cytotoxic effects of DOX, resulting in a significant reduction in tumor size. Further studies regarding drug transport and tumor growth biomarkers are necessary to establish the underlying mechanism and potential clinical use of BC in breast cancer patients.
    MeSH term(s) Humans ; Female ; Cimicifuga ; Positron Emission Tomography Computed Tomography ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Antineoplastic Agents/therapeutic use ; MCF-7 Cells ; Cell Line, Tumor
    Chemical Substances Doxorubicin (80168379AG) ; Antineoplastic Agents
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242417506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multimodal Assessment of Mesenchymal Stem Cell Therapy for Diabetic Vascular Complications.

    Hedhli, Jamila / Konopka, Christian J / Schuh, Sarah / Bouvin, Hannah / Cole, John A / Huntsman, Heather D / Kilian, Kristopher A / Dobrucki, Iwona T / Boppart, Marni D / Dobrucki, Lawrence W

    Theranostics

    2017  Volume 7, Issue 16, Page(s) 3876–3888

    Abstract: Peripheral arterial disease (PAD) is a debilitating complication of diabetes mellitus (DM) that leads to thousands of injuries, amputations, and deaths each year. The use of mesenchymal stem cells (MSCs) as a regenerative therapy holds the promise of ... ...

    Abstract Peripheral arterial disease (PAD) is a debilitating complication of diabetes mellitus (DM) that leads to thousands of injuries, amputations, and deaths each year. The use of mesenchymal stem cells (MSCs) as a regenerative therapy holds the promise of regrowing injured vasculature, helping DM patients live healthier and longer lives. We report the use of muscle-derived MSCs to treat surgically-induced hindlimb ischemia in a mouse model of type 1 diabetes (DM-1). We serially evaluate several facets of the recovery process, including
    MeSH term(s) Animals ; Diabetic Angiopathies/complications ; Diabetic Angiopathies/diagnostic imaging ; Diabetic Angiopathies/physiopathology ; Diabetic Angiopathies/therapy ; Gene Expression Regulation ; Image Processing, Computer-Assisted ; Integrin alphaVbeta3/metabolism ; Ischemia/pathology ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/metabolism ; Mice, Inbred C57BL ; Muscles/physiopathology ; Neovascularization, Physiologic ; Perfusion ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/pathology ; Peripheral Arterial Disease/therapy ; Positron Emission Tomography Computed Tomography ; Postmortem Changes ; Proteome/metabolism ; Tissue Distribution ; Transcriptome/genetics
    Chemical Substances Integrin alphaVbeta3 ; Proteome
    Language English
    Publishing date 2017
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.19547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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