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  1. Book ; Thesis: Die konservative Therapie der benignen Prostatahyperplasie

    Schuldes, Hellmut

    Probleme des Wirksamkeitsnachweises geschildert an zwei verschiedenen Studien mit unterschiedlichen Phytotherapeutika

    1990  

    Author's details vorgelegt von Hellmut Schuldes
    Size 146 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1990
    HBZ-ID HT003991572
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Thesis: Die Cystinurie

    Schuldes, Horst

    Unters. zur Differenzierung bei 5 Familien

    1984  

    Size 66 S.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1984
    HBZ-ID HT003249554
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Loss of in vitro cytotoxicity of cisplatin after storage as stock solution in cell culture medium at various temperatures.

    Schuldes, H / Bade, S / Knobloch, J / Jonas, D

    Cancer

    1997  Volume 79, Issue 9, Page(s) 1723–1728

    Abstract: Background: Cisplatin (cis-dichlorodiammineplatinum [II]) is one of the most potent and widely used cytotoxic drugs in cancer therapy. However, in vitro cytotoxicity assays often yield diverging results. Therefore, it is believed by many investigators ... ...

    Abstract Background: Cisplatin (cis-dichlorodiammineplatinum [II]) is one of the most potent and widely used cytotoxic drugs in cancer therapy. However, in vitro cytotoxicity assays often yield diverging results. Therefore, it is believed by many investigators that cisplatin is not effective in vitro. The authors investigated whether the experimental conditions used could be responsible for the diverging results.
    Methods: In vitro cytotoxicity assays were performed using the original cisplatin solution as distributed by the manufacturer or a 5-fold dilution of this in cell culture medium after storage for 2 weeks or 1 month at various temperatures (room temperature, 4 degrees C, and -20 degrees C).
    Results: The original solution of cisplatin retained the full cytotoxic potency for at least 1 month under all storage conditions tested. The highest loss of cytotoxicity resulted from storage of cisplatin in cell culture medium in which a >7-fold increase in the concentration that inhibits 50% occurred after 2 weeks' storage at room temperature. Solutions stored in culture medium at -20 degrees C retained full cytotoxic potency.
    Conclusions: Cisplatin is a potent cytotoxic drug in vitro when stored under appropriate conditions. These findings are of relevance for in vitro studies with cisplatin.
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/toxicity ; Cisplatin/chemistry ; Cisplatin/pharmacokinetics ; Cisplatin/toxicity ; Culture Media ; Drug Stability ; Drug Storage ; Humans ; Inactivation, Metabolic ; Solutions ; Temperature ; Tumor Cells, Cultured ; Urinary Bladder Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents ; Culture Media ; Solutions ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 1997-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Die konservative Therapie der beningnen Prostatahyperplasie

    Schuldes, Hellmut

    Probleme des Wirksamkeitsnachweises geschildert an zwei verschiedenen Studien mit unterschiedlichen Phytotherapeutika

    1990  

    Language Undetermined
    Size 146 S. : graph. Darst, graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @München, Univ., Diss. : 1990
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article: Erfahrungen in der Behandlung von Soor, Trichomonaden-Colpitis und mischinfiziertem Fluor vaginalis mit einem neuen Chemotherapeuticum.

    SCHULDES, H

    Medizinische Klinik

    1958  Volume 53, Issue 2, Page(s) 59–61

    Title translation Treatment of thrush, trichomonas colpitis and of mixed infection of the vaginal fluor with a new drug.
    MeSH term(s) Anti-Infective Agents, Local/therapeutic use ; Antifungal Agents/therapeutic use ; Coinfection ; Disease ; Female ; Halogens ; Humans ; Hydrocarbons, Halogenated/therapeutic use ; Trichomonas ; Trichomonas Vaginitis/therapy ; Vagina ; Vaginal Diseases ; Vaginitis
    Chemical Substances Anti-Infective Agents, Local ; Antifungal Agents ; Halogens ; Hydrocarbons, Halogenated
    Language German
    Publishing date 1958-01-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3232-3
    ISSN 1615-6722 ; 0025-8458 ; 0723-5003 ; 0724-3758 ; 0931-7171
    ISSN (online) 1615-6722
    ISSN 0025-8458 ; 0723-5003 ; 0724-3758 ; 0931-7171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Meigs-Syndrom bei Struma ovarii und Dermoidzyste.

    SCHULDES, H

    Geburtshilfe und Frauenheilkunde

    1956  Volume 16, Issue 5, Page(s) 450–456

    Title translation Meigs syndrome in struma ovarii and dermoid cysts.
    MeSH term(s) Dermoid Cyst ; Female ; Humans ; Meigs Syndrome ; Neoplasms ; Ovarian Neoplasms ; Ovary ; Struma Ovarii ; Teratoma/complications
    Language German
    Publishing date 1956-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 655: Show issues

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  7. Article ; Online: HERG1 gene expression as a specific tumor marker in colorectal tissues.

    Dolderer, J H / Schuldes, H / Bockhorn, H / Altmannsberger, M / Lambers, C / von Zabern, D / Jonas, D / Schwegler, H / Linke, R / Schröder, U H

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2010  Volume 36, Issue 1, Page(s) 72–77

    Abstract: Introduction: Colorectal carcinomas exhibit a frequent recurrence after curative surgery, which may partially be due to histopathologically inconspicuous minimal residual disease. Reliable markers for tumor cells in colorectal tissue are still missing. ... ...

    Abstract Introduction: Colorectal carcinomas exhibit a frequent recurrence after curative surgery, which may partially be due to histopathologically inconspicuous minimal residual disease. Reliable markers for tumor cells in colorectal tissue are still missing. Therefore, in this study we compared the predictive value of the putative tumor markers carcinoembryonic antigen (CEA), cytokeratin-19 (CK19) and cytokeratin-20 (CK20) to that of a novel marker, the human ether-a-go-go-related gene (HERG1) K(+) channel, a suggested regulator of tumor cell proliferation.
    Materials and methods: Using RT-PCR we studied HERG, CEA, CK19 and CK20 expression in colorectal carcinomas and non-carcinoma controls. HERG1 immunhistochemistry was performed in a total of 66 specimens, in colorectal carcinoma (n = 23), in matched histopathologically negative samples (n = 23) taken near the excision site from the same tumor patients and in healthy control biopsies (n = 20). In order to verify the relevance of HERG1 for tumor proliferation we studied the effect of HERG1 inhibition in the Colo-205 colon cancer carcinoma cell line using the MTT-assay.
    Results: HERG1 was expressed in all tumor samples regardless of their stage and in adenomas larger than 0.4 cm, but absent in small adenomas, sigmadiverticulitis specimen and healthy histopathologically negative samples, except for one which developed a tumor recurrence. In contrast, CEA, CK19 and CK20 were absent in some tumors. The selective HERG1 inhibitor E-4031 dose-dependently impaired tumor growth in the proliferation assays.
    Discussion: Our data indicate that HERG1, but not CEA, CK19 or CK20, is a highly sensitive and reliable tumor biomarker that may constitute a novel molecular target for tumor treatment.
    MeSH term(s) Adenocarcinoma/diagnosis ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Carcinoembryonic Antigen/analysis ; Carcinoembryonic Antigen/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Colorectal Neoplasms/diagnosis ; Dose-Response Relationship, Drug ; Ether-A-Go-Go Potassium Channels/analysis ; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors ; Ether-A-Go-Go Potassium Channels/genetics ; Female ; Gene Expression ; Humans ; Immunohistochemistry ; Keratin-19/analysis ; Keratin-19/genetics ; Keratin-20/analysis ; Keratin-20/genetics ; Male ; Middle Aged ; Piperidines/pharmacology ; Polymerase Chain Reaction ; Pyridines/pharmacology ; RNA, Messenger/analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Sensitivity and Specificity ; Tumor Cells, Cultured
    Chemical Substances Biomarkers, Tumor ; Carcinoembryonic Antigen ; Ether-A-Go-Go Potassium Channels ; KCNH1 protein, human ; Keratin-19 ; Keratin-20 ; Piperidines ; Pyridines ; RNA, Messenger ; E 4031 (113558-89-7)
    Language English
    Publishing date 2010-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2009.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1149: Show issues Location:
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    Zs.MO 549: Show issues

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  8. Book ; Thesis: Die Cystinurie

    Schuldes, Horst

    Untersuchungen zur Differenzierung bei 5 Familien

    1984  

    Author's details Horst Schuldes
    Language Undetermined
    Size 66 S
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Berlin, Freie Univ., Diss. : 1984
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article: Einsatz des Ultraschall-Aerosolgerätes "TuR" USI50 bei der Prüfung der bronchialen Reaktivität--vergleichende Untersuchungen zum "TuR" USI3.

    Roth, J / Schuldes, H

    Zeitschrift fur Erkrankungen der Atmungsorgane

    1980  Volume 154, Issue 1, Page(s) 73–77

    Abstract: By comparative studies with the ultrasonic aerosol apparatus "TuR" USI3 and "TuR" USI50 was shown that their applicability for tests of the bronchial reactivity leads to corresponding test results. Based on long experiences with the ultrasonic aerosol ... ...

    Title translation Application of the ultrasonic aerosol apparatus "TuR" USI50 for the test of the bronchial reactivity--comparative studies with "TuR" USI3 (author's transl).
    Abstract By comparative studies with the ultrasonic aerosol apparatus "TuR" USI3 and "TuR" USI50 was shown that their applicability for tests of the bronchial reactivity leads to corresponding test results. Based on long experiences with the ultrasonic aerosol method the USI50 apparatus may recommended also for use of the acetylcholine test (0.01% solution) in clinics and ambulances. Detailed references are given for use of the application technique to guarantee that uniform conditions of investigation are present.
    MeSH term(s) Acetylcholine/administration & dosage ; Adult ; Aerosols ; Aged ; Bronchial Provocation Tests/instrumentation ; Bronchial Provocation Tests/methods ; Humans ; Male ; Middle Aged ; Ultrasonics
    Chemical Substances Aerosols ; Acetylcholine (N9YNS0M02X)
    Language German
    Publishing date 1980
    Publishing country Germany
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 219659-1
    ISSN 0303-657X
    ISSN 0303-657X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Cytostatic sensitivity and MDR in bladder carcinoma cells: implications for tumor therapy.

    Schuldes, H / Dolderer, J H / Schoch, C / Bickeböller, R / Woodcock, B G

    International journal of clinical pharmacology and therapeutics

    1999  Volume 38, Issue 4, Page(s) 204–208

    Abstract: The clinical success generally seen in chemotherapy of advanced bladder carcinoma is far from optimal. The mechanism of resistance development is unclear and the expression of P-170 glycoprotein is generally low. The aim of this study, carried out in ... ...

    Abstract The clinical success generally seen in chemotherapy of advanced bladder carcinoma is far from optimal. The mechanism of resistance development is unclear and the expression of P-170 glycoprotein is generally low. The aim of this study, carried out in vitro in sensitive and cisplatin-resistant cell lines, was to examine sensitivity modulation using R-verapamil and cell membrane perturbing agents. Cell growth rates and changes in the order of the cell membrane, determined using electron-paramagnetic resonance spectrometry, were recorded. R-verapamil increased the toxic effect of doxorubicin in the cisplatin-resistant cell line which showed the highest membrane order. Linolenic acid had a similar effect and also increased sensitivity to cisplatin and methotrexate. Bile salts (tauro-cheno-deoxycholate,TCDC, and tauro-urso-deoxycholate TUDC), had little effect on cytotoxicity. These results indicate that R-verapamil and linolenic acid can act as sensitivity modulators in bladder carcinoma cells and that the action of these agents may involve membrane fluidity changes, a phenomenon noted previously in regard to sensitivity modulation in chinese hamster ovary cell lines.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Calcium Channel Blockers/pharmacology ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/pathology ; Cisplatin/therapeutic use ; Doxorubicin/therapeutic use ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Drug Synergism ; Electron Spin Resonance Spectroscopy ; Humans ; Male ; Methotrexate/therapeutic use ; Tumor Cells, Cultured/drug effects ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology ; Verapamil/analogs & derivatives ; Verapamil/pharmacology
    Chemical Substances Antineoplastic Agents ; Calcium Channel Blockers ; Doxorubicin (80168379AG) ; Verapamil (CJ0O37KU29) ; Cisplatin (Q20Q21Q62J) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 1999-04-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124384-6
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    DOI 10.5414/cpp38204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 467: Show issues Location:
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