Article: Spatiotemporal Control of Neuronal Remodeling by Cell Adhesion Molecules: Insights From
2022 Volume 16, Page(s) 897706
Abstract: Developmental neuronal remodeling is required for shaping the precise connectivity of the mature nervous system. Remodeling involves pruning of exuberant neural connections, often followed by regrowth of adult-specific ones, as a strategy to refine ... ...
| Abstract | Developmental neuronal remodeling is required for shaping the precise connectivity of the mature nervous system. Remodeling involves pruning of exuberant neural connections, often followed by regrowth of adult-specific ones, as a strategy to refine neural circuits. Errors in remodeling are associated with neurodevelopmental disorders such as schizophrenia and autism. Despite its fundamental nature, our understanding of the mechanisms governing neuronal remodeling is far from complete. Specifically, how precise spatiotemporal control of remodeling and rewiring is achieved is largely unknown. In recent years, cell adhesion molecules (CAMs), and other cell surface and secreted proteins of various families, have been implicated in processes of neurite pruning and wiring specificity during circuit reassembly. Here, we review some of the known as well as speculated roles of CAMs in these processes, highlighting recent advances in uncovering spatiotemporal aspects of regulation. Our focus is on the fruit fly |
|---|---|
| Language | English |
| Publishing date | 2022-05-12 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2411902-7 |
| ISSN | 1662-453X ; 1662-4548 |
| ISSN (online) | 1662-453X |
| ISSN | 1662-4548 |
| DOI | 10.3389/fnins.2022.897706 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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