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  1. Article ; Online: Aortic valve calcification and outcomes in severe aortic stenosis.

    Courtney, William A / Schultz, Carl J / Hillis, Graham S

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 19, Page(s) 1426–1428

    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/diagnostic imaging ; Transcatheter Aortic Valve Replacement ; Calcinosis/diagnosis ; Calcinosis/diagnostic imaging ; Multidetector Computed Tomography ; Heart Valve Prosthesis ; Treatment Outcome ; Prosthesis Design ; Heart Valve Prosthesis Implantation
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2023-322771
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    Ui IV Zs.40: Show issues Location:
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  2. Article ; Online: Optimizing arterial

    Bellinge, Jamie W / Schultz, Carl J

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2019  Volume 28, Issue 5, Page(s) 1887–1890

    MeSH term(s) Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/metabolism ; Fluorine Radioisotopes/pharmacokinetics ; Humans ; Image Processing, Computer-Assisted ; Positron-Emission Tomography ; Radiopharmaceuticals/pharmacokinetics ; Reproducibility of Results ; Sodium Fluoride/pharmacokinetics
    Chemical Substances Fluorine Radioisotopes ; Radiopharmaceuticals ; Sodium Fluoride (8ZYQ1474W7) ; Fluorine-18 (GZ5I74KB8G)
    Language English
    Publishing date 2019-12-23
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-019-01992-6
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    Zs.A 4121: Show issues Location:
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  3. Article ; Online: Use of cardiovascular imaging in risk restratification of the diabetic patient.

    Bellinge, Jamie W / Lee, Sing Ching / Schultz, Carl J

    Current opinion in endocrinology, diabetes, and obesity

    2021  Volume 28, Issue 2, Page(s) 122–133

    Abstract: Purpose of review: Diabetes mellitus is no longer considered a cardiovascular disease (CVD) risk equivalent, but the optimal methods of risk stratification are a matter of debate. The coronary calcium score (CCS) is a measure of the burden of ... ...

    Abstract Purpose of review: Diabetes mellitus is no longer considered a cardiovascular disease (CVD) risk equivalent, but the optimal methods of risk stratification are a matter of debate. The coronary calcium score (CCS) is a measure of the burden of atherosclerosis and is widely used for CVD risk stratification in the general population. We review recently published data to describe the role of the CCS in people with diabetes mellitus.
    Recent findings: People with diabetes mellitus have 10-year event rates for CVD and CVD mortality that are considered high, at a much lower level of CCS than the general population. Different categories of CCS are pertinent to men and women with diabetes mellitus. CCS may be particularly useful in clinical settings when CVD risk is known to be increased but difficult to quantify, for example peri-menopausal women, young persons with diabetes, type 1 diabetic individuals and others. With modern techniques, the radiation dose of a CSS has fallen to levels wherein screening and surveillance could be considered.
    Summary: The CCS is able to quantify CVD risk in people with diabetes mellitus when there is clinical uncertainty and identifies those with very high event rates. Future research should aim to identify effective risk reduction strategies in this important group.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Clinical Decision-Making ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Male ; Risk Factors ; Uncertainty
    Language English
    Publishing date 2021-01-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2272017-0
    ISSN 1752-2978 ; 1752-296X
    ISSN (online) 1752-2978
    ISSN 1752-296X
    DOI 10.1097/MED.0000000000000611
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  4. Article ; Online: Cardiovascular risk factors in younger versus older patients with acute coronary syndrome.

    Lan, Nick S R / Harty, Jacinda / Liow, Shaun / Taheri-Chivers, Justin / Ihdayhid, Abdul Rahman / Hillis, Graham S / Schultz, Carl J

    Coronary artery disease

    2024  Volume 35, Issue 3, Page(s) 252–254

    MeSH term(s) Humans ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/epidemiology ; Acute Coronary Syndrome/therapy ; Cardiovascular Diseases ; Risk Factors ; Heart Disease Risk Factors
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000001341
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    Zs.A 3039: Show issues Location:
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  5. Article ; Online: Plasma lipoprotein(a) is associated with calcification activity of the thoracic aorta and aortic valve in statin naïve individuals with diabetes mellitus.

    Bellinge, Jamie W / Chan, Dick C / Pang, Jing / Francis, Roslyn J / Page, Michael M / Watts, Gerald F / Schultz, Carl J

    European journal of clinical investigation

    2024  Volume 54, Issue 5, Page(s) e14167

    MeSH term(s) Humans ; Aorta, Thoracic/diagnostic imaging ; Aortic Valve/diagnostic imaging ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/complications ; Diabetes Mellitus ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Lipoprotein(a) ; Vascular Calcification/diagnostic imaging
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lipoprotein(a)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Letter
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14167
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    Zs.A 677: Show issues Location:
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  6. Article ; Online: A "light based biopsy" for high-risk atherosclerotic plaque.

    Majeed, Kamran / Hillis, Graham S / Schultz, Carl J

    Atherosclerosis

    2020  Volume 309, Page(s) 65–66

    MeSH term(s) Biopsy ; Coronary Vessels ; Humans ; Myocardial Infarction ; Plaque, Atherosclerotic ; Prognosis ; Tomography, Optical Coherence
    Language English
    Publishing date 2020-08-28
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2020.08.023
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    Zs.A 226: Show issues Location:
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  7. Article ; Online: What's new on therapies for elevated lipoprotein(a).

    Ward, Natalie C / Schultz, Carl J / Watts, Gerald F

    Expert review of clinical pharmacology

    2019  Volume 12, Issue 6, Page(s) 495–499

    MeSH term(s) Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Humans ; Hyperlipoproteinemias/complications ; Hyperlipoproteinemias/therapy ; Lipoprotein(a)/blood
    Chemical Substances Lipoprotein(a)
    Language English
    Publishing date 2019-04-30
    Publishing country England
    Document type Editorial
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2019.1610391
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  8. Article ; Online: Case report: Synergetic effect of ischaemia and increased vagal tone inducing ventricular fibrillation in a patient with Brugada syndrome.

    Van Malderen, Sophie C H / Schultz, Carl J / Jordaens, Luc

    European heart journal. Case reports

    2020  Volume 4, Issue 4, Page(s) 1–5

    Abstract: Background: Brugada syndrome (BS) is a hereditary channelopathy associated with syncope, malignant ventricular arrhythmia, and sudden cardiac death. Right ventricular ischaemia and BS have similar underlying substrates precipitating ventricular ... ...

    Abstract Background: Brugada syndrome (BS) is a hereditary channelopathy associated with syncope, malignant ventricular arrhythmia, and sudden cardiac death. Right ventricular ischaemia and BS have similar underlying substrates precipitating ventricular tachycardia or fibrillation (VF).
    Case summary: A 72-year-old woman with BS and a stenosis on the proximal right coronary artery received several subsequent implantable cardioverter-defibrillator shocks due to VF during an episode of extreme nausea with vomiting.
    Discussion: This case report emphasizes on the synergetic effect of mild ischaemia and increased vagal tone on the substrate responsible for BS to create pathophysiological changes precipitating VF.
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytaa202
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  9. Article ; Online: Coronary artery segmentation from intravascular optical coherence tomography using deep capsules.

    Balaji, Arjun / Kelsey, Lachlan J / Majeed, Kamran / Schultz, Carl J / Doyle, Barry J

    Artificial intelligence in medicine

    2021  Volume 116, Page(s) 102072

    Abstract: The segmentation and analysis of coronary arteries from intravascular optical coherence tomography (IVOCT) is an important aspect of diagnosing and managing coronary artery disease. Current image processing methods are hindered by the time needed to ... ...

    Abstract The segmentation and analysis of coronary arteries from intravascular optical coherence tomography (IVOCT) is an important aspect of diagnosing and managing coronary artery disease. Current image processing methods are hindered by the time needed to generate expert-labelled datasets and the potential for bias during the analysis. Therefore, automated, robust, unbiased and timely geometry extraction from IVOCT, using image processing, would be beneficial to clinicians. With clinical application in mind, we aim to develop a model with a small memory footprint that is fast at inference time without sacrificing segmentation quality. Using a large IVOCT dataset of 12,011 expert-labelled images from 22 patients, we construct a new deep learning method based on capsules which automatically produces lumen segmentations. Our dataset contains images with both blood and light artefacts (22.8 %), as well as metallic (23.1 %) and bioresorbable stents (2.5 %). We split the dataset into a training (70 %), validation (20 %) and test (10 %) set and rigorously investigate design variations with respect to upsampling regimes and input selection. We show that our developments lead to a model, DeepCap, that is on par with state-of-the-art machine learning methods in terms of segmentation quality and robustness, while using as little as 12 % of the parameters. This enables DeepCap to have per image inference times up to 70 % faster on GPU and up to 95 % faster on CPU compared to other state-of-the-art models. DeepCap is a robust automated segmentation tool that can aid clinicians to extract unbiased geometrical data from IVOCT.
    MeSH term(s) Algorithms ; Capsules ; Coronary Artery Disease/diagnostic imaging ; Humans ; Tomography, Optical Coherence
    Chemical Substances Capsules
    Language English
    Publishing date 2021-04-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645179-2
    ISSN 1873-2860 ; 0933-3657
    ISSN (online) 1873-2860
    ISSN 0933-3657
    DOI 10.1016/j.artmed.2021.102072
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    Zs.A 2547: Show issues Location:
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  10. Article ; Online: Low-dose colchicine and high-sensitivity C-reactive protein after myocardial infarction: A combined analysis using individual patient data from the COLCOT and LoDoCo-MI studies.

    Sun, Maxine / Dubé, Marie-Pierre / Hennessy, Thomas / Schultz, Carl J / Barhdadi, Amina / Rhainds, David / Hillis, Graham S / Tardif, Jean-Claude

    International journal of cardiology

    2022  Volume 363, Page(s) 20–22

    Abstract: Background: Low-dose colchicine is effective in reducing the risks of recurrent cardiovascular events following an acute myocardial infarction (MI). However, the influence of colchicine on inflammation remains inconclusive. In the current study, we ... ...

    Abstract Background: Low-dose colchicine is effective in reducing the risks of recurrent cardiovascular events following an acute myocardial infarction (MI). However, the influence of colchicine on inflammation remains inconclusive. In the current study, we conducted a combined analysis using individual patient data from the COLCOT and LoDoCo-MI trials to assess the effect of low-dose colchicine on high-sensitivity C reactive protein (hs-CRP) in patients with acute MI.
    Methods: We performed a combined analysis of individual patient data from two clinical trials (COLCOT, LoDoCo-MI). Paired pre-treatment and post-treatment hs-CRP (mg/L) were available in 222 patients for LoDoCo-MI and 207 patients for COLCOT (n
    Results: Colchicine was not significantly associated with post-treatment hs-CRP when it was considered as a continuous variable (beta: -0.41, P = 0.429). However, the intervention was significantly associated with increased odds of achieving post-treatment hs-CRP values ≤1.0 mg/L compared to placebo (odds ratio: 1.64, 95% confidence interval: 1.07 to 2.51, P = 0.024).
    Conclusions: Reduction of inflammation may be a key component in the clinical efficacy of low-dose colchicine with respect to decreased risk of recurrent cardiovascular events following MI. Systematic sampling of hs-CRP before and after treatment with colchicine may be relevant.
    MeSH term(s) Biomarkers ; C-Reactive Protein/metabolism ; Colchicine/therapeutic use ; Humans ; Inflammation/drug therapy ; Myocardial Infarction/therapy
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4) ; Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2022-06-15
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2022.06.028
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