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  1. AU="Schultz, Tracey L"
  2. AU=Stefanoska Kristie
  3. AU=Ray Debraj
  4. AU="Strahler, E A"
  5. AU="Lee, Wang Jun"
  6. AU="Fiona McDuie"
  7. AU="You, Kisung"
  8. AU="Sanjuan, Miguel A" AU="Sanjuan, Miguel A"
  9. AU=Weingarten-Gabbay Shira
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  11. AU="Mills, Mary Katherine"
  12. AU="Vajente, G."
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  25. AU="Banaszkiewicz, Paul A."
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  27. AU=Fala Loretta
  28. AU="McGuckin, M M"
  29. AU="Winlaw, David S"
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  31. AU="Islam, Tousif"
  32. AU="Szczepanczyk, Marek J"
  33. AU="Boregowda, Siddaraju"
  34. AU="Lomidzew, D."

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  1. Artikel ; Online: Acquisition of Host Cytosolic Protein by Toxoplasma gondii Bradyzoites.

    Kannan, Geetha / Thaprawat, Pariyamon / Schultz, Tracey L / Carruthers, Vern B

    mSphere

    2021  Band 6, Heft 1

    Abstract: Toxoplasma ... ...

    Abstract Toxoplasma gondii
    Mesh-Begriff(e) Animals ; CHO Cells ; Cricetulus ; Cytosol/metabolism ; Doxycycline/pharmacology ; Host-Parasite Interactions ; Luminescent Proteins/metabolism ; Male ; Mice ; Mice, Inbred CBA ; Toxoplasma/metabolism ; Red Fluorescent Protein
    Chemische Substanzen Luminescent Proteins ; Doxycycline (N12000U13O)
    Sprache Englisch
    Erscheinungsdatum 2021-01-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00934-20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: A

    Piro, Federica / Masci, Silvia / Kannan, Geetha / Focaia, Riccardo / Schultz, Tracey L / Carruthers, Vern B / Di Cristina, Manlio

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Toxoplasma gondii: Importance: T. ... ...

    Abstract Toxoplasma gondii
    Importance: T. gondii
    Sprache Englisch
    Erscheinungsdatum 2023-09-01
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.08.31.555807
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: A

    Piro, Federica / Masci, Silvia / Kannan, Geetha / Focaia, Riccardo / Schultz, Tracey L / Thaprawat, Pariyamon / Carruthers, Vern B / Di Cristina, Manlio

    mSphere

    2023  Band 9, Heft 1, Seite(n) e0059723

    Abstract: Toxoplasma ... ...

    Abstract Toxoplasma gondii
    Mesh-Begriff(e) Animals ; Humans ; Toxoplasma/metabolism ; Parasites ; Vacuoles/metabolism ; Amino Acid Transport Systems/metabolism ; Arginine/metabolism
    Chemische Substanzen Amino Acid Transport Systems ; Arginine (94ZLA3W45F)
    Sprache Englisch
    Erscheinungsdatum 2023-12-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00597-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Non-canonical activation of IRE1α during

    McFadden, Michael J / Reynolds, Mack B / Michmerhuizen, Britton C / Ólafsson, Einar B / Anderson, Faith M / Schultz, Tracey L / O'Riordan, Mary X D / O'Meara, Teresa R

    bioRxiv : the preprint server for biology

    2024  

    Abstract: While the canonical function of IRE1α is to detect misfolded proteins and activate the unfolded protein response (UPR) to maintain cellular homeostasis, microbial pathogens can also activate IRE1α, which modulates innate immunity and infection outcomes. ... ...

    Abstract While the canonical function of IRE1α is to detect misfolded proteins and activate the unfolded protein response (UPR) to maintain cellular homeostasis, microbial pathogens can also activate IRE1α, which modulates innate immunity and infection outcomes. However, how infection activates IRE1α and its associated inflammatory functions have not been fully elucidated. Recognition of microbe-associated molecular patterns can activate IRE1α, but it is unclear whether this depends on protein misfolding. Here, we report that a common and deadly fungal pathogen,
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.02.560560
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Translation initiation factor eIF1.2 promotes

    Wang, Fengrong / Holmes, Michael J / Hong, Hea Jin / Thaprawat, Pariyamon / Kannan, Geetha / Huynh, My-Hang / Schultz, Tracey L / Licon, M Haley / Lourido, Sebastian / Sullivan, William J / O'Leary, Seán E / Carruthers, Vern B

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... The ... ...

    Abstract The parasite
    Sprache Englisch
    Erscheinungsdatum 2023-11-03
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.11.03.565545
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus.

    Abuaita, Basel H / Schultz, Tracey L / O'Riordan, Mary X

    Cell host & microbe

    2018  Band 24, Heft 5, Seite(n) 625–636.e5

    Abstract: Pathogenic bacteria taken up into the macrophage phagosome are the target of many anti-microbial mechanisms. Although mitochondria-derived antimicrobial effectors like reactive oxygen species (mROS) aid in bacterial killing, it is unclear how these ... ...

    Abstract Pathogenic bacteria taken up into the macrophage phagosome are the target of many anti-microbial mechanisms. Although mitochondria-derived antimicrobial effectors like reactive oxygen species (mROS) aid in bacterial killing, it is unclear how these effectors reach bacteria within the phagosomal lumen. We show here that endoplasmic reticulum stress triggered upon methicillin-resistant Staphylococcus aureus (MRSA) infection induces mROS that are delivered to bacteria-containing phagosomes via mitochondria-derived vesicles (MDVs). The endoplasmic reticulum stress sensor IRE1α induces mROS, specifically hydrogen peroxide (mH
    Mesh-Begriff(e) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Drug Delivery Systems/methods ; Endoplasmic Reticulum ; Endoribonucleases/metabolism ; Female ; Hydrogen Peroxide/metabolism ; Hydrogen Peroxide/pharmacology ; Macrophages/microbiology ; Male ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microbial Viability ; Mitochondria/metabolism ; NADPH Oxidase 2/genetics ; Oxidation-Reduction ; Phagosomes/microbiology ; Protein Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Reactive Oxygen Species/pharmacology ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus/drug effects ; Stress, Physiological ; Superoxide Dismutase/metabolism ; Toll-Like Receptors/metabolism ; Ubiquitin-Protein Ligases/genetics
    Chemische Substanzen Anti-Bacterial Agents ; Anti-Infective Agents ; Reactive Oxygen Species ; Toll-Like Receptors ; Hydrogen Peroxide (BBX060AN9V) ; Superoxide Dismutase (EC 1.15.1.1) ; superoxide dismutase 2 (EC 1.15.1.1) ; Cybb protein, mouse (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; parkin protein (EC 2.3.2.27) ; Protein Kinases (EC 2.7.-) ; ERN1 protein, human (EC 2.7.11.1) ; PTEN-induced putative kinase (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-)
    Sprache Englisch
    Erscheinungsdatum 2018-10-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2018.10.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: The IRE1α Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function.

    Abuaita, Basel H / Sule, Gautam J / Schultz, Tracey L / Gao, Fushan / Knight, Jason S / O'Riordan, Mary X

    Journal of immunology (Baltimore, Md. : 1950)

    2021  Band 207, Heft 1, Seite(n) 210–220

    Abstract: Activation of the endoplasmic reticulum stress sensor, IRE1α, is required for effective immune responses against bacterial infection and is associated with human inflammatory diseases in which neutrophils are a key immune component. However, the specific ...

    Abstract Activation of the endoplasmic reticulum stress sensor, IRE1α, is required for effective immune responses against bacterial infection and is associated with human inflammatory diseases in which neutrophils are a key immune component. However, the specific role of IRE1α in regulating neutrophil effector function has not been studied. In this study, we show that infection-induced IRE1α activation licenses neutrophil antimicrobial capacity, including IL-1β production, formation of neutrophil extracellular traps (NETs), and methicillin-resistant
    Mesh-Begriff(e) Animals ; Endoribonucleases/immunology ; Healthy Volunteers ; Humans ; Interleukin-1beta/biosynthesis ; Methicillin-Resistant Staphylococcus aureus/immunology ; Mice ; Neutrophils/immunology ; Protein Serine-Threonine Kinases/immunology ; Signal Transduction/immunology
    Chemische Substanzen IL1B protein, human ; Interleukin-1beta ; ERN1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-)
    Sprache Englisch
    Erscheinungsdatum 2021-06-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2001321
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts.

    Smith, David / Kannan, Geetha / Coppens, Isabelle / Wang, Fengrong / Nguyen, Hoa Mai / Cerutti, Aude / Olafsson, Einar B / Rimple, Patrick A / Schultz, Tracey L / Mercado Soto, Nayanna M / Di Cristina, Manlio / Besteiro, Sébastien / Carruthers, Vern B

    eLife

    2021  Band 10

    Abstract: Many of the world's warm-blooded species are chronically infected ... ...

    Abstract Many of the world's warm-blooded species are chronically infected with
    Mesh-Begriff(e) Animals ; Autophagy ; Brain/parasitology ; Brain/pathology ; Cell Line ; Disease Models, Animal ; Female ; Host-Parasite Interactions ; Humans ; Life Cycle Stages ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Membrane Proteins/ultrastructure ; Mice, Inbred CBA ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Protozoan Proteins/ultrastructure ; Time Factors ; Toxoplasma/genetics ; Toxoplasma/metabolism ; Toxoplasma/pathogenicity ; Toxoplasma/ultrastructure ; Toxoplasmosis, Cerebral/parasitology ; Toxoplasmosis, Cerebral/pathology ; Vacuoles/genetics ; Vacuoles/metabolism ; Vacuoles/ultrastructure ; Virulence ; Mice
    Chemische Substanzen ATG9 protein, Toxoplasma gondii ; Membrane Proteins ; Protozoan Proteins
    Sprache Englisch
    Erscheinungsdatum 2021-04-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.59384
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia.

    Tomasik, Jakub / Schultz, Tracey L / Kluge, Wolfgang / Yolken, Robert H / Bahn, Sabine / Carruthers, Vern B

    Schizophrenia bulletin

    2016  Band 42, Heft 2, Seite(n) 386–395

    Abstract: Chronic neurologic infection with Toxoplasma gondii is relatively common in humans and is one of the strongest known risk factors for schizophrenia. Nevertheless, the exact neuropathological mechanisms linking T gondii infection and schizophrenia remain ... ...

    Abstract Chronic neurologic infection with Toxoplasma gondii is relatively common in humans and is one of the strongest known risk factors for schizophrenia. Nevertheless, the exact neuropathological mechanisms linking T gondii infection and schizophrenia remain unclear. Here we utilize a mouse model of chronic T gondii infection to identify protein biomarkers that are altered in serum and brain samples at 2 time points during chronic infection. Furthermore, we compare the identified biomarkers to those differing between "postmortem" brain samples from 35 schizophrenia patients and 33 healthy controls. Our findings suggest that T gondii infection causes substantial and widespread immune activation indicative of neural damage and reactive tissue repair in the animal model that partly overlaps with changes observed in the brains of schizophrenia patients. The overlapping changes include increases in C-reactive protein (CRP), interleukin-1 beta (IL-1β), interferon gamma (IFNγ), plasminogen activator inhibitor 1 (PAI-1), tissue inhibitor of metalloproteinases 1 (TIMP-1), and vascular cell adhesion molecule 1 (VCAM-1). Potential roles of these factors in the pathogenesis of schizophrenia and toxoplasmosis are discussed. Identifying a defined set of markers shared within the pathophysiological landscape of these diseases could be a key step towards understanding their specific contributions to pathogenesis.
    Mesh-Begriff(e) Animals ; Biomarkers/metabolism ; Brain/immunology ; Brain/metabolism ; Chronic Disease ; Disease Models, Animal ; Humans ; Mice ; Schizophrenia/immunology ; Schizophrenia/metabolism ; Toxoplasma/pathogenicity ; Toxoplasmosis, Cerebral/immunology ; Toxoplasmosis, Cerebral/metabolism
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2016-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbv134
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Role of

    Kannan, Geetha / Di Cristina, Manlio / Schultz, Aric J / Huynh, My-Hang / Wang, Fengrong / Schultz, Tracey L / Lunghi, Matteo / Coppens, Isabelle / Carruthers, Vern B

    mBio

    2019  Band 10, Heft 4

    Abstract: Toxoplasma ... ...

    Abstract Toxoplasma gondii
    Mesh-Begriff(e) Animals ; Autophagosomes/metabolism ; Cell Survival ; Female ; Humans ; Life Cycle Stages ; Lysosomes/genetics ; Lysosomes/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Proteolysis ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Toxoplasma/genetics ; Toxoplasma/growth & development ; Toxoplasma/metabolism ; Toxoplasmosis/parasitology ; Vacuoles/genetics ; Vacuoles/metabolism
    Chemische Substanzen Membrane Transport Proteins ; Protozoan Proteins
    Sprache Englisch
    Erscheinungsdatum 2019-08-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01324-19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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