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  1. Article ; Online: Building Trust in Medical Use of Artificial Intelligence - The Swarm Learning Principle.

    Schultze, Joachim L

    Journal of CME

    2023  Volume 12, Issue 1, Page(s) 2162202

    Abstract: An avalanche of medical data is starting to be build up. With the digitalisation of medicine and novel approaches such as the omics technologies, we are conquering ever bigger data spaces to be used to describe pathophysiology of diseases, define ... ...

    Abstract An avalanche of medical data is starting to be build up. With the digitalisation of medicine and novel approaches such as the omics technologies, we are conquering ever bigger data spaces to be used to describe pathophysiology of diseases, define biomarkers for diagnostic purposes or identify novel drug targets. Utilising this growing lake of medical data will only be possible, if we make use of machine learning, in particular artificial intelligence (AI)-based algorithms. While the technological developments and chances of the data and information sciences are enormous, the use of AI in medicine also bears challenges and many of the current information technologies (IT) do not follow established medical traditions of mentoring, learning together, sharing insights, while preserving patient's data privacy by patient physician privilege. Other challenges to the medical sector are demands from the scientific community such as "Open Science", "Open Data", "Open Access" principles. A major question to be solved is how to guide technological developments in the IT sector to serve well-established medical traditions and processes, yet allow medicine to benefit from the many advantages of state-of-the-art IT. Here, I provide the Swarm Learning (SL) principle as a conceptual framework designed to foster medical standards, processes and traditions. A major difference to current IT solutions is the inherent property of SL to appreciate and acknowledge existing regulations in medicine that have been proven beneficial for patients and medical personal alike for centuries.
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article
    ISSN 2833-8073
    ISSN (online) 2833-8073
    DOI 10.1080/28338073.2022.2162202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [No title information]

    Schultze, Joachim L

    Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)

    2021  Volume 27, Issue 3, Page(s) 227

    Title translation Deutsche COVID-19 Omics Initiative (DeCOI).
    Language German
    Publishing date 2021-05-11
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2203536-9
    ISSN 1868-6249 ; 0947-0867
    ISSN (online) 1868-6249
    ISSN 0947-0867
    DOI 10.1007/s12268-021-1586-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Systems analysis of human innate immunity in COVID-19.

    Müller, Sophie / Schultze, Joachim L

    Seminars in immunology

    2023  Volume 68, Page(s) 101778

    Abstract: Recent developments in sequencing technologies, the computer and data sciences, as well as increasingly high-throughput immunological measurements have made it possible to derive holistic views on pathophysiological processes of disease and treatment ... ...

    Abstract Recent developments in sequencing technologies, the computer and data sciences, as well as increasingly high-throughput immunological measurements have made it possible to derive holistic views on pathophysiological processes of disease and treatment effects directly in humans. We and others have illustrated that incredibly predictive data for immune cell function can be generated by single cell multi-omics (SCMO) technologies and that these technologies are perfectly suited to dissect pathophysiological processes in a new disease such as COVID-19, triggered by SARS-CoV-2 infection. Systems level interrogation not only revealed the different disease endotypes, highlighted the differential dynamics in context of disease severity, and pointed towards global immune deviation across the different arms of the immune system, but was already instrumental to better define long COVID phenotypes, suggest promising biomarkers for disease and therapy outcome predictions and explains treatment responses for the widely used corticosteroids. As we identified SCMO to be the most informative technologies in the vest to better understand COVID-19, we propose to routinely include such single cell level analysis in all future clinical trials and cohorts addressing diseases with an immunological component.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; Immunity, Innate ; Systems Analysis
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2023.101778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Specificity meets function.

    Schultze, Joachim L

    Nature immunology

    2019  Volume 20, Issue 12, Page(s) 1565–1567

    MeSH term(s) RNA-Seq ; Receptors, Antigen, T-Cell ; Sensitivity and Specificity ; T-Lymphocytes
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2019-11-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-019-0540-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Myocardial infarction cell by cell.

    Schultze, Joachim L

    Nature immunology

    2019  Volume 20, Issue 1, Page(s) 7–9

    MeSH term(s) Humans ; Macrophages ; Myocardial Infarction
    Language English
    Publishing date 2019-01-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-018-0277-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 and the human innate immune system.

    Schultze, Joachim L / Aschenbrenner, Anna C

    Cell

    2021  Volume 184, Issue 7, Page(s) 1671–1692

    Abstract: The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the human population represents a tremendous medical and economic crisis. Innate immunity-as the first line of defense of our immune system-plays a central role in ... ...

    Abstract The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the human population represents a tremendous medical and economic crisis. Innate immunity-as the first line of defense of our immune system-plays a central role in combating this novel virus. Here, we provide a conceptual framework for the interaction of the human innate immune system with SARS-CoV-2 to link the clinical observations with experimental findings that have been made during the first year of the pandemic. We review evidence that variability in innate immune system components among humans is a main contributor to the heterogeneous disease courses observed for coronavirus disease 2019 (COVID-19), the disease spectrum induced by SARS-CoV-2. A better understanding of the pathophysiological mechanisms observed for cells and soluble mediators involved in innate immunity is a prerequisite for the development of diagnostic markers and therapeutic strategies targeting COVID-19. However, this will also require additional studies addressing causality of events, which so far are lagging behind.
    MeSH term(s) COVID-19/immunology ; Host Microbial Interactions ; Humans ; Immunity, Innate ; SARS-CoV-2/physiology ; Severity of Illness Index
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.02.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Whole blood stimulation as a tool for studying the human immune system.

    Müller, Sophie / Kröger, Charlotte / Schultze, Joachim L / Aschenbrenner, Anna C

    European journal of immunology

    2023  Volume 54, Issue 2, Page(s) e2350519

    Abstract: The human immune system is best accessible via tissues and organs not requiring major surgical intervention, such as blood. In many circumstances, circulating immune cells correlate with an individual's health state and give insight into physiological ... ...

    Abstract The human immune system is best accessible via tissues and organs not requiring major surgical intervention, such as blood. In many circumstances, circulating immune cells correlate with an individual's health state and give insight into physiological and pathophysiological processes. Stimulating whole blood ex vivo is a powerful tool to investigate immune responses. In the context of clinical research, the applications of whole blood stimulation include host immunity, disease characterization, diagnosis, treatment, and drug development. Here, we summarize different setups and readouts of whole blood assays and discuss applications for preclinical research and clinical practice. Finally, we propose combining whole blood stimulation with high-throughput technologies, such as single-cell RNA-sequencing, to comprehensively analyze the human immune system for the identification of biomarkers, therapeutic interventions as well as companion diagnostics.
    MeSH term(s) Humans ; Immune System ; Blood
    Language English
    Publishing date 2023-12-16
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202350519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Swarm immunology: harnessing blockchain technology and artificial intelligence in human immunology.

    Schultze, Joachim L / Büttner, Maren / Becker, Matthias

    Nature reviews. Immunology

    2022  Volume 22, Issue 7, Page(s) 401–403

    MeSH term(s) Artificial Intelligence ; Blockchain ; Humans ; Technology
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-022-00740-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Time for a voluntary crisis research service.

    Schultze, Joachim L / Gabriel, Markus / Nicotera, Pierluigi

    Cell death and differentiation

    2022  Volume 29, Issue 4, Page(s) 888–890

    Language English
    Publishing date 2022-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-022-00968-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Das nationale Kompetenznetzwerk für Hochdurchsatzsequenzierung

    Schultze, Joachim L.

    Immunologie

    2019  Volume 3, Issue 4, Page(s) 266

    Language German
    Document type Article
    ZDB-ID 2935137-6
    ISSN 2625-3585 ; 2513-1583
    Database Current Contents Medicine

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