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Book ; Thesis: Auswirkungen von oxidativem Stress auf isolierte Pankreas-Azinuszellen und daraus abgeleitete experimentelle Ansätze für die Therapie der akuten Pankreatitis

Schulz, Hans-Ulrich

1998

Author's details	vorgelegt von Hans-Ulrich Schulz
Language	German
Size	126 Bl. : graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Magdeburg, Univ., Habil.-Schr., 1999
HBZ-ID	HT010831306
Database	Catalogue ZB MED Medicine, Health

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Book ; Thesis: Azinuszellen aus Rattenpankreas

Schulz, Hans-Ulrich

Isolierung, Charakterisierung und Möglichkeiten ihres Einsatzes in Untersuchungen zur Pathogenese der akuten Pankreatitis

1989

Author's details	vorgelegt von Hans-Ulrich Schulz
Keywords	Pancreatitis / immunology ; Acute Disease ; Disease Models, Animal ; Rats ; Cell Separation / methods ; Pancreas / cytology ; Pancreas / immunology ; Dose-Response Relationship, Immunologic ; Dinitrophenols
Size	64 Bl. : Ill., graph. Darst.
Publishing country	XA-DDDE
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Magdeburg, Med. Akad., Diss. A, 1989
HBZ-ID	HT003925907
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Genetic Analysis of the ATG16L1 c.898A>G (p.T300A) Variant in Acute and Chronic Pancreatitis.

Neubauer, Claudia / Ewers, Maren / Schulz, Hans-Ulrich / Weiß, Frank Ulrich / Lämmerhirt, Felix / Lerch, Markus M / Bugert, Peter / Landt, Olfert / Algül, Hana / Rosendahl, Jonas / Witt, Heiko

Pancreas

2023 Volume 51, Issue 9, Page(s) 1231–1234

Abstract: Objectives: Human and animal studies suggest an important role of autophagy in the pathogenesis of pancreatitis. ATG16L1 (autophagy-related 16 like 1) is part of a protein complex that is involved in the formation of autophagosomes. The c.898A > G (p ... ...

Abstract	Objectives: Human and animal studies suggest an important role of autophagy in the pathogenesis of pancreatitis. ATG16L1 (autophagy-related 16 like 1) is part of a protein complex that is involved in the formation of autophagosomes. The c.898A > G (p.T300A) variant of ATG16L1 is associated with Crohn disease. In this study, we analyzed ATG16L1 c.898A > G (p.T300A) for an association with pancreatitis. Methods: We genotyped 777 patients and 551 control subjects of German origin by melting curve analysis using fluorescence resonance energy transfer probes. The patient group included 429 patients with nonalcoholic chronic pancreatitis (CP), 141 patients with alcoholic CP, and 207 patients with acute pancreatitis (AP). We classified AP by severity according to the Atlanta symposium 1992. Results: Allele and genotype frequencies of ATG16L1 c.898A > G (p.T300A) did not differ significantly between patients and controls (G allele frequencies: nonalcoholic CP, 49.9%; alcoholic CP, 48.2%; AP, 49.5%; controls, 52.7%). We found no significant association with the severity of AP either. Conclusions: Our data do not support a role of ATG16L1 c.898A > G (p.T300A) in the pathogenesis of AP or CP or an influence on the severity of AP.
MeSH term(s)	Animals ; Humans ; Acute Disease ; Autophagy-Related Proteins/genetics ; Pancreatitis/genetics ; Crohn Disease ; Gene Frequency ; Genetic Predisposition to Disease ; Autophagy/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Autophagy-Related Proteins ; ATG16L1 protein, human
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000002177
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Book ; Online ; Thesis: Untersuchungen zum Einfluss des Body-Mass-Index auf den Verlauf biochemischer Marker bei der akuten Pankreatitis

Baatarkhuu, Munkhgerel / Schulz, Hans-Ulrich

2014

Author's details	von Munkhgerel Baatarkhuu
Language	German
Size	Online-Ressource (PDF-Datei), graph. Darst.
Edition	[Online-Ausg.]
Publisher	Medizinische Zentralbibl
Publishing place	Magdeburg
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Med. Fak., Diss.--Magdeburg, 2014
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online ; Thesis: Untersuchungen zum Einfluss des Body-Mass-Index auf den Verlauf biochemischer Marker bei der akuten Pankreatitis

Baatarkhuu, Munkhgerel [Verfasser] / Schulz, Hans-Ulrich [Akademischer Betreuer]

2014

Author's details	Munkhgerel Baatarkhuu. Betreuer: Hans-Ulrich Schulz
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek
Publishing place	Magdeburg
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Mittelfristiges, relativ tumorstabiles Outcome eines erfolgreich interdisziplinär lokal R0-resezierten, metastasierten Leiomyosarkoms der V. cava inferior mit multimodaler Behandlung.

Meyer, Frank / Weber, Mathias / Schulz, Hans-Ulrich / Halloul, Zuhir

Wiener medizinische Wochenschrift (1946)

2013 Volume 163, Issue 11-12, Page(s) 295–302

Abstract: Unlabelled: Progredient tumor-growth does not mean necessarily nihilism since (because of the latest multimodal therapeutic options) it might be possible to convert the malignant disease into a chronic stage depending on tumor entity, specific tumor- ... ...

Title translation	Mid-term, relatively tumor-stable outcome after an initially successful interdisciplinary surgical intervention with locally achieved R0 resection status including a multimodal therapeutic concept of a metastasized leiomyosarcoma of the inferior vena cava.
Abstract	Unlabelled: Progredient tumor-growth does not mean necessarily nihilism since (because of the latest multimodal therapeutic options) it might be possible to convert the malignant disease into a chronic stage depending on tumor entity, specific tumor-associated findings and expertise of the interdisciplinary oncological/oncosurgical team to utilize available and potential therapeutic measures. The aim of this report on an unusual case (with its patient-associated, therapeutic and prognostic aspects) of a leiomyosarcoma of the inferior vena cava with advanced tumor growth (characterized initially by pulmonary and hepatic, later on by additional vertebral metastases) is to illustrate its changeful clinical course after and during multimodal treatment episodes comprising surgical (abdomino-/vascular-/cardio- and neurosurgical-locally, R0 resection status), radiological and chemotherapeutic measures. A relatively stable disease over a specific time period of 5 years and 6 months was achieved. The 54-year old female patient with metastasized leiomyosarcoma of the inferior vena cava underwent local tumor resection en bloc with inferior vena cava segmental resection (following vascular surgical interposition of a prosthesis) and hemihepatectomy as well as resection of hepatic segment I. After recovery, a multistep and -modal treatment was initiated comprising of various protocols of systemic chemotherapy, thermoablation of recurrent hepatic metastases, various brachytherapy procedures (for hepatic and pulmonary metastases) and resection of a cerebral metastasis by a neurosurgeon including subsequent radiation. Conclusions: The patient demonstrates impressively that even in case of advanced tumor stage with initial, novel and recurrent metastases, a relatively stable disease over an intermediate time period (of more than 5 years) with an acceptable quality of life was achieved despite several complications.
MeSH term(s)	Blood Vessel Prosthesis Implantation ; Chemoradiotherapy, Adjuvant ; Combined Modality Therapy ; Cooperative Behavior ; Disease Progression ; Female ; Follow-Up Studies ; Germany ; Humans ; Interdisciplinary Communication ; Leiomyosarcoma/diagnosis ; Leiomyosarcoma/pathology ; Leiomyosarcoma/therapy ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Phlebography ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Prognosis ; Quality of Life ; Tomography, X-Ray Computed ; Treatment Outcome ; Vascular Neoplasms/diagnosis ; Vascular Neoplasms/pathology ; Vascular Neoplasms/therapy ; Vena Cava, Inferior/pathology
Language	German
Publishing date	2013-01-19
Publishing country	Austria
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	123613-1
ISSN	1563-258X ; 0254-7945 ; 0043-5341
ISSN (online)	1563-258X
ISSN	0254-7945 ; 0043-5341
DOI	10.1007/s10354-012-0172-2
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Zs.A 903: Show issues

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Article ; Online: Serological diagnosis and prognosis of severe acute pancreatitis by analysis of serum glycoprotein 2.

Roggenbuck, Dirk / Goihl, Alexander / Hanack, Katja / Holzlöhner, Pamela / Hentschel, Christian / Veiczi, Miklos / Schierack, Peter / Reinhold, Dirk / Schulz, Hans-Ulrich

Clinical chemistry and laboratory medicine

2017 Volume 55, Issue 6, Page(s) 854–864

Abstract: Background: Glycoprotein 2 (GP2), the pancreatic major zymogen granule membrane glycoprotein, was reported to be elevated in acute pancreatitis in animal models.: Methods: Enzyme-linked immunosorbent assays (ELISAs) were developed to evaluate human ... ...

Abstract	Background: Glycoprotein 2 (GP2), the pancreatic major zymogen granule membrane glycoprotein, was reported to be elevated in acute pancreatitis in animal models. Methods: Enzyme-linked immunosorbent assays (ELISAs) were developed to evaluate human glycoprotein 2 isoform alpha (GP2a) and total GP2 (GP2t) as specific markers for acute pancreatitis in sera of 153 patients with acute pancreatitis, 26 with chronic pancreatitis, 125 with pancreatic neoplasms, 324 with non-pancreatic neoplasms, 109 patients with liver/biliary disease, 67 with gastrointestinal disease, and 101 healthy subjects. GP2a and GP2t levels were correlated with procalcitonin and C-reactive protein in 152 and 146 follow-up samples of acute pancreatitis patients, respectively. Results: The GP2a ELISA revealed a significantly higher assay accuracy in contrast to the GP2t assay (sensitivity ≤3 disease days: 91.7%, specificity: 96.7%, positive likelihood ratio [LR+]: 24.6, LR-: 0.09). GP2a and GP2t levels as well as prevalences were significantly elevated in early acute pancreatitis (≤3 disease days) compared to all control cohorts (p<0.05, respectively). GP2a and GP2t levels were significantly higher in patients with severe acute pancreatitis at admission compared with mild cases (p<0.05, respectively). Odds ratio for GP2a regarding mild vs. severe acute pancreatitis with lethal outcome was 7.8 on admission (p=0.0222). GP2a and GP2t levels were significantly correlated with procalcitonin [Spearman's rank coefficient of correlation (ρ)=0.21, 0.26; p=0.0110, 0.0012; respectively] and C-reactive protein (ρ=0.37, 0.40; p<0.0001; respectively). Conclusions: Serum GP2a is a specific marker of acute pancreatitis and analysis of GP2a can aid in the differential diagnosis of acute upper abdominal pain and prognosis of severe acute pancreatitis.
MeSH term(s)	Acute Disease ; Adult ; Aged ; Blood Chemical Analysis ; Case-Control Studies ; Cohort Studies ; Female ; GPI-Linked Proteins/blood ; Humans ; Male ; Middle Aged ; Pancreatitis/blood ; Pancreatitis/diagnosis ; Prognosis ; Protein Isoforms/blood ; Serologic Tests
Chemical Substances	GP2 protein, human ; GPI-Linked Proteins ; Protein Isoforms
Language	English
Publishing date	2017-05-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2016-0797
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Article ; Online: Effects of the P-Glycoprotein Inhibitor Clarithromycin on the Pharmacokinetics of Intravenous and Oral Trospium Chloride: A 4-Way Crossover Drug-Drug Interaction Study in Healthy Subjects.

Abebe, Bayew Tsega / Weiss, Michael / Modess, Christiane / Roustom, Tarek / Tadken, Tobias / Wegner, Danilo / Schwantes, Ulrich / Neumeister, Claudia / Schulz, Hans-Ulrich / Scheuch, Eberhard / Siegmund, Werner

Journal of clinical pharmacology

2019 Volume 59, Issue 10, Page(s) 1319–1330

Abstract: The quaternary ammonium compound trospium chloride is poorly absorbed from 2 "absorption windows" in the jejunum and cecum/ascending colon, respectively. To confirm whether intestinal P-glycoprotein (P-gp) is involved, a 4-period, crossover drug ... ...

Abstract	The quaternary ammonium compound trospium chloride is poorly absorbed from 2 "absorption windows" in the jejunum and cecum/ascending colon, respectively. To confirm whether intestinal P-glycoprotein (P-gp) is involved, a 4-period, crossover drug interaction study with trospium chloride after intravenous (2 mg) and oral administration (30 mg) without and after comedication of clarithromycin (500 mg), an inhibitor for P-gp, was initiated in 12 healthy subjects. Pharmacokinetics of trospium was evaluated using gas chromatography-mass spectrometry, noncompartmental evaluation, and pharmacokinetic modeling. Trospium chloride was poorly absorbed after oral administration (absolute bioavailability, ∼8%-10%). About 30% of the bioavailable dose fraction was absorbed from the "narrow window". Comedication with clarithromycin increased steady-state distribution volumes by ∼27% (P < .01). Bioavailability was not increased as hypothesized. The geometric mean ratios (90% confidence interval) for area under the plasma concentration-time curve, maximum concentration, and renal clearance accounted for 0.75 (0.56-1.01), 0.64 (0.45-0.89), and 1.00 (0.90-1.13), respectively. The amount of trospium absorbed from the "narrow window" was reduced in all subjects but from the "wider window" in only 9 of them. Bioavailability was strongly predicted by the maximum absorption rate of trospium in the distal "window" (rs
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors ; Administration, Intravenous/methods ; Administration, Oral ; Adult ; Area Under Curve ; Benzilates/pharmacokinetics ; Biological Availability ; Clarithromycin/pharmacology ; Cross-Over Studies ; Drug Interactions/physiology ; Female ; Healthy Volunteers ; Humans ; Male ; Muscarinic Antagonists/pharmacokinetics ; Nortropanes/pharmacokinetics
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Benzilates ; Muscarinic Antagonists ; Nortropanes ; trospium chloride (1E6682427E) ; Clarithromycin (H1250JIK0A)
Language	English
Publishing date	2019-04-11
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.1421
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Article ; Online: Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects.

Abebe, Bayew Tsega / Weiss, Michael / Modess, Christiane / Tadken, Tobias / Wegner, Danilo / Meyer, Marleen J / Schwantes, Ulrich / Neumeister, Claudia / Scheuch, Eberhard / Schulz, Hans-Ulrich / Tzvetkov, Mladen / Siegmund, Werner

Journal of clinical pharmacology

2019 Volume 60, Issue 3, Page(s) 312–323

Abstract: Trospium chloride, a muscarinic receptor blocker, is poorly absorbed with different rates from areas in the jejunum and the cecum/ascending colon. To evaluate whether organic cation transporter (OCT) 1, OCT2 and multidrug and toxin extrusion (MATE) 1 and ...

Abstract	Trospium chloride, a muscarinic receptor blocker, is poorly absorbed with different rates from areas in the jejunum and the cecum/ascending colon. To evaluate whether organic cation transporter (OCT) 1, OCT2 and multidrug and toxin extrusion (MATE) 1 and MATE2-K are involved in pharmacokinetics, competitions with ranitidine, a probe inhibitor of the cation transporters, were evaluated in transfected HEK293 cells. Furthermore, a drug interaction study with trospium chloride after intravenous (2 mg) and oral dosing (30 mg) plus ranitidine (300 mg) was performed in 12 healthy subjects and evaluated by noncompartmental analysis and population pharmacokinetic modeling. Ranitidine inhibited OCT1, OCT2, MATE1, and MATE2-K with half maximal inhibitory concentration values of 186 ± 25 µM, 482 ± 105 µM, 134 ± 37 µM, and 35 ± 11 µM, respectively. In contrast to our hypothesis, coadministration of ranitidine did not significantly decrease oral absorption of trospium. Instead, renal clearance was lowered by ∼15% (530 ± 99 vs 460 ± 120 mL/min; P < .05). It is possible that ranitidine was not available in competitive concentrations at the major colonic absorption site, as the inhibitor is absorbed in the small intestine and undergoes degradation by microbiota. The renal effects apparently result from inhibition of MATE1 and/or MATE2-K by ranitidine as predicted by in vitro to in vivo extrapolation. However, all pharmacokinetic changes were not of clinical relevance for the drug with highly variable pharmacokinetics. Intravenous trospium significantly lowered mean absorption time and relative bioavailability of ranitidine, which was most likely caused by muscarinic receptor blocking effects on intestinal motility and water turnover.
MeSH term(s)	Administration, Intravenous ; Administration, Oral ; Adult ; Benzilates/administration & dosage ; Benzilates/adverse effects ; Benzilates/blood ; Benzilates/pharmacokinetics ; Biological Availability ; Cells, Cultured ; Drug Interactions ; Female ; Healthy Volunteers ; Humans ; Male ; Muscarinic Antagonists/administration & dosage ; Muscarinic Antagonists/adverse effects ; Muscarinic Antagonists/blood ; Muscarinic Antagonists/pharmacokinetics ; Nortropanes/administration & dosage ; Nortropanes/adverse effects ; Nortropanes/blood ; Nortropanes/pharmacokinetics ; Organic Cation Transport Proteins/antagonists & inhibitors ; Organic Cation Transport Proteins/metabolism ; Ranitidine/administration & dosage ; Ranitidine/blood ; Ranitidine/pharmacokinetics ; Ranitidine/pharmacology
Chemical Substances	Benzilates ; Muscarinic Antagonists ; Nortropanes ; Organic Cation Transport Proteins ; trospium chloride (1E6682427E) ; Ranitidine (884KT10YB7)
Language	English
Publishing date	2019-09-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.1523
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Conference proceedings: Spektrum, Häufigkeit und Versorgung intraoperativer, iatrogener Gefäßverletzung bei viszeralchirurgischen Eingriffen an einem tertiären Zentrum

Scholtz, Veronika / Meyer, Frank / Meißner, Carl / Schulz, Hans-Ulrich / Halloul, Zuhir

2016 , Page(s) 16dgch546

Event/congress	133. Kongress der Deutschen Gesellschaft für Chirurgie; Berlin; Deutsche Gesellschaft für Chirurgie; 2016
Keywords	Medizin, Gesundheit
Publishing date	2016-04-21
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/16dgch546
Database	German Medical Science

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