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  1. Book ; Thesis: Aortenisthmusstenosen bei Kindern

    Schuster, Cornelia

    Untersuchung des mittelfristigen postoperativen Verlaufs in Abhängigkeit von morphologischer Ausgangslage, Operationsalter und Operationstechnik

    2009  

    Author's details vorgelegt von Cornelia Schuster
    Subject code 617.41
    Language German
    Size VIII, 102 S., S. IX - XXXIII, Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2009
    HBZ-ID HT016302251
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 E 1621 order for loan Magazin

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  2. Article: Assessment of Variables Related to the Risk of Severe Adverse Events in Cutaneous Melanoma Patients Treated with Immune Checkpoint Inhibitors.

    Trichkova, Kremena Petrova / Görtler, Franziska / Bjørge, Line / Schuster, Cornelia

    Cancers

    2024  Volume 16, Issue 2

    Abstract: Malignant melanoma is a prevalent and aggressive cancer, with globally increasing incidences. While immune checkpoint inhibitors (ICIs) have prolonged the survival of patients with advanced melanoma over the last decade, this improvement comes with the ... ...

    Abstract Malignant melanoma is a prevalent and aggressive cancer, with globally increasing incidences. While immune checkpoint inhibitors (ICIs) have prolonged the survival of patients with advanced melanoma over the last decade, this improvement comes with the risk of severe immune-related adverse events (irAEs). This systematic review investigates patient baseline characteristics (BCs) as predictive factors for developing severe gastrointestinal, hepatic, and pulmonary irAEs in patients treated with ipilimumab (anti-CTLA-4) and/or nivolumab/pembrolizumab (anti-PD-1). A systematic literature search was conducted in the Ovid databases MEDLINE and EMBASE on 22 April 2022, following the PRISMA guidelines. Out of 1694 articles, 13 were included in the final analysis. We analyzed BCs and the occurrence of severe colitis, hepatitis, and pneumonitis in 22 treatment arms and 3 treatment groups: anti-CTLA-4 (
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Gata3 is detrimental to regulatory T cell function in autoimmune diabetes.

    Kiaf, Badr / Bode, Kevin / Schuster, Cornelia / Kissler, Stephan

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Regulatory T cells (Tregs) protect against autoimmunity. In type 1 diabetes (T1D), Tregs slow the progression of beta cell autoimmunity within pancreatic islets. Increasing the potency or frequency of Tregs can prevent diabetes, as evidenced by studies ... ...

    Abstract Regulatory T cells (Tregs) protect against autoimmunity. In type 1 diabetes (T1D), Tregs slow the progression of beta cell autoimmunity within pancreatic islets. Increasing the potency or frequency of Tregs can prevent diabetes, as evidenced by studies in the nonobese diabetic (NOD) mouse model for T1D. We report herein that a significant proportion of islets Tregs in NOD mice express
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.18.533297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: β2-adrenergic receptor expression in patients receiving bevacizumab therapy for metastatic melanoma.

    Schuster, Cornelia / Akslen, Lars A / Straume, Oddbjørn

    Cancer medicine

    2023  Volume 12, Issue 17, Page(s) 17891–17900

    Abstract: Background: Vascular endothelial growth factor (VEGF) was initially known as vascular permeability factor and identified as a driver of tumour angiogenesis. Recently, its role in supporting an immunosuppressive tumour microenvironment was demonstrated, ... ...

    Abstract Background: Vascular endothelial growth factor (VEGF) was initially known as vascular permeability factor and identified as a driver of tumour angiogenesis. Recently, its role in supporting an immunosuppressive tumour microenvironment was demonstrated, and anti-VEGF treatment combined with immune checkpoint blockade is currently investigated. Further, beta-adrenergic signalling as a modifier of cancer hallmarks like immune response, angiogenesis and metastasis gained increased attention during past years.
    Methods: Focusing on the aspect of immunosuppression in upregulated beta-adrenergic signalling, we investigated predictive markers in patients with metastatic melanoma who received bevacizumab monotherapy, a specific VEGF-A binding antibody. We explored the expression of beta-2 adrenergic receptor (β2-AR), interleukin 6-receptor (IL6-R), cyclooxygenase 2 (COX2) and VEGF-A by immunohistochemistry in melanoma to assess the correlation between these proteins in melanoma cells and response to treatment.
    Results: Strong β2-AR expression in metastases was associated with clinical benefit of bevacizumab. Furthermore, expression of the latter was positively linked to expression of VEGF-A and COX2. β2-AR expression in melanoma metastasis appears to distinguish a subgroup of patients that might benefit from anti-VEGF treatment.
    Conclusion: Our results strengthen further exploration of anti-VEGF therapy in combination with immune checkpoint blockade in clinical studies and the investigation of β2-AR as predictive marker.
    MeSH term(s) Humans ; Bevacizumab/therapeutic use ; Vascular Endothelial Growth Factor A/metabolism ; Receptors, Adrenergic, beta-2 ; Cyclooxygenase 2 ; Immune Checkpoint Inhibitors/therapeutic use ; Melanoma/pathology ; Adrenergic Agents/therapeutic use ; Tumor Microenvironment
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; Vascular Endothelial Growth Factor A ; Receptors, Adrenergic, beta-2 ; Cyclooxygenase 2 (EC 1.14.99.1) ; Immune Checkpoint Inhibitors ; Adrenergic Agents
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Prioritäten im botanischen Artenschutz im Wartburgkreis - Ersterfassungen von Arten, für die Thüringen eine besondere Verantwortung trägt

    Heck, Andreas / Schuster, Cornelia

    Landschaftspflege und Naturschutz in Thüringen

    2022  Volume 58, Issue 1, Page(s) 20

    Language German
    Document type Article
    ZDB-ID 129331-X
    ISSN 0323-8253
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 5229: Show issues

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  6. Article ; Online: Peripherally induced regulatory T cells contribute to the control of autoimmune diabetes in the NOD mouse model.

    Schuster, Cornelia / Jonas, Franziska / Zhao, Fangzhu / Kissler, Stephan

    European journal of immunology

    2018  Volume 48, Issue 7, Page(s) 1211–1216

    Abstract: Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic beta cells and is partly caused by deficiencies in the ... ...

    Abstract Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic beta cells and is partly caused by deficiencies in the Foxp3
    MeSH term(s) Animals ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Diabetes Mellitus, Type 1/immunology ; Forkhead Transcription Factors/metabolism ; HSP72 Heat-Shock Proteins/genetics ; Immunomodulation ; Insulin-Secreting Cells/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Regulatory/immunology ; Thymus Gland/immunology
    Chemical Substances FOXP3 protein, human ; Forkhead Transcription Factors ; HSP72 Heat-Shock Proteins
    Language English
    Publishing date 2018-04-25
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201847498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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  7. Article ; Online: The type 1 diabetes candidate gene Dexi does not affect disease risk in the nonobese diabetic mouse model.

    Nieves-Bonilla, Janice M / Kiaf, Badr / Schuster, Cornelia / Kissler, Stephan

    Genes and immunity

    2019  Volume 21, Issue 1, Page(s) 71–77

    Abstract: Genome-wide association studies have implicated more than 50 genomic regions in type 1 diabetes (T1D). A T1D region at chromosome 16p13.13 includes the candidate genes CLEC16A and DEXI. Conclusive evidence as to which gene is causal for the disease ... ...

    Abstract Genome-wide association studies have implicated more than 50 genomic regions in type 1 diabetes (T1D). A T1D region at chromosome 16p13.13 includes the candidate genes CLEC16A and DEXI. Conclusive evidence as to which gene is causal for the disease association of this region is missing. We previously reported that Clec16a deficiency modified immune reactivity and protected against autoimmunity in the nonobese diabetic (NOD) mouse model for T1D. However, the diabetes-associated SNPs at 16p13.13 were described to also impact on DEXI expression and others have argued that DEXI is the causal gene in this disease locus. To help resolve whether DEXI affects disease, we generated Dexi knockout (KO) NOD mice. We found that Dexi deficiency had no effect on the frequency of diabetes. To test for possible interactions between Dexi and Clec16a, we intercrossed Dexi KO and Clec16a knockdown (KD) NOD mice. Dexi KO did not modify the disease protection afforded by Clec16a KD. We conclude that Dexi plays no role in autoimmune diabetes in the NOD model. Our data provide strongly suggestive evidence that CLEC16A, not DEXI, is causal for the T1D association of variants in the 16p13.13 region.
    MeSH term(s) Animals ; Autoimmunity ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/metabolism ; Disease Models, Animal ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Lectins, C-Type/genetics ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred NOD ; Monosaccharide Transport Proteins/genetics ; Polymorphism, Single Nucleotide/genetics ; Risk Factors
    Chemical Substances CLEC16A protein, mouse ; DEXI protein, human ; DNA-Binding Proteins ; Lectins, C-Type ; Membrane Proteins ; Monosaccharide Transport Proteins
    Language English
    Publishing date 2019-08-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/s41435-019-0083-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5592: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online ; Thesis: Regulation of CD8 T cell-mediated diabetes induction by co-inhibitory and co-stimulatory signals delivered by pancreatic beta cells

    Schuster, Cornelia [Verfasser]

    2012  

    Author's details Cornelia Schuster
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universität Ulm. Medizinische Fakultät
    Publishing place Ulm
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article ; Online: Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy.

    Schuster, Cornelia / Akslen, Lars A / Stokowy, Tomasz / Straume, Oddbjørn

    The journal of pathology. Clinical research

    2018  Volume 5, Issue 1, Page(s) 53–62

    Abstract: The incidence of malignant melanoma is rising worldwide and survival for metastatic disease is still poor. Recently, new treatment options have become available. Still, predictive biomarkers are needed to optimise treatment for this patient group. In ... ...

    Abstract The incidence of malignant melanoma is rising worldwide and survival for metastatic disease is still poor. Recently, new treatment options have become available. Still, predictive biomarkers are needed to optimise treatment for this patient group. In this study, we investigated the predictive value of 60 angiogenic factors in patients with metastatic melanoma treated with the anti-vascular endothelial growth factor A antibody bevacizumab. Thirty-five patients were included in a clinical phase II trial and baseline serum samples were analysed by multiplex protein array. High-serum concentration of Activin A was significantly associated with objective response (OR) to treatment (p = 0.014). Candidate proteins that indicated a borderline association with treatment response were further investigated by immunohistochemistry. Strong expression of Activin A, interleukin-1β, and urokinase-type plasminogen activator receptor in metastases was significantly associated with OR (p = 0.011, p = 0.003, and p = 0.007, respectively), as well as with markers of activated angiogenesis, such as higher number of proliferating vessels and the presence of glomeruloid microvascular proliferations. Our findings indicate that these proteins may be potential predictive markers for treatment with bevacizumab monotherapy.
    MeSH term(s) Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/therapeutic use ; Biomarkers, Tumor/metabolism ; Colorectal Neoplasms/drug therapy ; Female ; Humans ; Male ; Melanoma/drug therapy ; Melanoma/secondary ; Neovascularization, Pathologic/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Biomarkers, Tumor ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2018-11-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814357-7
    ISSN 2056-4538 ; 2056-4538
    ISSN (online) 2056-4538
    ISSN 2056-4538
    DOI 10.1002/cjp2.116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Expression of Heat Shock Protein 27 in Melanoma Metastases Is Associated with Overall Response to Bevacizumab Monotherapy: Analyses of Predictive Markers in a Clinical Phase II Study.

    Schuster, Cornelia / Akslen, Lars A / Straume, Oddbjørn

    PloS one

    2016  Volume 11, Issue 5, Page(s) e0155242

    Abstract: The aim of this study was to identify potential predictive biomarkers in 35 patients with metastatic melanoma treated with anti-angiogenic bevacizumab monotherapy in a clinical phase II study. The immunohistochemical expression of various angiogenic ... ...

    Abstract The aim of this study was to identify potential predictive biomarkers in 35 patients with metastatic melanoma treated with anti-angiogenic bevacizumab monotherapy in a clinical phase II study. The immunohistochemical expression of various angiogenic factors in tissues from primary melanomas and metastases as well as their concentration in blood samples were examined. Strong expression of Heat Shock Protein 27 (HSP27) in metastases correlated significantly with complete or partial response to bevacizumab (p = 0.044). Furthermore, clinical benefit, i.e., complete or partial response or stable disease for at least 6 months, was more frequent in patients with strong expression of HSP27 in primary tumors (p = 0.046). Tissue expression of vascular endothelial growth factor (VEGF-A), its splicing variant VEGF165b or basic fibroblast growth factor (bFGF) did not correlate with response, and the concentration of HSP27, VEGF-A or bFGF measured in blood samples before treatment did not show predictive value. Further, microvessel density, proliferating microvessel density and presence of glomeruloid microvascular proliferations were assessed in sections of primary tumors and metastases. Microvessel density in primary melanomas was significantly higher in patients with clinical benefit than in non-responders (p = 0.042). In conclusion, our findings suggest that strong HSP27 expression in melanoma metastases predicts response to bevacizumab treatment.
    MeSH term(s) Adult ; Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/therapeutic use ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Female ; Fibroblast Growth Factor 2/blood ; Fibroblast Growth Factor 2/genetics ; Gene Expression Regulation, Neoplastic ; HSP27 Heat-Shock Proteins/blood ; HSP27 Heat-Shock Proteins/genetics ; Humans ; Liver Neoplasms/blood supply ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/secondary ; Lung Neoplasms/blood supply ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/secondary ; Lymphatic Metastasis ; Male ; Melanoma/blood supply ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/secondary ; Middle Aged ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; Prognosis ; Signal Transduction ; Skin Neoplasms/blood supply ; Skin Neoplasms/drug therapy ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Vascular Endothelial Growth Factor A/blood ; Vascular Endothelial Growth Factor A/genetics
    Chemical Substances Angiogenesis Inhibitors ; Biomarkers, Tumor ; HSP27 Heat-Shock Proteins ; HSPB1 protein, human ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Fibroblast Growth Factor 2 (103107-01-3) ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2016-05-11
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0155242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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