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  1. Article: Editorial: From mechanosensing to signalling and cell response: The ion channel force.

    Gkika, Dimitra / Schwab, Albrecht

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1183726

    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1183726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of the Na

    Loeck, Thorsten / Schwab, Albrecht

    Biological chemistry

    2023  Volume 404, Issue 4, Page(s) 325–337

    Abstract: Cancer is characterized by uncontrolled growth, invasion, and metastasis. In addition to solid cancer cells, cancer-associated fibroblasts (CAFs) play important roles in cancer pathophysiology. They arise from "healthy" cells but get manipulated by solid ...

    Abstract Cancer is characterized by uncontrolled growth, invasion, and metastasis. In addition to solid cancer cells, cancer-associated fibroblasts (CAFs) play important roles in cancer pathophysiology. They arise from "healthy" cells but get manipulated by solid cancer cells to supply them and develop a tumor microenvironment (TME) that protects the cancer cells from the immune defense. A wide variety of cell types can differentiate into CAFs, including fibroblasts, endothelial cells, and epithelial cells. Precise Ca
    MeSH term(s) Endothelial Cells/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Sodium-Calcium Exchanger/metabolism ; Fibroblasts/metabolism ; Calcium/metabolism ; Neoplasms
    Chemical Substances Sodium-Calcium Exchanger ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-01-04
    Publishing country Germany
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2022-0253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.50: Show issues Location:
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  3. Article ; Online: Na

    Koch, Alexander / Hofschröer, Verena / Schwab, Albrecht

    Experimental dermatology

    2023  Volume 33, Issue 1, Page(s) e14983

    Abstract: Tumour cell detachment from the primary tumour is an early and crucial step of the metastatic cascade. At the single cell level, it was already shown that migrating melanoma cells establish both intra- and extracellular pH gradients and that the ... ...

    Abstract Tumour cell detachment from the primary tumour is an early and crucial step of the metastatic cascade. At the single cell level, it was already shown that migrating melanoma cells establish both intra- and extracellular pH gradients and that the Na
    MeSH term(s) Humans ; Sodium-Hydrogen Exchanger 1/metabolism ; Melanoma/metabolism ; Cell Line, Tumor ; Sodium-Hydrogen Exchangers/metabolism ; Cell Communication ; Hydrogen-Ion Concentration ; Tumor Microenvironment
    Chemical Substances Sodium-Hydrogen Exchanger 1 ; Sodium-Hydrogen Exchangers
    Language English
    Publishing date 2023-11-27
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14983
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3508: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Membrane potential dynamics of C5a-stimulated neutrophil granulocytes.

    Becker, Stina / Swoboda, Aljoscha / Siemer, Henrik / Schimmelpfennig, Sandra / Sargin, Sarah / Shahin, Victor / Schwab, Albrecht / Najder, Karolina

    Pflugers Archiv : European journal of physiology

    2024  

    Abstract: Neutrophil granulocytes play a crucial role in host defense against invading pathogens and in inflammatory diseases. The aim of this study was to elucidate membrane potential dynamics during the initial phase of neutrophil activation and its relation to ... ...

    Abstract Neutrophil granulocytes play a crucial role in host defense against invading pathogens and in inflammatory diseases. The aim of this study was to elucidate membrane potential dynamics during the initial phase of neutrophil activation and its relation to migration and production of reactive oxygen species (ROS). We performed ROS production measurements of neutrophils from healthy C57BL/6J mice after TNFα-priming and/or C5a stimulation. The actin cytoskeleton was visualized with fluorescence microscopy. Furthermore, we combined migration assays and measurements of membrane potential dynamics after stimulating unprimed and/or TNFα-primed neutrophils with C5a. We show that C5a has a concentration-dependent effect on ROS production and chemokinetic migration. Chemokinetic migration and chemotaxis are impaired at C5a concentrations that induce ROS production. The actin cytoskeleton of unstimulated and of ROS-producing neutrophils is not distributed in a polarized way. Inhibition of the phagocytic NADPH oxidase NOX2 with diphenyleneiodonium (DPI) leads to a polarized distribution of the actin cytoskeleton and rescues chemokinetic migration of primed and C5a-stimulated neutrophils. Moreover, C5a evokes a pronounced depolarization of the cell membrane potential by 86.6 ± 4.2 mV starting from a resting membrane potential of -74.3 ± 0.7 mV. The C5a-induced depolarization occurs almost instantaneously (within less than one minute) in contrast to the more gradually developing depolarization induced by PMA (lag time of 3-4 min). This initial depolarization is accompanied by a decrease of the migration velocity. Collectively, our results show that stimulation with C5a evokes parallel changes in membrane potential dynamics, neutrophil ROS production and motility. Notably, the amplitude of membrane potential dynamics is comparable to that of excitable cells.
    Language English
    Publishing date 2024-04-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-024-02947-8
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    In stock of ZB MED Cologne/Königswinter

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  5. Book ; Thesis: Trans- und parazellulärer K+-Transport im Verdünnungssegment der Froschniere

    Schwab, Albrecht

    1988  

    Size 33 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1989
    HBZ-ID HT003388014
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    89 D 5795 order for loan Magazin

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  6. Article: Ion Channels in Lung Cancer.

    Bulk, Etmar / Todesca, Luca Matteo / Schwab, Albrecht

    Reviews of physiology, biochemistry and pharmacology

    2020  Volume 181, Page(s) 57–79

    Abstract: Ion channels are a major class of membrane proteins that play central roles in signaling within and among cells, as well as in the coupling of extracellular events with cellular responses. Dysregulated ion channel activity plays a causative role in many ... ...

    Abstract Ion channels are a major class of membrane proteins that play central roles in signaling within and among cells, as well as in the coupling of extracellular events with cellular responses. Dysregulated ion channel activity plays a causative role in many diseases including cancer. Here, we will review their role in lung cancer. Lung cancer is one of the most frequently diagnosed cancers, and it causes the highest number of deaths of all cancer types. The overall 5-year survival rate of lung cancer patients is only 19% and decreases to 5% when patients are diagnosed with stage IV. Thus, new therapeutical strategies are urgently needed. The important contribution of ion channels to the progression of various types of cancer has been firmly established so that ion channel-based therapeutic concepts are currently developed. Thus far, the knowledge on ion channel function in lung cancer is still relatively limited. However, the published studies clearly show the impact of ion channel inhibitors on a number of cellular mechanisms underlying lung cancer cell aggressiveness such as proliferation, migration, invasion, cell cycle progression, or adhesion. Additionally, in vivo experiments reveal that ion channel inhibitors diminish tumor growth in mice. Furthermore, some studies give evidence that ion channel inhibitors can have an influence on the resistance or sensitivity of lung cancer cells to common chemotherapeutics such as paclitaxel or cisplatin.
    MeSH term(s) Animals ; Humans ; Ion Channels ; Lung Neoplasms/drug therapy ; Mice ; Signal Transduction
    Chemical Substances Ion Channels
    Language English
    Publishing date 2020-08-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125106-5
    ISSN 1617-5786 ; 0303-4240
    ISSN (online) 1617-5786
    ISSN 0303-4240
    DOI 10.1007/112_2020_29
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  7. Article ; Online: STIM2: Redox-sensor and effector of the (tumor) microenvironment.

    Schwab, Albrecht / Loeck, Thorsten / Najder-Nalepa, Karolina

    Cell calcium

    2020  Volume 94, Page(s) 102335

    Abstract: Ion channels and their associated proteins are at the interface between the cytosol and the extracellular space. In cancer, this allows them to sense and transduce physico-chemical cues from the tumor microenvironment and thereby shape the aggressive ... ...

    Abstract Ion channels and their associated proteins are at the interface between the cytosol and the extracellular space. In cancer, this allows them to sense and transduce physico-chemical cues from the tumor microenvironment and thereby shape the aggressive cell behavior. In a recent paper Gibhardt et al. provide profound mechanistic insight how STIM2, an integral component of the store-operated Ca
    MeSH term(s) Calcium/metabolism ; Calcium Signaling ; Cysteine ; Oxidation-Reduction ; Oxidative Stress ; Stromal Interaction Molecule 1/metabolism ; Stromal Interaction Molecule 2/metabolism ; Tumor Microenvironment
    Chemical Substances Stromal Interaction Molecule 1 ; Stromal Interaction Molecule 2 ; Cysteine (K848JZ4886) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-12-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2020.102335
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    Zs.A 1596: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Unexpected localization of AQP3 and AQP4 induced by migration of primary cultured IMCD cells.

    Rose, Ralph / Kemper, Björn / Schwab, Albrecht / Schlatter, Eberhard / Edemir, Bayram

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 11930

    Abstract: Aquaporin-2-4 (AQP) are expressed in the principal cells of the renal collecting duct (CD). Beside their role in water transport across membranes, several studies showed that AQPs can influence the migration of cells. It is unknown whether this also ... ...

    Abstract Aquaporin-2-4 (AQP) are expressed in the principal cells of the renal collecting duct (CD). Beside their role in water transport across membranes, several studies showed that AQPs can influence the migration of cells. It is unknown whether this also applies for renal CD cells. Another fact is that the expression of these AQPs is highly modulated by the external osmolality. Here we analyzed the localization of AQP2-4 in primary cultured renal inner medullary CD (IMCD) cells and how osmolality influences the migration behavior of these cells. The primary IMCD cells showed a collective migration behavior and there were no differences in the migration speed between cells cultivated either at 300 or 600 mosmol/kg. Acute increase from 300 to 600 mosmol/kg led to a marked reduction and vice versa an acute decrease from 600 to 300 mosmol/kg to a marked increase in migration speed. Interestingly, none of the analyzed AQPs were localized at the leading edge. While AQP3 disappeared within the first 2-3 rows of cells, AQP4 was enriched at the rear end. Further analysis indicated that migration induced lysosomal degradation of AQP3. This could be prevented by activation of the protein kinase A, inducing localization of AQP3 and AQP2 at the leading edge and increasing the migration speed.
    MeSH term(s) Animals ; Aquaporin 3/genetics ; Aquaporin 3/metabolism ; Aquaporin 4/genetics ; Aquaporin 4/metabolism ; Bucladesine/pharmacology ; Cell Movement/drug effects ; Cell Movement/physiology ; Cell Shape ; Cells, Cultured ; Kidney Medulla/cytology ; Kidney Tubules, Collecting/cytology ; Kidney Tubules, Collecting/drug effects ; Kidney Tubules, Collecting/metabolism ; Microscopy, Fluorescence/methods ; Osmolar Concentration ; Primary Cell Culture ; Rats ; Sodium-Hydrogen Exchanger 1/metabolism ; beta Catenin/metabolism
    Chemical Substances Aquaporin 4 ; Sodium-Hydrogen Exchanger 1 ; beta Catenin ; Aquaporin 3 (158801-98-0) ; Bucladesine (63X7MBT2LQ)
    Language English
    Publishing date 2021-06-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-91369-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial: TRP Channels in Inflammation and Immunity.

    Partida-Sanchez, Santiago / Desai, Bimal N / Schwab, Albrecht / Zierler, Susanna

    Frontiers in immunology

    2021  Volume 12, Page(s) 684172

    MeSH term(s) Animals ; Humans ; Hypersensitivity ; Immunity, Innate/physiology ; Inflammation/metabolism ; Mast Cells/immunology ; Mast Cells/metabolism ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism
    Chemical Substances TRPM Cation Channels
    Language English
    Publishing date 2021-04-15
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.684172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression.

    Mesquita, Gonçalo / Prevarskaya, Natalia / Schwab, Albrecht / Lehen'kyi, V'yacheslav

    Cells

    2021  Volume 10, Issue 5

    Abstract: The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer. The great diversity of ... ...

    Abstract The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer. The great diversity of functions performed by these channels is represented by nine sub-families that constitute the TRP channel superfamily. From the mid-2000s, several reports have shown the potential role of the TRP channels in cancers of multiple origin. The pancreatic cancer is one of the deadliest cancers worldwide. Its prevalence is predicted to rise further. Disappointingly, the treatments currently used are ineffective. There is an urgency to find new ways to counter this disease and one of the answers may lie in the ion channels belonging to the superfamily of TRP channels. In this review, we analyse the existing knowledge on the role of TRP channels in the development and progression of pancreatic ductal adenocarcinoma (PDAC). The functions of these channels in other cancers are also considered. This might be of interest for an extrapolation to the pancreatic cancer in an attempt to identify potential therapeutic interventions.
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Signaling ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cations ; Cell Movement ; Cell Proliferation ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Ion Channels ; Mice ; Neoplasm Invasiveness ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Phylogeny ; Prevalence ; Transient Receptor Potential Channels/physiology ; Tumor Microenvironment
    Chemical Substances Cations ; Ion Channels ; Transient Receptor Potential Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-04-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10051021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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