Article ; Online: Anti-microtubule activity of the traditional Chinese medicine herb Northern Ban Lan (Isatis tinctoria) leads to glucobrassicin.
Journal of integrative plant biology
2021 Volume 63, Issue 12, Page(s) 2058–2074
Abstract: Traditional Chinese medicine (TCM) belongs to the most elaborate and extensive systems of plant-based healing. The herb Northern Ban Lan (Isatis tinctoria) is famous for its antiviral and anti-inflammatory activity. Although numerous components isolated ... ...
| Abstract | Traditional Chinese medicine (TCM) belongs to the most elaborate and extensive systems of plant-based healing. The herb Northern Ban Lan (Isatis tinctoria) is famous for its antiviral and anti-inflammatory activity. Although numerous components isolated from I. tinctoria have been characterized so far, their modes of action have remained unclear. Here, we show that extracts from I. tinctoria exert anti-microtubular activity. Using time-lapse microscopy in living tobacco BY-2 (Nicotiana tabacum L. cv Bright Yellow 2) cells expressing green fluorescent protein-tubulin, we use activity-guided fractionation to screen out the biologically active compounds of I. tinctoria. Among 54 fractions obtained from either leaves or roots of I. tinctoria by methanol (MeOH/H |
|---|---|
| MeSH term(s) | Glucosinolates ; HeLa Cells ; Humans ; Indoles ; Isatis/chemistry ; Medicine, Chinese Traditional ; Microtubules |
| Chemical Substances | Glucosinolates ; Indoles ; glucobrassicin (EA6EH0IU89) |
| Language | English |
| Publishing date | 2021-11-10 |
| Publishing country | China (Republic : 1949- ) |
| Document type | Journal Article |
| ZDB-ID | 2130095-1 |
| ISSN | 1744-7909 ; 1672-9072 |
| ISSN (online) | 1744-7909 |
| ISSN | 1672-9072 |
| DOI | 10.1111/jipb.13177 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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