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  1. Article ; Online: Towards Individually Tailored Diets in Prevention and Treatment of Diabetes?

    Uusitupa, Matti / Schwab, Ursula

    Nutrients

    2023  Volume 15, Issue 12

    Abstract: Type 2 diabetes (T2D) is a heterogenous disease regarding its phenotype and genotype [ ... ]. ...

    Abstract Type 2 diabetes (T2D) is a heterogenous disease regarding its phenotype and genotype [...].
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/therapy ; Diet ; Genotype ; Phenotype
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15122649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inferring personal intake recommendations of phosphorous and potassium for end-stage renal failure patients by simulating with Bayesian hierarchical multivariate model.

    Turkia, Jari / Schwab, Ursula / Hautamäki, Ville

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0291153

    Abstract: Most end-stage renal disease (ESRD) patients face a risk of malnutrition, partly due to dietary restrictions on phosphorous and, in some cases, potassium intake. These restrictions aim to regulate plasma phosphate and potassium concentrations and prevent ...

    Abstract Most end-stage renal disease (ESRD) patients face a risk of malnutrition, partly due to dietary restrictions on phosphorous and, in some cases, potassium intake. These restrictions aim to regulate plasma phosphate and potassium concentrations and prevent the adverse effects of hyperphosphatemia or hyperkalemia. However, individual responses to nutrition are known to vary, highlighting the need for personalized recommendations rather than relying solely on general guidelines. In this study, our objective was to develop a Bayesian hierarchical multivariate model that estimates the individual effects of nutrients on plasma concentrations and to present a recommendation algorithm that utilizes this model to infer personalized dietary intakes capable of achieving normal ranges for all considered concentrations. Considering the limited research on the reactions of ESRD patients, we collected dietary intake data and corresponding laboratory analyses from a cohort of 37 patients. The collected data were used to estimate the common hierarchical model, from which personalized models of the patients' diets and individual reactions were extracted. The application of our recommendation algorithm revealed substantial variations in phosphorus and potassium intakes recommended for each patient. These personalized recommendations deviate from the general guidelines, suggesting that a notably richer diet may be proposed for certain patients to mitigate the risk of malnutrition. Furthermore, all the participants underwent either hospital, home, or peritoneal dialysis treatments. We explored the impact of treatment type on nutritional reactions by incorporating it as a nested level in the hierarchical model. Remarkably, this incorporation improved the fit of the nutritional effect model by a notable reduction in the normalized root mean square error (NRMSE) from 0.078 to 0.003. These findings highlight the potential for personalized dietary modifications to optimize nutritional status, enhance patient outcomes, and mitigate the risk of malnutrition in the ESRD population.
    MeSH term(s) Humans ; Potassium ; Bayes Theorem ; Kidney Failure, Chronic/therapy ; Malnutrition ; Phosphorus ; Renal Dialysis
    Chemical Substances Potassium (RWP5GA015D) ; Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lifestyle Intervention Guided by Group and Internet-Based Counseling in the T2D-GENE Trial Supports Its Applicability and Feasibility.

    Schwab, Ursula / Lankinen, Maria / Uusitupa, Matti / Laakso, Markku

    Nutrients

    2023  Volume 15, Issue 7

    Abstract: Type 2 diabetes (T2D) can be prevented or postponed by lifestyle modifications as shown by previous intervention studies. In most of these studies, participants have received resource-demanding individual counseling. In the 3-year T2D-GENE trial with ... ...

    Abstract Type 2 diabetes (T2D) can be prevented or postponed by lifestyle modifications as shown by previous intervention studies. In most of these studies, participants have received resource-demanding individual counseling. In the 3-year T2D-GENE trial with lifestyle intervention, we investigated whether a less resource-demanding form of group and internet-based counseling is feasible and effective in preventing T2D in people with an increased risk for T2D. Altogether, 628 middle-aged to elderly men either with a high number or low number of T2D risk alleles were recruited. Five to seven group sessions were organized during the intervention, in addition to information and activities delivered via the web portal, and weekly monitoring of body weight and physical activity. Four-day food records with personal feedback were documented five times during the study. Of the 549 participants completing the study, over 90% participated in the group sessions and kept the food records. The four self-feedback tasks delivered during the second and the third years of the study were completed by 80-89% of the participants. In conclusion, a group and web portal-based lifestyle intervention is applicable for middle-aged to elderly men as a lifestyle modification aiming to prevent T2D.
    MeSH term(s) Aged ; Humans ; Male ; Middle Aged ; Counseling ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/prevention & control ; Diabetes Mellitus, Type 2/psychology ; Feasibility Studies ; Internet ; Life Style
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15071787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The impact of intermittent fasting on gut microbiota: a systematic review of human studies.

    Paukkonen, Isa / Törrönen, Elli-Noora / Lok, Johnson / Schwab, Ursula / El-Nezami, Hani

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1342787

    Abstract: Background: Intermittent fasting (IF) has gained popularity in interventions targeting overweight, obesity and metabolic syndrome. IF may affect the gut microbiome composition and therefore have various effects on gut microbiome mediated functions in ... ...

    Abstract Background: Intermittent fasting (IF) has gained popularity in interventions targeting overweight, obesity and metabolic syndrome. IF may affect the gut microbiome composition and therefore have various effects on gut microbiome mediated functions in humans. Research on the effects of IF on human gut microbiome is limited. Therefore, the objective of this systematic review was to determine how different types of IF affect the human gut microbiome.
    Methods: A literature search was conducted for studies investigating the association of different types of IF and gut microbiota richness, alpha and beta diversity, and composition in human subjects. Databases included Cochrane Library (RRID:SCR_013000), PubMed (RRID:SCR_004846), Scopus (RRID:SCR_022559) and Web of Science (RRID:SCR_022706). A total of 1,332 studies were retrieved, of which 940 remained after removing duplicates. Ultimately, a total of 8 studies were included in the review. The included studies were randomized controlled trials, quasi-experimental studies and pilot studies implementing an IF intervention (time-restricted eating, alternate day fasting or 5:2 diet) in healthy subjects or subjects with any disease.
    Results: Most studies found an association between IF and gut microbiota richness, diversity and compositional changes. There was heterogeneity in the results, and bacteria which were found to be statistically significantly affected by IF varied widely depending on the study.
    Conclusion: The findings in this systematic review suggest that IF influences gut microbiota. It seems possible that IF can improve richness and alpha diversity. Due to the substantial heterogeneity of the results, more research is required to validate these findings and clarify whether the compositional changes might be beneficial to human health.
    Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42021241619.
    Language English
    Publishing date 2024-02-12
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1342787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.

    Csader, Susanne / Korhonen, Sonja / Kaarniranta, Kai / Schwab, Ursula

    Nutrients

    2022  Volume 14, Issue 20

    Abstract: ... ...

    Abstract Purpose
    MeSH term(s) Humans ; Zeaxanthins ; Lutein ; Xanthophylls ; Visual Acuity ; Double-Blind Method ; Macular Degeneration/prevention & control ; Dietary Supplements ; Fatty Acids, Omega-3
    Chemical Substances Zeaxanthins ; Lutein (X72A60C9MT) ; Xanthophylls ; Fatty Acids, Omega-3
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14204273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Basteln mit Papier

    Schwab, Ursula

    (Pixi kreativ : Serie 6 ; 21 ; Topp)

    2015  

    Author's details [Schrittill.: Ursula Schwab]
    Series title Pixi kreativ : Serie 6 ; 21
    Topp
    Keywords Papierarbeit ; Basteln
    Language German
    Size 23 S., überw. Ill
    Publisher Carlsen
    Publishing place Hamburg
    Document type Book
    ISBN 3551188165 ; 9783551181800 ; 9783551188168 ; 3551181802
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book: Basteln mit Naturmaterial

    Schwab, Ursula

    (Pixi kreativ : Serie 6 ; 22 ; Topp)

    2015  

    Author's details [Schrittill.: Ursula Schwab]
    Series title Pixi kreativ : Serie 6 ; 22
    Topp
    Keywords Basteln ; Naturmaterial
    Language German
    Size 23 S., überw. Ill
    Publisher Carlsen
    Publishing place Hamburg
    Document type Book
    ISBN 3551188173 ; 9783551181800 ; 9783551188175 ; 3551181802
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: Basteln mit Fundsachen

    Schwab, Ursula

    (Pixi kreativ : Serie 6 ; 23 ; Topp)

    2015  

    Author's details [Schrittill.: Ursula Schwab]
    Series title Pixi kreativ : Serie 6 ; 23
    Topp
    Keywords Recycling ; Basteln
    Language German
    Size 23 S., überw. Ill
    Publisher Carlsen
    Publishing place Hamburg
    Document type Book
    ISBN 3551188181 ; 9783551181800 ; 9783551188182 ; 3551181802
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  9. Book: Basteln mit Knete

    Schwab, Ursula

    (Pixi kreativ : Serie 6 ; 24 ; Topp)

    2015  

    Author's details [Schrittill.: Ursula Schwab]
    Series title Pixi kreativ : Serie 6 ; 24
    Topp
    Keywords Basteln ; Knetmasse
    Language German
    Size 23 S., überw. Ill
    Publisher Carlsen
    Publishing place Hamburg
    Document type Book
    ISBN 355118819X ; 9783551181800 ; 9783551188199 ; 3551181802
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Evolving Nutritional Therapy for Diabetes Mellitus.

    Uusitupa, Matti / Schwab, Ursula

    Nutrients

    2020  Volume 12, Issue 2

    Abstract: One of the special issues ... ...

    Abstract One of the special issues in
    MeSH term(s) Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diet therapy ; Diabetes Mellitus, Type 2/prevention & control ; Feeding Behavior ; Humans ; Life Style ; Nutrition Policy ; Nutrition Therapy ; Nutritional Requirements ; Nutritional Support ; Overweight/etiology
    Language English
    Publishing date 2020-02-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12020423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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