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Conference proceedings: Perivascular macrophages mediate microvasospasms after subarachnoid hemorrhage

Schwarting, Julian

2022 , Page(s) BO–01

Title translation	Rolle perivaskulärer Makrophagen bei der posthämorrhagischen Mikrozirkulationsstörung nach experimenteller Subarachnoidalblutung
Event/congress	73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; Köln; Deutsche Gesellschaft für Neurochirurgie; 2022
Keywords	Medizin, Gesundheit
Publishing date	2022-05-25
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/22dgnc030
Database	German Medical Science

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Article ; Online: Pericytes Are Not Associated With Reduced Capillary Perfusion After Experimental Subarachnoid Hemorrhage.

Schwarting, Julian / Nehrkorn, Katrin / Harapan, Biyan N / Balbi, Matilde / Terpolilli, Nicole A / Plesnila, Nikolaus

Stroke

2023 Volume 54, Issue 8, Page(s) 2172–2177

Abstract: Background: Subarachnoid hemorrhage (SAH) is characterized by an acute reduction of cerebral blood flow and subsequent cortical infarcts, but the underlying mechanisms are not well understood. Since pericytes regulate cerebral perfusion on the capillary ...

Abstract	Background: Subarachnoid hemorrhage (SAH) is characterized by an acute reduction of cerebral blood flow and subsequent cortical infarcts, but the underlying mechanisms are not well understood. Since pericytes regulate cerebral perfusion on the capillary level, we hypothesize that pericytes may reduce cerebral perfusion after SAH. Methods: Pericytes and vessel diameters of cerebral microvessels were imaged in vivo using NG2 (neuron-glial antigen 2) reporter mice and 2-photon microscopy before and 3 hours after sham surgery or induction of SAH by perforating the middle cerebral artery with an intraluminal filament. Twenty-four hours after, SAH pericyte density was assessed by immunohistochemistry. Results: SAH caused pearl-string-like constrictions of pial arterioles, slowed down blood flow velocity in pial arterioles by 50%, and reduced the volume of intraparenchymal arterioles and capillaries by up to 70% but did not affect pericyte density or induce capillary constriction by pericytes. Conclusions: Our results suggest that perfusion deficits after SAH are not induced by pericyte-mediated capillary constrictions.
MeSH term(s)	Mice ; Animals ; Pericytes/physiology ; Capillaries ; Subarachnoid Hemorrhage/complications ; Vasoconstriction/physiology ; Perfusion
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.123.042936
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Perivascular Macrophages Mediate Microvasospasms After Experimental Subarachnoid Hemorrhage.

Lin, Xiangjiang / Khalin, Igor / Harapan, Biyan Nathanael / Terpolilli, Nicole Angela / Schwarting, Julian / Plesnila, Nikolaus

Stroke

2023 Volume 54, Issue 8, Page(s) 2126–2134

Abstract: Background: Subarachnoid hemorrhage (SAH) is characterized by acute and delayed reductions of cerebral blood flow (CBF) caused, among others, by spasms of cerebral arteries and arterioles. Recently, the inactivation of perivascular macrophages (PVM) has ...

Abstract	Background: Subarachnoid hemorrhage (SAH) is characterized by acute and delayed reductions of cerebral blood flow (CBF) caused, among others, by spasms of cerebral arteries and arterioles. Recently, the inactivation of perivascular macrophages (PVM) has been demonstrated to improve neurological outcomes after experimental SAH, but the underlying mechanisms of protection remain unclear. The aim of our exploratory study was, therefore, to investigate the role of PVM in the formation of acute microvasospasms after experimental SAH. Methods: PVMs were depleted in 8- to 10-week-old male C57BL/6 mice (n=8/group) by intracerebroventricular application of clodronate-loaded liposomes and compared with mice with vehicle liposome injections. Seven days later, SAH was induced by filament perforation under continuous monitoring of CBF and intracranial pressure. Results were compared with sham-operated animals and animals who underwent SAH induction but no liposome injection (n=4/group each). Six hours after SAH induction or sham surgery, numbers of microvasospasms per volume of interest and % of affected pial and penetrating arterioles were examined in 9 standardized regions of interest per animal by in vivo 2-photon microscopy. Depletion of PVMs was proven by quantification of PVMs/mm Results: PVMs were located around pial and intraparenchymal arterioles and were effectively depleted by clodronate from 671±28 to 46±14 PVMs/mm Conclusions: Our results suggest that PVMs contribute to the formation of microvasospasms after experimental SAH.
MeSH term(s)	Mice ; Male ; Animals ; Subarachnoid Hemorrhage/complications ; Clodronic Acid ; Mice, Inbred C57BL ; Arterioles ; Cerebrovascular Circulation/physiology ; Disease Models, Animal
Chemical Substances	Clodronic Acid (0813BZ6866)
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.122.042290
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nimodipine Reduces Microvasospasms After Experimental Subarachnoid Hemorrhage.

Schwarting, Julian / Harapan, Biyan Nathanael / Lin, Xiangjiang / Plesnila, Nikolaus / Terpolilli, Nicole A

Stroke

2023 Volume 54, Issue 10, Page(s) 2666–2670

Abstract: Background: The only established pharmacological treatment option improving outcomes for patients suffering from subarachnoid hemorrhage (SAH) is the L-type-calcium channel inhibitor nimodipine. However, the exact mechanisms of action of nimodipine ... ...

Abstract	Background: The only established pharmacological treatment option improving outcomes for patients suffering from subarachnoid hemorrhage (SAH) is the L-type-calcium channel inhibitor nimodipine. However, the exact mechanisms of action of nimodipine conferring neuroprotection after SAH have yet to be determined. More recently, spasms of the cerebral microcirculation were suggested to play an important role in reduced cerebral perfusion after SAH and, ultimately, outcome. It is unclear whether nimodipine may influence microvasospasms and, thus, microcirculatory dysfunction. The aim of the current study was, therefore, to assess the effect of nimodipine on microvasospasms after experimental SAH. Methods: Male C57Bl/6 N mice (n=3-5/group) were subjected to SAH using the middle cerebral artery perforation model. Six hours after SAH induction, a cranial window was prepared, and the diameter of cortical microvessels was assessed in vivo by 2-photon-microscopy before, during, and after nimodipine application. Results: Nimodipine significantly reduced the number of posthemorrhagic microvasospasms. The diameters of nonspastic vessels were not affected. Conclusions: Our results show that nimodipine reduces the formation of microvasospasms, thus, shedding new light on the mode of action of a drug routinely used for the treatment of SAH for >3 decades. Furthermore, L-type Ca2+ channels may be involved in the pathophysiology of microvasospasm formation.
MeSH term(s)	Humans ; Animals ; Mice ; Male ; Nimodipine/pharmacology ; Nimodipine/therapeutic use ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/drug therapy ; Microcirculation ; Mice, Inbred C57BL ; Microvessels
Chemical Substances	Nimodipine (57WA9QZ5WH)
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.123.043976
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 448: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Risk identification for the development of large-artery vasospasm after aneurysmatic subarachnoid hemorrhage - a multivariate, risk-, and location-adjusted prediction model.

Schwarting, Julian / Trost, Dominik / Albrecht, Carolin / Jörger, Ann-Kathrin / Zimmer, Claus / Wostrack, Maria / Meyer, Bernhard / Bodden, Jannis / Boeckh-Behrens, Tobias

Journal of neurointerventional surgery

2023

Abstract: Background: Vasospasm of the large cerebral arteries (CVS) after aneurysmatic subarachnoid hemorrhage (aSAH) reduces cerebral perfusion and causes delayed cerebral ischemia. Although endovascular spasmolysis shows convincing angiographic results, ... ...

Abstract	Background: Vasospasm of the large cerebral arteries (CVS) after aneurysmatic subarachnoid hemorrhage (aSAH) reduces cerebral perfusion and causes delayed cerebral ischemia. Although endovascular spasmolysis shows convincing angiographic results, patients often do not improve in outcome. Delayed recognition of CVS contributes substantially to this effect. Therefore, this study aimed to confirm established and to identify unknown risk factors for CVS, which can be used for risk stratification. Methods: In this monocentric, retrospective cohort study of 853 patients with aSAH, we compared demographics, clinical, and radiographic parameters at the time of aneurysm occlusion between patients who developed CVS and those who did not. Significant cohort differences were included as predictors in a multivariate analysis to address confounding. Logistic regression models were used to determine odds ratios (ORs) for the presence of CVS for each predictor. Results: Of the 853 patients treated with aSAH, 304 (32%) developed CVS. In the univariable analysis, CVS was significantly associated with young age, female sex, aneurysm location, modified Fisher score, Barrow Neurological Institute (BNI) score, and surgical interventions. In the multivariable regression analysis, we identified BNI score (OR 1.33, 95% CI 1.11 to 1.58, p=0.002), decompressive craniectomy (OR 1.93, 95% CI 1.22 to 3.04, p=0.005), and aneurysm clipping (OR 2.22, 95% CI 1.50 to 3.29, p<0.001), as independent risk factors. Conclusions: Young female patients with high BNI scores who undergo surgical interventions are more likely to develop CVS and should therefore be monitored most intensively after aneurysm occlusion.
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2023-020649
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6845: Show issues

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Article ; Online: Detection of caries lesions using a water-sensitive STIR sequence in dental MRI.

Burian, Egon / Lenhart, Nicolas / Greve, Tobias / Bodden, Jannis / Burian, Gintare / Palla, Benjamin / Probst, Florian / Probst, Monika / Beer, Meinrad / Folwaczny, Matthias / Schwarting, Julian

Scientific reports

2024 Volume 14, Issue 1, Page(s) 663

Abstract: In clinical practice, diagnosis of suspected carious lesions is verified by using conventional dental radiography (DR), including panoramic radiography (OPT), bitewing imaging, and dental X-ray. The aim of this study was to evaluate the use of magnetic ... ...

Abstract	In clinical practice, diagnosis of suspected carious lesions is verified by using conventional dental radiography (DR), including panoramic radiography (OPT), bitewing imaging, and dental X-ray. The aim of this study was to evaluate the use of magnetic resonance imaging (MRI) for caries visualization. Fourteen patients with clinically suspected carious lesions, verified by standardized dental examination including DR and OPT, were imaged with 3D isotropic T2-weighted STIR (short tau inversion recovery) and T1 FFE Black bone sequences. Intensities of dental caries, hard tissue and pulp were measured and calculated as aSNR (apparent signal to noise ratio) and aHTMCNR (apparent hard tissue to muscle contrast to noise ratio) in both sequences. Imaging findings were then correlated to clinical examination results. In STIR as well as in T1 FFE black bone images, aSNR and aHTMCNR was significantly higher in carious lesions than in healthy hard tissue (p < 0.001). Using water-sensitive STIR sequence allowed for detecting significantly lower aSNR and aHTMCNR in carious teeth compared to healthy teeth (p = 0.01). The use of MRI for the detection of caries is a promising imaging technique that may complement clinical exams and traditional imaging.
MeSH term(s)	Humans ; Dental Caries/diagnostic imaging ; Dental Caries Susceptibility ; Magnetic Resonance Imaging ; Chromosome Inversion ; Health Status
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51151-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Numerical simulation of endovascular treatment options for cerebral aneurysms

Frank, Martin / Holzberger, Fabian / Horvat, Medeea / Kirschke, Jan / Mayr, Matthias / Muhr, Markus / Nebulishvili, Natalia / Popp, Alexander / Schwarting, Julian / Wohlmuth, Barbara

2024

Abstract: Predicting the long-term success of endovascular interventions in the clinical management of cerebral aneurysms requires detailed insight into the patient-specific physiological conditions. In this work, we not only propose numerical representations of ... ...

Abstract	Predicting the long-term success of endovascular interventions in the clinical management of cerebral aneurysms requires detailed insight into the patient-specific physiological conditions. In this work, we not only propose numerical representations of endovascular medical devices such as coils, flow diverters or Woven EndoBridge but also outline numerical models for the prediction of blood flow patterns in the aneurysm cavity right after a surgical intervention. Detailed knowledge about the post-surgical state then lays the basis to assess the chances of a stable occlusion of the aneurysm required for a long-term treatment success. To this end, we propose mathematical and mechanical models of endovascular medical devices made out of thin metal wires. These can then be used for fully resolved flow simulations of the post-surgical blood flow, which in this work will be performed by means of a Lattice Boltzmann method applied to the incompressible Navier-Stokes equations and patient-specific geometries. To probe the suitability of homogenized models, we also investigate poro-elastic models to represent such medical devices. In particular, we examine the validity of this modeling approach for flow diverter placement across the opening of the aneurysm cavity. For both approaches, physiologically meaningful boundary conditions are provided from reduced-order models of the vascular system. The present study demonstrates our capabilities to predict the post-surgical state and lays a solid foundation to tackle the prediction of thrombus formation and, thus, the aneurysm occlusion in a next step.
Keywords	Mathematics - Numerical Analysis
Subject code	621
Publishing date	2024-02-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Conference proceedings: Perivascular Macrophages, new players in post-SAH microcirculatory dysfunction?

Schwarting, Julian / Liu, Xiangjiang / Plesnila, Nikolaus / Terpolilli, Nicole Angela

2022 , Page(s) V239

Title translation	Rolle perivaskulärer Makrophagen bei der posthämorrhagischen Mikrozirkulationsstörung nach experimenteller Subarachnoidalblutung
Event/congress	73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; Köln; Deutsche Gesellschaft für Neurochirurgie; 2022
Keywords	Medizin, Gesundheit
Publishing date	2022-05-25
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/22dgnc231
Database	German Medical Science

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Article ; Online: Influence of Organic Solvents on Secondary Brain Damage after Experimental Traumatic Brain Injury.

Walter, Johannes / Schwarting, Julian / Plesnila, Nikolaus / Terpolilli, Nicole A

Neurotrauma reports

2020 Volume 1, Issue 1, Page(s) 148–156

Abstract: Many compounds tested for a possible neuroprotective effect after traumatic brain injury (TBI) are not readily soluble and therefore organic solvents need to be used as a vehicle. It is, however, unclear whether these organic solvents have intrinsic ... ...

Abstract	Many compounds tested for a possible neuroprotective effect after traumatic brain injury (TBI) are not readily soluble and therefore organic solvents need to be used as a vehicle. It is, however, unclear whether these organic solvents have intrinsic pharmacological effects on secondary brain damage and may therefore interfere with experimental results. Thus, the aim of the current study was to evaluate the effect of four widely used organic solvents, dimethylsulfoxide (DMSO), Miglyol 812 (Miglyol
Language	English
Publishing date	2020-11-06
Document type	Journal Article
ISSN	2689-288X
ISSN (online)	2689-288X
DOI	10.1089/neur.2020.0029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Role of Pial Microvasospasms and Leukocyte Plugging for Parenchymal Perfusion after Subarachnoid Hemorrhage Assessed by In Vivo Multi-Photon Microscopy.

Schwarting, Julian / Nehrkorn, Kathrin / Liu, Hanhan / Plesnila, Nikolaus / Terpolilli, Nicole Angela

International journal of molecular sciences

2021 Volume 22, Issue 16

Abstract: Subarachnoid hemorrhage (SAH) is associated with acute and delayed cerebral ischemia. We suggested spasms of pial arterioles as a possible mechanism; however, it remained unclear whether and how pial microvasospasms (MVSs) induce cerebral ischemia. ... ...

Abstract	Subarachnoid hemorrhage (SAH) is associated with acute and delayed cerebral ischemia. We suggested spasms of pial arterioles as a possible mechanism; however, it remained unclear whether and how pial microvasospasms (MVSs) induce cerebral ischemia. Therefore, we used in vivo deep tissue imaging by two-photon microscopy to investigate MVSs together with the intraparenchymal microcirculation in a clinically relevant murine SAH model. Male C57BL/6 mice received a cranial window. Cerebral vessels and leukocytes were labelled with fluorescent dyes and imaged by in vivo two-photon microscopy before and three hours after SAH induced by filament perforation. After SAH, a large clot formed around the perforation site at the skull base, and blood distributed along the perivascular space of the middle cerebral artery up to the cerebral cortex. Comparing the cerebral microvasculature before and after SAH, we identified three different patterns of constrictions: pearl string, global, and bottleneck. At the same time, the volume of perfused intraparenchymal vessels and blood flow velocity in individual arterioles were significantly reduced by more than 60%. Plugging of capillaries by leukocytes was observed but infrequent. The current study demonstrates that perivascular blood is associated with spasms of pial arterioles and that these spasms result in a significant reduction in cortical perfusion after SAH. Thus, the pial microvasospasm seems to be an important mechanism by which blood in the subarachnoid space triggers cerebral ischemia after SAH. Identifying the mechanisms of pial vasospasm may therefore result in novel therapeutic options for SAH patients.
MeSH term(s)	Animals ; Brain/blood supply ; Brain/pathology ; Cerebrovascular Circulation ; Intravital Microscopy ; Leukocytes/pathology ; Male ; Mice, Inbred C57BL ; Microscopy, Fluorescence, Multiphoton ; Microvessels/pathology ; Subarachnoid Hemorrhage/pathology ; Vasospasm, Intracranial/pathology ; Mice
Language	English
Publishing date	2021-08-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22168444
Database	MEDical Literature Analysis and Retrieval System OnLINE

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