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  1. Article ; Online: Benzophenone-3 alters expression of genes encoding vascularization and epithelial-mesenchymal transition functions during Trp53-null mammary tumorigenesis.

    Morozova, Elena / Kariagina, Anastasia / Busch, Calista / Schwartz, Richard C

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2024  Volume 186, Page(s) 114540

    Abstract: Benzophenone-3 (also referred to as oxybenzone) is a putative endocrine disrupting chemical and common ingredient in sunscreens and other personal care products. We previously showed that benzophenone-3 was promotional for epithelial tumorigenesis in ... ...

    Abstract Benzophenone-3 (also referred to as oxybenzone) is a putative endocrine disrupting chemical and common ingredient in sunscreens and other personal care products. We previously showed that benzophenone-3 was promotional for epithelial tumorigenesis in mice fed adult high-fat diet, while protective against the incidence of more aggressive spindle cell tumors in the same treatment group. In this study, we show that benzophenone-3 reduces epithelial to mesenchymal transition in the epithelial tumors of these mice. This reduction in epithelial to mesenchymal transition is associated with altered expression of several genes involved in regulation of angiogenesis and epithelial to mesenchymal transition. Among the genes altered in expression, Timp1 is of particular interest because benzophenone-3 suppressed both migration and Timp1 expression in a mammary tumor cell line that displays epithelial to mesenchymal transition characteristics. These alterations in gene expression plausibly stabilize the vasculature of epithelial carcinomas and contribute to benzophenone-3 promotion of epithelial tumors, while at the same time suppress epithelial to mesenchymal transition and suppress incidence of spindle cell tumors.
    MeSH term(s) Mice ; Animals ; Epithelial-Mesenchymal Transition ; Cell Transformation, Neoplastic ; Carcinogenesis/genetics ; Carcinoma ; Neovascularization, Pathologic ; Cell Line, Tumor ; Benzophenones
    Chemical Substances oxybenzone (95OOS7VE0Y) ; Benzophenones
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2024.114540
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  2. Article ; Online: Development of the internal family systems model: Honoring contributions from family systems therapies.

    Brenner, Elizabeth G / Schwartz, Richard C / Becker, Carol

    Family process

    2023  Volume 62, Issue 4, Page(s) 1290–1306

    Abstract: We describe Richard Schwartz's development of the Internal Family Systems model (IFS) from his position as a Structural/Strategic family therapist. Four decades ago, Schwartz struggled to help clients who exhibited serious risk of harm to self and others. ...

    Abstract We describe Richard Schwartz's development of the Internal Family Systems model (IFS) from his position as a Structural/Strategic family therapist. Four decades ago, Schwartz struggled to help clients who exhibited serious risk of harm to self and others. Through a process of inquiry, he began to work with the positive intentions behind his most challenging clients' harmful thoughts and behaviors. He applied foundational ideas from family systems thinking to patterns of internal experiences. As he experimented with ways of applying these ideas, he created an approach to healing. We summarize the IFS model delineating ways a range of family systems theory and practice inform its development and contribute to its best practice. Our purposes are to inform IFS practitioners who are not trained in foundational family systems models as well as to acknowledge the significant contributions family therapy theories made in the development and best practice of the IFS model.
    MeSH term(s) Humans ; Family/psychology ; Psychoanalytic Theory
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212740-4
    ISSN 1545-5300 ; 0014-7370
    ISSN (online) 1545-5300
    ISSN 0014-7370
    DOI 10.1111/famp.12943
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  3. Book: Family therapy

    Nichols, Michael P. / Schwartz, Richard C.

    concepts and methods

    2001  

    Author's details Michael P. Nichols ; Richard C. Schwartz
    Keywords Family Therapy
    Language English
    Size XXI, 570 S. : graph. Darst.
    Edition 5. ed.
    Publisher Allyn and Bacon
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    Old title 2. Aufl. u.d.T. Nichols, Michael P.: Family therapy
    HBZ-ID HT013396202
    ISBN 0-205-31737-5 ; 978-0-205-31737-0
    Database Catalogue ZB MED Medicine, Health

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  4. Book: Systemische Therapie mit der inneren Familie

    Schwartz, Richard C. / Sweezy, Martha

    2021  

    Abstract: Die Systemische Therapie mit der inneren Familie (Internal Family Systems Therapy) wird in ihren Grundlagen und Methoden sowie der Anwendungspraxis beschrieben. Die Arbeit mit Persönlichkeitsanteilen bereichert seit gut 25 Jahren den "Werkzeugkoffer" von ...

    Title translation Internal family systems therapy
    Abstract Die Systemische Therapie mit der inneren Familie (Internal Family Systems Therapy) wird in ihren Grundlagen und Methoden sowie der Anwendungspraxis beschrieben. Die Arbeit mit Persönlichkeitsanteilen bereichert seit gut 25 Jahren den "Werkzeugkoffer" von Psychotherapeutinnen und Psychotherapeuten sowie beratenden Psychologinnen und Psychologen. Für die Neuausgabe des vorliegenden, zum Standardwerk avancierten Werks wurden die konzeptuellen Grundlagen einer kritischen Prüfung unterzogen, vor allem aber fanden die umfangreichen praktischen Erfahrungen vieler amerikanischer Therapeutinnen und Therapeuten Eingang. Neue Kapitel zur Anwendung bei verschiedenen Krankheitsbildern (etwa der Posttraumatischen Belastungsstörung, Depression und Angst) wurden integriert und es wurde größter Wert auf das richtige "How to do" gelegt. Die Techniken werden mittels Beispieldialogen, in kommentierten Fallbeispielen und zentralen Instruktionsanleitungen übersichtlich dargestellt und erhöhen so die Sicherheit und Effektivität in der praktischen Arbeit mit Einzelnen, Paaren, Familien und Gruppen bis hin zu Großgruppen. Das Buch richtet sich an: Psychotherapeutinnen und Psychotherapeuten aller Schulen, hypnosystemische Therapeutinnen und Therapeuten, systemische Familientherapeutinnen und Familientherapeuten, TeiletherapeuiInnen und Teiletherapeuten. - Inhalt: (A) Ein Überblick über die Therapie mit der inneren Familie. (1) Die Ursprünge der Therapie mit der inneren Familie. (2) Menschen als Systeme. (3) Das Selbst. (4) Lasten. (5) Das System der inneren Familie und der Körper. (6) Die Rolle des Therapeuten im IFS-Modell. - (B) Einzeltherapie mit IFS. (7) Die Behandlung vorbereiten. (8) Ein-Sicht und direkter Zugang. (9) Beschützer finden, fokussieren und füllen. (10) Beschützer - fühlen für, anfreunden mit und ihre Furcht erforschen. (11) Polarisierungen von Beschützern verändern. (12) Verbannte entlasten. (13) Innere Arbeit sicher durchführen. - (C) Die IFS-Therapie mit Familien, Paaren und größeren Systemen. (14) Die Sichtweise der Familie im IFS-Modell. (15) Einschränkungen in der IFS-Familientherapie lösen. (16) Entlastung in der IFS-Familientherapie. (17) Paare mit der IFS-Therapie behandeln. (18) Die Anwendung des IFS-Modells auf gesellschaftliche und kulturelle Systeme. - (D) Forschung und Fazit. (19) Die IFS-Forschung. (20) Die Gesetze der inneren Physik.
    Keywords Couples Therapy ; Einzelpsychotherapie ; Familiensystemtheorie ; Familientherapie ; Family Systems Theory ; Family Therapy ; Group Psychotherapy ; Gruppenpsychotherapie ; Individual Psychotherapy ; Paartherapie ; Psychotherapeutic Processes ; Psychotherapeutic Techniques ; Psychotherapeutische Prozesse ; Psychotherapeutische Techniken ; Psychotherapie ; Psychotherapy
    Language German
    Size 402 S.
    Publisher Klett-Cotta (Vollst. überarb. u. erw. Neuaufl.)
    Publishing place Stuttgart
    Document type Book
    Note Original: 2020. Internal family systems therapy. Second edition. New York City, NY: The Guilford Press
    ISBN 978-3-608-20502-2 ; 3-608-20502-0
    Database PSYNDEX

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  5. Article ; Online: Moving from acceptance toward transformation with Internal Family Systems Therapy (IFS).

    Schwartz, Richard C

    Journal of clinical psychology

    2013  Volume 69, Issue 8, Page(s) 805–816

    Abstract: Clients come to psychotherapy intent on changing, rather than accepting, their unwanted behaviors, emotions, or thoughts. The problem often is, however, that their lack of self-acceptance is the primary obstacle to change. This article describes how one ... ...

    Abstract Clients come to psychotherapy intent on changing, rather than accepting, their unwanted behaviors, emotions, or thoughts. The problem often is, however, that their lack of self-acceptance is the primary obstacle to change. This article describes how one approach, the Internal Family Systems (IFS) model, fosters clients' acceptance of all parts of themselves no matter how destructive, and how that acceptance can lead to the transformation of those parts and, in turn, of other people.
    MeSH term(s) Adaptation, Psychological ; Adult ; Humans ; Male ; Mind-Body Therapies ; Obsessive-Compulsive Disorder/therapy ; Psychotherapy/methods ; Self Concept
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219160-x
    ISSN 1097-4679 ; 0021-9762
    ISSN (online) 1097-4679
    ISSN 0021-9762
    DOI 10.1002/jclp.22016
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  6. Book: Systemische Therapie mit der inneren Familie

    Schwartz, Richard C.

    (Reihe leben lernen ; 114)

    1997  

    Title translation Internal family systems therapy
    Author's details Richard C. Schwartz. Mit einem Vorw. von Helm Stierlin
    Series title Reihe leben lernen ; 114
    Leben lernen
    Collection Leben lernen
    Keywords Family / psychology ; Family Therapy / methods ; Interpersonal Relations ; Selbst ; Multiple Realität ; Systemische Therapie
    Subject Systemische Psychotherapie
    Language German
    Size 343 S.
    Publisher Pfeiffer
    Publishing place München
    Publishing country Germany
    Document type Book
    Note Aus dem Engl. übers.
    HBZ-ID HT007481689
    ISBN 3-7904-0648-1 ; 978-3-7904-0648-1
    Database Catalogue ZB MED Medicine, Health

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    1998 A 2446 order for loan Magazin

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  7. Article ; Online: RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy.

    Zhang, Jing / Wang, Bin / Gao, Xiaoxiao / Peng, Cheng / Shan, Chao / Johnson, Silas F / Schwartz, Richard C / Zheng, Yong-Hui

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6007

    Abstract: Virus infection affects cellular proteostasis and provides an opportunity to study this cellular process under perturbation. The proteostasis network in the endoplasmic reticulum (ER) is composed of the calnexin cycle, and the two protein degradation ... ...

    Abstract Virus infection affects cellular proteostasis and provides an opportunity to study this cellular process under perturbation. The proteostasis network in the endoplasmic reticulum (ER) is composed of the calnexin cycle, and the two protein degradation pathways ER-associated protein degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD/ER-phagy/reticulophagy). Here we show that calnexin and calreticulin trigger Zaire Ebolavirus (EBOV) glycoprotein GP
    MeSH term(s) Autophagy ; Calnexin/metabolism ; Calreticulin/metabolism ; Endoplasmic Reticulum-Associated Degradation ; Hemorrhagic Fever, Ebola ; Humans ; Ligases/metabolism ; Lysine/metabolism ; Mitochondrial Proteins/metabolism ; Molecular Chaperones/metabolism ; Proteostasis ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Calreticulin ; Mitochondrial Proteins ; Molecular Chaperones ; Sequestosome-1 Protein ; Ubiquitin ; Calnexin (139873-08-8) ; RNF185 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Ligases (EC 6.-) ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33805-9
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  8. Book: Family therapy

    Nichols, Michael P. / Schwartz, Richard C.

    concepts and methods

    1990  

    Author's details Michael P. Nichols ; Richard C. Schwartz
    Keywords Family Therapy
    Language English
    Size XIV, 610 S.
    Edition 2. ed., 1. [Dr.]
    Publisher Allyn and Bacon
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    New title 5. Aufl. u.d.T. Family therapy
    HBZ-ID HT003963393
    ISBN 0-205-12887-4 ; 978-0-205-12887-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 6008 order for loan Magazin

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  9. Article ; Online: The Association between Sex Hormones, Pubertal Milestones and Benzophenone-3 Exposure, Measured by Urinary Biomarker or Questionnaire.

    Giannini, Courtney M / Huang, Bin / Chandler, Donald W / Fassler, Cecily S / Schwartz, Richard C / Biro, Frank M / Pinney, Susan M

    International journal of environmental health research

    2021  Volume 32, Issue 10, Page(s) 2135–2148

    Abstract: Experimental studies have suggested benzophenone-3 (BP-3), a sunscreen ingredient, may have endocrine-disrupting properties. A cohort of girls were recruited at ages 6-7 years and returned semi-annually for pubertal maturation staging, provided blood for ...

    Abstract Experimental studies have suggested benzophenone-3 (BP-3), a sunscreen ingredient, may have endocrine-disrupting properties. A cohort of girls were recruited at ages 6-7 years and returned semi-annually for pubertal maturation staging, provided blood for serum hormone analyses [estradiol, estrone, testosterone, dehydroepiandrosterone-sulfate (DHEA-S)], and urine to measure BP-3 concentrations. We found a significant negative linear association between amount of reported sunscreen use and testosterone levels at the onset of puberty (N = 157, adjusted β = -0.0163, 97.5% CI:-0.0300,-0.0026). The 2nd quartile of the BP-3 biomarker had earlier thelarche compared to the 1st quartile (N = 282, adjusted HR = 1.584, 97.5% CI:1.038,2.415). Results suggest that higher report of sunscreen use may be associated with lower testosterone levels at thelarche and a non-linear relationship between the BP-3 urinary biomarker and onset of puberty, although the clinical significance of the finding is limited and may be a random effect. Improved methods of BP-3 exposure characterization are needed.
    MeSH term(s) Benzophenones ; Biomarkers ; Child ; Dehydroepiandrosterone ; Estradiol ; Estrone ; Female ; Gonadal Steroid Hormones ; Humans ; Longitudinal Studies ; Sulfates ; Sunscreening Agents ; Surveys and Questionnaires ; Testosterone
    Chemical Substances Benzophenones ; Biomarkers ; Gonadal Steroid Hormones ; Sulfates ; Sunscreening Agents ; Estrone (2DI9HA706A) ; Testosterone (3XMK78S47O) ; Dehydroepiandrosterone (459AG36T1B) ; Estradiol (4TI98Z838E) ; oxybenzone (95OOS7VE0Y)
    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104887-6
    ISSN 1369-1619 ; 0960-3123
    ISSN (online) 1369-1619
    ISSN 0960-3123
    DOI 10.1080/09603123.2021.1947990
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  10. Book: Metaframeworks

    Breunlin, Douglas C. / Schwartz, Richard C. / MacKune-Karrer, Betty

    transcending the models of family therapy

    (Jossey-Bass social and behavioral science series)

    1992  

    Author's details [Douglas C. Breunlin ; Richard C. Schwartz ; Betty Mac Kune-Karrer]
    Series title Jossey-Bass social and behavioral science series
    Keywords Family Therapy ; Familientherapie
    Subject Familienpsychotherapie
    Size XX, 396 S. : Ill., graph. Darst.
    Edition 1. ed., 1. print.
    Publisher Jossey-Bass
    Publishing place San Francisco
    Publishing country United States
    Document type Book
    HBZ-ID HT004338348
    ISBN 1-55542-426-0 ; 978-1-55542-426-8
    Database Catalogue ZB MED Medicine, Health

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    1992 A 5186 order for loan Magazin

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