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  1. Article ; Online: Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells.

    Cheng, Ya-Wen / Anzell, Anthony R / Morosky, Stefanie A / Schwartze, Tristin A / Hinck, Cynthia S / Hinck, Andrew P / Roman, Beth L / Davidson, Lance A

    Cells

    2024  Volume 13, Issue 3

    Abstract: Endothelial cells (ECs) respond to concurrent stimulation by biochemical factors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed ... ...

    Abstract Endothelial cells (ECs) respond to concurrent stimulation by biochemical factors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed mechanisms linking flow-mechanical cues and biochemical signaling remain unclear. Activin receptor-like kinase 1 (ALK1) integrates SS and ALK1-ligand cues in ECs;
    MeSH term(s) Humans ; Endothelial Cells ; Ligands ; Telangiectasia, Hereditary Hemorrhagic/genetics ; Arteriovenous Malformations ; Signal Transduction ; Bone Morphogenetic Proteins
    Chemical Substances Ligands ; BMP10 protein, human ; Bone Morphogenetic Proteins
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13030285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts.

    White, Stephen E / Schwartze, Tristin A / Mukundan, Ananya / Schoenherr, Christina / Singh, Shashi P / van Dinther, Maarten / Cunningham, Kyle T / White, Madeleine P J / Campion, Tiffany / Pritchard, John / Hinck, Cynthia S / Ten Dijke, Peter / Inman, Gareth / Maizels, Rick M / Hinck, Andrew P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The murine helminth ... ...

    Abstract The murine helminth parasite
    Language English
    Publishing date 2023-12-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.22.573140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Design of High Affinity Binders to Convex Protein Target Sites.

    Baker, David / Yang, Wei / Hicks, Derrick R / Ghosh, Agnidipta / Schwartze, Tristin A / Coventry, Brian / Goreshnik, Inna / Allen, Aza / Halabiya, Samer / Kim, ChanJohng / Hinck, Cynthia S / Lee, David S / Bera, Asim / Li, Zhe / Wang, Yujia / Schlichthaerle, Thomas / Cao, Longxing / Huang, Buwei / Garrett, Sarah /
    Gerben, Stacey R / Rettie, Stephen / Heine, Piper / Edman, Natasha / Murray, Analisa N / Carter, Lauren P / Stewart, Lance / Almo, Steven / Hinck, Andrew P

    bioRxiv : the preprint server for biology

    2024  

    Abstract: While there has been progress in the de novo design of small globular miniproteins (50-65 residues) to bind to primarily concave regions of a target protein surface, computational design of minibinders to convex binding sites remains an outstanding ... ...

    Abstract While there has been progress in the de novo design of small globular miniproteins (50-65 residues) to bind to primarily concave regions of a target protein surface, computational design of minibinders to convex binding sites remains an outstanding challenge due to low level of overall shape complementarity. Here, we describe a general approach to generate computationally designed proteins which bind to convex target sites that employ geometrically matching concave scaffolds. We used this approach to design proteins binding to TGFβRII, CTLA-4 and PD-L1 which following experimental optimization have low nanomolar to picomolar affinities and potent biological activity. Co-crystal structures of the TGFβRII and CTLA-4 binders in complex with the receptors are in close agreement with the design models. Our approach provides a general route to generating very high affinity binders to convex protein target sites.
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.05.01.592114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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