Article ; Online: CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone mRNA processing.
2024 Volume 30, Issue 3, Page(s) 281–297
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited effective treatment options, potentiating the importance of uncovering novel drug targets. Here, we target cleavage and polyadenylation specificity factor 3 (CPSF3), the 3' ... ...
| Abstract | Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited effective treatment options, potentiating the importance of uncovering novel drug targets. Here, we target cleavage and polyadenylation specificity factor 3 (CPSF3), the 3' endonuclease that catalyzes mRNA cleavage during polyadenylation and histone mRNA processing. We find that |
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| MeSH term(s) | Humans ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Histones/genetics ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Polyadenylation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism | |||||
| Chemical Substances | Histones ; RNA, Messenger ; CPSF3 protein, human | |||||
| Language | English | |||||
| Publishing date | 2024-02-16 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1241540-6 | |||||
| ISSN | 1469-9001 ; 1355-8382 | |||||
| ISSN (online) | 1469-9001 | |||||
| ISSN | 1355-8382 | |||||
| DOI | 10.1261/rna.079931.123 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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