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  1. Article ; Online: Advancing Psychiatric Biomarker Discovery Through Multimodal Machine Learning.

    Schwarz, Emanuel

    Biological psychiatry

    2022  Volume 91, Issue 6, Page(s) 524–525

    MeSH term(s) Biomarkers ; Biomedical Research ; Machine Learning
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2021.12.009
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    Zs.A 720: Show issues Location:
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  2. Article ; Online: Delayed-onset Angioedema Following a Snakebite in a Patient on ACE Inhibitors: A Case Report.

    Sampson, Christopher Scott / Schwarz, Evan

    Clinical practice and cases in emergency medicine

    2023  Volume 7, Issue 3, Page(s) 178–181

    Abstract: Introduction: Angiotensin converting enzyme inhibitors (ACEI) are a common class of medications prescribed to patients for hypertension. Anti-hypertensive use is not normally considered an important factor when treating patients with crotalid ... ...

    Abstract Introduction: Angiotensin converting enzyme inhibitors (ACEI) are a common class of medications prescribed to patients for hypertension. Anti-hypertensive use is not normally considered an important factor when treating patients with crotalid envenomations; however, in combination with the venom in this patient, it may have resulted in angioedema.
    Case report: A 65-year-old male on ACEI presented to his community emergency department following a snake envenomation to his thumb. Six vials of Crotalidae polyvalent immune fab were administered, and he was transferred to a referral center. Approximately 18 hours after the envenomation, the patient complained of tongue swelling and difficulty speaking. There was evidence of angioedema, with the right side of the tongue significantly enlarged compared to the left. He was intubated for airway protection and remained on a ventilator for three days.
    Conclusion: Angiotensin converting enzyme inhibitors may potentiate the effects of exogenous bradykinin as some snake venom has naturally occurring bradykinin, which may further amplify its effects. Extra vigilance may be warranted for the development of angioedema in patients receiving ACEI.
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2474-252X
    ISSN (online) 2474-252X
    DOI 10.5811/cpcem.1463
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  3. Article ; Online: How do you justify GMC fees?

    Schwarz, Ed

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2019  Volume 69, Issue 684, Page(s) 333

    MeSH term(s) Fees and Charges ; General Practice ; General Practitioners ; Humans ; Licensure, Medical/economics
    Language English
    Publishing date 2019-06-27
    Publishing country England
    Document type Letter
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp19X704273
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    Zs.B 576: Show issues Location:
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  4. Article ; Online: From mechanistic insight towards clinical implementation using normative modeling.

    Rieg, Thilo / Schwarz, Emanuel

    Nature computational science

    2022  Volume 2, Issue 5, Page(s) 278–280

    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 2662-8457
    ISSN (online) 2662-8457
    DOI 10.1038/s43588-022-00248-7
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  5. Article ; Online: Analysis of potential biomarkers of response to IL-12 therapy.

    Schwarz, Emily / Carson, William E

    Journal of leukocyte biology

    2022  Volume 112, Issue 3, Page(s) 557–567

    Abstract: IL-12 is a proinflammatory cytokine capable of inducing a wide range of effects on both innate and adaptive immune responses. Its stimulatory effects on T cells and NK cells have led to its classification as a potential inducer of antitumor immunity. ... ...

    Abstract IL-12 is a proinflammatory cytokine capable of inducing a wide range of effects on both innate and adaptive immune responses. Its stimulatory effects on T cells and NK cells have led to its classification as a potential inducer of antitumor immunity. Clinical trials have been attempting to harness its immune-stimulating capacity since the 1990s and have had much success despite notable toxicity issues early on. Several methods of IL-12 delivery have been employed including i.v., s.c., and local administrations as well as plasmid and gene therapies. However, despite differing methods, dosages, and cancer types utilized in these clinical trials, there are still many patients who do not respond to IL-12 therapy. This creates an opportunity for further investigation into the immunologic differences between responding and nonresponding patients in order to better understand the variable efficacy of IL-12 therapy. This review focuses on a limited collection of IL-12 clinical trials, which further analyzed these individual subsets and detected biologic variables correlating with differential patient responses. A comprehensive review of these potential biomarkers identified 7 analytes that correlated with beneficial patient responses in 3 or more clinical trials. These were increased levels of IFN-γ, IP-10, TNF-α, MIP-1α, MIG, and CD4
    MeSH term(s) Biomarkers ; Cytokines ; Humans ; Interleukin-12/therapeutic use ; Killer Cells, Natural ; T-Lymphocyte Subsets
    Chemical Substances Biomarkers ; Cytokines ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2022-07-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.5RU1221-675R
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    Zs.A 603: Show issues Location:
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  6. Article: Locum Tenens

    Jotte, Randy / Gaddis, Gary / Lewis, Larry / Schwarz, Evan

    Missouri medicine

    2023  Volume 120, Issue 5, Page(s) 333–337

    MeSH term(s) Humans ; Physicians ; Personnel Staffing and Scheduling
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
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    Zs.B 182: Show issues Location:
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  7. Article ; Online: Cystine knot growth factors and their functionally versatile proregions.

    Schwarz, Elisabeth

    Biological chemistry

    2017  Volume 398, Issue 12, Page(s) 1295–1308

    Abstract: The cystine knot disulfide pattern has been found to be widespread in nature, since it has been detected in proteins from plants, marine snails, spiders and mammals. Cystine knot proteins are secreted proteins. Their functions range from defense ... ...

    Abstract The cystine knot disulfide pattern has been found to be widespread in nature, since it has been detected in proteins from plants, marine snails, spiders and mammals. Cystine knot proteins are secreted proteins. Their functions range from defense mechanisms as toxins, e.g. ion channel or enzyme inhibitors, to hormones, blood factors and growth factors. Cystine knot proteins can be divided into two superordinate groups. (i) The cystine knot peptides, also referred to - with other non-cystine knot proteins - as knottins, with linear and cyclic polypeptide chains. (ii) The cystine knot growth factor family, which is in the focus of this article. The disulfide ring structure of the cystine knot peptides is made up by the half-cystines 1-4 and 2-5, and the threading disulfide bond is formed by the half-cystines, 3-6. In the growth factor group, the disulfides of half-cystines 1 and 4 pass the ring structure formed by the half-cystines 2-5 and 3-6. In this review, special emphasis will be devoted to the growth factor cystine knot proteins and their proregions. The latter have shifted into the focus of scientific interest as their important biological roles are just to be unravelled.
    MeSH term(s) Animals ; Cystine/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/chemistry ; Intercellular Signaling Peptides and Proteins/metabolism ; Protein Conformation
    Chemical Substances Intercellular Signaling Peptides and Proteins ; Cystine (48TCX9A1VT)
    Language English
    Publishing date 2017-11-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2017-0163
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  8. Article ; Online: A gene-based review of RGS4 as a putative risk gene for psychiatric illness.

    Schwarz, Emanuel

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

    2017  Volume 177, Issue 2, Page(s) 267–273

    Abstract: Considerable efforts have been made to characterize RGS4 as a potential candidate gene for schizophrenia. Investigations span across numerous modalities and include explorations of genetic risk associations, mRNA and protein levels in the brain, and ... ...

    Abstract Considerable efforts have been made to characterize RGS4 as a potential candidate gene for schizophrenia. Investigations span across numerous modalities and include explorations of genetic risk associations, mRNA and protein levels in the brain, and functionally relevant interactions with other candidate genes as well as links to schizophrenia relevant neural phenotypes. While these lines of investigations have yielded partially inconsistent findings, they provide a perspective on RGS4 as an important part of a larger biological system contributing to schizophrenia risk. This gene-based review aims to provide a comprehensive overview of published data from different experimental modalities and discusses the current knowledge of RGS4's systems-biological impact on the schizophrenia pathology.
    MeSH term(s) Genetic Predisposition to Disease ; Humans ; Mental Disorders/genetics ; Phenotype ; Prefrontal Cortex/pathology ; RGS Proteins/genetics ; RGS Proteins/physiology ; RNA, Messenger/genetics ; Risk Factors ; Schizophrenia/genetics
    Chemical Substances RGS Proteins ; RNA, Messenger ; RGS4 protein (175335-35-0)
    Language English
    Publishing date 2017-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2143866-3
    ISSN 1552-485X ; 1552-4841
    ISSN (online) 1552-485X
    ISSN 1552-4841
    DOI 10.1002/ajmg.b.32547
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  9. Conference proceedings: Können Sprechende von CI-Tragenden nach ihren Stimmen unterschieden werden?

    Schwarz, Eva / Durisin, Martin / Stadler, Beate

    2024  , Page(s) 84

    Event/congress 26. Jahrestagung der Deutschen Gesellschaft für Audiologie; Aalen; Deutsche Gesellschaft für Audiologie e.V.; 2024
    Keywords Medizin, Gesundheit
    Publishing date 2024-03-05
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/24dga084
    Database German Medical Science

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  10. Article ; Online: Identification and Clinical Translation of Biomarker Signatures: Statistical Considerations.

    Schwarz, Emanuel

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1546, Page(s) 103–114

    Abstract: Powerful machine learning tools exist to extract biological patterns for diagnosis or prediction from high-dimensional datasets. Simultaneous advances in high-throughput profiling technologies have led to a rapid acceleration of biomarker discovery ... ...

    Abstract Powerful machine learning tools exist to extract biological patterns for diagnosis or prediction from high-dimensional datasets. Simultaneous advances in high-throughput profiling technologies have led to a rapid acceleration of biomarker discovery investigations across all areas of medicine. However, the translation of biomarker signatures into clinically useful tools has thus far been difficult. In this chapter, several important considerations are discussed that influence such translation in the context of classifier design. These include aspects of variable selection that go beyond classification accuracy, as well as effects of variability on assay stability and sample size. The consideration of such factors may lead to an adaptation of biomarker discovery approaches, aimed at an optimal balance of performance and clinical translatability.
    MeSH term(s) Biomarkers ; High-Throughput Screening Assays/methods ; High-Throughput Screening Assays/standards ; Humans ; Machine Learning ; Molecular Diagnostic Techniques/methods ; Molecular Diagnostic Techniques/standards ; Reproducibility of Results ; Sample Size ; Scientific Experimental Error ; Translational Medical Research/methods ; Translational Medical Research/standards
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-11-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-6730-8_6
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