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Book ; Thesis: Die Epiphyseolysis capitis femoris

Schwarz, Jan-Hendrik

Nachuntersuchungsergebnisse von 67 Patienten über einen Zeitraum bis zu 11 Jahren

1987

Size	81 S. : Ill., graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hamburg, Univ., Diss., 1987
HBZ-ID	HT003325265
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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89 D 4100	order for loan	Magazin

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Book ; Online ; Thesis: Characterization of recombinant Modified Vaccinia virus Ankara delivering Zika virus nonstructural proteins NS2B and NS3pro

Schwarz, Jan Hendrik [Verfasser] / Sutter, Gerd [Akademischer Betreuer]

2021

Author's details	Jan Hendrik Schwarz ; Betreuer: Gerd Sutter
Keywords	Tiere (Zoologie) ; Animals (Zoology)
Subject code	sg590
Language	English
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Obstetric Ultrasonography to Detect Fetal Abnormalities in a Mouse Model for Zika Virus Infection

Forster, Dominik / Schwarz, Jan Hendrik / Brosinski, Katrin / Kalinke, Ulrich / Sutter, Gerd / Volz, Asisa

Viruses. 2020 Jan. 07, v. 12, no. 1

2020

Abstract: In 2015 Zika virus (ZIKV) emerged for the first time in South America. The following ZIKV epidemic resulted in the appearance of a clinical phenotype with microcephaly and other severe malformations in newborns. So far, mechanisms of ZIKV induced damage ... ...

Abstract	In 2015 Zika virus (ZIKV) emerged for the first time in South America. The following ZIKV epidemic resulted in the appearance of a clinical phenotype with microcephaly and other severe malformations in newborns. So far, mechanisms of ZIKV induced damage to the fetus are not completely understood. Previous data suggest that ZIKV may bypass the placenta to reach the fetus. Thus, animal models for ZIKV infection are important to facilitate studies about ZIKV infection during pregnancy. Here, we used ultrasound based imaging (USI) to characterize ZIKV induced pathogenesis in the pregnant Type I interferon receptor-deficient (IFNAR-/-) mouse model. Based on USI we suggest the placenta to be a primary target organ of ZIKV infection enabling ZIKV spreading to the fetus. Moreover, in addition to direct infection of the fetus, the placental ZIKV infection may cause an indirect damage to the fetus through reduced uteroplacental perfusion leading to intrauterine growth retardation (IUGR) and fetal complications as early as embryonic day (ED) 12.5. Our data confirmed the capability of USI to characterize ZIKV induced modifications in mouse fetuses. Data from further studies using USI to monitor ZIKV infections will contribute to a better understanding of ZIKV infection in pregnant IFNAR-/- mice.
Keywords	Zika virus ; abnormal development ; animal models ; congenital abnormalities ; fetus ; growth retardation ; image analysis ; interferons ; mice ; neonates ; pathogenesis ; phenotype ; placenta ; pregnancy ; ultrasonics ; ultrasonography
Language	English
Dates of publication	2020-0107
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v12010072
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Obstetric Ultrasonography to Detect Fetal Abnormalities in a Mouse Model for Zika Virus Infection.

Forster, Dominik / Schwarz, Jan Hendrik / Brosinski, Katrin / Kalinke, Ulrich / Sutter, Gerd / Volz, Asisa

Viruses

2020 Volume 12, Issue 1

Abstract	In 2015 Zika virus (ZIKV) emerged for the first time in South America. The following ZIKV epidemic resulted in the appearance of a clinical phenotype with microcephaly and other severe malformations in newborns. So far, mechanisms of ZIKV induced damage to the fetus are not completely understood. Previous data suggest that ZIKV may bypass the placenta to reach the fetus. Thus, animal models for ZIKV infection are important to facilitate studies about ZIKV infection during pregnancy. Here, we used ultrasound based imaging (USI) to characterize ZIKV induced pathogenesis in the pregnant Type I interferon receptor-deficient (IFNAR-/-) mouse model. Based on USI we suggest the placenta to be a primary target organ of ZIKV infection enabling ZIKV spreading to the fetus. Moreover, in addition to direct infection of the fetus, the placental ZIKV infection may cause an indirect damage to the fetus through reduced uteroplacental perfusion leading to intrauterine growth retardation (IUGR) and fetal complications as early as embryonic day (ED) 12.5. Our data confirmed the capability of USI to characterize ZIKV induced modifications in mouse fetuses. Data from further studies using USI to monitor ZIKV infections will contribute to a better understanding of ZIKV infection in pregnant IFNAR-/- mice.
MeSH term(s)	Animals ; Disease Models, Animal ; Female ; Fetus/diagnostic imaging ; Fetus/pathology ; Fetus/virology ; Infectious Disease Transmission, Vertical ; Mice ; Mice, Inbred C57BL ; Placenta/diagnostic imaging ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/diagnostic imaging ; Pregnancy Complications, Infectious/virology ; Receptor, Interferon alpha-beta/genetics ; Specific Pathogen-Free Organisms ; Ultrasonography ; Zika Virus Infection/diagnostic imaging ; Zika Virus Infection/pathology
Chemical Substances	Receptor, Interferon alpha-beta (156986-95-7)
Language	English
Publishing date	2020-01-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12010072
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Short- and Long-Interval Prime-Boost Vaccination with the Candidate Vaccines MVA-SARS-2-ST and MVA-SARS-2-S Induces Comparable Humoral and Cell-Mediated Immunity in Mice.

Kalodimou, Georgia / Jany, Sylvia / Freudenstein, Astrid / Schwarz, Jan Hendrik / Limpinsel, Leonard / Rohde, Cornelius / Kupke, Alexandra / Becker, Stephan / Volz, Asisa / Tscherne, Alina / Sutter, Gerd

Viruses

2023 Volume 15, Issue 5

Abstract: The COVID-19 pandemic caused significant human health and economic consequences. Due to the ability of SARS-CoV-2 to spread rapidly and to cause severe disease and mortality in certain population groups, vaccines are essential for controlling the ... ...

Abstract	The COVID-19 pandemic caused significant human health and economic consequences. Due to the ability of SARS-CoV-2 to spread rapidly and to cause severe disease and mortality in certain population groups, vaccines are essential for controlling the pandemic in the future. Several licensed vaccines have shown improved protection against SARS-CoV-2 after extended-interval prime-boost immunizations in humans. Therefore, in this study, we aimed to compare the immunogenicity of our two Modified Vaccinia virus Ankara (MVA) based COVID-19 candidate vaccines MVA-SARS-2-S and MVA-SARS-2-ST after short- and long-interval prime-boost immunization schedules in mice. We immunized BALB/c mice using 21-day (short-interval) or 56-day (long-interval) prime-boost vaccination protocols and analyzed spike (S)-specific CD8 T cell immunity and humoral immunity. The two schedules induced robust CD8 T cell responses with no significant differences in their magnitude. Furthermore, both candidate vaccines induced comparable levels of total S, and S2-specific IgG binding antibodies. However, MVA-SARS-2-ST consistently elicited higher amounts of S1-, S receptor binding domain (RBD), and SARS-CoV-2 neutralizing antibodies in both vaccination protocols. Overall, we found very comparable immune responses following short- or long-interval immunization. Thus, our results suggest that the chosen time intervals may not be suitable to observe potential differences in antigen-specific immunity when testing different prime-boost intervals with our candidate vaccines in the mouse model. Despite this, our data clearly showed that MVA-SARS-2-ST induced superior humoral immune responses relative to MVA-SARS-2-S after both immunization schedules.
MeSH term(s)	Humans ; Animals ; Mice ; SARS-CoV-2 ; Pandemics ; COVID-19/prevention & control ; Vaccinia virus ; Vaccination/methods ; Antibodies, Viral ; Immunity, Cellular ; Immunity, Humoral
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15051180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Obstetric Ultrasonography to Detect Fetal Abnormalities in a Mouse Model for Zika Virus Infection.

Forster, Dominik / Schwarz, Jan Hendrik / Brosinski, Katrin / Kalinke, Ulrich / Sutter, Gerd / Volz, Asisa

Viruses

2020

Abstract	In 2015 Zika virus (ZIKV) emerged for the first time in South America. The following ZIKV epidemic resulted in the appearance of a clinical phenotype with microcephaly and other severe malformations in newborns. So far, mechanisms of ZIKV induced damage to the fetus are not completely understood. Previous data suggest that ZIKV may bypass the placenta to reach the fetus. Thus, animal models for ZIKV infection are important to facilitate studies about ZIKV infection during pregnancy. Here, we used ultrasound based imaging (USI) to characterize ZIKV induced pathogenesis in the pregnant Type I interferon receptor-deficient (IFNAR-/-) mouse model. Based on USI we suggest the placenta to be a primary target organ of ZIKV infection enabling ZIKV spreading to the fetus. Moreover, in addition to direct infection of the fetus, the placental ZIKV infection may cause an indirect damage to the fetus through reduced uteroplacental perfusion leading to intrauterine growth retardation (IUGR) and fetal complications as early as embryonic day (ED) 12.5. Our data confirmed the capability of USI to characterize ZIKV induced modifications in mouse fetuses. Data from further studies using USI to monitor ZIKV infections will contribute to a better understanding of ZIKV infection in pregnant IFNAR-/- mice.
Keywords	Zika virus ; pregnancy ; ultrasound ; uteroplacental infection ; viral pathogenesis
Subject code	570
Language	English
Publishing date	2020-01-07
Publisher	MDPI
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in Rodents.

Bošnjak, Berislav / Odak, Ivan / Barros-Martins, Joana / Sandrock, Inga / Hammerschmidt, Swantje I / Permanyer, Marc / Patzer, Gwendolyn E / Greorgiev, Hristo / Gutierrez Jauregui, Rodrigo / Tscherne, Alina / Schwarz, Jan Hendrik / Kalodimou, Georgia / Ssebyatika, George / Ciurkiewicz, Malgorzata / Willenzon, Stefanie / Bubke, Anja / Ristenpart, Jasmin / Ritter, Christiane / Tuchel, Tamara /

Meyer Zu Natrup, Christian / Shin, Dai-Lun / Clever, Sabrina / Limpinsel, Leonard / Baumgärtner, Wolfgang / Krey, Thomas / Volz, Asisa / Sutter, Gerd / Förster, Reinhold

Frontiers in immunology

2021 Volume 12, Page(s) 772240

Abstract: Antigen-specific tissue-resident memory T cells (Trms) and neutralizing IgA antibodies provide the most effective protection of the lungs from viral infections. To induce those essential components of lung immunity against SARS-CoV-2, we tested various ... ...

Abstract	Antigen-specific tissue-resident memory T cells (Trms) and neutralizing IgA antibodies provide the most effective protection of the lungs from viral infections. To induce those essential components of lung immunity against SARS-CoV-2, we tested various immunization protocols involving intranasal delivery of a novel Modified Vaccinia virus Ankara (MVA)-SARS-2-spike vaccine candidate. We show that a single intranasal MVA-SARS-CoV-2-S application in mice strongly induced pulmonary spike-specific CD8
MeSH term(s)	Administration, Intranasal ; Animals ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Cell Line ; Chlorocebus aethiops ; Cricetinae ; Genetic Vectors ; Immunization, Secondary ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Lung/immunology ; Male ; Mice ; Mice, Inbred C57BL ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Th1 Cells/immunology ; Vaccination ; Vaccines, Subunit/immunology ; Vaccinia virus/immunology ; Vero Cells ; Viral Load/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; Vaccines, Subunit ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-11-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.772240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA-SARS-2-S in preclinical vaccination.

Tscherne, Alina / Schwarz, Jan Hendrik / Rohde, Cornelius / Kupke, Alexandra / Kalodimou, Georgia / Limpinsel, Leonard / Okba, Nisreen M A / Bošnjak, Berislav / Sandrock, Inga / Odak, Ivan / Halwe, Sandro / Sauerhering, Lucie / Brosinski, Katrin / Liangliang, Nan / Duell, Elke / Jany, Sylvia / Freudenstein, Astrid / Schmidt, Jörg / Werner, Anke /

Gellhorn Serra, Michelle / Klüver, Michael / Guggemos, Wolfgang / Seilmaier, Michael / Wendtner, Clemens-Martin / Förster, Reinhold / Haagmans, Bart L / Becker, Stephan / Sutter, Gerd / Volz, Asisa

Proceedings of the National Academy of Sciences of the United States of America

2021 Volume 118, Issue 28

Abstract: Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) has emerged as the infectious agent causing the pandemic coronavirus disease 2019 (COVID-19) with dramatic consequences for global human health and economics. Previously, we reached ... ...

Abstract	Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) has emerged as the infectious agent causing the pandemic coronavirus disease 2019 (COVID-19) with dramatic consequences for global human health and economics. Previously, we reached clinical evaluation with our vector vaccine based on modified vaccinia virus Ankara (MVA) against the Middle East respiratory syndrome coronavirus (MERS-CoV), which causes an infection in humans similar to SARS and COVID-19. Here, we describe the construction and preclinical characterization of a recombinant MVA expressing full-length SARS-CoV-2 spike (S) protein (MVA-SARS-2-S). Genetic stability and growth characteristics of MVA-SARS-2-S, plus its robust expression of S protein as antigen, make it a suitable candidate vaccine for industrial-scale production. Vaccinated mice produced S-specific CD8
MeSH term(s)	Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/standards ; Dose-Response Relationship, Immunologic ; Humans ; Mice ; Mice, Inbred BALB C ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes ; Vaccination ; Vaccinia virus
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-06-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2026207118
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Die Epiphyseolysis capitis femoris

Schwarz, Jan-Hendrik

Nachuntersuchungsergebnisse von 67 Patienten über einen Zeitraum bis zu 11 Jahren

1987

Author's details	vorgelegt von Jan-Hendrik Schwarz
Language	German
Size	81 S, graph. Darst., Ill, 21 cm
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ.--Hamburg, 1988
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA SARS 2 S in preclinical vaccination

Tscherne, Alina / Schwarz, Jan Hendrik / Rohde, Cornelius / Kupke, Alexandra / Kalodimou, Georgia / Limpinsel, Leonard / Okba, Nisreen M.A. / Bosnjak, Berislav / Sandrock, Inga / Halwe, Sandro / Sauerhering, Lucie / Printz, Katrin / Nan, Liangliang / Duell, Elke / Jany, Sylvia / Freudenstein, Astrid / Schmidt, Joerg / Werner, Anke / Gellhorn, Michelle /

Kluever, Michael / Guggemos, Wolfgang / Seilmaier, Michael / Wendtner, Clemens / Foerster, Reinhold / Haagmans, Bart / Becker, Stephan / Sutter, Gerd / Volz, Asisa

bioRxiv

Abstract: The severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) has emerged as the infectious agent causing the pandemic coronavirus disease 2019 (COVID-19) with dramatic consequences for global human health and economics. Previously, we reached ... ...

Abstract	The severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) has emerged as the infectious agent causing the pandemic coronavirus disease 2019 (COVID-19) with dramatic consequences for global human health and economics. Previously, we reached clinical evaluation with our vector vaccine based on vaccinia virus MVA against the Middle East respiratory syndrome coronavirus (MERS-CoV), which causes an infection in humans similar to SARS and COVID-19. Here, we describe the construction and preclinical characterization of a recombinant MVA expressing full-length SARS-CoV-2 spike (S) protein (MVA-SARS-2-S). Genetic stability and growth characteristics of MVA-SARS-2-S, plus its robust synthesis of S antigen, make it a suitable candidate vaccine for industrial scale production. Vaccinated mice produced S antigen-specific CD8+ T cells and serum antibodies binding to S glycoprotein that neutralized SARS-CoV 2. Prime-boost vaccination with MVA-SARS-2-S protected mice sensitized with a human ACE2-expressing adenovirus from SARS-CoV-2 infection. MVA-SARS-2-S is currently being investigated in a phase I clinical trial as aspirant for developing a safe and efficacious vaccine against COVID-19.
Keywords	covid19
Language	English
Publishing date	2021-01-11
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2021.01.09.426032
Database	COVID19

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