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  1. Book: Autismusbilder

    Schwarz, Katja

    zur Geschichte der Autismusforschung

    2020  

    Abstract: Wie ist das Phänomen "Autismus" zu verstehen? Als definierbares Krankheitsbild, als Störung oder als Normalvariante menschlicher Existenz, als eine Form menschlichen Seins? Vor dem Hintergrund dieses Spannungsfeldes bietet die Publikation einen Überblick ...

    Author's details Katja Schwarz
    Abstract Wie ist das Phänomen "Autismus" zu verstehen? Als definierbares Krankheitsbild, als Störung oder als Normalvariante menschlicher Existenz, als eine Form menschlichen Seins? Vor dem Hintergrund dieses Spannungsfeldes bietet die Publikation einen Überblick über die Geschichte des Autismus und der Autismusforschung. In der Auseinandersetzung mit zahlreichen Autorinnen und Autoren, die sich vom frühen 20. Jahrhundert bis in die Gegenwart mit dem Thema befasst haben, entsteht ein deutliches Bild davon, wie Autismus beschrieben wurde und wird, und nicht zuletzt, welche Haltungen respektive Menschenbilder hinter dem jeweiligen Zugang zu entdecken sind.
    Keywords Autismus ; Behinderung ; Inklusion ; Krankheitsbilder ; Norm ; Deutschland ; Forschung ; Geschichte 1896-2017
    Subject Wissenschaftliche Forschung ; Forschungen ; Autismus-Spektrum-Störung ; Autism
    Subject code 370
    Language German
    Size 339 Seiten, Illustrationen, Diagramme, 23 cm x 15 cm
    Edition 1. Auflage
    Publisher Beltz Juventa
    Publishing place Weinheim ; Basel
    Publishing country Germany
    Document type Book
    HBZ-ID HT020465957
    ISBN 978-3-7799-6284-7 ; 3-7799-6284-5 ; 9783779955849 ; 3779955849
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 993 available for loan (reading room) Lesesaal EG

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  2. Book ; Thesis: Messung der Feinstaubemissionen der Partikelfraktionen PM10, PM2,5 und PM1 und der Stickoxidemissionen NO, NO2 und NOx beim Verrauchen der Zigarillomarken Moods und Cohiba mini im Vergleich zur 3R4F-Kentucky Referenz-Zigarette

    Schwarz, Katharina

    2016  

    Author's details vorgelegt von Katharina Schwarz
    Subject code 610
    Language German
    Size IX, 97 Seiten, Illustrationen, Diagramme
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann-Wolfgang Goethe-Universität in Frankfurt am Main, 2017
    Note Zusammenfassung in deutscher und englischer Sprache ; Im Titel sind "10", "2,5", "1", "2" und "x" tiefgestellt
    HBZ-ID HT019417652
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 D 792 order for loan Magazin

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  3. Book ; Online ; Thesis: Zur Entstehung, Charakterisierung und diagnostischen Nutzbarkeit in der menschlichen Lunge endogen generierter exhalierter Aerosole

    Schwarz, Katharina

    2013  

    Author's details Katharina Schwarz
    Language German
    Publisher Universitätsbibliothek Clausthal
    Publishing place Clausthal-Zellerfeld
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Clausthal-Zellerfeld, Techn. Univ., Diss., 2012
    HBZ-ID HT018277950
    ISBN 978-394-39175-3-6 ; 394-39175-3-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Breeding options for nematode resistance in Lacaune dairy sheep.

    Werne, S / Schwarz, K / Thüer, S / Bapst, B

    Animal : an international journal of animal bioscience

    2023  Volume 17, Issue 5, Page(s) 100772

    Abstract: Due to progressing anthelmintic resistance of gastrointestinal nematodes (GIN), supportive measures are needed to control these parasites. In sheep, it has been shown that selection towards an increased nematode resistance is feasible and that faecal egg ...

    Abstract Due to progressing anthelmintic resistance of gastrointestinal nematodes (GIN), supportive measures are needed to control these parasites. In sheep, it has been shown that selection towards an increased nematode resistance is feasible and that faecal egg count (FEC) is the generally acknowledged trait for selection. However, a selection based on FEC would come with certain costs, therefore auxiliary, cheaper resistance traits would be most welcome. FAMACHA©, a colour classification of the eyelid, usually used to determine the manifestation of an infection with Haemonchus contortus, could serve as such. Therefore, we collected FAMACHA©, packed cell volume (PVC) and FEC phenotypes of approx. 1150 naturally infected Lacaune ewes on 15 commercial farms in Switzerland. The Haemonchus-proportion was determined on farm level. Phenotypic correlations of FEC and FAMACHA© as well as FAMACHA© and PCV were 0.25 (SE 0.03) and -0.35 (SE 0.08), respectively, and correspond well with the results of other studies. A multi-trait animal model was applied to estimate genetic parameters with FEC, FAMACHA©, PVC and milk yield as dependent variables. The heritabilities of FEC, FAMACHA©, PCV and milk yield were estimated to be moderate with values of 0.33 (SE 0.08), 0.30 (SE 0.08), 0.36 (SE 0.08) and 0.34 (SE 0.08), respectively. The genetic correlations between FEC and FAMACHA© and between FEC and PCV were estimated to be close to zero with values of 0.03 (SE 0.22) and 0.01 (SE 0.21), respectively. The average Haemonchus-proportion compared to other GIN was found to be 43%. The FAMACHA© classification of the Lacaune ewes seems to indicate a rather high worm challenge, with 38, 14 and 2% of observations classified to scores 3, 4 and 5, respectively. However, the worm challenge according to FEC was moderate. It has been suggested that the genetic correlation between FAMACHA© and FEC is more pronounced when FEC was high. It could therefore be that the lack of genetic correlation was due to an insufficient worm challenge, even though the Lacaune were grazing at least 70 days before phenotyping. The genetic correlation between FEC and milk yield was estimated to be 0.07 (SE 0.22, slightly unfavourable). We conclude that if FEC is used as trait, the Lacaune could be selected for lower susceptibility towards nematode infection. The use of FAMACHA© as an auxiliary trait for FEC is not feasible, due to an inexistent genetic correlation between these two traits.
    MeSH term(s) Animals ; Female ; Sheep/genetics ; Sheep Diseases/genetics ; Sheep Diseases/parasitology ; Nematoda ; Haemonchus ; Nematode Infections/genetics ; Nematode Infections/veterinary ; Nematode Infections/parasitology ; Milk ; Feces/parasitology ; Parasite Egg Count/veterinary ; Haemonchiasis/genetics ; Haemonchiasis/veterinary ; Haemonchiasis/parasitology
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2257920-5
    ISSN 1751-732X ; 1751-7311
    ISSN (online) 1751-732X
    ISSN 1751-7311
    DOI 10.1016/j.animal.2023.100772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7718: Show issues

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  5. Book ; Thesis: Risikofaktoren für Lepra in Nordostbrasilien

    Schwarz, Karolin / Lehmacher, Walter / Seifert, Harald

    gepaarte Fall-Kontroll-Studie

    2016  

    Institution Universität zu Köln / Institut für Medizinische Statistik, Informatik und Epidemiologie
    Author's details vorgelegt von Karolin Schwarz ; 1. Berichterstatter: Universitätsprofessor Dr. rer. nat. W. Lehmacher, 2. Berichterstatter: Universitätsprofessor Dr. med. H. Seifert ; aus dem Institut für Medizinische Statistik, Informatik und Epidemiologie der Universität zu Köln
    Language German
    Size 91 Seiten, Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Fakultät der Universität zu Köln, 2015
    HBZ-ID HT018943282
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 D 380 order for loan Magazin

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  6. Book ; Online ; Thesis: Risikofaktoren für Lepra in Nordostbrasilien

    Schwarz, Karolin / Lehmacher, Walter / Seifert, Harald

    gepaarte Fall-Kontroll-Studie

    2016  

    Institution Universität zu Köln / Institut für Medizinische Statistik, Informatik und Epidemiologie
    Author's details vorgelegt von Karolin Schwarz ; 1. Berichterstatter: Universitätsprofessor Dr. rer. nat. W. Lehmacher, 2. Berichterstatter: Universitätsprofessor Dr. med. H. Seifert ; aus dem Institut für Medizinische Statistik, Informatik und Epidemiologie der Universität zu Köln
    Subject code 610
    Language German
    Size 91 Seiten, Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Fakultät der Universität zu Köln, 2015
    HBZ-ID HT018875738
    DOI 10.4126/FRL01-006399669
    Database Repository for Life Sciences

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  7. Article ; Online: Synapse Dysfunctions in Multiple Sclerosis.

    Schwarz, Karin / Schmitz, Frank

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system (CNS) affecting nearly three million humans worldwide. In MS, cells of an auto-reactive immune system invade the brain and cause neuroinflammation. ... ...

    Abstract Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system (CNS) affecting nearly three million humans worldwide. In MS, cells of an auto-reactive immune system invade the brain and cause neuroinflammation. Neuroinflammation triggers a complex, multi-faceted harmful process not only in the white matter but also in the grey matter of the brain. In the grey matter, neuroinflammation causes synapse dysfunctions. Synapse dysfunctions in MS occur early and independent from white matter demyelination and are likely correlates of cognitive and mental symptoms in MS. Disturbed synapse/glia interactions and elevated neuroinflammatory signals play a central role. Glutamatergic excitotoxic synapse damage emerges as a major mechanism. We review synapse/glia communication under normal conditions and summarize how this communication becomes malfunctional during neuroinflammation in MS. We discuss mechanisms of how disturbed glia/synapse communication can lead to synapse dysfunctions, signaling dysbalance, and neurodegeneration in MS.
    MeSH term(s) Humans ; Multiple Sclerosis ; Neuroinflammatory Diseases ; Brain ; Synapses ; White Matter
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Exploring the relationship between context and obsessions in individuals with obsessive-compulsive disorder symptoms: a narrative review.

    Weiss, Franziska / Schwarz, Kristina / Endrass, Tanja

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1353962

    Abstract: Obsessions in obsessive-compulsive disorder (OCD) have long been proposed to differ from intrusive thoughts in unaffected individuals based on appraisal of the thoughts. However, more recent research indicates that cognitive processes behind obsessions ... ...

    Abstract Obsessions in obsessive-compulsive disorder (OCD) have long been proposed to differ from intrusive thoughts in unaffected individuals based on appraisal of the thoughts. However, more recent research indicates that cognitive processes behind obsessions may differ significantly from those in healthy individuals concerning their contextual relationship. This narrative literature review summarizes current evidence for the role of context-relatedness for obsessions in OCD and intrusive thoughts in affected and unaffected individuals. The review encompasses a total of five studies, two of which include individuals diagnosed with OCD (one study also includes a group of unaffected control individuals), while the other three studies investigate the relationship between OCD symptoms and context in unaffected individuals. As assessed by mainly self-reports, the review examines the connection between thoughts and their context, shedding light on how the repetition and automaticity of thoughts, as well as their detachment from context over time contribute to defining obsessions in contrast to intrusive thoughts. However, the link with context depends on the content of the obsessions. We propose the term "decontextualization of thoughts" to describe the phenomenon that obsessions gradually lose their connection with external context during the development of OCD. Future research should investigate whether this hypothesis can be supported by experimental evidence and identify whether this shift might be more likely a cause or a consequence of the disorder.
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1353962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Insights Into Electrophysiological Metrics of Cochlear Health in Cochlear Implant Users Using a Computational Model.

    Takanen, Marko / Strahl, Stefan / Schwarz, Konrad

    Journal of the Association for Research in Otolaryngology : JARO

    2024  Volume 25, Issue 1, Page(s) 63–78

    Abstract: Purpose: The hearing outcomes of cochlear implant users depend on the functional status of the electrode-neuron interface inside the cochlea. This can be assessed by measuring electrically evoked compound action potentials (eCAPs). Variations in ... ...

    Abstract Purpose: The hearing outcomes of cochlear implant users depend on the functional status of the electrode-neuron interface inside the cochlea. This can be assessed by measuring electrically evoked compound action potentials (eCAPs). Variations in cochlear neural health and survival are reflected in eCAP-based metrics. The difficulty in translating promising results from animal studies into clinical use has raised questions about to what degree eCAP-based metrics are influenced by non-neural factors. Here, we addressed these questions using a computational model.
    Methods: A 2-D computational model was designed to simulate how electrical signals from the stimulating electrode reach the auditory nerve fibers distributed along the cochlea, evoking action potentials that can be recorded as compound responses at the recording electrodes. Effects of physiologically relevant variations in neural survival and in electrode-neuron and stimulating-recording electrode distances on eCAP amplitude growth functions (AGFs) were investigated.
    Results: In line with existing literature, the predicted eCAP AGF slopes and the inter-phase gap (IPG) effects depended on the neural survival, but only when the IPG effect was calculated as the difference between the slopes of the two AGFs expressed in linear input-output scale. As expected, shallower eCAP AGF slopes were obtained for increased stimulating-recording electrode distance and larger eCAP thresholds for greater electrode-neuron distance. These non-neural factors had also minor interference on the predicted IPG effect.
    Conclusions: The model predictions demonstrate previously found dependencies of eCAP metrics on neural survival and non-neural aspects. The present findings confirm data from animal studies and provide insights into applying described metrics in clinical practice.
    MeSH term(s) Animals ; Cochlear Implants ; Cochlea ; Cochlear Implantation ; Cochlear Nerve ; Action Potentials
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021417-0
    ISSN 1438-7573 ; 1525-3961
    ISSN (online) 1438-7573
    ISSN 1525-3961
    DOI 10.1007/s10162-023-00924-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: New perspectives on 'Breathomics': metabolomic profiling of non-volatile organic compounds in exhaled breath using DI-FT-ICR-MS.

    Malik, Madiha / Demetrowitsch, Tobias / Schwarz, Karin / Kunze, Thomas

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 258

    Abstract: Breath analysis offers tremendous potential for diagnostic approaches, since it allows for easy and non-invasive sample collection. "Breathomics" as one major research field comprehensively analyses the metabolomic profile of exhaled breath providing ... ...

    Abstract Breath analysis offers tremendous potential for diagnostic approaches, since it allows for easy and non-invasive sample collection. "Breathomics" as one major research field comprehensively analyses the metabolomic profile of exhaled breath providing insights into various (patho)physiological processes. Recent research, however, primarily focuses on volatile compounds. This is the first study that evaluates the non-volatile organic compounds (nVOCs) in breath following an untargeted metabolomic approach. Herein, we developed an innovative method utilizing a filter-based device for metabolite extraction. Breath samples of 101 healthy volunteers (female n = 50) were analysed using DI-FT-ICR-MS and biostatistically evaluated. The characterisation of the non-volatile core breathome identified more than 1100 metabolites including various amino acids, organic and fatty acids and conjugates thereof, carbohydrates as well as diverse hydrophilic and lipophilic nVOCs. The data shows gender-specific differences in metabolic patterns with 570 significant metabolites. Male and female metabolomic profiles of breath were distinguished by a random forest approach with an out-of-bag error of 0.0099. Additionally, the study examines how oral contraceptives and various lifestyle factors, like alcohol consumption, affect the non-volatile breathome. In conclusion, the successful application of a filter-based device combined with metabolomics-analyses delineate a non-volatile breathprint laying the foundation for discovering clinical biomarkers in exhaled breath.
    MeSH term(s) Humans ; Male ; Female ; Volatile Organic Compounds/analysis ; Metabolomics/methods ; Exhalation ; Breath Tests/methods ; Biomarkers/analysis
    Chemical Substances Volatile Organic Compounds ; Biomarkers
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-024-05943-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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