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Buch ; Dissertation / Habilitation: Metaphysäre und epiphysäre Frakturen des distalen Humerus bei Kindern und Jugendlichen

Schwarz, Patricia Yasmin

klinische und epidemiologische Ergebnisse

2011

Verfasserangabe	vorgelegt von Patricia Yasmin Schwarz
Sprache	Deutsch
Umfang	124 S. : graph. Darst.
Erscheinungsland	Deutschland
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Tübingen, Univ., Diss., 2011
HBZ-ID	HT017096131
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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2012 D 44	bestellbar zur Ausleihe	Magazin

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Artikel ; Online: Development of an innovative analytical method for forensic detection of cocaine, antidepressants, and metabolites in postmortem blood using magnetic nanoparticles.

de Souza Schwarz, Patricia / Dos Santos, Bruno Pereira / Birk, Letícia / Eller, Sarah / de Oliveira, Tiago Franco

Analytical and bioanalytical chemistry

2024 Band 416, Heft 13, Seite(n) 3239–3250

Abstract: Cocaine and antidepressants rank high globally in substance consumption, emphasizing their impact on public health. The determination of these compounds and related substances in biological samples is crucial for forensic toxicology. This study focused ... ...

Abstract	Cocaine and antidepressants rank high globally in substance consumption, emphasizing their impact on public health. The determination of these compounds and related substances in biological samples is crucial for forensic toxicology. This study focused on developing an innovative analytical method for the determination of cocaine, antidepressants, and their related metabolites in postmortem blood samples, using unmodified commercial Fe
Mesh-Begriff(e)	Humans ; Cocaine/blood ; Cocaine/analogs & derivatives ; Antidepressive Agents/blood ; Tandem Mass Spectrometry/methods ; Forensic Toxicology/methods ; Solid Phase Extraction/methods ; Magnetite Nanoparticles/chemistry ; Chromatography, Liquid/methods ; Limit of Detection ; Substance Abuse Detection/methods ; Male ; Female ; Adult
Chemische Substanzen	Cocaine (I5Y540LHVR) ; Antidepressive Agents ; Magnetite Nanoparticles
Sprache	Englisch
Erscheinungsdatum	2024-04-04
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-024-05273-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online ; Dissertation / Habilitation: Analyse der Proteinkorona von thermosensitiven DPPG2-Liposomen

Schwarz, Patricia [Verfasser] / Lindner, Lars [Akademischer Betreuer]

2022

Verfasserangabe	Patricia Schwarz ; Betreuer: Lars Lindner
Schlagwörter	Medizin, Gesundheit ; Medicine, Health
Thema/Rubrik (Code)	sg610
Sprache	Deutsch
Verlag	Universitätsbibliothek der Ludwig-Maximilians-Universität
Erscheinungsort	München
Dokumenttyp	Buch ; Online ; Dissertation / Habilitation
Datenquelle	Digitale Dissertationen im Internet

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Artikel ; Online: Impact of crowded environments on binding between protein and single-stranded DNA.

Köhn, Birgit / Schwarz, Patricia / Wittung-Stafshede, Pernilla / Kovermann, Michael

Scientific reports

2021 Band 11, Heft 1, Seite(n) 17682

Abstract: The concept of Molecular Crowding depicts the high density of diverse molecules present in the cellular interior. Here, we determine the impact of low molecular weight and larger molecules on binding capacity of single-stranded DNA (ssDNA) to the cold ... ...

Abstract	The concept of Molecular Crowding depicts the high density of diverse molecules present in the cellular interior. Here, we determine the impact of low molecular weight and larger molecules on binding capacity of single-stranded DNA (ssDNA) to the cold shock protein B (CspB). Whereas structural features of ssDNA-bound CspB are fully conserved in crowded environments as probed by high-resolution NMR spectroscopy, intrinsic fluorescence quenching experiments reveal subtle changes in equilibrium affinity. Kinetic stopped-flow data showed that DNA-to-protein association is significantly retarded independent of choice of the molecule that is added to the solution, but dissociation depends in a nontrivial way on its size and chemical characteristics. Thus, for this DNA-protein interaction, excluded volume effect does not play the dominant role but instead observed effects are dictated by the chemical properties of the crowder. We propose that surrounding molecules are capable of specific modification of the protein's hydration shell via soft interactions that, in turn, tune protein-ligand binding dynamics and affinity.
Mesh-Begriff(e)	Cold Shock Proteins and Peptides/metabolism ; DNA, Single-Stranded/metabolism ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Protein Binding
Chemische Substanzen	Cold Shock Proteins and Peptides ; DNA, Single-Stranded
Sprache	Englisch
Erscheinungsdatum	2021-09-03
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-97219-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: All that glitters is not gold: an unusual presentation of S. aureus sepsis during ECMO.

Pellegrini, José Augusto Santos / Schwarz, Patrícia / Parolo, Édino / Cremonese, Ricardo Viegas

Intensive care medicine

2021 Band 47, Heft 6, Seite(n) 701

Mesh-Begriff(e)	Extracorporeal Membrane Oxygenation/adverse effects ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Sepsis/etiology ; Staphylococcus aureus
Sprache	Englisch
Erscheinungsdatum	2021-03-21
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-021-06366-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Effect of Cyproheptadine on Ventilatory Support-free Days in Critically Ill Patients with COVID-19: An Open-label, Randomized Clinical Trial.

Boniatti, Márcio Manozzo / Nedel, Wagner Luis / Rihl, Marcos Frata / Schwarz, Patricia / Parolo, Edino / Moretti, Miriane Melo Silveira / Lisboa, Thiago Costa

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2023 Band 27, Heft 7, Seite(n) 517–521

Abstract: Background: Serotonin is a mediator of pulmonary hypoxic vasoconstriction. Experimental studies have shown that serotonin-mediated pulmonary vasoconstriction can be inhibited by cyproheptadine. The aim of this study is to assess whether treatment with ... ...

Abstract	Background: Serotonin is a mediator of pulmonary hypoxic vasoconstriction. Experimental studies have shown that serotonin-mediated pulmonary vasoconstriction can be inhibited by cyproheptadine. The aim of this study is to assess whether treatment with cyproheptadine compared to usual care increases ventilatory support-free days during the first 28 days in patients with coronavirus disease 2019 (COVID-19) requiring ventilatory support. Materials and methods: This randomized, single-center, open-label clinical trial included patients who were admitted to the intensive care unit (ICU) requiring ventilatory support due to COVID-19. Patients allocated to the intervention group received cyproheptadine for 10 days. The primary outcome was ventilator-free days during the first 28 days. Results: Nineteen patients were randomized to receive cyproheptadine and 21 to the control group. The number of ventilatory support-free days during the first 28 days was not different between the two groups (15.0; 95% CI, 0.0-24.0 days in the control group vs 7.0; 95% CI, 0.0-19.0 days in the intervention group; Conclusion: In patients with COVID-19 and in need of ventilatory support, the use of cyproheptadine plus usual care, compared with usual care alone, did not increase the number of ventilatory support-free days in 28 days. How to cite this article: Boniatti MM, Nedel WL, Rihl MF, Schwarz P, Parolo E, Moretti MMS,
Sprache	Englisch
Erscheinungsdatum	2023-07-26
Erscheinungsland	India
Dokumenttyp	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-24482
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Diagnosis of Froin's Syndrome by Parallel Analysis of Ventriculoperitoneal Shunt and Lumbar Cerebrospinal Fluid in a Patient with Cervical Spinal Stenosis.

Fries, Franca Laura / Kleiser, Benedict / Schwarz, Patricia / Tieck, Maria P / Laichinger, Kornelia / Mengel, Annerose / Ziemann, Ulf / Kowarik, Markus C

Journal of clinical medicine

2023 Band 12, Heft 15

Abstract: Elevated protein levels in cerebrospinal fluid (CSF) can occur in various pathologies and are sometimes difficult to interpret. We report a 62-year-old male patient with subacute neurological deterioration, progressive tetraparesis, and cytoalbumin ... ...

Abstract	Elevated protein levels in cerebrospinal fluid (CSF) can occur in various pathologies and are sometimes difficult to interpret. We report a 62-year-old male patient with subacute neurological deterioration, progressive tetraparesis, and cytoalbumin dissociation in the lumbar CSF. The patient had a pre-existing cervical spinal stenosis with mild tetraparesis. Based on the initial cytoalbumin dissociation (protein 938 mg/dL, 4 leucocytes/µL), Guillain-Barré syndrome was initially considered. For further diagnosis, a CSF sample was taken from a pre-existing ventriculoperitoneal shunt, which showed a normal protein and cell count considering the patient's age (protein 70 mg/dL, 1 leucocyte/µL). In conclusion, we suggest that intermediate aggravation of tetraparesis was due to pneumonia with septic constellation, and the cytoalbumin dissociation was interpreted as Froin's syndrome (FS) due to spinal stenosis. In this unique case, we were able to prove the -often suspected- case of FS by parallel analysis of ventriculoperitoneal shunt and lumbar CSF. The triad of xanthochromia, high protein levels, and marked coagulation was first described by Georges Froin and occurs in various processes leading to severe spinal stenosis. The altered composition of lumbar CSF might be due to impaired CSF circulation; however, the exact mechanisms of this phenomenon require further investigation.
Sprache	Englisch
Erscheinungsdatum	2023-07-30
Erscheinungsland	Switzerland
Dokumenttyp	Case Reports
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12155012
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Association between prolonged corticosteroids use in COVID-19 and increased mortality in hospitalized patients: a retrospective study with inverse probability of treatment weighting analysis.

Viana, Marina Verçoza / Pellegrini, José Augusto Santos / Perez, Amanda Vilaverde / Schwarz, Patrícia / da Silva, Daiandy / Teixeira, Cassiano / Gazzana, Marcelo Basso / Rech, Tatiana Helena

Critical care (London, England)

2023 Band 27, Heft 1, Seite(n) 143

Abstract: Background: Previous studies have demonstrated a beneficial effect of early use of corticosteroids in patients with COVID-19. This study aimed to compare hospitalized patients with COVID-19 who received short-course corticosteroid treatment with those ... ...

Abstract	Background: Previous studies have demonstrated a beneficial effect of early use of corticosteroids in patients with COVID-19. This study aimed to compare hospitalized patients with COVID-19 who received short-course corticosteroid treatment with those who received prolonged-course corticosteroid treatment to determine whether prolonged use of corticosteroids improves clinical outcomes, including mortality. Methods: This is a retrospective cohort study including adult patients with positive testing for Sars-CoV-2 hospitalized for more than 10 days. Data were obtained from electronic medical records. Patients were divided into two groups, according to the duration of treatment with corticosteroids: a short-course (10 days) and a prolonged-course (longer than 10 days) group. Inverse probability treatment weighting (IPTW) analysis was used to evaluate whether prolonged use of corticosteroids improved outcomes. The primary outcome was in-hospital mortality. Secondary outcomes were hospital infection and the association of different doses of corticosteroids with hospital mortality. Restricted cubic splines were used to assess the nonlinear association between mortality and dose and duration of corticosteroids use. Results: We enrolled 1,539 patients with COVID-19. Among them, 1127 received corticosteroids for more than 10 days (prolonged-course group). The in-hospital mortality was higher in patients that received prolonged course corticosteroids (39.5% vs. 26%, p < 0.001). The IPTW revealed that prolonged use of corticosteroids significantly increased mortality [relative risk (RR) = 1.52, 95% confidence interval (95% CI): 1.24-1.89]. In comparison to short course treatment, the cubic spline analysis showed an inverted U-shaped curve for mortality, with the highest risk associated with the prolonged use at 30 days (RR = 1.50, 95% CI 1.21-1.78). Conclusions: Prolonged course of treatment with corticosteroids in hospitalized patients with COVID-19 was associated with higher mortality.
Mesh-Begriff(e)	Adult ; Humans ; COVID-19 ; Retrospective Studies ; SARS-CoV-2 ; Adrenal Cortex Hormones/therapeutic use ; Adrenal Cortex Hormones/pharmacology ; Probability
Chemische Substanzen	Adrenal Cortex Hormones
Sprache	Englisch
Erscheinungsdatum	2023-04-15
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-023-04434-5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A validated dilute-and-shoot LC-MS/MS urine screening for the analysis of 95 illicit drugs and medicines: insights from clinical and forensic Brazilian cases.

Pereira Dos Santos, Bruno / Birk, Letícia / Schwarz, Patrícia / Sebben, Viviane Cristina / Sgaravatti, Ângela Malysz / de Gouveia, Giovanna Cristiano / Petry, Adriana Ubirajara Silva / de Menezes, Francisco Paz / Gonzaga, Alexsandro Pinto / Schlickmann, Paula Flores / Arbo, Marcelo Dutra / de Oliveira, Tiago Franco / Eller, Sarah

Journal of analytical toxicology

2024

Abstract: Urine toxicological analysis is a relevant tool in both clinical and forensic scenarios, enabling the diagnosis of acute poisonings, elucidation of deaths, verification of substance use in the workplace, and identification of drug-facilitated crimes. For ...

Abstract	Urine toxicological analysis is a relevant tool in both clinical and forensic scenarios, enabling the diagnosis of acute poisonings, elucidation of deaths, verification of substance use in the workplace, and identification of drug-facilitated crimes. For these analyses, the dilute-and-shoot technique associated with liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS) is a promising alternative since it has demonstrated satisfactory results and broad applicability. This study developed and validated a comprehensive LC-MS-MS screening method to analyze 95 illicit drugs and medicines in urine samples and application to clinical and forensic Brazilian cases. The dilute-and-shoot protocol was defined through multivariate optimization studies and was set using 100 µL of sample and 300 µL of solvent. The total chromatographic run time was 7.5 minutes. The method was validated following the recommendations of the ANSI/ASB Standard 036 Guideline. The lower limits of quantification varied from 20 to 100 ng/mL. Within-run and between-run precision CVs% were lower than 20%, and bias was within ± 20%. Only four of the 95 analytes presented significant ionization suppression or enhancement (> 25%). As proof of applicability, 839 urine samples from in vivo and postmortem cases were analyzed. In total, 90.9% of the analyzed samples were positive for at least one substance, and 78 of the 95 analytes were detected. The most prevalent substances were lidocaine (40.2%), acetaminophen (38.0%), and benzoylecgonine (31.5%). The developed method proved to be an efficient and simplified alternative for analyzing 95 therapeutic and illicit drugs in urine samples. Additionally, the results obtained from sample analysis are essential to understanding the profile of Brazilian substance use, serving as a valuable database for the promotion of health and safety public policies.
Sprache	Englisch
Erscheinungsdatum	2024-02-08
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	752391-9
ISSN	1945-2403 ; 0146-4760
ISSN (online)	1945-2403
ISSN	0146-4760
DOI	10.1093/jat/bkae005
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Der Post-Merger-Integration-Prozess als Teil des Mergers & Acquisition-Prozesses

Schwarz, Patricia

Prozessmanagement in der Praxis : Wertschöpfungsketten planen, optimieren und erfolgreich steuern , p. 233-245

2008 , Seite(n) 233–245

Verfasserangabe	Patricia Schwarz
Schlagwörter	Übernahme ; Post-Merger-Integration ; Organisatorischer Wandel ; Synergie
Sprache	Deutsch
Umfang	Ill., graph. Darst.
Verlag	Gabler
Erscheinungsort	Wiesbaden
Dokumenttyp	Artikel
ISBN	978-383-49027-5-7 ; 383-49027-5-6
Datenquelle	ECONomics Information System

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