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Book ; Thesis: Effects of BDNF Val⁶⁶Met genotype and schizophrenia familial risk on an neural functional network for cognitive control using functional magnetic resonance imaging in humans

Schweiger, Janina / Meyer-Lindenberg, Andreas

2021

Institution	Universität Heidelberg
Author's details	vorgelegt von Janina Isabel Schweiger ; Doktorvater: Herr Prof. Dr. med. Andreas Meyer-Lindenberg
Language	English
Size	42 Blätter, Illustrationen, Diagramme, 30 cm
Publishing place	Heidelberg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
HBZ-ID	HT030043570
Database	Catalogue ZB MED Medicine, Health

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Article: [In process].

Schweiger, Janina

Pflege Zeitschrift

2017 Volume 70, Issue 6, Page(s) 18–21

MeSH term(s)	Disclosure ; Humans ; Information Management/organization & administration ; Interdisciplinary Communication ; Intersectoral Collaboration ; Nursing Staff, Hospital/organization & administration ; Patient Care Team/organization & administration ; Quality of Health Care/organization & administration ; Tertiary Care Centers/organization & administration ; United States ; Waiting Lists
Language	German
Publishing date	2017-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178530-5
ISSN	0945-1129
ISSN	0945-1129
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Kognitive Störungen und Schlafstörungen bei Long-COVID.

Schilling, Claudia / Meyer-Lindenberg, Andreas / Schweiger, Janina Isabel

Der Nervenarzt

2022 Volume 93, Issue 8, Page(s) 779–787

Abstract: Background: During the last 2 years of the coronavirus disease 2019 (COVID-19) pandemic, knowledge about the long-term effects of the disease, the so-called long COVID, has rapidly grown; however, many questions remain unanswered, especially regarding ... ...

Title translation	Cognitive disorders and sleep disturbances in long COVID.
Abstract	Background: During the last 2 years of the coronavirus disease 2019 (COVID-19) pandemic, knowledge about the long-term effects of the disease, the so-called long COVID, has rapidly grown; however, many questions remain unanswered, especially regarding the causes of persistent symptoms and their prognosis. Cognitive disorders and sleep disturbances are among the most frequent complaints. Both are associated with severe suffering and significant impairment in everyday functioning. Objective: What is known about the occurrence of cognitive disorders and sleep disturbances in long COVID? What are the influencing factors and what is known about the course over time and possible underlying mechanisms? What treatment options are available? Material and method: In a narrative review, the most important findings on cognitive disorders and sleep disturbances in long COVID are presented. An overview of cohort studies with data on the prevalence and influencing factors of both symptom complexes is given. Current knowledge and hypotheses on pathophysiological mechanisms are presented and an outlook on treatment approaches is given. Results: About one in five of those affected report cognitive impairment more than 3 months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and about one third report sleep disturbances. The latter comprise symptoms of insomnia as well as hypersomnia. Cognitive impairment and sleep disturbances occur in patients with all levels of initial disease severity. There are indications of an improvement of cognitive deficits over time but further longitudinal studies are needed. Conclusion: In addition to the prognosis, the underlying disease mechanisms are still insufficiently understood. Furthermore, there is a great need for research on the efficacy and specific effective factors of therapeutic interventions.
MeSH term(s)	COVID-19/complications ; Cognition ; Humans ; SARS-CoV-2 ; Sleep ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/therapy
Language	German
Publishing date	2022-05-16
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	123291-5
ISSN	1433-0407 ; 0028-2804
ISSN (online)	1433-0407
ISSN	0028-2804
DOI	10.1007/s00115-022-01297-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.MO 446: Show issues

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Article: Metakognitive Therapie (MCT)

Schweiger, Janina I. / Putschögl, Franziska / Winter, Lotta / Kahl, Kai G.

Verhaltenstherapie und Verhaltensmedizin

2023 Volume 44, Issue 3, Page(s) 302–318

Abstract: Die Metakognitive Therapie (MCT) wird den verhaltenstherapeutischen Methoden der dritten Welle zugeordnet. Ausgehend von der Prämisse, dass nicht dysfunktionale Denkinhalte für psychische Störungen verantwortlich sind, sondern die Art und Weise, wie wir ... ...

Title translation	Metacognitive therapy (MCT)
Abstract	Die Metakognitive Therapie (MCT) wird den verhaltenstherapeutischen Methoden der dritten Welle zugeordnet. Ausgehend von der Prämisse, dass nicht dysfunktionale Denkinhalte für psychische Störungen verantwortlich sind, sondern die Art und Weise, wie wir unsere Denkprozesse steuern und monitoren, entwickelte der Begründer Adrian Wells ein transdiagnostisches Therapiemodell, welches auf der Beeinflussbarkeit von Denkvorgängen und flexibler Aufmerksamkeitslenkung beruht (Wells, 2011). Dieses Modell sieht repetitive Denkprozesse wie Grübeln und Sich-Sorgen sowie eine verstärkte Lenkung der Aufmerksamkeit auf Bedrohungen als latente Faktoren, die psychische Erkrankungen bedingen und aufrechterhalten. Aufgrund verschiedener metakognitiver Überzeugungen werden diese repetitiven Denkprozesse von den Betroffenen aufrechterhalten, was langfristig zu einer Persistenz der psychischen Beschwerden führen kann. Durch den Beitrag von Ulrich Schweiger hat MCT auch im deutschsprachigen Raum Einzug erhalten und sich etabliert. Ihm ist es zu verdanken, dass die Umsetzbarkeit von MCT in Deutschland durch Machbarkeitsstudien und vergleichende Psychotherapiestudien sowie die neurobiologischen Grundlagen von Schlüsselelementen der MCT beforscht wurden.
Keywords	Metacognition ; Metakognition
Language	German
Document type	Article
ZDB-ID	1381082-0
ISSN	1865-9985
ISSN	1865-9985
Database	PSYNDEX

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Zs.MO 637: Show issues

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Article: Kognitive Störungen und Schlafstörungen bei Long-COVID

Schilling, Claudia / Meyer-Lindenberg, Andreas / Schweiger, Janina Isabel

Der Nervenarzt

2022 Volume 93, Issue 8, Page(s) 779–787

Abstract: Hintergrund: In den letzten 2 Jahren der COVID-19 ("coronavirus disease 2019")- Pandemie ist das Wissen um Langzeitfolgen der Erkrankung, das sog. "Long-COVID", rapide gewachsen. Es bleiben jedoch noch viele Fragen offen, v. a. was die Ursachen ... ...

Title translation	Cognitive disorders and sleep disturbances in long COVID
Abstract	Hintergrund: In den letzten 2 Jahren der COVID-19 ("coronavirus disease 2019")- Pandemie ist das Wissen um Langzeitfolgen der Erkrankung, das sog. "Long-COVID", rapide gewachsen. Es bleiben jedoch noch viele Fragen offen, v. a. was die Ursachen überdauernder Beschwerden und ihre Prognose betrifft. Kognitive Störungen und Schlafstörungen gehören zu den häufig beklagten Beschwerden. Beide gehen mit starkem Leidensdruck und deutlicher Alltagsbeeinträchtigung einher. Ziel der Arbeit: Wie ist die Datenlage zum Auftreten kognitiver Störungen und Schlafstörungen bei Long-COVID? Welches sind Einflussfaktoren und was ist bekannt zum Verlauf und zu möglichen zugrunde liegenden Mechanismen? Welche Therapieoptionen gibt es? Material und Methode: In einem narrativen Review werden die wichtigsten Befunde zu kognitiven Störungen und Schlafstörungen bei Long-COVID dargestellt. Es wird ein Überblick gegeben über die Kohortenstudien mit Daten zu Prävalenz und Einflussfaktoren beider Symptomkomplexe. Es werden derzeitige Kenntnisse und Hypothesen zu pathophysiologischen Mechanismen dargestellt und ein Ausblick auf Behandlungsansätze gegeben. Ergebnisse: Etwa ein Fünftel der Betroffenen berichtet mehr als 3 Monate nach einer SARS-CoV-2("severe acute respiratory syndrome coronavirus 2")-Infektion über kognitive Einschränkungen, etwa ein Drittel über Schlafstörungen, wobei es neben insomnischen auch zu hypersomnische Beschwerden kommt. Kognitive Störungen und Schlafstörungen treten bei Betroffenen aller Schweregrade auf. Es gibt Hinweise auf eine Besserung kognitiver Defizite im Verlauf, allerdings sind weitere Längsschnittstudien notwendig. Diskussion:Neben der Prognose sind die zugrunde liegenden Krankheitsmechanismen noch unzureichend verstanden. Zudem besteht großer Forschungsbedarf zur Wirksamkeit und zu spezifischen Wirkfaktoren therapeutischer Interventionen. (c) The Author(s), under exclusive licence to Springer Medizin Verlag GmbH
Keywords	COVID-19 ; Chronic Illness ; Chronische Krankheit ; Cognitive Impairment ; Disease Course ; Gedächtnisstörungen ; Hypersomnia ; Hypersomnie ; Insomnia ; Kognitive Beeinträchtigung ; Krankheitsverlauf ; Memory Disorders ; Pandemics ; Pandemie ; Schlaf-Wach-Störungen ; Schlaflosigkeit ; Sleep Wake Disorders
Language	German
Document type	Article
ZDB-ID	123291-5
ISSN	1433-0407 ; 0028-2804
ISSN (online)	1433-0407
ISSN	0028-2804
DOI	10.1007/s00115-022-01297-z
Database	PSYNDEX

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Article ; Online: Common Variation in the GTF2I Gene: A Promising Neurogenetic Mechanism for Affiliative Drive and Social Anxiety.

Schweiger, Janina I / Meyer-Lindenberg, Andreas

Biological psychiatry

2017 Volume 81, Issue 3, Page(s) 175–176

Language	English
Publishing date	2017-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2016.11.008
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Article: Innovation in Psychotherapy, Challenges, and Opportunities: An Opinion Paper.

Schweiger, Janina Isabel / Kahl, Kai G / Klein, Jan Philipp / Sipos, Valerija / Schweiger, Ulrich

Frontiers in psychology

2019 Volume 10, Page(s) 495

Abstract: Psychotherapy as a field tends toward conservativism, and the rate of innovation and development of new evidence-based effective treatments has been slow. The paper explores important barriers to innovation like the dodo bird verdict and the habit of ... ...

Abstract	Psychotherapy as a field tends toward conservativism, and the rate of innovation and development of new evidence-based effective treatments has been slow. The paper explores important barriers to innovation like the dodo bird verdict and the habit of starting the development of therapeutic methods from techniques. The paper looks at the opportunities for translating basic science in psychology into psychotherapeutic techniques. Metacognitive therapy stands out from other psychotherapies by its development from basic science. The paper describes the development of the techniques detached mindfulness and attention training, how they were derived from basic science and tested for their suitability in the therapy of patients with anxiety disorders. By this process, metacognitive therapy may be an important model for the innovation process in psychotherapy.
Language	English
Publishing date	2019-03-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2019.00495
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Article ; Online: Multimodal Associations of FKBP5 Methylation With Emotion-Regulatory Brain Circuits.

Biological psychiatry

2024

Abstract: Background: Understanding the biological processes that underlie individual differences in emotion regulation and stress responsivity is a key challenge for translational neuroscience. The gene FKBP5 is a core regulator in molecular stress signaling ... ...

Abstract	Background: Understanding the biological processes that underlie individual differences in emotion regulation and stress responsivity is a key challenge for translational neuroscience. The gene FKBP5 is a core regulator in molecular stress signaling that is implicated in the development of psychiatric disorders. However, it remains unclear how FKBP5 DNA methylation in peripheral blood is related to individual differences in measures of neural structure and function and their relevance to daily-life stress responsivity. Methods: Here, we characterized multimodal correlates of FKBP5 DNA methylation by combining epigenetic data with neuroimaging and ambulatory assessment in a sample of 395 healthy individuals. Results: First, we showed that FKBP5 demethylation as a psychiatric risk factor was related to an anxiety-associated reduction of gray matter volume in the ventromedial prefrontal cortex, a brain area that is involved in emotion regulation and mental health risk and resilience. This effect of epigenetic upregulation of FKBP5 on neuronal structure is more pronounced where FKBP5 is epigenetically downregulated at baseline. Leveraging 208 functional magnetic resonance imaging scans during a well-established emotion-processing task, we found that FKBP5 DNA methylation in peripheral blood was associated with functional differences in prefrontal-limbic circuits that modulate affective responsivity to daily stressors, which we measured using ecological momentary assessment in daily life. Conclusions: Overall, we demonstrated how FKBP5 contributes to interindividual differences in neural and real-life affect regulation via structural and functional changes in prefrontal-limbic brain circuits.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2024.03.003
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Article ; Online: Effective connectivity during face processing in major depression - distinguishing markers of pathology, risk, and resilience.

Sacu, Seda / Wackerhagen, Carolin / Erk, Susanne / Romanczuk-Seiferth, Nina / Schwarz, Kristina / Schweiger, Janina I / Tost, Heike / Meyer-Lindenberg, Andreas / Heinz, Andreas / Razi, Adeel / Walter, Henrik

Psychological medicine

2022 Volume 53, Issue 9, Page(s) 4139–4151

Abstract: Background: Aberrant brain connectivity during emotional processing, especially within the fronto-limbic pathway, is one of the hallmarks of major depressive disorder (MDD). However, the methodological heterogeneity of previous studies made it difficult ...

Abstract	Background: Aberrant brain connectivity during emotional processing, especially within the fronto-limbic pathway, is one of the hallmarks of major depressive disorder (MDD). However, the methodological heterogeneity of previous studies made it difficult to determine the functional and etiological implications of specific alterations in brain connectivity. We previously reported alterations in psychophysiological interaction measures during emotional face processing, distinguishing depressive pathology from at-risk/resilient and healthy states. Here, we extended these findings by effective connectivity analyses in the same sample to establish a refined neural model of emotion processing in depression. Methods: Thirty-seven patients with MDD, 45 first-degree relatives of patients with MDD and 97 healthy controls performed a face-matching task during functional magnetic resonance imaging. We used dynamic causal modeling to estimate task-dependent effective connectivity at the subject level. Parametric empirical Bayes was performed to quantify group differences in effective connectivity. Results: MDD patients showed decreased effective connectivity from the left amygdala and left lateral prefrontal cortex to the fusiform gyrus compared to relatives and controls, whereas patients and relatives showed decreased connectivity from the right orbitofrontal cortex to the left insula and from the left orbitofrontal cortex to the right fusiform gyrus compared to controls. Relatives showed increased connectivity from the anterior cingulate cortex to the left dorsolateral prefrontal cortex compared to patients and controls. Conclusions: Our results suggest that the depressive state alters top-down control of higher visual regions during face processing. Alterations in connectivity within the cognitive control network present potential risk or resilience mechanisms.
MeSH term(s)	Humans ; Depressive Disorder, Major/diagnostic imaging ; Depression ; Facial Recognition ; Bayes Theorem ; Brain Mapping ; Brain ; Magnetic Resonance Imaging
Language	English
Publishing date	2022-04-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291722000824
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Article ; Online: Brain structural correlates of upward social mobility in ethnic minority individuals.

Schweiger, Janina I / Capraz, Necip / Akdeniz, Ceren / Braun, Urs / Ebalu, Tracie / Moessnang, Carolin / Berhe, Oksana / Zang, Zhenxiang / Schwarz, Emanuel / Bilek, Edda / Meyer-Lindenberg, Andreas / Tost, Heike

Social psychiatry and psychiatric epidemiology

2021 Volume 57, Issue 10, Page(s) 2037–2047

Abstract: Purpose: Perigenual anterior cingulate cortex (pACC) is a neural convergence site for social stress-related risk factors for mental health, including ethnic minority status. Current social status, a strong predictor of mental and somatic health, has ... ...

Abstract	Purpose: Perigenual anterior cingulate cortex (pACC) is a neural convergence site for social stress-related risk factors for mental health, including ethnic minority status. Current social status, a strong predictor of mental and somatic health, has been related to gray matter volume in this region, but the effects of social mobility over the lifespan are unknown and may differ in minorities. Recent studies suggest a diminished health return of upward social mobility for ethnic minority individuals, potentially due to sustained stress-associated experiences and subsequent activation of the neural stress response system. Methods: To address this issue, we studied an ethnic minority sample with strong upward social mobility. In a cross-sectional design, we examined 64 young adult native German and 76 ethnic minority individuals with comparable sociodemographic attributes using whole-brain structural magnetic resonance imaging. Results: Results showed a significant group-dependent interaction between perceived upward social mobility and pACC gray matter volume, with a significant negative association in the ethnic minority individuals. Post-hoc analysis showed a significant mediation of the relationship between perceived upward social mobility and pACC volume by perceived chronic stress, a variable that was significantly correlated with perceived discrimination in our ethnic minority group. Conclusion: Our findings extend prior work by pointing to a biological signature of the "allostatic costs" of socioeconomic attainment in socially disadvantaged upwardly mobile individuals in a key neural node implicated in the regulation of stress and negative affect.
MeSH term(s)	Cross-Sectional Studies ; Ethnic and Racial Minorities ; Ethnicity ; Gyrus Cinguli ; Humans ; Minority Groups/psychology ; Social Mobility ; Young Adult
Language	English
Publishing date	2021-08-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	623071-4
ISSN	1433-9285 ; 0037-7813 ; 0933-7954
ISSN (online)	1433-9285
ISSN	0037-7813 ; 0933-7954
DOI	10.1007/s00127-021-02163-0
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