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  1. Article ; Online: Evaluation of honokiol, magnolol and of a library of new nitrogenated neolignans as pancreatic lipase inhibitors.

    Sciacca, Claudia / Cardullo, Nunzio / Pulvirenti, Luana / Di Francesco, Antonella / Muccilli, Vera

    Bioorganic chemistry

    2023  Volume 134, Page(s) 106455

    Abstract: Obesity is a complex disease defined as an excessive amount of body fat. It is considered a risk factor for several pathologies; therefore, there is an increasing interest in its treatment. Pancreatic lipase (PL) plays a key role in fat digestion, and ... ...

    Abstract Obesity is a complex disease defined as an excessive amount of body fat. It is considered a risk factor for several pathologies; therefore, there is an increasing interest in its treatment. Pancreatic lipase (PL) plays a key role in fat digestion, and its inhibition is a preliminary step in the search for anti-obesity agents. For this reason, many natural compounds and their derivatives are studied as new PL inhibitors. This study reports the synthesis of a library of new compounds inspired by two natural neolignans, honokiol (1) and magnolol (2) and bearing amino or nitro groups linked to a biphenyl core. The synthesis of unsymmetrically substituted biphenyls was achieved through an optimisation of the Suzuki-Miyaura cross-coupling reaction followed by the insertion of allyl chains, thus furnishing the O- and/or N-allyl derivatives, and finally, a sigmatropic rearrangement yielding in some cases, the C-allyl analogues. Magnolol, honokiol and the twenty-one synthesised biphenyls were evaluated for their in vitro inhibitory activity toward PL. Three compounds (15b, 16 and 17b) were more effective inhibitors than the natural neolignans (magnolol IC
    MeSH term(s) Lignans/chemistry ; Biphenyl Compounds/pharmacology ; Biphenyl Compounds/chemistry
    Chemical Substances magnolol (001E35HGVF) ; honokiol (11513CCO0N) ; diphenyl (2L9GJK6MGN) ; Lignans ; Biphenyl Compounds
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Serological and Molecular Evidence of Pathogenic

    Grippi, Francesca / Cannella, Vincenza / Macaluso, Giusi / Blanda, Valeria / Emmolo, Giovanni / Santangelo, Francesco / Vicari, Domenico / Galluzzo, Paola / Sciacca, Carmela / D'Agostino, Rosalia / Giacchino, Ilenia / Bertasio, Cristina / D'Incau, Mario / Guercio, Annalisa / Torina, Alessandra

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: Leptospirosis is a zoonosis of public health concern. Its prevalence in stray animals in the South of Italy is unknown. This study aimed to ... ...

    Abstract Leptospirosis is a zoonosis of public health concern. Its prevalence in stray animals in the South of Italy is unknown. This study aimed to investigate
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020385
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  3. Article ; Online: A Canine Leptospirosis Clinical Case Due to

    Grippi, Francesca / Blanda, Valeria / Galluzzo, Paola / Bongiorno, Manuel / Sciacca, Carmela / Arcuri, Francesca / D'Agostino, Rosalia / Giacchino, Ilenia / Gucciardi, Francesca / D'Incau, Mario / Bertasio, Cristina / Torina, Alessandra / Guercio, Annalisa

    Veterinary sciences

    2023  Volume 10, Issue 8

    Abstract: Leptospirosis is a worldwide widespread zoonosis caused ... ...

    Abstract Leptospirosis is a worldwide widespread zoonosis caused by
    Language English
    Publishing date 2023-08-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci10080508
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  4. Article ; Online: Seroprevalence of Coxiella burnetii in dairy cattle from Sicily.

    Galluzzo, Paola / Villari, Sara / Geraci, Francesco / Sciacca, Carmela / Grippi, Francesca / Currò, Vittoria / Chiarenza, Giuseppina

    Veterinaria italiana

    2019  Volume 55, Issue 3, Page(s) 247–252

    Abstract: Q fever is a widespread zoonotic disease caused by Coxiella burnetii, an obligate intracellular bacterium with a wide range of hosts. The aim of this study was to estimate the seroprevalence of C. burnetii infection in cattle in Sicilian farms. A total ... ...

    Abstract Q fever is a widespread zoonotic disease caused by Coxiella burnetii, an obligate intracellular bacterium with a wide range of hosts. The aim of this study was to estimate the seroprevalence of C. burnetii infection in cattle in Sicilian farms. A total of 4,661 serum samples, from cattle belonging to 198 Sicilian farms, were examined by ELISA test and 246 resulted positive. The average seroprevalence at the farm level was 38.8% (77/198) (95% CI), while at the animal level it was 5.28% (246/4,661) (95% CI). The present study highlights the need for continuous monitoring of C. burnetii spread as it represents a serious risk for human health.
    MeSH term(s) Animals ; Cattle ; Cattle Diseases/epidemiology ; Cattle Diseases/microbiology ; Coxiella burnetii/isolation & purification ; Humans ; Q Fever/blood ; Q Fever/epidemiology ; Q Fever/veterinary ; Seroepidemiologic Studies ; Sicily/epidemiology ; Zoonoses
    Language English
    Publishing date 2019-09-20
    Publishing country Italy
    Document type Journal Article
    ISSN 1828-1427
    ISSN (online) 1828-1427
    DOI 10.12834/VetIt.1391.7602.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Leptospira

    Macaluso, Giusi / Torina, Alessandra / Blanda, Valeria / Guercio, Annalisa / Lastra, Antonio / Giacchino, Ilenia / D'Agostino, Rosalia / Sciacca, Carmela / D'Incau, Mario / Bertasio, Cristina / Grippi, Francesca

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 5

    Abstract: Leptospirosis is a re-emerging zoonosis of worldwide significance; a wide spectrum of wild and domestic animal species act as natural or accidental hosts. Swine can act as maintenance or accidental hosts of ... ...

    Abstract Leptospirosis is a re-emerging zoonosis of worldwide significance; a wide spectrum of wild and domestic animal species act as natural or accidental hosts. Swine can act as maintenance or accidental hosts of pathogenic
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12050585
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  6. Article ; Online: Leptospira interrogans

    Aliberti, Antonino / Blanda, Valeria / Di Marco Lo Presti, Vincenzo / Macaluso, Giusi / Galluzzo, Paola / Bertasio, Cristina / Sciacca, Carmela / Arcuri, Francesca / D'Agostino, Rosalia / Ippolito, Dorotea / Pruiti Ciarello, Flavia / Torina, Alessandra / Grippi, Francesca

    Veterinary sciences

    2022  Volume 9, Issue 2

    Abstract: Bovine leptospirosis is an infectious zoonotic disease causing reproductive problems and economic losses in livestock. This work reports, for the first time in Sicily (South Italy), an outbreak ... ...

    Abstract Bovine leptospirosis is an infectious zoonotic disease causing reproductive problems and economic losses in livestock. This work reports, for the first time in Sicily (South Italy), an outbreak of
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci9020083
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  7. Article ; Online: Occurrence and risk factors of Coxiella burnetii in domestic ruminants in Lebanon.

    Dabaja, M F / Greco, G / Villari, S / Vesco, G / Bayan, A / Bazzal, B El / Ibrahim, E / Gargano, V / Sciacca, C / Lelli, R / Ezzedine, M / Mortada, H / Tempesta, M / Mortada, M

    Comparative immunology, microbiology and infectious diseases

    2019  Volume 64, Page(s) 109–116

    Abstract: Coxiella burnetii causes diseases in humans (Q fever) and animals, domestic ruminants playing a major role in the epidemiology of the infection. Information on C. burnetii infection in Lebanon is scanty. In order to assess the prevalence of C. burnetii ... ...

    Abstract Coxiella burnetii causes diseases in humans (Q fever) and animals, domestic ruminants playing a major role in the epidemiology of the infection. Information on C. burnetii infection in Lebanon is scanty. In order to assess the prevalence of C. burnetii infection in ruminants, a cross-sectional study was undertaken in 2014. A total of 1633 sera from ruminants (865 cattle, 384 sheep and 384 goats) from 429 farms (173 cattle, 128 sheep and 128 goats), in seven provinces of Lebanon were randomly selected and assayed for the presence of antibodies. 39.86% of farms (95% CI: 35.23-44.56) resulted positive. The seroprevalence was 30.63% in Cattle-farms, 46.88% in sheep-farms and 45.31% in goat-farms. Milk samples collected from 282 seropositive animals (86 cows, 93 sheep and 103 goats) from 171 positive farms were tested by a high sensitive Real-Time PCR targeted to the IS1111 transposon of C. burnetii. The overall prevalence in farms was estimated to be 14.04%. Cattle-, sheep- and goat farm prevalence rates were 15.09%, 10% and 17.24%, respectively. The findings of the study show that C. burnetii prevalence in Lebanese domestic ruminants is related to animal species and farming practices. Indeed, the mixed herds with sheep (p < 0.01), the presence of common lambing/kidding areas (p < 0.001) in farms where the use of disinfectants was not a routine practice (p < 0.05) were identified as important risk factors. The results of the study provide baseline information for setting up herd management and public health measures for the prevention and control of Q fever in Lebanon.
    MeSH term(s) Animals ; Antibodies, Bacterial/blood ; Bacterial Proteins/genetics ; Cattle ; Cattle Diseases/epidemiology ; Coxiella burnetii/genetics ; Coxiella burnetii/isolation & purification ; Cross-Sectional Studies ; Farms ; Goat Diseases/epidemiology ; Goats ; Lebanon/epidemiology ; Milk/microbiology ; Prevalence ; Q Fever/epidemiology ; Q Fever/veterinary ; Real-Time Polymerase Chain Reaction ; Risk Factors ; Ruminants/microbiology ; Seroepidemiologic Studies ; Sheep ; Sheep Diseases/epidemiology
    Chemical Substances Antibodies, Bacterial ; Bacterial Proteins
    Language English
    Publishing date 2019-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2019.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1443: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: Leptospira Interrogans

    Grippi, Francesca / Giudice, Elisabetta / Pietro, Simona Di / Sciacca, Carmela / Santangelo, Francesco / Galluzzo, Paola / Barreca, Santino / Guercio, Annalisa

    Journal of veterinary research

    2020  Volume 64, Issue 1, Page(s) 73–78

    Abstract: Introduction: The aim of this study was to present two outbreaks of bovine abortion due to : Material and methods: A total of 23 Charolaise cows (farm A) and 75 Limousine bulls and Cinisara and Modicana cows (farm B) were enrolled in this study. The ... ...

    Abstract Introduction: The aim of this study was to present two outbreaks of bovine abortion due to
    Material and methods: A total of 23 Charolaise cows (farm A) and 75 Limousine bulls and Cinisara and Modicana cows (farm B) were enrolled in this study. The blood samples were collected from all subjects at the following time points: before a cycle of intramuscular treatment with oxytetracycline dihydrate (T0), after 5-6 weeks from the treatment (T1), and every 10 weeks until seronegativisation (T2 in Farm A and T3 in Farm B). A serological test (MAT) was used for the diagnosis of leptospirosis.
    Results: Two samples from farm A (2/23) and 29 samples from farm B (29/75) were positive to
    Conclusion: It is important to use serological and molecular diagnostic techniques complementarily to identify infected individuals.
    Language English
    Publishing date 2020-03-24
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2855010-9
    ISSN 2450-8608 ; 2450-7393
    ISSN (online) 2450-8608
    ISSN 2450-7393
    DOI 10.2478/jvetres-2020-0021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Long-term Inhibition of Soleus H-reflex with Epidural Adhesiolysis and Pulsed Radiofrequency in Lumbosacral Neuropathic Pain.

    Vigneri, Simone / Sindaco, Gianfranco / La Grua, Marco / Zanella, Matteo / Paci, Valentina / Vinci, Francesca Maria / Sciacca, Chiara / Merlini, Alberto / Pari, Gilberto

    Pain practice : the official journal of World Institute of Pain

    2020  Volume 21, Issue 3, Page(s) 277–284

    Abstract: Introduction: Scientific data about neurophysiological changes subsequent to pulsed radiofrequency (PRF) are still lacking. The goal of this study was to evaluate sural nerve conduction and Hoffmann reflex (H-reflex) in soleus muscle following ... ...

    Abstract Introduction: Scientific data about neurophysiological changes subsequent to pulsed radiofrequency (PRF) are still lacking. The goal of this study was to evaluate sural nerve conduction and Hoffmann reflex (H-reflex) in soleus muscle following adhesiolysis and PRF in patients with unilateral chronic lumbosacral L5-S1 neuropathic radiating pain.
    Methods: Seventeen patients received two cycles of 240 seconds high-voltage PRF and epidural adhesiolysis. Sural nerve action potential (SNAP) and the ratio of maximum H-reflex to maximum M response (H/M ratio) as well as pain scores were collected in both lower limbs before, immediately following, and 1 month after the treatment.
    Results: At follow-up, a significant reduction in numeric rating scale (NRS) and Douleur Neuropathique 4 Questions (DN4) scores was observed in 53% of patients reporting pain improvement of ≥ 30% over baseline. The H/M ratio was decreased in the affected limb following PRF (P = 0.01) and 1 month after the treatment (P = 0.04). A direct correlation was observed between H/M ratio variation and NRS score at follow-up in the treated limb (P = 0.04). No significant difference in sural nerve latency, amplitude, and velocity was detected between affected and normal side after treatment and at follow-up.
    Conclusions: Epidural adhesiolysis and PRF of the dorsal root ganglion seem to significantly affect spinal reflexes in patients with lumbosacral neuropathic radiating pain.
    MeSH term(s) Adult ; Aged ; Epidural Space ; Female ; Follow-Up Studies ; Ganglia, Spinal/physiopathology ; Ganglia, Spinal/radiation effects ; Humans ; Italy ; Lumbosacral Region ; Male ; Middle Aged ; Muscle, Skeletal/innervation ; Muscle, Skeletal/physiopathology ; Neural Inhibition/physiology ; Neuralgia/physiopathology ; Neuralgia/therapy ; Pain Management/methods ; Pulsed Radiofrequency Treatment/methods ; Reflex/physiology ; Tissue Adhesions/pathology ; Tissue Adhesions/therapy ; Treatment Outcome
    Language English
    Publishing date 2020-10-25
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2151272-3
    ISSN 1533-2500 ; 1530-7085
    ISSN (online) 1533-2500
    ISSN 1530-7085
    DOI 10.1111/papr.12955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5928: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Book ; Thesis: Finding the right words

    Di Sciacca, Claudia

    Isidore's Synonyma in Anglo-Saxon England

    (Toronto Old English series ; 19)

    2008  

    Author's details Claudia Di Sciacca
    Series title Toronto Old English series ; 19
    Keywords Devotional literature, Latin (Medieval and modern) ; Devotional literature, Latin (Medieval and modern)/History and criticism ; English prose literature/History and criticism ; Spirituality/History
    Language English
    Size XVI, 323 S.
    Publisher Univ. of Toronto Press
    Publishing place Toronto u.a.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Cambridge, 2002
    ISBN 0802091296 ; 9780802091291
    Database Former special subject collection: coastal and deep sea fishing

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